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The map label for this gene is sdhA [H]

Identifier: 88607253

GI number: 88607253

Start: 159802

End: 161616

Strand: Direct

Name: sdhA [H]

Synonym: APH_0158

Alternate gene names: 88607253

Gene position: 159802-161616 (Clockwise)

Preceding gene: 88607286

Following gene: 88606897

Centisome position: 10.86

GC content: 45.95

Gene sequence:

>1815_bases
GTGATTGAAGTGTCTAGATCCGCATACGAAGTTGTGGACCATGAGTATGACGTGGTTGTTGTTGGTGCGGGTGGTGCAGG
ATTGCGCGCTGTAGTGGGTATGACGGCAGCGGGTCTTTCGGTTGCGTGCGTTACTAAAGTATTTCCAACACGGAGCCACA
CTGTTGCTGCACAAGGTGGTATTAGCGCTGCGTTGGGTAATATAGCAGAAGATGATTGGCGATGGCACATGTTCGATACA
GTCAAGGGTTCTGATTGGCTAGGTGATCAGGATGCGATTGAGTACATGTGTAAGAATGCTATGCAGTCCGTTGTGGAGCT
TGAGCATTGTGGAGTGCCTTTCTCTAGAACTAAGGAAGGTAAGATATATCAGCGTCCTTTTGGTGGGATGACAACTGAAT
ACGGCAAGGGTAAGCCTGCAGTACGTACATGTGCTGCATCAGATAAAACAGGACATGCTATATTGCATGCTTTGTATCAG
CAGTCTTTGAGGTTTGATGCGAAGTTTTTCGTCGAGTACTTCGCAATAGACTTGATAATGAGTGAAGATAATCGGTCATG
TTGTGGGGTGTTGGCATGGTCTTTGTGCGATGGTGTTTTACATAGATTTCGTGCTCATGCAGTAGTTTTAGCTACTGGTG
GGTATGGGCGTGTATATTTTTCTGCAACTAGCGCACATACATGTACTGGAGATGGTGGTGGAATGGCGGCAAGGGCTGGT
ATTCCGCTTGAGGATATGGAATTTGTGCAATTTCACCCTACGGGCATATATGGTTCTGGGTGCTTGATGACAGAAGGCTG
CCGTGGTGAAGGGGGCTACTTGCTGAATTCTGCTGGGGAGAGATTTATGGAGCGATATGCTCCAAAGGCAAAGGACTTGG
CTTCGCGTGATGTTGTAAGTCGTTCAATGACTATGGAGATACGTGAAGGCAGGGGAGTAGGTGAGAAGAAGGATCACATA
TATTTGTCTATTGCGCATCTAGATCCTAAAGTAATCCATGAGAGGCTTCCTGGTATAAGTGAAACAGCGAAGACGTTTGC
TGGTGTTGATGTTACTAAGGAGCCAATACCGGTGATTCCTACGGTTCACTACAACATGGGTGGTATCCCTACTAACTATC
ACGGAGAGGTTCTATCATTAAATAGCAGTAGTGGAAGTTACGAAGTGGTAGAGGGTTTATTTGCTATAGGTGAAGCCGCT
TGTGTATCTGTACATGGTGCGAATCGTTTAGGGTCGAATTCTCTATTGGATTTGGTGGTATTTGGACGAGCAGCTGCGAT
AAGGGCGAAAGAGGTTATAAAGCCTGGAGGTTTGCATAGACCTATTAGGAAGGATTTTGAAGATAGTATAATAGATAGAT
TTGATCGCATGCGTTACGCTAACGGTGCTACGAGGGTTGCGGAGATACGTAGTCGTATGCAAAATGTGATGCAGGAGCAT
GCTGCAGTATTCCGTGTTGCGGAGGTGCTAGAGAAGGGTAAAAAGGAGATCAGGGGAGTTGCCGCAATGATGAAAGATAT
TTCGGTAACTGATAGGAGTATGGTCTGGAACAGCGATCTGGTAGAGGCATTAGAGCTATCGAATATGATGCCGCAAGCTG
TAGTGACTGTAGATTGTGCTGCAAATCGAAAGGAGAGCAGGGGTGCGCATGCGCGGGAAGATTTCCCAGAGCGTGATGAT
GAAAATTGGATGAAGCATACGATGGCGTGGTGTAACTGCGATACGTATGAAGTGAAGATAGGCTATAAAGAGGTAGCTAC
TTATACTTTGACAAATGAAGTAGAGTATTTTCCTCCGCAGAAAAGGGTTTATTAG

Upstream 100 bases:

>100_bases
GGCTTGACTAACGTTTCTTAAGTTCTAAACGAGTTCAAAGTTGTGTTGACTCCATAGGGGATTGTGGTAGCCTAAAAGTA
GTTCCAGTTAAGTTATCAGT

Downstream 100 bases:

>100_bases
AGAGGGTTAATAATATGGTGCAGTTTTCTTTGCCAAAAAACTCCAAGATAAACCCGAATGGTAAGGTATACAATGCTACG
GAGGGTGCTAAGCGCACTGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MIEVSRSAYEVVDHEYDVVVVGAGGAGLRAVVGMTAAGLSVACVTKVFPTRSHTVAAQGGISAALGNIAEDDWRWHMFDT
VKGSDWLGDQDAIEYMCKNAMQSVVELEHCGVPFSRTKEGKIYQRPFGGMTTEYGKGKPAVRTCAASDKTGHAILHALYQ
QSLRFDAKFFVEYFAIDLIMSEDNRSCCGVLAWSLCDGVLHRFRAHAVVLATGGYGRVYFSATSAHTCTGDGGGMAARAG
IPLEDMEFVQFHPTGIYGSGCLMTEGCRGEGGYLLNSAGERFMERYAPKAKDLASRDVVSRSMTMEIREGRGVGEKKDHI
YLSIAHLDPKVIHERLPGISETAKTFAGVDVTKEPIPVIPTVHYNMGGIPTNYHGEVLSLNSSSGSYEVVEGLFAIGEAA
CVSVHGANRLGSNSLLDLVVFGRAAAIRAKEVIKPGGLHRPIRKDFEDSIIDRFDRMRYANGATRVAEIRSRMQNVMQEH
AAVFRVAEVLEKGKKEIRGVAAMMKDISVTDRSMVWNSDLVEALELSNMMPQAVVTVDCAANRKESRGAHAREDFPERDD
ENWMKHTMAWCNCDTYEVKIGYKEVATYTLTNEVEYFPPQKRVY

Sequences:

>Translated_604_residues
MIEVSRSAYEVVDHEYDVVVVGAGGAGLRAVVGMTAAGLSVACVTKVFPTRSHTVAAQGGISAALGNIAEDDWRWHMFDT
VKGSDWLGDQDAIEYMCKNAMQSVVELEHCGVPFSRTKEGKIYQRPFGGMTTEYGKGKPAVRTCAASDKTGHAILHALYQ
QSLRFDAKFFVEYFAIDLIMSEDNRSCCGVLAWSLCDGVLHRFRAHAVVLATGGYGRVYFSATSAHTCTGDGGGMAARAG
IPLEDMEFVQFHPTGIYGSGCLMTEGCRGEGGYLLNSAGERFMERYAPKAKDLASRDVVSRSMTMEIREGRGVGEKKDHI
YLSIAHLDPKVIHERLPGISETAKTFAGVDVTKEPIPVIPTVHYNMGGIPTNYHGEVLSLNSSSGSYEVVEGLFAIGEAA
CVSVHGANRLGSNSLLDLVVFGRAAAIRAKEVIKPGGLHRPIRKDFEDSIIDRFDRMRYANGATRVAEIRSRMQNVMQEH
AAVFRVAEVLEKGKKEIRGVAAMMKDISVTDRSMVWNSDLVEALELSNMMPQAVVTVDCAANRKESRGAHAREDFPERDD
ENWMKHTMAWCNCDTYEVKIGYKEVATYTLTNEVEYFPPQKRVY
>Mature_604_residues
MIEVSRSAYEVVDHEYDVVVVGAGGAGLRAVVGMTAAGLSVACVTKVFPTRSHTVAAQGGISAALGNIAEDDWRWHMFDT
VKGSDWLGDQDAIEYMCKNAMQSVVELEHCGVPFSRTKEGKIYQRPFGGMTTEYGKGKPAVRTCAASDKTGHAILHALYQ
QSLRFDAKFFVEYFAIDLIMSEDNRSCCGVLAWSLCDGVLHRFRAHAVVLATGGYGRVYFSATSAHTCTGDGGGMAARAG
IPLEDMEFVQFHPTGIYGSGCLMTEGCRGEGGYLLNSAGERFMERYAPKAKDLASRDVVSRSMTMEIREGRGVGEKKDHI
YLSIAHLDPKVIHERLPGISETAKTFAGVDVTKEPIPVIPTVHYNMGGIPTNYHGEVLSLNSSSGSYEVVEGLFAIGEAA
CVSVHGANRLGSNSLLDLVVFGRAAAIRAKEVIKPGGLHRPIRKDFEDSIIDRFDRMRYANGATRVAEIRSRMQNVMQEH
AAVFRVAEVLEKGKKEIRGVAAMMKDISVTDRSMVWNSDLVEALELSNMMPQAVVTVDCAANRKESRGAHAREDFPERDD
ENWMKHTMAWCNCDTYEVKIGYKEVATYTLTNEVEYFPPQKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=616, Percent_Identity=59.7402597402597, Blast_Score=720, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=592, Percent_Identity=53.0405405405405, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1790597, Length=581, Percent_Identity=41.4802065404475, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=31.5412186379928, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=616, Percent_Identity=58.4415584415584, Blast_Score=705, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=617, Percent_Identity=56.4019448946515, Blast_Score=680, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=604, Percent_Identity=62.7483443708609, Blast_Score=787, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=61.4740368509213, Blast_Score=759, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=485, Percent_Identity=28.0412371134021, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17137288, Length=613, Percent_Identity=59.8694942903752, Blast_Score=748, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=613, Percent_Identity=59.8694942903752, Blast_Score=748, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=613, Percent_Identity=59.8694942903752, Blast_Score=748, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=618, Percent_Identity=53.5598705501618, Blast_Score=668, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66357; Mature: 66357

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVSRSAYEVVDHEYDVVVVGAGGAGLRAVVGMTAAGLSVACVTKVFPTRSHTVAAQGG
CCCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCC
ISAALGNIAEDDWRWHMFDTVKGSDWLGDQDAIEYMCKNAMQSVVELEHCGVPFSRTKEG
HHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KIYQRPFGGMTTEYGKGKPAVRTCAASDKTGHAILHALYQQSLRFDAKFFVEYFAIDLIM
CEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEEE
SEDNRSCCGVLAWSLCDGVLHRFRAHAVVLATGGYGRVYFSATSAHTCTGDGGGMAARAG
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCEECCCCCCEEEECC
IPLEDMEFVQFHPTGIYGSGCLMTEGCRGEGGYLLNSAGERFMERYAPKAKDLASRDVVS
CCCCCCCEEEEECCCEECCCCEEECCCCCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHH
RSMTMEIREGRGVGEKKDHIYLSIAHLDPKVIHERLPGISETAKTFAGVDVTKEPIPVIP
HHHHEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
TVHYNMGGIPTNYHGEVLSLNSSSGSYEVVEGLFAIGEAACVSVHGANRLGSNSLLDLVV
EEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHEEEEECCCCCCCCHHHHHHH
FGRAAAIRAKEVIKPGGLHRPIRKDFEDSIIDRFDRMRYANGATRVAEIRSRMQNVMQEH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AAVFRVAEVLEKGKKEIRGVAAMMKDISVTDRSMVWNSDLVEALELSNMMPQAVVTVDCA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCCCCEEEEEECC
ANRKESRGAHAREDFPERDDENWMKHTMAWCNCDTYEVKIGYKEVATYTLTNEVEYFPPQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHEEEEEECCCEECCCC
KRVY
CCCC
>Mature Secondary Structure
MIEVSRSAYEVVDHEYDVVVVGAGGAGLRAVVGMTAAGLSVACVTKVFPTRSHTVAAQGG
CCCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCC
ISAALGNIAEDDWRWHMFDTVKGSDWLGDQDAIEYMCKNAMQSVVELEHCGVPFSRTKEG
HHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KIYQRPFGGMTTEYGKGKPAVRTCAASDKTGHAILHALYQQSLRFDAKFFVEYFAIDLIM
CEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEEE
SEDNRSCCGVLAWSLCDGVLHRFRAHAVVLATGGYGRVYFSATSAHTCTGDGGGMAARAG
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCEECCCCCCEEEECC
IPLEDMEFVQFHPTGIYGSGCLMTEGCRGEGGYLLNSAGERFMERYAPKAKDLASRDVVS
CCCCCCCEEEEECCCEECCCCEEECCCCCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHH
RSMTMEIREGRGVGEKKDHIYLSIAHLDPKVIHERLPGISETAKTFAGVDVTKEPIPVIP
HHHHEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
TVHYNMGGIPTNYHGEVLSLNSSSGSYEVVEGLFAIGEAACVSVHGANRLGSNSLLDLVV
EEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHEEEEECCCCCCCCHHHHHHH
FGRAAAIRAKEVIKPGGLHRPIRKDFEDSIIDRFDRMRYANGATRVAEIRSRMQNVMQEH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AAVFRVAEVLEKGKKEIRGVAAMMKDISVTDRSMVWNSDLVEALELSNMMPQAVVTVDCA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCCCCEEEEEECC
ANRKESRGAHAREDFPERDDENWMKHTMAWCNCDTYEVKIGYKEVATYTLTNEVEYFPPQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHEEEEEECCCEECCCC
KRVY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA