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The map label for this gene is tsaA [H]

Identifier: 88607183

GI number: 88607183

Start: 677536

End: 678147

Strand: Reverse

Name: tsaA [H]

Synonym: APH_0659

Alternate gene names: 88607183

Gene position: 678147-677536 (Counterclockwise)

Preceding gene: 88607737

Following gene: 88607417

Centisome position: 46.09

GC content: 44.77

Gene sequence:

>612_bases
GTGAGACGCCTTATGAATTTGGTAACAAAGCCGGCCATAGACTTTACTGCACGTGCCGTTATGTCTGATGGTAAGATGTG
TGATCTTACGCTTAGTAAGCACGTCGCTGGAAAATATGCAGTATTGTTCTTCTACCCTCGTGACTTTACATTCGTGTGTC
CGACTGAGATACTGTCTCTGCATAGCAGAATACCTCAATTCAGTGAGCAAAACGCCGAAGTCATAGCGATCAGCACAGAC
TCCGAGTTCGCGCACTCTCATTGGCGTAACACACCTTTAGAAAAAGGTGGTATAGGGATGGTAAGTTTCCCCCTAGTAGC
GGATGATTCTCATAGCATATCGGAGAGTTATGGTATGCTATTCGCAGGTAAGGTATCCCTGCGCGGCACCATTATTATCG
ATGAAAATTTTGTCGTTCGTCATCAATCCATAAATGACCTCCCTATTGGAAGGAATGTTGATGAGTTCCTCAGAATAATA
GATGCGATCGAGCATCACAAAAAGCATGGAGAGGTATGTCCTGCAGGTTGGTCAAAAGGAAAGGTCGCTATGGAGGCGAC
TCAACAAGGGGTAGAACACTACCTTCAATCTCATATAGATAGTCTGAGCTAA

Upstream 100 bases:

>100_bases
CTGCTAACCTGGAATACAAATGTCAGCATGCTACGTTTTATGTTCCAAAAAACACATTGTTGATCTAGTAATATTTTGTA
TACTGTTCCAAGTTTTTTTT

Downstream 100 bases:

>100_bases
TAGTGATGTCAGAAGTGCATAAAGATGCAGTTAAAGTTCTGATTCTAGGTTCAGGGGCAGCAGGTTGTACTGCTGCCATC
TATGCTGGCAGAGCTAATCT

Product: anti-oxidant AhpCTSA family protein

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MRRLMNLVTKPAIDFTARAVMSDGKMCDLTLSKHVAGKYAVLFFYPRDFTFVCPTEILSLHSRIPQFSEQNAEVIAISTD
SEFAHSHWRNTPLEKGGIGMVSFPLVADDSHSISESYGMLFAGKVSLRGTIIIDENFVVRHQSINDLPIGRNVDEFLRII
DAIEHHKKHGEVCPAGWSKGKVAMEATQQGVEHYLQSHIDSLS

Sequences:

>Translated_203_residues
MRRLMNLVTKPAIDFTARAVMSDGKMCDLTLSKHVAGKYAVLFFYPRDFTFVCPTEILSLHSRIPQFSEQNAEVIAISTD
SEFAHSHWRNTPLEKGGIGMVSFPLVADDSHSISESYGMLFAGKVSLRGTIIIDENFVVRHQSINDLPIGRNVDEFLRII
DAIEHHKKHGEVCPAGWSKGKVAMEATQQGVEHYLQSHIDSLS
>Mature_203_residues
MRRLMNLVTKPAIDFTARAVMSDGKMCDLTLSKHVAGKYAVLFFYPRDFTFVCPTEILSLHSRIPQFSEQNAEVIAISTD
SEFAHSHWRNTPLEKGGIGMVSFPLVADDSHSISESYGMLFAGKVSLRGTIIIDENFVVRHQSINDLPIGRNVDEFLRII
DAIEHHKKHGEVCPAGWSKGKVAMEATQQGVEHYLQSHIDSLS

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=189, Percent_Identity=46.5608465608466, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32455266, Length=189, Percent_Identity=46.5608465608466, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32455264, Length=189, Percent_Identity=46.5608465608466, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32189392, Length=192, Percent_Identity=45.3125, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI5453549, Length=174, Percent_Identity=47.7011494252874, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI5802974, Length=190, Percent_Identity=44.7368421052632, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI32483377, Length=183, Percent_Identity=44.8087431693989, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI33188454, Length=81, Percent_Identity=50.6172839506173, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4758638, Length=161, Percent_Identity=26.7080745341615, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786822, Length=183, Percent_Identity=28.9617486338798, Blast_Score=98, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193204376, Length=201, Percent_Identity=45.273631840796, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI32565831, Length=193, Percent_Identity=45.5958549222798, Blast_Score=179, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17554494, Length=142, Percent_Identity=50.7042253521127, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25153706, Length=178, Percent_Identity=26.4044943820225, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=191, Percent_Identity=43.979057591623, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320661, Length=191, Percent_Identity=40.3141361256544, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319407, Length=165, Percent_Identity=27.8787878787879, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656348, Length=175, Percent_Identity=48, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17864676, Length=175, Percent_Identity=48, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17738015, Length=172, Percent_Identity=48.8372093023256, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17157991, Length=194, Percent_Identity=43.8144329896907, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24641739, Length=194, Percent_Identity=43.8144329896907, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21357347, Length=198, Percent_Identity=39.8989898989899, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24581278, Length=153, Percent_Identity=28.7581699346405, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17975518, Length=161, Percent_Identity=31.6770186335404, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652436, Length=161, Percent_Identity=31.055900621118, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24652434, Length=161, Percent_Identity=31.055900621118, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22699; Mature: 22699

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLMNLVTKPAIDFTARAVMSDGKMCDLTLSKHVAGKYAVLFFYPRDFTFVCPTEILSL
CHHHHHHHHCCCHHHHHHHHHCCCCEEEEEHHHHCCCCEEEEEEECCCCEEECHHHHHHH
HSRIPQFSEQNAEVIAISTDSEFAHSHWRNTPLEKGGIGMVSFPLVADDSHSISESYGML
HHHCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHCCEE
FAGKVSLRGTIIIDENFVVRHQSINDLPIGRNVDEFLRIIDAIEHHKKHGEVCPAGWSKG
EEEEEEEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KVAMEATQQGVEHYLQSHIDSLS
CCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRLMNLVTKPAIDFTARAVMSDGKMCDLTLSKHVAGKYAVLFFYPRDFTFVCPTEILSL
CHHHHHHHHCCCHHHHHHHHHCCCCEEEEEHHHHCCCCEEEEEEECCCCEEECHHHHHHH
HSRIPQFSEQNAEVIAISTDSEFAHSHWRNTPLEKGGIGMVSFPLVADDSHSISESYGML
HHHCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHCCEE
FAGKVSLRGTIIIDENFVVRHQSINDLPIGRNVDEFLRIIDAIEHHKKHGEVCPAGWSKG
EEEEEEEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KVAMEATQQGVEHYLQSHIDSLS
CCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]