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The map label for this gene is pccB [H]

Identifier: 88607086

GI number: 88607086

Start: 430072

End: 431601

Strand: Direct

Name: pccB [H]

Synonym: APH_0415

Alternate gene names: 88607086

Gene position: 430072-431601 (Clockwise)

Preceding gene: 88607741

Following gene: 88607275

Centisome position: 29.23

GC content: 46.54

Gene sequence:

>1530_bases
ATGGGTCCCGTGGTGCTCCAGGAGTTAGAGAATAAGAAAATTCAGTTAAAACTGGGTGGTGGGCCATCTAGGATAGAGAA
GCAACATAGTAGGGGTAGGCTTACTGCCCGAGAAAGGTTGGGCGTTTTTCTCGATAAGGGGTCGTTTCAAGAATACGGAG
TATTTGTCGAACATAGGTCGGTAAACTTTGGTATGAGTGAATCCAAAGTTGCTGGTGATGGGGTTGTCACAGGGTGCGGT
ACTGTTTACGGGCAGCGCGTTTGTGTATATTCGCAGGATTTCACTGTATTTGGCGGATCTCTGAGTGAGATGAATGCGAA
AAAGATTTGCCACGTCATGGATATGGCAGCGAAGGCGGGAGTGCCCGTAATCGGGATCAACGATTCTGGGGGAGCCAGGA
TACAGGAAGGAGTAGATTCTTTGGCGGGTTACGGTGAGATTTTTCAGCGTAATGTAGATATGTCGGGTGTTGTGCCGCAG
ATATCTCTTATTATGGGTTCATGCGCTGGTGGTGCTGTGTATTCTCCTGCACTTACGGATTTTGTATTTATGGTCAGGGG
CTCGTGTATGTTTGTTACCGGGCCGGACGTGATTAAGAAAGTCACTTTCGAAGATGTGACTCAGGAGGAGCTTGGTGGTG
CCGCGGTGCATACTCGTAAGACAGGAGTTGCAGATTTGGCTTTTGATGATGAAGTGGATGCTCTAAGTCAGGTGCGTAAG
TTTTTGTCATTTCTTCCTCCGAACAACAGGAGCTCAGCAAGGGCTATGCCGACGTCAGATCCTGTAGATCGTGAAAATGA
GTCGCTGAACACACTTATTCCCAGGAACAGTACGGTTCCGTATGATATGTATGAATTGATTGCGAAGGTGTGCGATGAGG
GGGTGTTTTTTGAGATAAAGCCAGATTTTGCCAAGAATATCATTGTGGGTTTTGGTAGGATAGGTGGTAGCGCGGTTGGT
ATTGTCGCGAATCAACCTATGCACTTGGCTGGGTGTCTGGACATAGATTCCTCGCGAAAGGCTGCGAGGTTTGTGAGATT
TTGTGATGCTTTTAATATTCCGCTAGTGACGCTGATAGACGTCCCAGGGTTCTTACCTGGCGTGTCGCAGGAATATTCAG
GAATTATAGATCATGGTGCTAAGTTGTTATATGCATATGCTGAAGCATCAGTACCAAAGGTTAGCGTGATTGTGCGTAAG
GCATACGGTGGTGCGTATATAGTGATGAACTCAAGACACCTAAGGGGAGATGTTAATTATGCATGGCCCAGTGCTGAAAT
AGCCGTTATGGGTTCAGAAGGTGCGGTGGGAATAATATTCCGTAAAGAAAAAGACCAAGAGTACTTAAAGCAGCTAATAA
AGGAGTACAACGACAAGGTGGTGAACCCGTACGTTGCAGCTTCTCGAGGATTTATAGACGATGTGATCATGCCATCAACT
ACTAGGTGGCATATATACAATGCATTACATATGCTGCGTGATAAGAAGGTTGATCGCCCATGGCGTAAGCATGATAACCT
CCCGCTATAG

Upstream 100 bases:

>100_bases
TGGCAGGGCATATCTCTGTGTTTTGTGCATTAGTTTAACGTACAGGGCCTTTTTTTTGCTATAATCAAAAAGTTAATAGT
TCAATTTTTCAGGGTATATC

Downstream 100 bases:

>100_bases
GTCAGGTAGAGCATTTTATATATAGGTGCTTAGAGAGGGAGAGAAGGGGTGTTCACTAGCTGTTCTGATACTTTGTTACG
ATGTTATGCAACAAAGTAGG

Product: propionyl-CoA carboxylase, beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MGPVVLQELENKKIQLKLGGGPSRIEKQHSRGRLTARERLGVFLDKGSFQEYGVFVEHRSVNFGMSESKVAGDGVVTGCG
TVYGQRVCVYSQDFTVFGGSLSEMNAKKICHVMDMAAKAGVPVIGINDSGGARIQEGVDSLAGYGEIFQRNVDMSGVVPQ
ISLIMGSCAGGAVYSPALTDFVFMVRGSCMFVTGPDVIKKVTFEDVTQEELGGAAVHTRKTGVADLAFDDEVDALSQVRK
FLSFLPPNNRSSARAMPTSDPVDRENESLNTLIPRNSTVPYDMYELIAKVCDEGVFFEIKPDFAKNIIVGFGRIGGSAVG
IVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPLVTLIDVPGFLPGVSQEYSGIIDHGAKLLYAYAEASVPKVSVIVRK
AYGGAYIVMNSRHLRGDVNYAWPSAEIAVMGSEGAVGIIFRKEKDQEYLKQLIKEYNDKVVNPYVAASRGFIDDVIMPST
TRWHIYNALHMLRDKKVDRPWRKHDNLPL

Sequences:

>Translated_509_residues
MGPVVLQELENKKIQLKLGGGPSRIEKQHSRGRLTARERLGVFLDKGSFQEYGVFVEHRSVNFGMSESKVAGDGVVTGCG
TVYGQRVCVYSQDFTVFGGSLSEMNAKKICHVMDMAAKAGVPVIGINDSGGARIQEGVDSLAGYGEIFQRNVDMSGVVPQ
ISLIMGSCAGGAVYSPALTDFVFMVRGSCMFVTGPDVIKKVTFEDVTQEELGGAAVHTRKTGVADLAFDDEVDALSQVRK
FLSFLPPNNRSSARAMPTSDPVDRENESLNTLIPRNSTVPYDMYELIAKVCDEGVFFEIKPDFAKNIIVGFGRIGGSAVG
IVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPLVTLIDVPGFLPGVSQEYSGIIDHGAKLLYAYAEASVPKVSVIVRK
AYGGAYIVMNSRHLRGDVNYAWPSAEIAVMGSEGAVGIIFRKEKDQEYLKQLIKEYNDKVVNPYVAASRGFIDDVIMPST
TRWHIYNALHMLRDKKVDRPWRKHDNLPL
>Mature_508_residues
GPVVLQELENKKIQLKLGGGPSRIEKQHSRGRLTARERLGVFLDKGSFQEYGVFVEHRSVNFGMSESKVAGDGVVTGCGT
VYGQRVCVYSQDFTVFGGSLSEMNAKKICHVMDMAAKAGVPVIGINDSGGARIQEGVDSLAGYGEIFQRNVDMSGVVPQI
SLIMGSCAGGAVYSPALTDFVFMVRGSCMFVTGPDVIKKVTFEDVTQEELGGAAVHTRKTGVADLAFDDEVDALSQVRKF
LSFLPPNNRSSARAMPTSDPVDRENESLNTLIPRNSTVPYDMYELIAKVCDEGVFFEIKPDFAKNIIVGFGRIGGSAVGI
VANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPLVTLIDVPGFLPGVSQEYSGIIDHGAKLLYAYAEASVPKVSVIVRKA
YGGAYIVMNSRHLRGDVNYAWPSAEIAVMGSEGAVGIIFRKEKDQEYLKQLIKEYNDKVVNPYVAASRGFIDDVIMPSTT
RWHIYNALHMLRDKKVDRPWRKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=508, Percent_Identity=61.8110236220472, Blast_Score=629, Evalue=1e-180,
Organism=Homo sapiens, GI295821216, Length=528, Percent_Identity=59.280303030303, Blast_Score=615, Evalue=1e-176,
Organism=Homo sapiens, GI11545863, Length=497, Percent_Identity=32.9979879275654, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI134142062, Length=396, Percent_Identity=25, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI38679974, Length=379, Percent_Identity=25.065963060686, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI38679971, Length=379, Percent_Identity=25.065963060686, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI38679960, Length=379, Percent_Identity=25.065963060686, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI38679977, Length=379, Percent_Identity=25.065963060686, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI38679967, Length=379, Percent_Identity=25.065963060686, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=59.0909090909091, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=59.0909090909091, Blast_Score=627, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17552936, Length=498, Percent_Identity=32.9317269076305, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71997163, Length=355, Percent_Identity=23.6619718309859, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323863, Length=361, Percent_Identity=24.0997229916898, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324343, Length=364, Percent_Identity=22.2527472527473, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24586065, Length=510, Percent_Identity=34.1176470588235, Blast_Score=246, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55646; Mature: 55514

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPVVLQELENKKIQLKLGGGPSRIEKQHSRGRLTARERLGVFLDKGSFQEYGVFVEHRS
CCCHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCEEEECCCCHHHCEEEEEEC
VNFGMSESKVAGDGVVTGCGTVYGQRVCVYSQDFTVFGGSLSEMNAKKICHVMDMAAKAG
CCCCCCCCCCCCCCEEECCHHHHCCEEEEEECCCEEECCCHHHCCHHHHHHHHHHHHHCC
VPVIGINDSGGARIQEGVDSLAGYGEIFQRNVDMSGVVPQISLIMGSCAGGAVYSPALTD
CCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEECHHHHH
FVFMVRGSCMFVTGPDVIKKVTFEDVTQEELGGAAVHTRKTGVADLAFDDEVDALSQVRK
HHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCHHHHHHHHH
FLSFLPPNNRSSARAMPTSDPVDRENESLNTLIPRNSTVPYDMYELIAKVCDEGVFFEIK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEC
PDFAKNIIVGFGRIGGSAVGIVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPLVTLID
CHHHCCCEEEECCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEC
VPGFLPGVSQEYSGIIDHGAKLLYAYAEASVPKVSVIVRKAYGGAYIVMNSRHLRGDVNY
CCCCCCCCCHHHHHHHHCCHHEEEEEHHCCCCEEEEEEEECCCCEEEEECCCEECCCCCE
AWPSAEIAVMGSEGAVGIIFRKEKDQEYLKQLIKEYNDKVVNPYVAASRGFIDDVIMPST
ECCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHCCCCC
TRWHIYNALHMLRDKKVDRPWRKHDNLPL
CHHHHHHHHHHHHHCCCCCCHHCCCCCCC
>Mature Secondary Structure 
GPVVLQELENKKIQLKLGGGPSRIEKQHSRGRLTARERLGVFLDKGSFQEYGVFVEHRS
CCHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCEEEECCCCHHHCEEEEEEC
VNFGMSESKVAGDGVVTGCGTVYGQRVCVYSQDFTVFGGSLSEMNAKKICHVMDMAAKAG
CCCCCCCCCCCCCCEEECCHHHHCCEEEEEECCCEEECCCHHHCCHHHHHHHHHHHHHCC
VPVIGINDSGGARIQEGVDSLAGYGEIFQRNVDMSGVVPQISLIMGSCAGGAVYSPALTD
CCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEECHHHHH
FVFMVRGSCMFVTGPDVIKKVTFEDVTQEELGGAAVHTRKTGVADLAFDDEVDALSQVRK
HHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCHHHHHHHHH
FLSFLPPNNRSSARAMPTSDPVDRENESLNTLIPRNSTVPYDMYELIAKVCDEGVFFEIK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEC
PDFAKNIIVGFGRIGGSAVGIVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPLVTLID
CHHHCCCEEEECCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEC
VPGFLPGVSQEYSGIIDHGAKLLYAYAEASVPKVSVIVRKAYGGAYIVMNSRHLRGDVNY
CCCCCCCCCHHHHHHHHCCHHEEEEEHHCCCCEEEEEEEECCCCEEEEECCCEECCCCCE
AWPSAEIAVMGSEGAVGIIFRKEKDQEYLKQLIKEYNDKVVNPYVAASRGFIDDVIMPST
ECCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHCCCCC
TRWHIYNALHMLRDKKVDRPWRKHDNLPL
CHHHHHHHHHHHHHCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]