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The map label for this gene is folP [C]

Identifier: 88606956

GI number: 88606956

Start: 251662

End: 252474

Strand: Reverse

Name: folP [C]

Synonym: APH_0254

Alternate gene names: 88606956

Gene position: 252474-251662 (Counterclockwise)

Preceding gene: 88607359

Following gene: 88607909

Centisome position: 17.16

GC content: 43.91

Gene sequence:

>813_bases
TTGCAACACTCTGCTGTCACCACAAAAATTGTTGGTATATTGAATGTAACCCCAAATTCGTTCTCCGACGGGGGTAAGTT
TTTGGAAGCTAATGCTGCAATTAGACACGCTACAGATCTAATAGAGCATGGTGCAGATGTGATTGATGTAGGTGCGGAGT
CCACAGCACCTGGCGTATCTCCCATAACACAGGAAGAAGAATGGAGCAGGCTGAAGGAGGTTTTACCTGAAATCATACGC
ATTGCTCATAATGCACATGTAGAAGTCAGCATAGATACAAGAAATGCTAAGACCGCTGAGCTAGCTCTGAAACTGGGTGT
AGATTACATAAATGATCAGGGAGGTCTTCTGGATCCTGATATGCCGGCAATCGCGGCAGCAAGTTCTGCCAAAATCATTA
TTATGCACCACTTTGGGCTGCCCGTATCCCAAGACAGAAGCTATGTTGGGCAACCTGAACAGTTACTAAATGAAATAATA
GAATGGCTGTGCTCGAGAGTTGATACTCTCATTGCGCAGGGTGTAGTTCGTGAACGCATAATTTTAGATCCGGGTCTCGG
CTTTGGTAAGTTGCCTGAATACTCGTGGTACATTGCTAAAAACATAGGGAAACTAAAAAAACTTGGCTTTCCAGTCTGCG
TGGGGCATTCACGCAAATCTATGTTTTCTTTGATACCCGTTGAACTATCAGAAAGAGATGTTCCAACGGCCATGCTGTCC
ACGTTTCTTGCACAACAACAGGTAGACTTCCTGCGTGTCCATGACGTGAAATTAACTGGAATATCTATCAAAATAGCAAA
CTTGCTTGTGTAA

Upstream 100 bases:

>100_bases
AGCAGTTTCTATGAAAAATACAAAAACAAGCTCATGCTGATAAGGGTTGTGTTACACGCCATTACGGTAGTTTCAGCTGT
TTTTTTGATTAGGTAATGTT

Downstream 100 bases:

>100_bases
TTTCTACCTACGGCAGTTCTCTTCATTAATACCTGTTGAGTTGTCGTTCCATAAGCGTTGCTATCTATGCTTCTTGCAGA
ACAACAGGTAGACTCCATGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MQHSAVTTKIVGILNVTPNSFSDGGKFLEANAAIRHATDLIEHGADVIDVGAESTAPGVSPITQEEEWSRLKEVLPEIIR
IAHNAHVEVSIDTRNAKTAELALKLGVDYINDQGGLLDPDMPAIAAASSAKIIIMHHFGLPVSQDRSYVGQPEQLLNEII
EWLCSRVDTLIAQGVVRERIILDPGLGFGKLPEYSWYIAKNIGKLKKLGFPVCVGHSRKSMFSLIPVELSERDVPTAMLS
TFLAQQQVDFLRVHDVKLTGISIKIANLLV

Sequences:

>Translated_270_residues
MQHSAVTTKIVGILNVTPNSFSDGGKFLEANAAIRHATDLIEHGADVIDVGAESTAPGVSPITQEEEWSRLKEVLPEIIR
IAHNAHVEVSIDTRNAKTAELALKLGVDYINDQGGLLDPDMPAIAAASSAKIIIMHHFGLPVSQDRSYVGQPEQLLNEII
EWLCSRVDTLIAQGVVRERIILDPGLGFGKLPEYSWYIAKNIGKLKKLGFPVCVGHSRKSMFSLIPVELSERDVPTAMLS
TFLAQQQVDFLRVHDVKLTGISIKIANLLV
>Mature_270_residues
MQHSAVTTKIVGILNVTPNSFSDGGKFLEANAAIRHATDLIEHGADVIDVGAESTAPGVSPITQEEEWSRLKEVLPEIIR
IAHNAHVEVSIDTRNAKTAELALKLGVDYINDQGGLLDPDMPAIAAASSAKIIIMHHFGLPVSQDRSYVGQPEQLLNEII
EWLCSRVDTLIAQGVVRERIILDPGLGFGKLPEYSWYIAKNIGKLKKLGFPVCVGHSRKSMFSLIPVELSERDVPTAMLS
TFLAQQQVDFLRVHDVKLTGISIKIANLLV

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=257, Percent_Identity=33.4630350194552, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324073, Length=315, Percent_Identity=31.1111111111111, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29485; Mature: 29485

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHSAVTTKIVGILNVTPNSFSDGGKFLEANAAIRHATDLIEHGADVIDVGAESTAPGVS
CCCCHHHEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
PITQEEEWSRLKEVLPEIIRIAHNAHVEVSIDTRNAKTAELALKLGVDYINDQGGLLDPD
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCEECCCCCCCCCC
MPAIAAASSAKIIIMHHFGLPVSQDRSYVGQPEQLLNEIIEWLCSRVDTLIAQGVVRERI
CCHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
ILDPGLGFGKLPEYSWYIAKNIGKLKKLGFPVCVGHSRKSMFSLIPVELSERDVPTAMLS
EECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHEECCEECCCCCCCHHHHH
TFLAQQQVDFLRVHDVKLTGISIKIANLLV
HHHHHHHHHHEEEEEEEEEEEEEEEEECCC
>Mature Secondary Structure
MQHSAVTTKIVGILNVTPNSFSDGGKFLEANAAIRHATDLIEHGADVIDVGAESTAPGVS
CCCCHHHEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
PITQEEEWSRLKEVLPEIIRIAHNAHVEVSIDTRNAKTAELALKLGVDYINDQGGLLDPD
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCEECCCCCCCCCC
MPAIAAASSAKIIIMHHFGLPVSQDRSYVGQPEQLLNEIIEWLCSRVDTLIAQGVVRERI
CCHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
ILDPGLGFGKLPEYSWYIAKNIGKLKKLGFPVCVGHSRKSMFSLIPVELSERDVPTAMLS
EECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHEECCEECCCCCCCHHHHH
TFLAQQQVDFLRVHDVKLTGISIKIANLLV
HHHHHHHHHHEEEEEEEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]