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The map label for this gene is fabH [H]

Identifier: 88606851

GI number: 88606851

Start: 302458

End: 303417

Strand: Direct

Name: fabH [H]

Synonym: APH_0317

Alternate gene names: 88606851

Gene position: 302458-303417 (Clockwise)

Preceding gene: 88607397

Following gene: 88606949

Centisome position: 20.56

GC content: 46.46

Gene sequence:

>960_bases
ATGAAAGCTGTATTGTGTGGAGTAGGGTCCTTTTTGCCGCATAAGGCTGTTACGAATGAGGATTTGTCGCTGATTGTTGA
TACTACAGATGAGTGGATATTTCGTAGGACTGGTATAAAGCGCAGGTATTTGGTAAGTGAGGGAGAAGCTACGTCCGATA
TGGCTGTGAAGGCGGCGGAAGCTGCGCTCAGTGATGCAGGAGTTTCTGCGGAGGAAGTGGATCTTATTGTTGTTGCGACT
TCTACTCCGGATTCTACTTTGCCGAGTTGTGCCACTATGGTGCAGGGAAAGCTTGGCTGTACGAAGGCGTTTGCTTTTGA
CATGAACGCTGCGTGCTCGGGTTTTGTATATGCGATTTCTGTTGTTGATAGTTTGATAAAAACTGGTCAAGTTGGGGTTG
CTTTGCTAATAGGCGCCGAGTCTATGTCTAAGATAGTGGATTGGCATGATAGGTCCACTTGTGTTTTGTTCGGTGATGGT
GCGGGGGCATGTGTCTTCAAGGGAGATGGAAAAGCCTCAAATAGGGGTATTGTCGATACAGCGCTGTATACGGATGGGAC
ACTGGGTGATATTCTGTACACGGATGGAGGGGTTGCTTCTACCTGTACGGCAGGCCATATACGCATGAAGGGAACGGTTT
TATTTGAGCACGCTATCTTGAAATTGTCATCATCAGTTGAAGGGTTGCTTAAAAAGAATGCTATAGGCATTGATGCGATT
GATTGGTTTATTCCTCATCAGGCAAATGTGAGAATTGTAGACTTGGTTGCCAAAAGGCTCGGTATTTCTCAGGATAAGGT
TGTGCTTGGAATAGGTGATCACGCAAATACTTCAGCTGCGTCAATTCCTTTGGCTATGAGTGATGCAAGGAGAGATGGTA
AATTGCAGGAAGGGCAGCTTGTATTACTTGCGGCTATAGGCGCGGGGGTGACTTGGGGTGCTAGTTTGATAAGGCTGTAA

Upstream 100 bases:

>100_bases
CGGATGGCAAGGCTTACGCTTGTGCGATTAAAACTGCTGTGCATTCTGCGCGTTATGCTATAGTTTCAAAGATAGCTTCG
GAAATAAGTGAAATGGGGTG

Downstream 100 bases:

>100_bases
GACGTTTTAAGGTGATATCTTTAGGCTGCTCTTCTTGGTGATACTACAGTTCAGTGTTTAGCAAGCTGAGAGATTTTAGT
GTAAGGGAAAGACTGAGGTG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKAVLCGVGSFLPHKAVTNEDLSLIVDTTDEWIFRRTGIKRRYLVSEGEATSDMAVKAAEAALSDAGVSAEEVDLIVVAT
STPDSTLPSCATMVQGKLGCTKAFAFDMNAACSGFVYAISVVDSLIKTGQVGVALLIGAESMSKIVDWHDRSTCVLFGDG
AGACVFKGDGKASNRGIVDTALYTDGTLGDILYTDGGVASTCTAGHIRMKGTVLFEHAILKLSSSVEGLLKKNAIGIDAI
DWFIPHQANVRIVDLVAKRLGISQDKVVLGIGDHANTSAASIPLAMSDARRDGKLQEGQLVLLAAIGAGVTWGASLIRL

Sequences:

>Translated_319_residues
MKAVLCGVGSFLPHKAVTNEDLSLIVDTTDEWIFRRTGIKRRYLVSEGEATSDMAVKAAEAALSDAGVSAEEVDLIVVAT
STPDSTLPSCATMVQGKLGCTKAFAFDMNAACSGFVYAISVVDSLIKTGQVGVALLIGAESMSKIVDWHDRSTCVLFGDG
AGACVFKGDGKASNRGIVDTALYTDGTLGDILYTDGGVASTCTAGHIRMKGTVLFEHAILKLSSSVEGLLKKNAIGIDAI
DWFIPHQANVRIVDLVAKRLGISQDKVVLGIGDHANTSAASIPLAMSDARRDGKLQEGQLVLLAAIGAGVTWGASLIRL
>Mature_319_residues
MKAVLCGVGSFLPHKAVTNEDLSLIVDTTDEWIFRRTGIKRRYLVSEGEATSDMAVKAAEAALSDAGVSAEEVDLIVVAT
STPDSTLPSCATMVQGKLGCTKAFAFDMNAACSGFVYAISVVDSLIKTGQVGVALLIGAESMSKIVDWHDRSTCVLFGDG
AGACVFKGDGKASNRGIVDTALYTDGTLGDILYTDGGVASTCTAGHIRMKGTVLFEHAILKLSSSVEGLLKKNAIGIDAI
DWFIPHQANVRIVDLVAKRLGISQDKVVLGIGDHANTSAASIPLAMSDARRDGKLQEGQLVLLAAIGAGVTWGASLIRL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=320, Percent_Identity=41.875, Blast_Score=268, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 33305; Mature: 33305

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVLCGVGSFLPHKAVTNEDLSLIVDTTDEWIFRRTGIKRRYLVSEGEATSDMAVKAAE
CCEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
AALSDAGVSAEEVDLIVVATSTPDSTLPSCATMVQGKLGCTKAFAFDMNAACSGFVYAIS
HHHHHCCCCHHHEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHH
VVDSLIKTGQVGVALLIGAESMSKIVDWHDRSTCVLFGDGAGACVFKGDGKASNRGIVDT
HHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEE
ALYTDGTLGDILYTDGGVASTCTAGHIRMKGTVLFEHAILKLSSSVEGLLKKNAIGIDAI
EEECCCCCCCEEEECCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHH
DWFIPHQANVRIVDLVAKRLGISQDKVVLGIGDHANTSAASIPLAMSDARRDGKLQEGQL
HEECCCCCCEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCE
VLLAAIGAGVTWGASLIRL
EEEEEECCCHHHHHHHHCC
>Mature Secondary Structure
MKAVLCGVGSFLPHKAVTNEDLSLIVDTTDEWIFRRTGIKRRYLVSEGEATSDMAVKAAE
CCEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
AALSDAGVSAEEVDLIVVATSTPDSTLPSCATMVQGKLGCTKAFAFDMNAACSGFVYAIS
HHHHHCCCCHHHEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHH
VVDSLIKTGQVGVALLIGAESMSKIVDWHDRSTCVLFGDGAGACVFKGDGKASNRGIVDT
HHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEE
ALYTDGTLGDILYTDGGVASTCTAGHIRMKGTVLFEHAILKLSSSVEGLLKKNAIGIDAI
EEECCCCCCCEEEECCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHH
DWFIPHQANVRIVDLVAKRLGISQDKVVLGIGDHANTSAASIPLAMSDARRDGKLQEGQL
HEECCCCCCEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCE
VLLAAIGAGVTWGASLIRL
EEEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA