Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 88606811

GI number: 88606811

Start: 427134

End: 427940

Strand: Direct

Name: mutM [H]

Synonym: APH_0411

Alternate gene names: 88606811

Gene position: 427134-427940 (Clockwise)

Preceding gene: 88607524

Following gene: 88607741

Centisome position: 29.03

GC content: 44.61

Gene sequence:

>807_bases
ATGCCAGAACTACCAGAAGTTGAGGTGATTGCAAGGTCTCTTGCGGATAAAATAATAGGTCAGCGCATACGTGATGTCGA
GGTGAAGAGACGTGATCTGCGGGTCCGTATAGCTGATGATTTCGAGCAGTTAGTGACCGGAAGAGAAATATGTTCCGTAT
ATAGGGTTGCCAAGTATTTGGTGATGCAGCTGGATTCTGGAGCAAAGCTTGTATTCCATATGGGTATGAGTGGCAGAATC
CTATATATGCACGCTCCTGTTCCGGAGAAGCATGATTGTGTGGTTTTTGCTATGCAGCATGGCTATAGTCTTGTGTTCAA
TGATACACGCAGATTTGGACTAGTTACACTGCTGGATGGGGAAGGTTACAGATCTTTGCTGGAAAAGATGGGTCCTGATC
CGTTTTCGGAAGCCTTCAATGCAGATTGTTTGCTGAATATGCATGGGAAAGCTCGTATAAAGTCTGTCTTAATGAATAGT
GCTGTTGTTGTAGGAATAGGCAACATATATGCATCGGAGATACTGTTCACTGCTGCTATATTGCCACACAGGGAAGTTAG
CACTCTTTCCAGGGAGGAGTGCTGTAGAATTGTGGAGTCTACACGAGAAGTACTCAAGCTTGCTATAGCAACTGGGGGGT
CGTCAATTCGCGACTACCGTACACCTACAGGTGACGTTGGTAATTTTTCGAAGCACTTTAGGGTTTATGGCAGAAAAGGC
GAAAAGTGCTATACATGTGGAGGTGAGATACAAGTAGAAAAGCAAGGAGGGAGAAGTACGTTTTTTTGTAGGCACTGTCA
GAAATGA

Upstream 100 bases:

>100_bases
AAGAGAAACACGAACATTGAGGAGAGGAAGAAAAAGTTAGCAATTCTCCTTAAAGAGAACATAACCCGAAGGAAGCAGAA
GAAAAGAGCTTGTTGCGACG

Downstream 100 bases:

>100_bases
TATAGATGCAGTTGATTATATGTTGAGTTTTATCGTATGGTTCGGTAAGTATTTTTTTCCTGTTTGCTTTTGGTTATTCA
AACACTATAATGCCTGCCTT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MPELPEVEVIARSLADKIIGQRIRDVEVKRRDLRVRIADDFEQLVTGREICSVYRVAKYLVMQLDSGAKLVFHMGMSGRI
LYMHAPVPEKHDCVVFAMQHGYSLVFNDTRRFGLVTLLDGEGYRSLLEKMGPDPFSEAFNADCLLNMHGKARIKSVLMNS
AVVVGIGNIYASEILFTAAILPHREVSTLSREECCRIVESTREVLKLAIATGGSSIRDYRTPTGDVGNFSKHFRVYGRKG
EKCYTCGGEIQVEKQGGRSTFFCRHCQK

Sequences:

>Translated_268_residues
MPELPEVEVIARSLADKIIGQRIRDVEVKRRDLRVRIADDFEQLVTGREICSVYRVAKYLVMQLDSGAKLVFHMGMSGRI
LYMHAPVPEKHDCVVFAMQHGYSLVFNDTRRFGLVTLLDGEGYRSLLEKMGPDPFSEAFNADCLLNMHGKARIKSVLMNS
AVVVGIGNIYASEILFTAAILPHREVSTLSREECCRIVESTREVLKLAIATGGSSIRDYRTPTGDVGNFSKHFRVYGRKG
EKCYTCGGEIQVEKQGGRSTFFCRHCQK
>Mature_267_residues
PELPEVEVIARSLADKIIGQRIRDVEVKRRDLRVRIADDFEQLVTGREICSVYRVAKYLVMQLDSGAKLVFHMGMSGRIL
YMHAPVPEKHDCVVFAMQHGYSLVFNDTRRFGLVTLLDGEGYRSLLEKMGPDPFSEAFNADCLLNMHGKARIKSVLMNSA
VVVGIGNIYASEILFTAAILPHREVSTLSREECCRIVESTREVLKLAIATGGSSIRDYRTPTGDVGNFSKHFRVYGRKGE
KCYTCGGEIQVEKQGGRSTFFCRHCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=41.025641025641, Blast_Score=193, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30130; Mature: 29999

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVIARSLADKIIGQRIRDVEVKRRDLRVRIADDFEQLVTGREICSVYRVAKYL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHH
VMQLDSGAKLVFHMGMSGRILYMHAPVPEKHDCVVFAMQHGYSLVFNDTRRFGLVTLLDG
HHHCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEEEEEECC
EGYRSLLEKMGPDPFSEAFNADCLLNMHGKARIKSVLMNSAVVVGIGNIYASEILFTAAI
CCHHHHHHHHCCCHHHHHCCCCEEEECCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHH
LPHREVSTLSREECCRIVESTREVLKLAIATGGSSIRDYRTPTGDVGNFSKHFRVYGRKG
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCHHHHEEECCCC
EKCYTCGGEIQVEKQGGRSTFFCRHCQK
CEEEECCCEEEEECCCCCCEEHHHCCCC
>Mature Secondary Structure 
PELPEVEVIARSLADKIIGQRIRDVEVKRRDLRVRIADDFEQLVTGREICSVYRVAKYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHH
VMQLDSGAKLVFHMGMSGRILYMHAPVPEKHDCVVFAMQHGYSLVFNDTRRFGLVTLLDG
HHHCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEEEEEECC
EGYRSLLEKMGPDPFSEAFNADCLLNMHGKARIKSVLMNSAVVVGIGNIYASEILFTAAI
CCHHHHHHHHCCCHHHHHCCCCEEEECCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHH
LPHREVSTLSREECCRIVESTREVLKLAIATGGSSIRDYRTPTGDVGNFSKHFRVYGRKG
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCHHHHEEECCCC
EKCYTCGGEIQVEKQGGRSTFFCRHCQK
CEEEECCCEEEEECCCCCCEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA