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The map label for this gene is pccA [H]

Identifier: 88606799

GI number: 88606799

Start: 352446

End: 354425

Strand: Direct

Name: pccA [H]

Synonym: APH_0364

Alternate gene names: 88606799

Gene position: 352446-354425 (Clockwise)

Preceding gene: 88607515

Following gene: 88607333

Centisome position: 23.96

GC content: 44.24

Gene sequence:

>1980_bases
ATGATAAAAAAGATACTAATTGCTAATAGGGGGGAGATTGCGTGTAGGATAGCACGCACTGCTCGTAAGATGGGGATAAA
GTGTGTTGGGGTGTACTCAGATGCCGATATGGGGGCGCTGCACACGAGGTGTGTTGATGAAGCTGTTTACATTGGCCCAA
GTCCTGCAAGTCAAAGTTACTTGGATATAGATAAAATATGTAATGTTGCAGTGGCTACAGGAGCTGACGCGGTGCATCCT
GGATATGGGTTCCTTTCTGAGAATGCCGAGTTCCCTGATAGGTTATCTGAGAGCGGCATAGGCTTTATAGGTCCTTCGTC
GGCTTCTATGAGGATGATGGCTGATAAGGTCGTATCGAAAAAGATCGCTAAAGATGCAGGAGTAGCTGTTGTCCCTGGAT
ATATGGGGGTTGTAGAGAGCGCAGCGGAAGCTTTAAGCATAGCTGAGTCAATGGGTTTTCCAGTAATGATAAAGGCTGCT
GCTGGTGGCGGTGGTAAGGGCATGAGGATTGTTCGTTCTGTAGGGGAGATGGAACAGGCTTTTGTGTCTGCCACAAATGA
AGCTGAGAAAAGCTTTAGTGACTGTAGGATATTCATTGAAAAATACATAGAGTCTCCTAGGCATATAGAGATTCAGATAA
TAGCTGATAAGCACGGCAATGTGGTGTGTCTCGGAGAGAGAGAGTGCTCAATACAGCGTAATAATCAGAAGGTTATAGAA
GAAACTCCTAGCCCATTTTTGGATGAGAAGACTAGACGGGCAATGTATGCACAGTGTGTGAGTTTAGCAGAGAAGGTGGG
TTATTTCTCCGCGGGTACTGTAGAGTTTATAGTTAATGCTGAGAGAGAGTTTTATTTTCTAGAAATGAACACTAGGTTAC
AGGTCGAACATCCGGTAACTGAGCTGGTTACGGGGATAGACCTTGTAGCTGAGATGATACATATTGCCGATGGCAAGACT
CTTTCATTTTCTCAAGAGGACGTGCGTTTTGTAGGGGCAGCCATTGAGGCAAGGGTTTATGCAGAAGACCCTAGAAAAGG
CTTTTTGCCTTCAAGTGGTAGAATATCACATTATCATGAGCCTCCTGCTAGCGTGAATCTTAGGATAGACAGTGGGGTGA
CCGAGGGTTCTGTTGTCAGCATGTTTTACGATCCTATGATAGCTAAGGTCTCGTCCTATGCTGAGACTAGAGTAGGGGCT
ATAGAGGTTATGAAGAAGTCCCTTTGTAGTTTTTATGTAGAAGGTGTTGTCAATAACATAGATTTTTTATTATCAGTTTT
TTGCAAGCCAGCTTTCGTTGCAGGAGATATCAGTACTGGGTTTATTGCGCAGTTTTATAAATCAGGTTTTGAGGGTGATG
AGCTTACTCCTGAAATAGGTGAGATTTTCGCATTTGCACTGCTGTATATATACTTGGAAGATGAAGCCAGGCAGTATGGT
GAGCACTGGAGCATAGATGGTAAGGTATGTGCACGAGTTGGAGAGCTTAAGTACTTGTTGAATGCGCGTCGTGTAGATGG
CAGGATCTTTGCTGCTTTGGATGGTCAAGACGGGTATGTTGTATTATCTGGGGCATGGCGCGGCAATTACAAAATGTTGG
ATGTCAGCATAGACAGTAATTCATACTGCATAAAAGTTAAGAGGAGTTCCAGTAGGTATCATCTAAGGTATATGGCGGTT
TCTGCTGTATGTACGGTTTGTGAAGAGAACGTAGGTCAGTTTCTTGAGTTCATGCCTGAGCCTCAGGAGGATGAAATATT
GCGTGATGCCATAGTATCCCCTATCGCGGGTATGATCGTTGATATATACGTGAAGAAGGGAGATAAGGTAAGCGTAGGTC
AGCCTGTTCTCGTCATAGAAGCTATGAAGATGGAAAATTTGATATGCTCGGAAGTAGAGGCGGAAGTAGAAGAAGTGCTT
CTATCGCCGGGAAGCAGCGTTGCTGATGGGGAAATTATATTGAAGTTTGTTGCGAGTTAG

Upstream 100 bases:

>100_bases
ATATTGTTTGCAGTGTGATAGCACGAATGTAGAATCTGGCGTTGTATTTGCTGCTGGTGGATTACGGCAGCTCTTAGTTT
GAATTTATCTGTTTGGCTGC

Downstream 100 bases:

>100_bases
CAATCTATTGTTGAGTATAGGGAAACAGCCAGCATTCTTTGCTATGTGTTAATTATACGTTGTATAGCTAGCTCTGTTGA
GGGTTGTAGCGCTTAGGCTG

Product: propionyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MIKKILIANRGEIACRIARTARKMGIKCVGVYSDADMGALHTRCVDEAVYIGPSPASQSYLDIDKICNVAVATGADAVHP
GYGFLSENAEFPDRLSESGIGFIGPSSASMRMMADKVVSKKIAKDAGVAVVPGYMGVVESAAEALSIAESMGFPVMIKAA
AGGGGKGMRIVRSVGEMEQAFVSATNEAEKSFSDCRIFIEKYIESPRHIEIQIIADKHGNVVCLGERECSIQRNNQKVIE
ETPSPFLDEKTRRAMYAQCVSLAEKVGYFSAGTVEFIVNAEREFYFLEMNTRLQVEHPVTELVTGIDLVAEMIHIADGKT
LSFSQEDVRFVGAAIEARVYAEDPRKGFLPSSGRISHYHEPPASVNLRIDSGVTEGSVVSMFYDPMIAKVSSYAETRVGA
IEVMKKSLCSFYVEGVVNNIDFLLSVFCKPAFVAGDISTGFIAQFYKSGFEGDELTPEIGEIFAFALLYIYLEDEARQYG
EHWSIDGKVCARVGELKYLLNARRVDGRIFAALDGQDGYVVLSGAWRGNYKMLDVSIDSNSYCIKVKRSSSRYHLRYMAV
SAVCTVCEENVGQFLEFMPEPQEDEILRDAIVSPIAGMIVDIYVKKGDKVSVGQPVLVIEAMKMENLICSEVEAEVEEVL
LSPGSSVADGEIILKFVAS

Sequences:

>Translated_659_residues
MIKKILIANRGEIACRIARTARKMGIKCVGVYSDADMGALHTRCVDEAVYIGPSPASQSYLDIDKICNVAVATGADAVHP
GYGFLSENAEFPDRLSESGIGFIGPSSASMRMMADKVVSKKIAKDAGVAVVPGYMGVVESAAEALSIAESMGFPVMIKAA
AGGGGKGMRIVRSVGEMEQAFVSATNEAEKSFSDCRIFIEKYIESPRHIEIQIIADKHGNVVCLGERECSIQRNNQKVIE
ETPSPFLDEKTRRAMYAQCVSLAEKVGYFSAGTVEFIVNAEREFYFLEMNTRLQVEHPVTELVTGIDLVAEMIHIADGKT
LSFSQEDVRFVGAAIEARVYAEDPRKGFLPSSGRISHYHEPPASVNLRIDSGVTEGSVVSMFYDPMIAKVSSYAETRVGA
IEVMKKSLCSFYVEGVVNNIDFLLSVFCKPAFVAGDISTGFIAQFYKSGFEGDELTPEIGEIFAFALLYIYLEDEARQYG
EHWSIDGKVCARVGELKYLLNARRVDGRIFAALDGQDGYVVLSGAWRGNYKMLDVSIDSNSYCIKVKRSSSRYHLRYMAV
SAVCTVCEENVGQFLEFMPEPQEDEILRDAIVSPIAGMIVDIYVKKGDKVSVGQPVLVIEAMKMENLICSEVEAEVEEVL
LSPGSSVADGEIILKFVAS
>Mature_659_residues
MIKKILIANRGEIACRIARTARKMGIKCVGVYSDADMGALHTRCVDEAVYIGPSPASQSYLDIDKICNVAVATGADAVHP
GYGFLSENAEFPDRLSESGIGFIGPSSASMRMMADKVVSKKIAKDAGVAVVPGYMGVVESAAEALSIAESMGFPVMIKAA
AGGGGKGMRIVRSVGEMEQAFVSATNEAEKSFSDCRIFIEKYIESPRHIEIQIIADKHGNVVCLGERECSIQRNNQKVIE
ETPSPFLDEKTRRAMYAQCVSLAEKVGYFSAGTVEFIVNAEREFYFLEMNTRLQVEHPVTELVTGIDLVAEMIHIADGKT
LSFSQEDVRFVGAAIEARVYAEDPRKGFLPSSGRISHYHEPPASVNLRIDSGVTEGSVVSMFYDPMIAKVSSYAETRVGA
IEVMKKSLCSFYVEGVVNNIDFLLSVFCKPAFVAGDISTGFIAQFYKSGFEGDELTPEIGEIFAFALLYIYLEDEARQYG
EHWSIDGKVCARVGELKYLLNARRVDGRIFAALDGQDGYVVLSGAWRGNYKMLDVSIDSNSYCIKVKRSSSRYHLRYMAV
SAVCTVCEENVGQFLEFMPEPQEDEILRDAIVSPIAGMIVDIYVKKGDKVSVGQPVLVIEAMKMENLICSEVEAEVEEVL
LSPGSSVADGEIILKFVAS

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=671, Percent_Identity=43.9642324888227, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI65506442, Length=671, Percent_Identity=43.9642324888227, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI295821183, Length=669, Percent_Identity=42.8998505231689, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI116805327, Length=680, Percent_Identity=39.7058823529412, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=44.8430493273543, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=44.8430493273543, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=44.8430493273543, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679960, Length=736, Percent_Identity=27.5815217391304, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679977, Length=735, Percent_Identity=27.4829931972789, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI38679967, Length=735, Percent_Identity=27.4829931972789, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI38679974, Length=735, Percent_Identity=27.4829931972789, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI38679971, Length=735, Percent_Identity=27.4829931972789, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI134142062, Length=698, Percent_Identity=28.2234957020057, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=44.9438202247191, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17567343, Length=674, Percent_Identity=41.9881305637982, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71987519, Length=669, Percent_Identity=40.0597907324365, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17562816, Length=472, Percent_Identity=43.2203389830509, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=683, Percent_Identity=29.1361639824305, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=506, Percent_Identity=29.8418972332016, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=29.8418972332016, Blast_Score=214, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=43.7219730941704, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=41.5178571428571, Blast_Score=332, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=42.6339285714286, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6324343, Length=742, Percent_Identity=28.4366576819407, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=689, Percent_Identity=29.6081277213353, Blast_Score=245, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24651757, Length=678, Percent_Identity=39.3805309734513, Blast_Score=467, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24651759, Length=640, Percent_Identity=37.96875, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI281363050, Length=454, Percent_Identity=43.3920704845815, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652224, Length=454, Percent_Identity=43.3920704845815, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652222, Length=454, Percent_Identity=43.3920704845815, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652220, Length=454, Percent_Identity=43.3920704845815, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652218, Length=454, Percent_Identity=43.3920704845815, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652212, Length=454, Percent_Identity=43.3920704845815, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24652210, Length=454, Percent_Identity=43.3920704845815, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24652214, Length=454, Percent_Identity=43.3920704845815, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI19921944, Length=454, Percent_Identity=43.3920704845815, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24652216, Length=454, Percent_Identity=43.3920704845815, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24586458, Length=729, Percent_Identity=27.8463648834019, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI161076409, Length=729, Percent_Identity=27.8463648834019, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI161076407, Length=729, Percent_Identity=27.8463648834019, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24586460, Length=729, Percent_Identity=27.8463648834019, Blast_Score=239, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 72062; Mature: 72062

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKILIANRGEIACRIARTARKMGIKCVGVYSDADMGALHTRCVDEAVYIGPSPASQSY
CCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEEEECCCCCCCCC
LDIDKICNVAVATGADAVHPGYGFLSENAEFPDRLSESGIGFIGPSSASMRMMADKVVSK
CCHHHHCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCHHHHHHHHHHHH
KIAKDAGVAVVPGYMGVVESAAEALSIAESMGFPVMIKAAAGGGGKGMRIVRSVGEMEQA
HHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
FVSATNEAEKSFSDCRIFIEKYIESPRHIEIQIIADKHGNVVCLGERECSIQRNNQKVIE
HHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCCEECCCCHHHH
ETPSPFLDEKTRRAMYAQCVSLAEKVGYFSAGTVEFIVNAEREFYFLEMNTRLQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCEEEECCCHH
ELVTGIDLVAEMIHIADGKTLSFSQEDVRFVGAAIEARVYAEDPRKGFLPSSGRISHYHE
HHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCC
PPASVNLRIDSGVTEGSVVSMFYDPMIAKVSSYAETRVGAIEVMKKSLCSFYVEGVVNNI
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFLLSVFCKPAFVAGDISTGFIAQFYKSGFEGDELTPEIGEIFAFALLYIYLEDEARQYG
HHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECHHHHHCC
EHWSIDGKVCARVGELKYLLNARRVDGRIFAALDGQDGYVVLSGAWRGNYKMLDVSIDSN
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCEEEEEEEECCC
SYCIKVKRSSSRYHLRYMAVSAVCTVCEENVGQFLEFMPEPQEDEILRDAIVSPIAGMIV
CEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEE
DIYVKKGDKVSVGQPVLVIEAMKMENLICSEVEAEVEEVLLSPGSSVADGEIILKFVAS
EEEEECCCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECC
>Mature Secondary Structure
MIKKILIANRGEIACRIARTARKMGIKCVGVYSDADMGALHTRCVDEAVYIGPSPASQSY
CCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEEEECCCCCCCCC
LDIDKICNVAVATGADAVHPGYGFLSENAEFPDRLSESGIGFIGPSSASMRMMADKVVSK
CCHHHHCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCHHHHHHHHHHHH
KIAKDAGVAVVPGYMGVVESAAEALSIAESMGFPVMIKAAAGGGGKGMRIVRSVGEMEQA
HHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
FVSATNEAEKSFSDCRIFIEKYIESPRHIEIQIIADKHGNVVCLGERECSIQRNNQKVIE
HHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCCEECCCCHHHH
ETPSPFLDEKTRRAMYAQCVSLAEKVGYFSAGTVEFIVNAEREFYFLEMNTRLQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCEEEECCCHH
ELVTGIDLVAEMIHIADGKTLSFSQEDVRFVGAAIEARVYAEDPRKGFLPSSGRISHYHE
HHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCC
PPASVNLRIDSGVTEGSVVSMFYDPMIAKVSSYAETRVGAIEVMKKSLCSFYVEGVVNNI
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFLLSVFCKPAFVAGDISTGFIAQFYKSGFEGDELTPEIGEIFAFALLYIYLEDEARQYG
HHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECHHHHHCC
EHWSIDGKVCARVGELKYLLNARRVDGRIFAALDGQDGYVVLSGAWRGNYKMLDVSIDSN
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCEEEEEEEECCC
SYCIKVKRSSSRYHLRYMAVSAVCTVCEENVGQFLEFMPEPQEDEILRDAIVSPIAGMIV
CEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEE
DIYVKKGDKVSVGQPVLVIEAMKMENLICSEVEAEVEEVLLSPGSSVADGEIILKFVAS
EEEEECCCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]