Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 88606723

GI number: 88606723

Start: 238396

End: 240048

Strand: Reverse

Name: groEL

Synonym: APH_0240

Alternate gene names: 88606723

Gene position: 240048-238396 (Counterclockwise)

Preceding gene: 88607332

Following gene: 88607762

Centisome position: 16.32

GC content: 43.32

Gene sequence:

>1653_bases
ATGTCAAATACGGTAGTCACGGGTGAGGTATTAGATAAGTCTATTAGGGAGGTAGTACGCATCCTAGAAGATGCAGTTGG
TTGTACTGCTGGTCCTAAAGGCCTCACTGTAGCGATTAGTAAGCCTTATGGGTCGCCAGAGATCACAAAGGATGGCTACA
AGGTAATGAAGAGTATAAAGCCTGAAGAACCACTGGCTGCCGCTATAGCGAGCATCATTACTCAGAGTGCTTCTCAGTGT
AATGATAAGGTGGGAGATGGAACTACTACATGCTCCATACTAACGGCAAAAGTGATTGAAGAAGTCTCAAAAGCGAAAGC
TGCTGGATCTGATATTGTTAGCATAAAGAATGGTATTCTCAAGGCTAAGGAAGCGGTTCTTACAGCGCTTATGTCTATGA
GACGTGAAGTAGAAGAAGACGAAATTGCACAAGTTGCAACATTGTCTGCGAATGGAGACAAGAACATAGGAAGTAAGATT
GCACAGTGTGTTAAAGAAGTCGGTAAAGACGGTGTTATAACTGTTGAAGAAAGCAAAGGCTTCAAGGATCTAGAAGTTGA
AAAGACTGATGGTATGCAGTTTGATCGCGGATATCTTTCGCCTTACTTTGTTACAAATGCTGAAAAAATGCTGGTGGAAT
TTGAAAATCCATACATATTCCTTACTGAAAAGAAGATTAATCTTGTACAAAGCATTCTACCAATCTTAGAAAACGTTGCA
CGGTCTGGAAGACCATTGCTCATCATAGCTGAAGACGTTGAAGGTGAAGCTCTGAGCACGCTTGTACTCAATAAGCTCCG
TGGTGGCCTTCAAGTTGCTGCTGTAAAGGCGCCTGGTTTCGGTGACAGAAGAAAAGACATGCTTGGCGATATTGCTGTAA
TAGTAGGCGCTAAGTATGTAGTAAATGACGAGCTTGCTGTTAAGATGGAAGACATCGCTCTAAGCGATCTTGGTACTGCT
AAGAGCGTGCGAATCACAAAAGACGCAACTACTATTATAGGTAGTGTTGATAGCAGTTCTGAAAGCATAGCTAGCAGGAC
TAATCAAATCAAAGCTCAGATAGAAAATTCTAGTTCTGATTATGACAAGGAAAAGCTTAGAGAACGTTTAGCGAAGCTTT
CCGGTGGCGTTGCTGTACTCAAGGTTGGTGGATCCAGCGAAGTTGAGGTGAAGGAACGCAAAGACAGAGTAGAAGATGCA
TTACATGCTACTAGAGCTGCTGTTGAGGAAGGTGTAGTACCTGGTGGTGGGGCTGCATTGCTTTATGCGCTTTCGTCTCT
AGACGGTCTAAAAGGCAAGAATGACGACGAACAATGGGGTATAGACATTATACGTCGCGCTGCTTGTGCTCCAATCAAAA
GAATCATCAAGAATTCTGGTTCTGAAGAAGCACCATGCGTAATTCAACACTTGTTGAAGCAAAACGACAAGGAACTTATC
TACAATGTGGATACTATGAACTACGCGAATGCTTTTACATCTGGAGTTATGGATCCTCTCAAAGTAGTACGTATCGCGTT
TGATTTAGCTGTATCACTCGCTGCAGTATTCATGACTTTGAATGCAGTGGTTGTTGATGTTCCTAGTAAGAACGACGCTG
CTGGTGCTGGCGCTGGTGGTATGGGCGGCATGGGTGGTATGGGCGGATTTTAA

Upstream 100 bases:

>100_bases
AAGTTCATAGTGATGAAGGAGAGTGACATAATAGCTAAGGAAGCATAGTCTTATGCTACGGTTGTTTGTTCTATTGGTCT
AAAGTTTAGGAGGTTCAAAA

Downstream 100 bases:

>100_bases
ATATTGGGAATCGTTTCGTATACTGCTTGATGCAAGCATATCTTATTGATTAAACTTGAAAGGTGTCGCGATTTGTCGGT
TGCGACGCCTTTTAGGTTGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MSNTVVTGEVLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGSPEITKDGYKVMKSIKPEEPLAAAIASIITQSASQC
NDKVGDGTTTCSILTAKVIEEVSKAKAAGSDIVSIKNGILKAKEAVLTALMSMRREVEEDEIAQVATLSANGDKNIGSKI
AQCVKEVGKDGVITVEESKGFKDLEVEKTDGMQFDRGYLSPYFVTNAEKMLVEFENPYIFLTEKKINLVQSILPILENVA
RSGRPLLIIAEDVEGEALSTLVLNKLRGGLQVAAVKAPGFGDRRKDMLGDIAVIVGAKYVVNDELAVKMEDIALSDLGTA
KSVRITKDATTIIGSVDSSSESIASRTNQIKAQIENSSSDYDKEKLRERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDA
LHATRAAVEEGVVPGGGAALLYALSSLDGLKGKNDDEQWGIDIIRRAACAPIKRIIKNSGSEEAPCVIQHLLKQNDKELI
YNVDTMNYANAFTSGVMDPLKVVRIAFDLAVSLAAVFMTLNAVVVDVPSKNDAAGAGAGGMGGMGGMGGF

Sequences:

>Translated_550_residues
MSNTVVTGEVLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGSPEITKDGYKVMKSIKPEEPLAAAIASIITQSASQC
NDKVGDGTTTCSILTAKVIEEVSKAKAAGSDIVSIKNGILKAKEAVLTALMSMRREVEEDEIAQVATLSANGDKNIGSKI
AQCVKEVGKDGVITVEESKGFKDLEVEKTDGMQFDRGYLSPYFVTNAEKMLVEFENPYIFLTEKKINLVQSILPILENVA
RSGRPLLIIAEDVEGEALSTLVLNKLRGGLQVAAVKAPGFGDRRKDMLGDIAVIVGAKYVVNDELAVKMEDIALSDLGTA
KSVRITKDATTIIGSVDSSSESIASRTNQIKAQIENSSSDYDKEKLRERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDA
LHATRAAVEEGVVPGGGAALLYALSSLDGLKGKNDDEQWGIDIIRRAACAPIKRIIKNSGSEEAPCVIQHLLKQNDKELI
YNVDTMNYANAFTSGVMDPLKVVRIAFDLAVSLAAVFMTLNAVVVDVPSKNDAAGAGAGGMGGMGGMGGF
>Mature_549_residues
SNTVVTGEVLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGSPEITKDGYKVMKSIKPEEPLAAAIASIITQSASQCN
DKVGDGTTTCSILTAKVIEEVSKAKAAGSDIVSIKNGILKAKEAVLTALMSMRREVEEDEIAQVATLSANGDKNIGSKIA
QCVKEVGKDGVITVEESKGFKDLEVEKTDGMQFDRGYLSPYFVTNAEKMLVEFENPYIFLTEKKINLVQSILPILENVAR
SGRPLLIIAEDVEGEALSTLVLNKLRGGLQVAAVKAPGFGDRRKDMLGDIAVIVGAKYVVNDELAVKMEDIALSDLGTAK
SVRITKDATTIIGSVDSSSESIASRTNQIKAQIENSSSDYDKEKLRERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDAL
HATRAAVEEGVVPGGGAALLYALSSLDGLKGKNDDEQWGIDIIRRAACAPIKRIIKNSGSEEAPCVIQHLLKQNDKELIY
NVDTMNYANAFTSGVMDPLKVVRIAFDLAVSLAAVFMTLNAVVVDVPSKNDAAGAGAGGMGGMGGMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=512, Percent_Identity=46.09375, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI31542947, Length=512, Percent_Identity=46.09375, Blast_Score=418, Evalue=1e-117,
Organism=Escherichia coli, GI1790586, Length=517, Percent_Identity=50.2901353965184, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17555558, Length=513, Percent_Identity=47.1734892787524, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=47.8672985781991, Blast_Score=182, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6323288, Length=512, Percent_Identity=46.2890625, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24641193, Length=516, Percent_Identity=47.4806201550388, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24641191, Length=516, Percent_Identity=47.4806201550388, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45550936, Length=513, Percent_Identity=45.8089668615984, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45550132, Length=513, Percent_Identity=45.8089668615984, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45550935, Length=513, Percent_Identity=45.8089668615984, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=41.1439114391144, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24584129, Length=515, Percent_Identity=33.5922330097087, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI19921262, Length=515, Percent_Identity=33.5922330097087, Blast_Score=251, Evalue=9e-67,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_ANAPZ (Q2GL94)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_504857.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2GL94
- SMR:   Q2GL94
- STRING:   Q2GL94
- GeneID:   3930333
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0240
- NMPDR:   fig|212042.5.peg.229
- TIGR:   APH_0240
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- ProtClustDB:   PRK00013
- BioCyc:   APHA212042:APH_0240-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58301; Mature: 58169

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTVVTGEVLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGSPEITKDGYKVMKSIK
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCC
PEEPLAAAIASIITQSASQCNDKVGDGTTTCSILTAKVIEEVSKAKAAGSDIVSIKNGIL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAKEAVLTALMSMRREVEEDEIAQVATLSANGDKNIGSKIAQCVKEVGKDGVITVEESKG
HHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCC
FKDLEVEKTDGMQFDRGYLSPYFVTNAEKMLVEFENPYIFLTEKKINLVQSILPILENVA
CCCCEEECCCCCEECCCCCCCEEECCHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHHH
RSGRPLLIIAEDVEGEALSTLVLNKLRGGLQVAAVKAPGFGDRRKDMLGDIAVIVGAKYV
HCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHE
VNDELAVKMEDIALSDLGTAKSVRITKDATTIIGSVDSSSESIASRTNQIKAQIENSSSD
ECCCCEEEEHHHHHHCCCCCCEEEEECCHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCC
YDKEKLRERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDALHATRAAVEEGVVPGGGAAL
CCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LYALSSLDGLKGKNDDEQWGIDIIRRAACAPIKRIIKNSGSEEAPCVIQHLLKQNDKELI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEE
YNVDTMNYANAFTSGVMDPLKVVRIAFDLAVSLAAVFMTLNAVVVDVPSKNDAAGAGAGG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCC
MGGMGGMGGF
CCCCCCCCCC
>Mature Secondary Structure 
SNTVVTGEVLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGSPEITKDGYKVMKSIK
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCC
PEEPLAAAIASIITQSASQCNDKVGDGTTTCSILTAKVIEEVSKAKAAGSDIVSIKNGIL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAKEAVLTALMSMRREVEEDEIAQVATLSANGDKNIGSKIAQCVKEVGKDGVITVEESKG
HHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCC
FKDLEVEKTDGMQFDRGYLSPYFVTNAEKMLVEFENPYIFLTEKKINLVQSILPILENVA
CCCCEEECCCCCEECCCCCCCEEECCHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHHH
RSGRPLLIIAEDVEGEALSTLVLNKLRGGLQVAAVKAPGFGDRRKDMLGDIAVIVGAKYV
HCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHE
VNDELAVKMEDIALSDLGTAKSVRITKDATTIIGSVDSSSESIASRTNQIKAQIENSSSD
ECCCCEEEEHHHHHHCCCCCCEEEEECCHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCC
YDKEKLRERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDALHATRAAVEEGVVPGGGAAL
CCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LYALSSLDGLKGKNDDEQWGIDIIRRAACAPIKRIIKNSGSEEAPCVIQHLLKQNDKELI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEE
YNVDTMNYANAFTSGVMDPLKVVRIAFDLAVSLAAVFMTLNAVVVDVPSKNDAAGAGAGG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCC
MGGMGGMGGF
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA