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The map label for this gene is apbA [H]

Identifier: 87199694

GI number: 87199694

Start: 1761461

End: 1762420

Strand: Reverse

Name: apbA [H]

Synonym: Saro_1677

Alternate gene names: 87199694

Gene position: 1762420-1761461 (Counterclockwise)

Preceding gene: 87199695

Following gene: 87199691

Centisome position: 49.48

GC content: 68.54

Gene sequence:

>960_bases
ATGTACGAGCGAGGGACTATCCAGATGGAGCGCGTGGTTATCGTCGGTGCCGGCGCGATGGGCTGCCTCTTTGCGGCAAG
GCTGGCCCTGGCCGGAAAGCAGGTCACGCTGGTTGACGTCGACACCGCGCGGCTGGAGCAAATCGCGGCCCGCGGAATAG
TCCTGCACGACGACCACGGCGACCGCACGGCCCGCGTCACCGCCTGCACTGCGGCAGATGCCGAGCCGGCAGACCTCGTG
CTCGTTTTCACCAAGGCAATGCATACCGCAGCAGCCATCCGTTCGGTCGCGCATCTGAACGACGGACATTGCTGCGCCCT
TACCCTGCAGAACGGCCTGGGTAACGCCGAAGCCTTGGCTGAGGTCTTCCCGGCAGATCGCGTGCTGATCGGCGTGACCG
ACTGGCCCGCAGACCTCCTGCCGCCGAACGGCGTCGCCGCGCACGGCACGGGCCACGTGTGGCTGGGCCCCTGCGACAAG
GCCGGCGCAGACCATGCGCAAGCCGCAACCACGCTGCTCAACGCGGGCCGGATGGATGCCCGGCACGATCCCGATGTCCT
TGCGGCAGTGTGGGAAAAAGCCGCGTTCAACGCCGCGCTGAATGCGCTCTCCACCGTGCTTGGCCTGCCGGTGGGCGGAC
TGGACACGCCAGAGGGCCGTCGCATTGCGGTTGCCGTGGTCGACGAGACCGTCGCCGTCGCGGCCAGTCGGGGCATTGCC
ATGGACCGCGCGAGACTGGCGGCGAAGATCGACTTCGCCCTCGCCAACCACAAGGCGCACAAGCCATCGATGCTACAGGA
CCGCCTCGCCGGGCGGCCGACCGAAATCGACGCGATCAACGGACAGATCGTGAATGCGGCGACGGCAGCGGGGCTCACCG
CGCCAGTGACCGCGACGCTTGCCGATCTGGTGCGAATGGGCGAGCCGGGGCGGACCCAGGCCCGCCCCGCGCTCTCCTAG

Upstream 100 bases:

>100_bases
CGGCCTTCTACCGGATGCGGCGAGCCAGTTCGTACGTCATTTTCCGCTTGTCGGCAGCGGGGCTTGACCGACCAATCCAC
CCGCCGGGATACTCGCGCGC

Downstream 100 bases:

>100_bases
CCCGCGATCAGAACTTCGCGCCCGCGCGCAGGCCGAACATGCGCGGCGTGGTGGGCACGATATAGGGACGCTGGCCGCAC
GATCCGCACTGCTGGAAGCG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MYERGTIQMERVVIVGAGAMGCLFAARLALAGKQVTLVDVDTARLEQIAARGIVLHDDHGDRTARVTACTAADAEPADLV
LVFTKAMHTAAAIRSVAHLNDGHCCALTLQNGLGNAEALAEVFPADRVLIGVTDWPADLLPPNGVAAHGTGHVWLGPCDK
AGADHAQAATTLLNAGRMDARHDPDVLAAVWEKAAFNAALNALSTVLGLPVGGLDTPEGRRIAVAVVDETVAVAASRGIA
MDRARLAAKIDFALANHKAHKPSMLQDRLAGRPTEIDAINGQIVNAATAAGLTAPVTATLADLVRMGEPGRTQARPALS

Sequences:

>Translated_319_residues
MYERGTIQMERVVIVGAGAMGCLFAARLALAGKQVTLVDVDTARLEQIAARGIVLHDDHGDRTARVTACTAADAEPADLV
LVFTKAMHTAAAIRSVAHLNDGHCCALTLQNGLGNAEALAEVFPADRVLIGVTDWPADLLPPNGVAAHGTGHVWLGPCDK
AGADHAQAATTLLNAGRMDARHDPDVLAAVWEKAAFNAALNALSTVLGLPVGGLDTPEGRRIAVAVVDETVAVAASRGIA
MDRARLAAKIDFALANHKAHKPSMLQDRLAGRPTEIDAINGQIVNAATAAGLTAPVTATLADLVRMGEPGRTQARPALS
>Mature_319_residues
MYERGTIQMERVVIVGAGAMGCLFAARLALAGKQVTLVDVDTARLEQIAARGIVLHDDHGDRTARVTACTAADAEPADLV
LVFTKAMHTAAAIRSVAHLNDGHCCALTLQNGLGNAEALAEVFPADRVLIGVTDWPADLLPPNGVAAHGTGHVWLGPCDK
AGADHAQAATTLLNAGRMDARHDPDVLAAVWEKAAFNAALNALSTVLGLPVGGLDTPEGRRIAVAVVDETVAVAASRGIA
MDRARLAAKIDFALANHKAHKPSMLQDRLAGRPTEIDAINGQIVNAATAAGLTAPVTATLADLVRMGEPGRTQARPALS

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=299, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320057, Length=334, Percent_Identity=24.251497005988, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33008; Mature: 33008

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYERGTIQMERVVIVGAGAMGCLFAARLALAGKQVTLVDVDTARLEQIAARGIVLHDDHG
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEEEECCCC
DRTARVTACTAADAEPADLVLVFTKAMHTAAAIRSVAHLNDGHCCALTLQNGLGNAEALA
CCEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
EVFPADRVLIGVTDWPADLLPPNGVAAHGTGHVWLGPCDKAGADHAQAATTLLNAGRMDA
HHCCCCEEEEEECCCCHHCCCCCCEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCC
RHDPDVLAAVWEKAAFNAALNALSTVLGLPVGGLDTPEGRRIAVAVVDETVAVAASRGIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHCCCH
MDRARLAAKIDFALANHKAHKPSMLQDRLAGRPTEIDAINGQIVNAATAAGLTAPVTATL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCEEEEHHHHCCCCCHHHHHH
ADLVRMGEPGRTQARPALS
HHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MYERGTIQMERVVIVGAGAMGCLFAARLALAGKQVTLVDVDTARLEQIAARGIVLHDDHG
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEEEECCCC
DRTARVTACTAADAEPADLVLVFTKAMHTAAAIRSVAHLNDGHCCALTLQNGLGNAEALA
CCEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
EVFPADRVLIGVTDWPADLLPPNGVAAHGTGHVWLGPCDKAGADHAQAATTLLNAGRMDA
HHCCCCEEEEEECCCCHHCCCCCCEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCC
RHDPDVLAAVWEKAAFNAALNALSTVLGLPVGGLDTPEGRRIAVAVVDETVAVAASRGIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHCCCH
MDRARLAAKIDFALANHKAHKPSMLQDRLAGRPTEIDAINGQIVNAATAAGLTAPVTATL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCEEEEHHHHCCCCCHHHHHH
ADLVRMGEPGRTQARPALS
HHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]