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The map label for this gene is fadH [C]

Identifier: 87199589

GI number: 87199589

Start: 1629369

End: 1630460

Strand: Reverse

Name: fadH [C]

Synonym: Saro_1572

Alternate gene names: 87199589

Gene position: 1630460-1629369 (Counterclockwise)

Preceding gene: 87199590

Following gene: 87199577

Centisome position: 45.78

GC content: 67.86

Gene sequence:

>1092_bases
ATGACACTGCCAAGCCTTTTCCGCCCCGCCGCACTGCCCGGCCTCGACCTGCCCAACCGCCTCGTCATGGCCCCCATGAC
GAGGCGCATGAGTCCGGGCGGCATCCCCGGCGCAGACGTCGCCGCCTACTACCGTCGCCGCGCCGAGGGCGGCGTCGGCC
TCATCATCACCGAGGGTACCGGCATCGCAGATCCGGCCGCGCTGGCCGAGCGGGACGTGCCGGAGTTCCACGGCGATGCG
CTTCGGGGATGGTCAACGGTGGTTGACGAAGTCCACGCGGGCGGCGCGAAAATCTTTCCGCAGTTGTGGCATGTCGGCAG
CGCGCGGCGGCCGGACATGACCAACACCCCCGAAGTTCCGGCAGTGTCGCCGGCAGGCCTGTTCGCCCCCGGCCAGCCCA
ACGGCGAAGCGCTGGACGAAGCCCGGATCGGGCGGATCATCACGGCCTACGGCGAAGCCGCCGCACAGGCATTGCGGATG
GGGTTCGACGGCATCGAACTGCACTTCGCGCACGGCTATCTGGTGGACCAGTTCCTGTGGGAGCCGACAAACGGACGGGC
CGACGGATGGGGTCGCACGCCGTGGCTGTTGGCCCGCGAGGTGGTAGCCGAATGCCGTCGCCAGACGAATCCCGACTTCC
CCATCTGCATGCGATTTTCTCAATGGAAACAGCAGGACTACGGCGCGCGCCTGTTCGCAGACCCGGCCTGCCTGGAGGCT
TTCCTGGGCCCCATGGTCGATGCGGGCGTCGACATGTTCCATTGCTCCACCCGCCGGTTCTGGGAGCCCGAGTTCGCGGG
AAGCCGGATGAACCTGGCCGGCTGGACGCGGCGCCTTTCGGGCAAGCCGGTCATCACCGTTGGATCGGTGGGGCTGGACG
AAGACTTCCTCGTAACGCGCGTCGGCGATGACCCGACGGCAGACGGTGCAAGGCTTGAACTGCTCGAGGACATGCTGGCG
ACCGGCGAGGTCGATCTTGTGGCCGTGGGCCGTGCGCTGATCGGCGATCCGCAATGGAGTGCCAAGGTGCGCGAGGGACG
GTTCGACCAGATCCGGACGTTCACGCGGGACGATCTGGCGCGCCTCGACTAG

Upstream 100 bases:

>100_bases
GCGTGAACGCCGGGCCTGCGGGGCAATCCGAGAGGCGATAATCGCGCACCCGAGGCGCTGATACGGGACAGGCGCGGTAC
GGATCGGCACATTGCGCGCG

Downstream 100 bases:

>100_bases
CCCTTGAGCAGAAGCGACTGCGCCCCCGTCGCGAGCAGGCGGCCCGACTGGTCCCAGAGCGTGACCTGCCCCTGGGCAAA
GCCGGACGCAGACGAGGGAA

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTLPSLFRPAALPGLDLPNRLVMAPMTRRMSPGGIPGADVAAYYRRRAEGGVGLIITEGTGIADPAALAERDVPEFHGDA
LRGWSTVVDEVHAGGAKIFPQLWHVGSARRPDMTNTPEVPAVSPAGLFAPGQPNGEALDEARIGRIITAYGEAAAQALRM
GFDGIELHFAHGYLVDQFLWEPTNGRADGWGRTPWLLAREVVAECRRQTNPDFPICMRFSQWKQQDYGARLFADPACLEA
FLGPMVDAGVDMFHCSTRRFWEPEFAGSRMNLAGWTRRLSGKPVITVGSVGLDEDFLVTRVGDDPTADGARLELLEDMLA
TGEVDLVAVGRALIGDPQWSAKVREGRFDQIRTFTRDDLARLD

Sequences:

>Translated_363_residues
MTLPSLFRPAALPGLDLPNRLVMAPMTRRMSPGGIPGADVAAYYRRRAEGGVGLIITEGTGIADPAALAERDVPEFHGDA
LRGWSTVVDEVHAGGAKIFPQLWHVGSARRPDMTNTPEVPAVSPAGLFAPGQPNGEALDEARIGRIITAYGEAAAQALRM
GFDGIELHFAHGYLVDQFLWEPTNGRADGWGRTPWLLAREVVAECRRQTNPDFPICMRFSQWKQQDYGARLFADPACLEA
FLGPMVDAGVDMFHCSTRRFWEPEFAGSRMNLAGWTRRLSGKPVITVGSVGLDEDFLVTRVGDDPTADGARLELLEDMLA
TGEVDLVAVGRALIGDPQWSAKVREGRFDQIRTFTRDDLARLD
>Mature_362_residues
TLPSLFRPAALPGLDLPNRLVMAPMTRRMSPGGIPGADVAAYYRRRAEGGVGLIITEGTGIADPAALAERDVPEFHGDAL
RGWSTVVDEVHAGGAKIFPQLWHVGSARRPDMTNTPEVPAVSPAGLFAPGQPNGEALDEARIGRIITAYGEAAAQALRMG
FDGIELHFAHGYLVDQFLWEPTNGRADGWGRTPWLLAREVVAECRRQTNPDFPICMRFSQWKQQDYGARLFADPACLEAF
LGPMVDAGVDMFHCSTRRFWEPEFAGSRMNLAGWTRRLSGKPVITVGSVGLDEDFLVTRVGDDPTADGARLELLEDMLAT
GEVDLVAVGRALIGDPQWSAKVREGRFDQIRTFTRDDLARLD

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=381, Percent_Identity=27.5590551181102, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787939, Length=371, Percent_Identity=29.1105121293801, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321973, Length=202, Percent_Identity=29.2079207920792, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 39683; Mature: 39552

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPSLFRPAALPGLDLPNRLVMAPMTRRMSPGGIPGADVAAYYRRRAEGGVGLIITEGT
CCCCHHHCCCCCCCCCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCC
GIADPAALAERDVPEFHGDALRGWSTVVDEVHAGGAKIFPQLWHVGSARRPDMTNTPEVP
CCCCHHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCC
AVSPAGLFAPGQPNGEALDEARIGRIITAYGEAAAQALRMGFDGIELHFAHGYLVDQFLW
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHC
EPTNGRADGWGRTPWLLAREVVAECRRQTNPDFPICMRFSQWKQQDYGARLFADPACLEA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCEEECCHHHHHH
FLGPMVDAGVDMFHCSTRRFWEPEFAGSRMNLAGWTRRLSGKPVITVGSVGLDEDFLVTR
HHHHHHHCCCHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCEEEEE
VGDDPTADGARLELLEDMLATGEVDLVAVGRALIGDPQWSAKVREGRFDQIRTFTRDDLA
CCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHH
RLD
HCC
>Mature Secondary Structure 
TLPSLFRPAALPGLDLPNRLVMAPMTRRMSPGGIPGADVAAYYRRRAEGGVGLIITEGT
CCCHHHCCCCCCCCCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCC
GIADPAALAERDVPEFHGDALRGWSTVVDEVHAGGAKIFPQLWHVGSARRPDMTNTPEVP
CCCCHHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCC
AVSPAGLFAPGQPNGEALDEARIGRIITAYGEAAAQALRMGFDGIELHFAHGYLVDQFLW
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHC
EPTNGRADGWGRTPWLLAREVVAECRRQTNPDFPICMRFSQWKQQDYGARLFADPACLEA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCEEECCHHHHHH
FLGPMVDAGVDMFHCSTRRFWEPEFAGSRMNLAGWTRRLSGKPVITVGSVGLDEDFLVTR
HHHHHHHCCCHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCEEEEE
VGDDPTADGARLELLEDMLATGEVDLVAVGRALIGDPQWSAKVREGRFDQIRTFTRDDLA
CCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHH
RLD
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]