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The map label for this gene is penA [H]

Identifier: 87199149

GI number: 87199149

Start: 1170678

End: 1172423

Strand: Direct

Name: penA [H]

Synonym: Saro_1127

Alternate gene names: 87199149

Gene position: 1170678-1172423 (Clockwise)

Preceding gene: 87199148

Following gene: 87199150

Centisome position: 32.87

GC content: 65.29

Gene sequence:

>1746_bases
GTGAATGCGCTCACCGCCTCCGCCGCCATCGCATCGGGCCGGGTTCGCCTGGCCAACGTCCGCCAGCGTTCGCTGGTCGA
GGCCAAGGTACGCGTGCTTGTCGTCGCGTTCCTGTTCCTGTTCGCGGGAGTGGCCGCACTGGTCCGCATCCTGCAACTCG
GGCTGTTCGAGGATGCGCCCGAGCGCCGCTCGCTTGCCGAGGCCCTGCTGCCCCCGCGCGGCGAGATCACCGACCGCAAC
GGCGTTCCGCTTGCCCGCGCTTTTCCAGCCTATGCCCTGTGGTACAATCCCAAGGCCTTCGGAGAGAACGGCTCGCCTTT
GGTGAAGTCGCCCGAGGAAGTGGCCAAGGCGCTGCTCGCGATCTTCCCTGACGCTGATTACAACGACCTCCTCAAGCGGC
TGAAGTCTGACAAGCCGAGCTATCTGCGCCAGCGCGTGATGCCCGAAGATGCCAACCGCATCTTTGCATTGGGTGAGCCT
GCTCTGGAATTCCCGCGCGAGAACCAGCGCTACTATCCGCAAGGTTCATTGGGCGCGCACGTCCTCGGCTACGTTGATAC
CGAAGGTCACGGTCATGTCGGCATGGAGCAGGTGCTGGAGAAGCAGCTGCTTGACCCGGCACAGCGCGGCAGGCCGGTGG
CGCTTTCGATCGACATGCGGGCGCAAGGGGCGCTTGAGGACGAGCTCGGCCGCGGCATGCTCGAAACCGAGGCCAAGGGC
GCGGCGGGCGTGATCCTCGATGTCGATACAGGCGAGGTGGTTGCGCTGGCATCGCTGCCGTCGTTCAACCCGAACCGTTC
GGATCAGGCGCTCAACAACCTCGTTTTCAACAAGGTGACCAACCAGGTCTATGAACTAGGCTCCACGTTCAAGCCGCTGA
GCATTGCCGCCGCCATTGATGCGGGAGTGGTGACCGACCTTTCGGTGCGCTATCCGTCGGACAAGCCGCTGGCGATCGGC
GGTTTCCACATTCGCGACAGCCACAGCTTCGGCGCATCGCTCAACGTGCCCGAAGCGCTGATCCACTCCTCGAATATCGT
CACCGCGCAAGTGGCCGACAAACTTGGCGGACCGGCGCTCAAGAAGACGATGGCCGCGCTCGGCATGAACGAGCGGCCCT
ATATCGAGCTGCCCGCACGCGGCTTCCCGCTCTGGCCGCGCGGCACAAACAAGAACGGCGACTGGGCCCGCATCACGACG
ATGACGGTGAGCTATGGTCATGGCATCGCGGTCACGCCGCTGCACCTCGCTGCCGCCTATGCCGCGCTGGTGAATGGCGG
CATCTGGCGTCCGGCCACGCTGTTCAAGCGCGATCCTTCGCAGATCCCCGAAGGCCGCCGCGTCTACAAGGCCTCGACCA
GCGCGCGCATGCGCCAGCTCCTGCGCATGATCGTGGTCGATGGCACCGGCAAGAGCGCCAATGCCGTCGGTTTTCGCGTC
GGCGGCAAGACCGGTTCCGCTGAAAAGCCGGGCGGGAAAGGCGGATACAACCGGACCTCGCTGATCGCCACCTTCGCCGC
CGCCTTCCCGATGGACAAGCCGCGCTATGTGGTGATCGCCATGCTCGACGAACCCAAGGGCACGGCCGCGACTTCCTACC
AGCGCACGGCGGCTTGGAACGCGGCGCCCATCGTCGGACGCGTCGTGCCCCGCATCGGCCCGCTGCTCGGCGTCGTGCCC
GACGACAGTCGCGACATCGACATTTCCGATCTTTCGCCCCTCGTCGGCAACGGAGAAGGCGAATGA

Upstream 100 bases:

>100_bases
AGGCAAAGGCGACGTCAGTTGCGGATAAGTCGCCCGCGAAGAAGGACAAGTCGGCCCTGGGGTCTCGCCCCGCGGCGAGG
AAGGAGGCTAAGGCAGCCCG

Downstream 100 bases:

>100_bases
AGCTCGGCGCGATCCTCGATGCGGCAGGCTATCCGGTGGCTGCGGCCGATGCCAACGTCACCGGCTTTGCCATCGATCAT
CGCAAGGTCGCCCCCGGCAC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MNALTASAAIASGRVRLANVRQRSLVEAKVRVLVVAFLFLFAGVAALVRILQLGLFEDAPERRSLAEALLPPRGEITDRN
GVPLARAFPAYALWYNPKAFGENGSPLVKSPEEVAKALLAIFPDADYNDLLKRLKSDKPSYLRQRVMPEDANRIFALGEP
ALEFPRENQRYYPQGSLGAHVLGYVDTEGHGHVGMEQVLEKQLLDPAQRGRPVALSIDMRAQGALEDELGRGMLETEAKG
AAGVILDVDTGEVVALASLPSFNPNRSDQALNNLVFNKVTNQVYELGSTFKPLSIAAAIDAGVVTDLSVRYPSDKPLAIG
GFHIRDSHSFGASLNVPEALIHSSNIVTAQVADKLGGPALKKTMAALGMNERPYIELPARGFPLWPRGTNKNGDWARITT
MTVSYGHGIAVTPLHLAAAYAALVNGGIWRPATLFKRDPSQIPEGRRVYKASTSARMRQLLRMIVVDGTGKSANAVGFRV
GGKTGSAEKPGGKGGYNRTSLIATFAAAFPMDKPRYVVIAMLDEPKGTAATSYQRTAAWNAAPIVGRVVPRIGPLLGVVP
DDSRDIDISDLSPLVGNGEGE

Sequences:

>Translated_581_residues
MNALTASAAIASGRVRLANVRQRSLVEAKVRVLVVAFLFLFAGVAALVRILQLGLFEDAPERRSLAEALLPPRGEITDRN
GVPLARAFPAYALWYNPKAFGENGSPLVKSPEEVAKALLAIFPDADYNDLLKRLKSDKPSYLRQRVMPEDANRIFALGEP
ALEFPRENQRYYPQGSLGAHVLGYVDTEGHGHVGMEQVLEKQLLDPAQRGRPVALSIDMRAQGALEDELGRGMLETEAKG
AAGVILDVDTGEVVALASLPSFNPNRSDQALNNLVFNKVTNQVYELGSTFKPLSIAAAIDAGVVTDLSVRYPSDKPLAIG
GFHIRDSHSFGASLNVPEALIHSSNIVTAQVADKLGGPALKKTMAALGMNERPYIELPARGFPLWPRGTNKNGDWARITT
MTVSYGHGIAVTPLHLAAAYAALVNGGIWRPATLFKRDPSQIPEGRRVYKASTSARMRQLLRMIVVDGTGKSANAVGFRV
GGKTGSAEKPGGKGGYNRTSLIATFAAAFPMDKPRYVVIAMLDEPKGTAATSYQRTAAWNAAPIVGRVVPRIGPLLGVVP
DDSRDIDISDLSPLVGNGEGE
>Mature_581_residues
MNALTASAAIASGRVRLANVRQRSLVEAKVRVLVVAFLFLFAGVAALVRILQLGLFEDAPERRSLAEALLPPRGEITDRN
GVPLARAFPAYALWYNPKAFGENGSPLVKSPEEVAKALLAIFPDADYNDLLKRLKSDKPSYLRQRVMPEDANRIFALGEP
ALEFPRENQRYYPQGSLGAHVLGYVDTEGHGHVGMEQVLEKQLLDPAQRGRPVALSIDMRAQGALEDELGRGMLETEAKG
AAGVILDVDTGEVVALASLPSFNPNRSDQALNNLVFNKVTNQVYELGSTFKPLSIAAAIDAGVVTDLSVRYPSDKPLAIG
GFHIRDSHSFGASLNVPEALIHSSNIVTAQVADKLGGPALKKTMAALGMNERPYIELPARGFPLWPRGTNKNGDWARITT
MTVSYGHGIAVTPLHLAAAYAALVNGGIWRPATLFKRDPSQIPEGRRVYKASTSARMRQLLRMIVVDGTGKSANAVGFRV
GGKTGSAEKPGGKGGYNRTSLIATFAAAFPMDKPRYVVIAMLDEPKGTAATSYQRTAAWNAAPIVGRVVPRIGPLLGVVP
DDSRDIDISDLSPLVGNGEGE

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=575, Percent_Identity=29.7391304347826, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786854, Length=499, Percent_Identity=27.6553106212425, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62323; Mature: 62323

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALTASAAIASGRVRLANVRQRSLVEAKVRVLVVAFLFLFAGVAALVRILQLGLFEDAP
CCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ERRSLAEALLPPRGEITDRNGVPLARAFPAYALWYNPKAFGENGSPLVKSPEEVAKALLA
HHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEEEECCHHCCCCCCCCCCCHHHHHHHHHH
IFPDADYNDLLKRLKSDKPSYLRQRVMPEDANRIFALGEPALEFPRENQRYYPQGSLGAH
HCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCCCE
VLGYVDTEGHGHVGMEQVLEKQLLDPAQRGRPVALSIDMRAQGALEDELGRGMLETEAKG
EEEEEECCCCCCCCHHHHHHHHHCCHHHCCCCEEEEECCCCCCCCHHHHCCCEEHHCCCC
AAGVILDVDTGEVVALASLPSFNPNRSDQALNNLVFNKVTNQVYELGSTFKPLSIAAAID
CCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHC
AGVVTDLSVRYPSDKPLAIGGFHIRDSHSFGASLNVPEALIHSSNIVTAQVADKLGGPAL
CCCEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHCCCEEEHHHHHHHCCHHH
KKTMAALGMNERPYIELPARGFPLWPRGTNKNGDWARITTMTVSYGHGIAVTPLHLAAAY
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEHHHHHHHHH
AALVNGGIWRPATLFKRDPSQIPEGRRVYKASTSARMRQLLRMIVVDGTGKSANAVGFRV
HHHHCCCCCCCHHHHCCCHHHCCCCCEEEECHHHHHHHHHHHHHEECCCCCCCCEEEEEE
GGKTGSAEKPGGKGGYNRTSLIATFAAAFPMDKPRYVVIAMLDEPKGTAATSYQRTAAWN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHCCCC
AAPIVGRVVPRIGPLLGVVPDDSRDIDISDLSPLVGNGEGE
CCHHHHHHHHHHCCCEEECCCCCCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MNALTASAAIASGRVRLANVRQRSLVEAKVRVLVVAFLFLFAGVAALVRILQLGLFEDAP
CCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ERRSLAEALLPPRGEITDRNGVPLARAFPAYALWYNPKAFGENGSPLVKSPEEVAKALLA
HHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEEEECCHHCCCCCCCCCCCHHHHHHHHHH
IFPDADYNDLLKRLKSDKPSYLRQRVMPEDANRIFALGEPALEFPRENQRYYPQGSLGAH
HCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCCCE
VLGYVDTEGHGHVGMEQVLEKQLLDPAQRGRPVALSIDMRAQGALEDELGRGMLETEAKG
EEEEEECCCCCCCCHHHHHHHHHCCHHHCCCCEEEEECCCCCCCCHHHHCCCEEHHCCCC
AAGVILDVDTGEVVALASLPSFNPNRSDQALNNLVFNKVTNQVYELGSTFKPLSIAAAID
CCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHC
AGVVTDLSVRYPSDKPLAIGGFHIRDSHSFGASLNVPEALIHSSNIVTAQVADKLGGPAL
CCCEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHCCCEEEHHHHHHHCCHHH
KKTMAALGMNERPYIELPARGFPLWPRGTNKNGDWARITTMTVSYGHGIAVTPLHLAAAY
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEHHHHHHHHH
AALVNGGIWRPATLFKRDPSQIPEGRRVYKASTSARMRQLLRMIVVDGTGKSANAVGFRV
HHHHCCCCCCCHHHHCCCHHHCCCCCEEEECHHHHHHHHHHHHHEECCCCCCCCEEEEEE
GGKTGSAEKPGGKGGYNRTSLIATFAAAFPMDKPRYVVIAMLDEPKGTAATSYQRTAAWN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHCCCC
AAPIVGRVVPRIGPLLGVVPDDSRDIDISDLSPLVGNGEGE
CCHHHHHHHHHHCCCEEECCCCCCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]