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The map label for this gene is prs [H]

Identifier: 87198993

GI number: 87198993

Start: 1017201

End: 1018136

Strand: Direct

Name: prs [H]

Synonym: Saro_0971

Alternate gene names: 87198993

Gene position: 1017201-1018136 (Clockwise)

Preceding gene: 87198988

Following gene: 87198995

Centisome position: 28.56

GC content: 65.92

Gene sequence:

>936_bases
ATGAAGATCATGGCCGGCAACTCCAATCTGCCGCTCGCCCGCGCCATTTCGGCCTATCTCGAAATGCCGCTGACCGACGC
CAGCGTGCGCCGCTTCGCGGACGAGGAGGTTTTCGTCGAAATCCACGAGAACGTGCGTGGCGAAGACGTGTTCGTGGTCC
AGTCGACCAGCTATCCGGCGAACGACAACCTGATGGAACTACTGATCTGCATCGACGCGCTGCGCCGTGCATCGGCAAAG
CGCATCACGGCGGTGGTTCCGTATTTCGGCTATGCCCGCCAGGACCGCAAGCCGGGGCCGCGCACGCCGATCTCGGCAAA
GCTGGTGGCGAACCTCATCACCCAAGCCGGCGCCGACCGCGTCCTGTCGGTCGACCTTCACGCCGGGCAGATCCAGGGCT
TCTTCGACATCCCGACCGACAACCTGTTCGCGGCGCCCGTCATGGCCGCGGACATCCAGACGCGCTATGGCGCGCAGGAA
CTGATGGTCGTCTCGCCGGACGTCGGCGGCGTGGTCCGCGCCCGCGCGCTGGCCAAGCGGCTCAACAACGCCCCGCTGGC
GATCGTCGACAAGCGCCGCGACCGGCCGGGCCAGTCCGAAGTGATGAACATCATCGGCGAAGTGAAGGGGCGCATGTGCA
TCCTGATCGACGACATCATCGATTCGGGCGGTACGCTCTGCAACGCGGCGCAGGCGTTGATGGATGCGGGCGCGGTCGGC
GTTTCCGCCTACATCACGCACGGCGTCCTTTCGGGCGGCGCGGTTGCGCGCGTGGCTGGGTCGGCGCTCAAGGAACTGGT
CATCACCGACACGATCATGCCGACGGAAGCCACCGCATCGTGCGACCGCATCCGCGTGTTGACGATCGCGCCGCTGATTG
GCGAGGCGGTCCGCCGCATCGCCGATGAAAGCTCGGTGTCGAGCCTTTTCGACTGA

Upstream 100 bases:

>100_bases
GAGCGTTACGTAGGCTTCAACGCCCGACCACCGCAAGAGTTGCAAACCTGTCATCTTGGGCTAAGGGCCGCAGGGGATCG
AATCCGAGGGAATCGCACGC

Downstream 100 bases:

>100_bases
GAGCGCTGATCTGGCGGATGACGTGTTAAGGGGCCGGAATTCCGGCCCCTTTTCATTTGGCGCGCTGCAATTGCAGTTCC
AGGCCCTTGCGGTCGGTCTG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKIMAGNSNLPLARAISAYLEMPLTDASVRRFADEEVFVEIHENVRGEDVFVVQSTSYPANDNLMELLICIDALRRASAK
RITAVVPYFGYARQDRKPGPRTPISAKLVANLITQAGADRVLSVDLHAGQIQGFFDIPTDNLFAAPVMAADIQTRYGAQE
LMVVSPDVGGVVRARALAKRLNNAPLAIVDKRRDRPGQSEVMNIIGEVKGRMCILIDDIIDSGGTLCNAAQALMDAGAVG
VSAYITHGVLSGGAVARVAGSALKELVITDTIMPTEATASCDRIRVLTIAPLIGEAVRRIADESSVSSLFD

Sequences:

>Translated_311_residues
MKIMAGNSNLPLARAISAYLEMPLTDASVRRFADEEVFVEIHENVRGEDVFVVQSTSYPANDNLMELLICIDALRRASAK
RITAVVPYFGYARQDRKPGPRTPISAKLVANLITQAGADRVLSVDLHAGQIQGFFDIPTDNLFAAPVMAADIQTRYGAQE
LMVVSPDVGGVVRARALAKRLNNAPLAIVDKRRDRPGQSEVMNIIGEVKGRMCILIDDIIDSGGTLCNAAQALMDAGAVG
VSAYITHGVLSGGAVARVAGSALKELVITDTIMPTEATASCDRIRVLTIAPLIGEAVRRIADESSVSSLFD
>Mature_311_residues
MKIMAGNSNLPLARAISAYLEMPLTDASVRRFADEEVFVEIHENVRGEDVFVVQSTSYPANDNLMELLICIDALRRASAK
RITAVVPYFGYARQDRKPGPRTPISAKLVANLITQAGADRVLSVDLHAGQIQGFFDIPTDNLFAAPVMAADIQTRYGAQE
LMVVSPDVGGVVRARALAKRLNNAPLAIVDKRRDRPGQSEVMNIIGEVKGRMCILIDDIIDSGGTLCNAAQALMDAGAVG
VSAYITHGVLSGGAVARVAGSALKELVITDTIMPTEATASCDRIRVLTIAPLIGEAVRRIADESSVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=45.3376205787781, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=44.336569579288, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=44.3729903536978, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=43.9102564102564, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=32.7485380116959, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=32.1739130434783, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=53.8461538461538, Blast_Score=338, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=44.6945337620579, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=44.6945337620579, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=44.6945337620579, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.6601941747573, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=33.5311572700297, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=43.9102564102564, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=41.1575562700965, Blast_Score=244, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=43.4504792332268, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=41.8367346938776, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=39.6396396396396, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=44.6945337620579, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=41.6167664670659, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24651458, Length=352, Percent_Identity=31.25, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24651456, Length=352, Percent_Identity=31.25, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI281362873, Length=352, Percent_Identity=31.25, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24651454, Length=352, Percent_Identity=31.25, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24651462, Length=370, Percent_Identity=30.2702702702703, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24651464, Length=370, Percent_Identity=30.2702702702703, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45552010, Length=370, Percent_Identity=30.2702702702703, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33248; Mature: 33248

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMAGNSNLPLARAISAYLEMPLTDASVRRFADEEVFVEIHENVRGEDVFVVQSTSYPA
CEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHCCCCCCEEEEEECCCCCC
NDNLMELLICIDALRRASAKRITAVVPYFGYARQDRKPGPRTPISAKLVANLITQAGADR
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VLSVDLHAGQIQGFFDIPTDNLFAAPVMAADIQTRYGAQELMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
LNNAPLAIVDKRRDRPGQSEVMNIIGEVKGRMCILIDDIIDSGGTLCNAAQALMDAGAVG
HCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHCCCHH
VSAYITHGVLSGGAVARVAGSALKELVITDTIMPTEATASCDRIRVLTIAPLIGEAVRRI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHH
ADESSVSSLFD
HCHHHHHHHCC
>Mature Secondary Structure
MKIMAGNSNLPLARAISAYLEMPLTDASVRRFADEEVFVEIHENVRGEDVFVVQSTSYPA
CEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHCCCCCCEEEEEECCCCCC
NDNLMELLICIDALRRASAKRITAVVPYFGYARQDRKPGPRTPISAKLVANLITQAGADR
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VLSVDLHAGQIQGFFDIPTDNLFAAPVMAADIQTRYGAQELMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
LNNAPLAIVDKRRDRPGQSEVMNIIGEVKGRMCILIDDIIDSGGTLCNAAQALMDAGAVG
HCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHCCCHH
VSAYITHGVLSGGAVARVAGSALKELVITDTIMPTEATASCDRIRVLTIAPLIGEAVRRI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHH
ADESSVSSLFD
HCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]