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The map label for this gene is pyrC

Identifier: 87198957

GI number: 87198957

Start: 982797

End: 983837

Strand: Direct

Name: pyrC

Synonym: Saro_0935

Alternate gene names: 87198957

Gene position: 982797-983837 (Clockwise)

Preceding gene: 87198955

Following gene: 87198959

Centisome position: 27.59

GC content: 65.71

Gene sequence:

>1041_bases
ATGACCGAGACGCTGACGATCCGCCGCCCCGACGACTGGCATGTCCACCTGCGCGACCGCGACGTACTGCGGGGCGTCGT
TCCCTATACCGCCCGGCAGTTTGCCCGCGCCATCGTCATGCCCAACCTTTCGCCGCCGATGACCGACGTTGCGGGCGTTG
CCGCCTATCGCGATCGCATCCTTGCCGCCCTGCCGCAGGGTAGCGCCTTCACGCCGCTGATGACGCTGTACCTTACCGAT
TCGACCGACATCGAAGAGGTTGCGCGCGGCTTTGCCGAAGGCGTGTTCGTCGCCGCCAAGCTCTATCCAGCCCATGCGAC
GACCGGTTCCGCGCACGGCGTCACCGACATCCGCAACATCTATCCGGTGCTGGAGAAGATGCAGGAGATCGGGATGCCAC
TGCTGATCCACGGCGAGGTGACCGATTCCCATGTCGACATCTTCGACCGCGAAGCCGTGTTCATCGAGCGGACGCTGACC
CGCCTCGTGGCCGACATGCCGGCCCTTCGCATCGTCTTCGAGCATATCACGACCGAGGAGGCGGCCCAGTTCGTGGAAGG
CGCGGGCGACAGCATCGCCGCGACGATCACGCCGCAGCATCTCCACATCAACCGCAACGCCATGCTCGTCGGCGGCATCC
GTCCGCACGCCTTCTGCCTGCCGGTCGCCAAGCGCGAGAAGCACCGGCTTGCCCTGCGCAAGCTTGCCACCTCGGGCTTT
TCGCGGGTGTTCCTGGGAACCGATACCGCGCCTCATGCCAAGCACCTGAAGGAAGCGGCATGCGGCTGTGCGGGGATATT
CAACGCGCCCTTCGCGCTCGAAAGCTATGTCACGGTCTTCGACGAGGAAGGCGCGCTCGACCGGTTCGAGGCCTTTGCCT
CGCTCAACGGGCCCGCGTTCTACCGGATGCCGGTGAACGAGGACCGCATCGTGCTGGAAAGGGCGCCCATCGAGGTGCCT
GAGGTGATCGACTGCAACGGCACCGCAATCGTGCCCTTCCACGCCGGTGAGACGCTCGGCTGGCGAATCGCCGCGGCCTG
A

Upstream 100 bases:

>100_bases
TCTTCGGGAGCAAGGCGCACGAGGGCGCGGTCGAACAGGCGCGTGCCGGGAACGTGGTTCATGGGTGGAAGATAGGCAGG
ACCATCGCTAAGGGGAAGGC

Downstream 100 bases:

>100_bases
CCGTCAGGCCGACCGGGCGCGGCGTAGCATGTCCCAGCTATAGAGCGCGATGGCCGACCAGATCAGCGCGAAGCAGCCGA
GCCTTGCCGGATCGAGGCTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTETLTIRRPDDWHVHLRDRDVLRGVVPYTARQFARAIVMPNLSPPMTDVAGVAAYRDRILAALPQGSAFTPLMTLYLTD
STDIEEVARGFAEGVFVAAKLYPAHATTGSAHGVTDIRNIYPVLEKMQEIGMPLLIHGEVTDSHVDIFDREAVFIERTLT
RLVADMPALRIVFEHITTEEAAQFVEGAGDSIAATITPQHLHINRNAMLVGGIRPHAFCLPVAKREKHRLALRKLATSGF
SRVFLGTDTAPHAKHLKEAACGCAGIFNAPFALESYVTVFDEEGALDRFEAFASLNGPAFYRMPVNEDRIVLERAPIEVP
EVIDCNGTAIVPFHAGETLGWRIAAA

Sequences:

>Translated_346_residues
MTETLTIRRPDDWHVHLRDRDVLRGVVPYTARQFARAIVMPNLSPPMTDVAGVAAYRDRILAALPQGSAFTPLMTLYLTD
STDIEEVARGFAEGVFVAAKLYPAHATTGSAHGVTDIRNIYPVLEKMQEIGMPLLIHGEVTDSHVDIFDREAVFIERTLT
RLVADMPALRIVFEHITTEEAAQFVEGAGDSIAATITPQHLHINRNAMLVGGIRPHAFCLPVAKREKHRLALRKLATSGF
SRVFLGTDTAPHAKHLKEAACGCAGIFNAPFALESYVTVFDEEGALDRFEAFASLNGPAFYRMPVNEDRIVLERAPIEVP
EVIDCNGTAIVPFHAGETLGWRIAAA
>Mature_345_residues
TETLTIRRPDDWHVHLRDRDVLRGVVPYTARQFARAIVMPNLSPPMTDVAGVAAYRDRILAALPQGSAFTPLMTLYLTDS
TDIEEVARGFAEGVFVAAKLYPAHATTGSAHGVTDIRNIYPVLEKMQEIGMPLLIHGEVTDSHVDIFDREAVFIERTLTR
LVADMPALRIVFEHITTEEAAQFVEGAGDSIAATITPQHLHINRNAMLVGGIRPHAFCLPVAKREKHRLALRKLATSGFS
RVFLGTDTAPHAKHLKEAACGCAGIFNAPFALESYVTVFDEEGALDRFEAFASLNGPAFYRMPVNEDRIVLERAPIEVPE
VIDCNGTAIVPFHAGETLGWRIAAA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=342, Percent_Identity=61.4035087719298, Blast_Score=437, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6323452, Length=366, Percent_Identity=31.4207650273224, Blast_Score=165, Evalue=8e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_NOVAD (Q2G9U3)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496214.1
- ProteinModelPortal:   Q2G9U3
- SMR:   Q2G9U3
- STRING:   Q2G9U3
- GeneID:   3918021
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0935
- NMPDR:   fig|48935.1.peg.1059
- eggNOG:   COG0418
- HOGENOM:   HBG628648
- OMA:   KESACGC
- PhylomeDB:   Q2G9U3
- ProtClustDB:   PRK05451
- BioCyc:   NARO279238:SARO_0935-MONOMER
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 38002; Mature: 37871

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETLTIRRPDDWHVHLRDRDVLRGVVPYTARQFARAIVMPNLSPPMTDVAGVAAYRDRI
CCCEEEEECCCCCEEEECCHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LAALPQGSAFTPLMTLYLTDSTDIEEVARGFAEGVFVAAKLYPAHATTGSAHGVTDIRNI
HHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCHHHHHH
YPVLEKMQEIGMPLLIHGEVTDSHVDIFDREAVFIERTLTRLVADMPALRIVFEHITTEE
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCHHH
AAQFVEGAGDSIAATITPQHLHINRNAMLVGGIRPHAFCLPVAKREKHRLALRKLATSGF
HHHHHHCCCCCEEEEECCCEEEECCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCC
SRVFLGTDTAPHAKHLKEAACGCAGIFNAPFALESYVTVFDEEGALDRFEAFASLNGPAF
CEEEEECCCCCHHHHHHHHHCCHHHHCCCCHHHHHHEEEECCCCCHHHHHHHHCCCCCEE
YRMPVNEDRIVLERAPIEVPEVIDCNGTAIVPFHAGETLGWRIAAA
EEECCCCCEEEEEECCCCCCCEECCCCCEEEEECCCCCCCEEEECC
>Mature Secondary Structure 
TETLTIRRPDDWHVHLRDRDVLRGVVPYTARQFARAIVMPNLSPPMTDVAGVAAYRDRI
CCEEEEECCCCCEEEECCHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LAALPQGSAFTPLMTLYLTDSTDIEEVARGFAEGVFVAAKLYPAHATTGSAHGVTDIRNI
HHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCHHHHHH
YPVLEKMQEIGMPLLIHGEVTDSHVDIFDREAVFIERTLTRLVADMPALRIVFEHITTEE
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCHHH
AAQFVEGAGDSIAATITPQHLHINRNAMLVGGIRPHAFCLPVAKREKHRLALRKLATSGF
HHHHHHCCCCCEEEEECCCEEEECCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCC
SRVFLGTDTAPHAKHLKEAACGCAGIFNAPFALESYVTVFDEEGALDRFEAFASLNGPAF
CEEEEECCCCCHHHHHHHHHCCHHHHCCCCHHHHHHEEEECCCCCHHHHHHHHCCCCCEE
YRMPVNEDRIVLERAPIEVPEVIDCNGTAIVPFHAGETLGWRIAAA
EEECCCCCEEEEEECCCCCCCEECCCCCEEEEECCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA