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The map label for this gene is pepA [H]

Identifier: 87198912

GI number: 87198912

Start: 947659

End: 949116

Strand: Direct

Name: pepA [H]

Synonym: Saro_0890

Alternate gene names: 87198912

Gene position: 947659-949116 (Clockwise)

Preceding gene: 87198907

Following gene: 87198913

Centisome position: 26.61

GC content: 68.52

Gene sequence:

>1458_bases
ATGAAGGTCGTGTTCCGCACCAGCGATGCCCCGCTTCCCCGCCTCGTCGCCCGTCTCGTCGCGCAGGATGCGCTTCCCGG
CGATCTCGACGCGGTGGTCCGCGAGGGTGCGGCGGCCGCGCGCTTCGCCGGCAAGGCCGGGCAGGTGTTCGAGGCTTTCG
TGGCCGGAACCGGCGGCGTCACGCGCCTCGCTCTTGCCGGCATCGGCAAGGCTGATGCTGCGGACCGCCTCGTCGCGCTT
GAAAAGGCCGGCGCCGCGCTGACTGCCAAGTACCTGACCTCCGGCGAAACTTCGTTGGCGATCGACTTCTCCAACTCGGG
CCTTTCGGGCGCGGAAGCCGCCGCCATCCTGTTCGGCGCGCGCCTGCGCGGCTGGCGCCACGACGTCTATCGCACTCGCC
TGAAGGACGAGCAGAAGCCCTCGCTGGCGGAAATCGTTGCGGTCGCGGCGCCCGAGGGTGCGGCCGCCGCATGGGAGATC
GAGAGCGCGCTGGCCGAGGGCGTCGAGTTCACCCGCGAACTGGTCGCCGAACCGGCCAACGTGATCTACCCTGAAAGCTT
CGTCGAACGCGCGAAGGCGCGCCTCGAAGGCACCGGGGTCGAGATCGTGGTGCTCGGCCTGGAGGAAATGACCCGGCTCG
GCATGGGTGCGCTGCTTGGCGTGGCGCAGGGTTCGGTGCGCGAGCCGAAGCTGCTGGCCATGCGCTGGAAGGGCGCTGAA
GCGGACAAGCCCACCGCCTTCGTCGGCAAGGGCGTGACCTTCGATACCGGCGGCATCTCGATCAAACCTGCCGCCGGCAT
GGAAGACATGAAGTGGGACATGGGTGGCGCCGCTGCCGTGGCCGGTACCATGCTCGCGCTGGCCAAGCGGAAGGCCAAGG
CCGACGTGATCGGCGTGTGCGGCCTGGTCGAGAACATGCCCGACGGCAATGCGCAGCGTCCCGGCGACGTCGTTACCTCG
ATGTCGGGCCAGACGGTCGAGGTCATCAACACCGACGCCGAGGGTCGCCTCGTGTTGTGCGACGCGCTGACCTGGGTGCA
GAAGGAATATGGCCCCCGGACCATCGTGGATCTCGCCACGCTGACGGGCGCGATGATCATCTCGCTCGGCCACGAGTACG
GCGGCCTCTTTGCCAATGACGATGCGCTGGCCGCCAACCTTGACGCGGCGGGCAAGACTTCCGGCGACAAGCTGTGGCGC
TTCCCGCTCGGGCCCGCCTACGACAAGCTGATCGACAGCCCGATTGCCGACATGAAGAACGTCGGTCCGCGCTATGGCGG
GTCGATCACCGCCGCGCAGTTCCTGCAGCGCTACATCGATGCGGGCGTGGCCTGGGCGCACCTCGACATCGCGGGCATGG
TCTGGGCGGACAAGCCCGGCCAGACCTGGGACAAGGGCGCGACCGGCTATGGCGTGCGCCTGCTCGACCGCTACGTGCGC
GACGTTCTGGAAGCGTAA

Upstream 100 bases:

>100_bases
CGCTTGCCTATCGCACCAGTGCACCCTAACTGCAATTCCACAATTTTCGCCTTGGCCGTTCCGCGCCGAAGCGTGACGTC
TTTCCGACAGGAGTTCCCGA

Downstream 100 bases:

>100_bases
TCGCGGGCCGGTACCGTTCGCAATCCGTGGATGCGGATTGCGCACCCCGAAGGGATCGACAAGAATGCCCCGCATGCGGC
GCAAGTCCGATCTTCCGACG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKVVFRTSDAPLPRLVARLVAQDALPGDLDAVVREGAAAARFAGKAGQVFEAFVAGTGGVTRLALAGIGKADAADRLVAL
EKAGAALTAKYLTSGETSLAIDFSNSGLSGAEAAAILFGARLRGWRHDVYRTRLKDEQKPSLAEIVAVAAPEGAAAAWEI
ESALAEGVEFTRELVAEPANVIYPESFVERAKARLEGTGVEIVVLGLEEMTRLGMGALLGVAQGSVREPKLLAMRWKGAE
ADKPTAFVGKGVTFDTGGISIKPAAGMEDMKWDMGGAAAVAGTMLALAKRKAKADVIGVCGLVENMPDGNAQRPGDVVTS
MSGQTVEVINTDAEGRLVLCDALTWVQKEYGPRTIVDLATLTGAMIISLGHEYGGLFANDDALAANLDAAGKTSGDKLWR
FPLGPAYDKLIDSPIADMKNVGPRYGGSITAAQFLQRYIDAGVAWAHLDIAGMVWADKPGQTWDKGATGYGVRLLDRYVR
DVLEA

Sequences:

>Translated_485_residues
MKVVFRTSDAPLPRLVARLVAQDALPGDLDAVVREGAAAARFAGKAGQVFEAFVAGTGGVTRLALAGIGKADAADRLVAL
EKAGAALTAKYLTSGETSLAIDFSNSGLSGAEAAAILFGARLRGWRHDVYRTRLKDEQKPSLAEIVAVAAPEGAAAAWEI
ESALAEGVEFTRELVAEPANVIYPESFVERAKARLEGTGVEIVVLGLEEMTRLGMGALLGVAQGSVREPKLLAMRWKGAE
ADKPTAFVGKGVTFDTGGISIKPAAGMEDMKWDMGGAAAVAGTMLALAKRKAKADVIGVCGLVENMPDGNAQRPGDVVTS
MSGQTVEVINTDAEGRLVLCDALTWVQKEYGPRTIVDLATLTGAMIISLGHEYGGLFANDDALAANLDAAGKTSGDKLWR
FPLGPAYDKLIDSPIADMKNVGPRYGGSITAAQFLQRYIDAGVAWAHLDIAGMVWADKPGQTWDKGATGYGVRLLDRYVR
DVLEA
>Mature_485_residues
MKVVFRTSDAPLPRLVARLVAQDALPGDLDAVVREGAAAARFAGKAGQVFEAFVAGTGGVTRLALAGIGKADAADRLVAL
EKAGAALTAKYLTSGETSLAIDFSNSGLSGAEAAAILFGARLRGWRHDVYRTRLKDEQKPSLAEIVAVAAPEGAAAAWEI
ESALAEGVEFTRELVAEPANVIYPESFVERAKARLEGTGVEIVVLGLEEMTRLGMGALLGVAQGSVREPKLLAMRWKGAE
ADKPTAFVGKGVTFDTGGISIKPAAGMEDMKWDMGGAAAVAGTMLALAKRKAKADVIGVCGLVENMPDGNAQRPGDVVTS
MSGQTVEVINTDAEGRLVLCDALTWVQKEYGPRTIVDLATLTGAMIISLGHEYGGLFANDDALAANLDAAGKTSGDKLWR
FPLGPAYDKLIDSPIADMKNVGPRYGGSITAAQFLQRYIDAGVAWAHLDIAGMVWADKPGQTWDKGATGYGVRLLDRYVR
DVLEA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=333, Percent_Identity=39.3393393393393, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI47155554, Length=315, Percent_Identity=36.5079365079365, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1790710, Length=306, Percent_Identity=48.6928104575163, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=36.9085173501577, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=321, Percent_Identity=35.8255451713396, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17565172, Length=438, Percent_Identity=26.027397260274, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI20129969, Length=428, Percent_Identity=31.0747663551402, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI21355725, Length=297, Percent_Identity=35.6902356902357, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24662227, Length=348, Percent_Identity=32.4712643678161, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24661038, Length=354, Percent_Identity=34.180790960452, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI161077148, Length=460, Percent_Identity=28.9130434782609, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI20130057, Length=460, Percent_Identity=28.9130434782609, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI21355645, Length=374, Percent_Identity=29.6791443850267, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24662223, Length=374, Percent_Identity=29.6791443850267, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21357381, Length=317, Percent_Identity=36.2776025236593, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI221379063, Length=317, Percent_Identity=36.2776025236593, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI221379062, Length=317, Percent_Identity=36.2776025236593, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129963, Length=345, Percent_Identity=31.5942028985507, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19922386, Length=391, Percent_Identity=29.6675191815857, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646701, Length=190, Percent_Identity=33.6842105263158, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646703, Length=190, Percent_Identity=33.6842105263158, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358201, Length=190, Percent_Identity=33.6842105263158, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50875; Mature: 50875

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVFRTSDAPLPRLVARLVAQDALPGDLDAVVREGAAAARFAGKAGQVFEAFVAGTGGV
CEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHCCCCCH
TRLALAGIGKADAADRLVALEKAGAALTAKYLTSGETSLAIDFSNSGLSGAEAAAILFGA
HHHHHHCCCCCCHHHHHHHHHHCCCCEEEHHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
RLRGWRHDVYRTRLKDEQKPSLAEIVAVAAPEGAAAAWEIESALAEGVEFTRELVAEPAN
HHHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
VIYPESFVERAKARLEGTGVEIVVLGLEEMTRLGMGALLGVAQGSVREPKLLAMRWKGAE
EECCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
ADKPTAFVGKGVTFDTGGISIKPAAGMEDMKWDMGGAAAVAGTMLALAKRKAKADVIGVC
CCCCCEEEECCEEECCCCEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
GLVENMPDGNAQRPGDVVTSMSGQTVEVINTDAEGRLVLCDALTWVQKEYGPRTIVDLAT
HHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCHHHHHHHH
LTGAMIISLGHEYGGLFANDDALAANLDAAGKTSGDKLWRFPLGPAYDKLIDSPIADMKN
HHHHHHHHHCHHHCCEEECCCCCEECCCCCCCCCCCCEEECCCCHHHHHHHCCHHHHHHH
VGPRYGGSITAAQFLQRYIDAGVAWAHLDIAGMVWADKPGQTWDKGATGYGVRLLDRYVR
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
DVLEA
HHHCC
>Mature Secondary Structure
MKVVFRTSDAPLPRLVARLVAQDALPGDLDAVVREGAAAARFAGKAGQVFEAFVAGTGGV
CEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHCCCCCH
TRLALAGIGKADAADRLVALEKAGAALTAKYLTSGETSLAIDFSNSGLSGAEAAAILFGA
HHHHHHCCCCCCHHHHHHHHHHCCCCEEEHHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
RLRGWRHDVYRTRLKDEQKPSLAEIVAVAAPEGAAAAWEIESALAEGVEFTRELVAEPAN
HHHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
VIYPESFVERAKARLEGTGVEIVVLGLEEMTRLGMGALLGVAQGSVREPKLLAMRWKGAE
EECCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
ADKPTAFVGKGVTFDTGGISIKPAAGMEDMKWDMGGAAAVAGTMLALAKRKAKADVIGVC
CCCCCEEEECCEEECCCCEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
GLVENMPDGNAQRPGDVVTSMSGQTVEVINTDAEGRLVLCDALTWVQKEYGPRTIVDLAT
HHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCHHHHHHHH
LTGAMIISLGHEYGGLFANDDALAANLDAAGKTSGDKLWRFPLGPAYDKLIDSPIADMKN
HHHHHHHHHCHHHCCEEECCCCCEECCCCCCCCCCCCEEECCCCHHHHHHHCCHHHHHHH
VGPRYGGSITAAQFLQRYIDAGVAWAHLDIAGMVWADKPGQTWDKGATGYGVRLLDRYVR
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
DVLEA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]