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The map label for this gene is adhI [H]

Identifier: 87198896

GI number: 87198896

Start: 929439

End: 930590

Strand: Direct

Name: adhI [H]

Synonym: Saro_0874

Alternate gene names: 87198896

Gene position: 929439-930590 (Clockwise)

Preceding gene: 87198888

Following gene: 87198902

Centisome position: 26.1

GC content: 65.1

Gene sequence:

>1152_bases
ATGCTATCGGACCGCCACGTCAAAGGGAGACCGCACGAAATGAAGACCCGCGCCGCAGTTGCGTTCGCGCCCAAGCAGCC
GCTCGAGATCGTCGAACTGGACCTCGAAGGCCCCAAGGCTGGCGAAGTGCTGGTCGAGATCATGGCGACCGGCGTGTGCC
ACACCGATGCCTACACGCTCGACGGGTTCGACAGCGAAGGCATCTTCCCCAGCGTGCTGGGCCACGAAGGCGCCGGTATC
GTGCGCGAGGTGGGCCCTGGGGTCACTTCGGTGAAGCCCGGCGATCACGTGATCCCGCTCTACACGCCGGAATGCCGCCA
GTGCAAATCGTGCCTCTCGGGCAAGACCAACCTGTGCACCGCGATCCGCGCCACGCAAGGGCAGGGCCTGATGCCCGACG
GCACCAGCCGCTTTTCGTACAAGGGCCAGACCGTGTTCCACTACATGGGCTGCTCGACCTTCTCTAACTTCACCGTCCTG
CCCGAGATCGCGGTTGCCAAGATCCGCGAGGACGCGCCGTTCAAGACCTCGTGCTATATCGGCTGCGGCGTGACGACGGG
CGTCGGCGCGGTGATCAACACCGCCAAGGTCCAGGTCGGTGACAACGTCGTGGTCTTCGGCCTCGGCGGCATCGGCCTCA
ACGTGATCCAGGGCGCGCGGCTTGCCGGTGCCGGCAAGATCATCGGCGTCGACATCAACCCCGACCGCGAGGAATGGGGC
CGCAAGTTCGGCATGACCGACTTCCTCAACAGCAAGGGCATGAGCCGCGAGGACGTCGTCGCCAAGGTCGTCGCCATGAC
CGACGGCGGCGCGGACTACACCTTCGACGCCACCGGCAACACCGAAGTGATGCGCACGGCGCTTGAAGCCTGCCATCGCG
GCTGGGGCACCTCCATCATCATCGGCGTGGCCGAGGCGGGCAAGGAAATCAGCACGCGTCCGTTCCAGCTCGTCACCGGC
CGCAACTGGCGCGGCACGGCCTTCGGCGGCGCCAAGGGCCGCACCGACGTGCCCAAGATCGTCGACATGTACATGACCGG
CAAGATCGAGATCGACCCGATGATCACCCATGTCATGGGCCTGGAAGAGATCAACACCGCCTTCGACCTGATGCACGCCG
GCAAGTCGATCCGTTCAGTCGTGGTGTTCTGA

Upstream 100 bases:

>100_bases
ACTGCCACGACCTCGTCTATCCCGTCCCAGCGATTGCTCATTATTCTCGTCTTGCAACAGTGTTTCGCGTATTGCGCAAT
TTAACAGGGCTGTAGCAATT

Downstream 100 bases:

>100_bases
ACCTGAACGGGTTTACACGGTTTACACTGTCCAGAGCAAAACATCAGGGCCGGTCGGACATCTCGTTCGACCGGCCCTTT
TCGTGTGCGGAAACAGCGCG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLSDRHVKGRPHEMKTRAAVAFAPKQPLEIVELDLEGPKAGEVLVEIMATGVCHTDAYTLDGFDSEGIFPSVLGHEGAGI
VREVGPGVTSVKPGDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGQGLMPDGTSRFSYKGQTVFHYMGCSTFSNFTVL
PEIAVAKIREDAPFKTSCYIGCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGAGKIIGVDINPDREEWG
RKFGMTDFLNSKGMSREDVVAKVVAMTDGGADYTFDATGNTEVMRTALEACHRGWGTSIIIGVAEAGKEISTRPFQLVTG
RNWRGTAFGGAKGRTDVPKIVDMYMTGKIEIDPMITHVMGLEEINTAFDLMHAGKSIRSVVVF

Sequences:

>Translated_383_residues
MLSDRHVKGRPHEMKTRAAVAFAPKQPLEIVELDLEGPKAGEVLVEIMATGVCHTDAYTLDGFDSEGIFPSVLGHEGAGI
VREVGPGVTSVKPGDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGQGLMPDGTSRFSYKGQTVFHYMGCSTFSNFTVL
PEIAVAKIREDAPFKTSCYIGCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGAGKIIGVDINPDREEWG
RKFGMTDFLNSKGMSREDVVAKVVAMTDGGADYTFDATGNTEVMRTALEACHRGWGTSIIIGVAEAGKEISTRPFQLVTG
RNWRGTAFGGAKGRTDVPKIVDMYMTGKIEIDPMITHVMGLEEINTAFDLMHAGKSIRSVVVF
>Mature_383_residues
MLSDRHVKGRPHEMKTRAAVAFAPKQPLEIVELDLEGPKAGEVLVEIMATGVCHTDAYTLDGFDSEGIFPSVLGHEGAGI
VREVGPGVTSVKPGDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGQGLMPDGTSRFSYKGQTVFHYMGCSTFSNFTVL
PEIAVAKIREDAPFKTSCYIGCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGAGKIIGVDINPDREEWG
RKFGMTDFLNSKGMSREDVVAKVVAMTDGGADYTFDATGNTEVMRTALEACHRGWGTSIIIGVAEAGKEISTRPFQLVTG
RNWRGTAFGGAKGRTDVPKIVDMYMTGKIEIDPMITHVMGLEEINTAFDLMHAGKSIRSVVVF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=57.8804347826087, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=44.9197860962567, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=43.2432432432432, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=44.3548387096774, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=44.3548387096774, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI156523966, Length=370, Percent_Identity=41.8918918918919, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=43.2432432432432, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=42.4324324324324, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=42.2651933701657, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI156627571, Length=357, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=62.6344086021505, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1788073, Length=364, Percent_Identity=27.1978021978022, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=26.8929503916449, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790045, Length=359, Percent_Identity=26.7409470752089, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=345, Percent_Identity=28.695652173913, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=371, Percent_Identity=26.1455525606469, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=24.5014245014245, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786518, Length=137, Percent_Identity=33.5766423357664, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786825, Length=210, Percent_Identity=27.1428571428571, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=54.1554959785523, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=53.8666666666667, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=53.6443148688047, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562584, Length=360, Percent_Identity=27.5, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=26.8817204301075, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=372, Percent_Identity=25.8064516129032, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=376, Percent_Identity=57.1808510638298, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6323729, Length=377, Percent_Identity=27.5862068965517, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=389, Percent_Identity=26.9922879177378, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=28.9693593314763, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=28.9693593314763, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=372, Percent_Identity=25.8064516129032, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=371, Percent_Identity=25.6064690026954, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=363, Percent_Identity=24.7933884297521, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=287, Percent_Identity=26.1324041811847, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=357, Percent_Identity=24.6498599439776, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=57.0652173913043, Blast_Score=444, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 40868; Mature: 40868

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDRHVKGRPHEMKTRAAVAFAPKQPLEIVELDLEGPKAGEVLVEIMATGVCHTDAYTL
CCCCCCCCCCCHHHHHCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEE
DGFDSEGIFPSVLGHEGAGIVREVGPGVTSVKPGDHVIPLYTPECRQCKSCLSGKTNLCT
CCCCCCCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEE
AIRATQGQGLMPDGTSRFSYKGQTVFHYMGCSTFSNFTVLPEIAVAKIREDAPFKTSCYI
EEEECCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCEECHHHHHHHHHCCCCCCEEEEE
GCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGAGKIIGVDINPDREEWG
ECCCHHCHHHHEEEEEEEECCCEEEEEECCCCHHHHCCCEEECCCCEEEEECCCCHHHHH
RKFGMTDFLNSKGMSREDVVAKVVAMTDGGADYTFDATGNTEVMRTALEACHRGWGTSII
HHCCCHHHHHCCCCCHHHHHEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
IGVAEAGKEISTRPFQLVTGRNWRGTAFGGAKGRTDVPKIVDMYMTGKIEIDPMITHVMG
EEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHEECCEEEECHHHHHHHH
LEEINTAFDLMHAGKSIRSVVVF
HHHHHHHHHHHHCCHHHHEEECC
>Mature Secondary Structure
MLSDRHVKGRPHEMKTRAAVAFAPKQPLEIVELDLEGPKAGEVLVEIMATGVCHTDAYTL
CCCCCCCCCCCHHHHHCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEE
DGFDSEGIFPSVLGHEGAGIVREVGPGVTSVKPGDHVIPLYTPECRQCKSCLSGKTNLCT
CCCCCCCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEE
AIRATQGQGLMPDGTSRFSYKGQTVFHYMGCSTFSNFTVLPEIAVAKIREDAPFKTSCYI
EEEECCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCEECHHHHHHHHHCCCCCCEEEEE
GCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGAGKIIGVDINPDREEWG
ECCCHHCHHHHEEEEEEEECCCEEEEEECCCCHHHHCCCEEECCCCEEEEECCCCHHHHH
RKFGMTDFLNSKGMSREDVVAKVVAMTDGGADYTFDATGNTEVMRTALEACHRGWGTSII
HHCCCHHHHHCCCCCHHHHHEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
IGVAEAGKEISTRPFQLVTGRNWRGTAFGGAKGRTDVPKIVDMYMTGKIEIDPMITHVMG
EEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHEECCEEEECHHHHHHHH
LEEINTAFDLMHAGKSIRSVVVF
HHHHHHHHHHHHCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]