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The map label for this gene is metA

Identifier: 87198708

GI number: 87198708

Start: 723040

End: 723945

Strand: Direct

Name: metA

Synonym: Saro_0684

Alternate gene names: 87198708

Gene position: 723040-723945 (Clockwise)

Preceding gene: 87198707

Following gene: 87198709

Centisome position: 20.3

GC content: 63.69

Gene sequence:

>906_bases
GTGCCGATCAGGATTGCCGACAATCTCCCCGCCCGCCGCACGCTGGAAGCCGAGGGCGTGATCGTGATGAGCGAGACCGA
GGCCGCACGCCAGGACATCCGGCCGATGCGCATCGCCCTTCTCAACCTGATGCCCGACAAGATCACCACCGAAACGCAGA
TCGCCCGTCTTCTCGGCGCGACGCCGCTGCAGGTGGATCTCGAACTGGTCCGCATTTCCGACCACGTCAGCAAGAACACC
TCGGCGGGGCACATCTCGGCCTTCTACCGTCCGTGGGATGACGTCCGCGCCGAGAAGTATGACGGCCTGATCGTCACCGG
CGCGCCGGTCGAGACGATCCCATACGAGGAAGTGAGCTACTGGGACGAGTTGCGGCGCATTTTCGACTGGTCGCAGAGCA
ACGTTCACCGCACTCTGTCGGTCTGCTGGGGCGCCATGGCTGCGCTCTATCACTTCCATGGCATCGAAAAGCACGGCCTG
CCGACCAAGGCGTCCGGCGTGTTCCGTCATGTCAATCATGCCCCCGCGAGCCCGTGGATGCGGGGTTTGCCCGACGTGTT
CGACGTGCCCGTCTCGCGCTGGAGCGAGGTCCGCCGCGAGGACCTGCCCGAAGGGCGGGGCTTGTCGGTGCTGGCCGACA
GCGCCGAGACCGGGCTGTGCCTGATTGACGATCCGGCCATGCGCACGCTGCATATGTTCAACCATCTCGAGTACGACACG
CTCACCCTTGCAGGCGAATATGCGCGGGATGAAGGCAAGTATCTTCCGCGCAACTATTTCCCCGGCGATGACCCGCAGGC
GATGCCTGCCAACACGTGGCGTGGCCACGGGCACCTGCTGTACGGCAACTGGATCAACGAGACGTATCAGACGACGCCAT
ACGATCTCGCAGACATTGGAAGGTAA

Upstream 100 bases:

>100_bases
CCCCGGCCGAATTGCGAAAGGGGATGTGGCCGATCCGGCAACCAAACGGACACGGACACCTTGCAGCGTCTTCCCCACCA
GATTGCAGGAAGACGCAGAA

Downstream 100 bases:

>100_bases
CCGAACGGGGGGAACATAAGGGGCCGGGCCGGAGCGACACCTCCGACAAGGACTCTCTTCCCTTGCCTTTCCGCGCCGCT
TCGCCTAACGGCCCCACCTT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MPIRIADNLPARRTLEAEGVIVMSETEAARQDIRPMRIALLNLMPDKITTETQIARLLGATPLQVDLELVRISDHVSKNT
SAGHISAFYRPWDDVRAEKYDGLIVTGAPVETIPYEEVSYWDELRRIFDWSQSNVHRTLSVCWGAMAALYHFHGIEKHGL
PTKASGVFRHVNHAPASPWMRGLPDVFDVPVSRWSEVRREDLPEGRGLSVLADSAETGLCLIDDPAMRTLHMFNHLEYDT
LTLAGEYARDEGKYLPRNYFPGDDPQAMPANTWRGHGHLLYGNWINETYQTTPYDLADIGR

Sequences:

>Translated_301_residues
MPIRIADNLPARRTLEAEGVIVMSETEAARQDIRPMRIALLNLMPDKITTETQIARLLGATPLQVDLELVRISDHVSKNT
SAGHISAFYRPWDDVRAEKYDGLIVTGAPVETIPYEEVSYWDELRRIFDWSQSNVHRTLSVCWGAMAALYHFHGIEKHGL
PTKASGVFRHVNHAPASPWMRGLPDVFDVPVSRWSEVRREDLPEGRGLSVLADSAETGLCLIDDPAMRTLHMFNHLEYDT
LTLAGEYARDEGKYLPRNYFPGDDPQAMPANTWRGHGHLLYGNWINETYQTTPYDLADIGR
>Mature_300_residues
PIRIADNLPARRTLEAEGVIVMSETEAARQDIRPMRIALLNLMPDKITTETQIARLLGATPLQVDLELVRISDHVSKNTS
AGHISAFYRPWDDVRAEKYDGLIVTGAPVETIPYEEVSYWDELRRIFDWSQSNVHRTLSVCWGAMAALYHFHGIEKHGLP
TKASGVFRHVNHAPASPWMRGLPDVFDVPVSRWSEVRREDLPEGRGLSVLADSAETGLCLIDDPAMRTLHMFNHLEYDTL
TLAGEYARDEGKYLPRNYFPGDDPQAMPANTWRGHGHLLYGNWINETYQTTPYDLADIGR

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=301, Percent_Identity=42.5249169435216, Blast_Score=248, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_NOVAD (Q2GAJ2)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_495965.1
- HSSP:   Q72X44
- ProteinModelPortal:   Q2GAJ2
- SMR:   Q2GAJ2
- STRING:   Q2GAJ2
- GeneID:   3918109
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0684
- NMPDR:   fig|48935.1.peg.1923
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q2GAJ2
- ProtClustDB:   PRK05368
- BioCyc:   NARO279238:SARO_0684-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 34106; Mature: 33975

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRIADNLPARRTLEAEGVIVMSETEAARQDIRPMRIALLNLMPDKITTETQIARLLGA
CCEEECCCCCCCCEECCCCEEEEECCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
TPLQVDLELVRISDHVSKNTSAGHISAFYRPWDDVRAEKYDGLIVTGAPVETIPYEEVSY
CCCEEEEEEEEEHHHHCCCCCCCEEEEECCCHHHHHHHHCCCEEEECCCCCCCCCHHHHH
WDELRRIFDWSQSNVHRTLSVCWGAMAALYHFHGIEKHGLPTKASGVFRHVNHAPASPWM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCCCCHH
RGLPDVFDVPVSRWSEVRREDLPEGRGLSVLADSAETGLCLIDDPAMRTLHMFNHLEYDT
HCCCHHHHCCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHCCCCCE
LTLAGEYARDEGKYLPRNYFPGDDPQAMPANTWRGHGHLLYGNWINETYQTTPYDLADIG
EEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCC
R
C
>Mature Secondary Structure 
PIRIADNLPARRTLEAEGVIVMSETEAARQDIRPMRIALLNLMPDKITTETQIARLLGA
CEEECCCCCCCCEECCCCEEEEECCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
TPLQVDLELVRISDHVSKNTSAGHISAFYRPWDDVRAEKYDGLIVTGAPVETIPYEEVSY
CCCEEEEEEEEEHHHHCCCCCCCEEEEECCCHHHHHHHHCCCEEEECCCCCCCCCHHHHH
WDELRRIFDWSQSNVHRTLSVCWGAMAALYHFHGIEKHGLPTKASGVFRHVNHAPASPWM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCCCCHH
RGLPDVFDVPVSRWSEVRREDLPEGRGLSVLADSAETGLCLIDDPAMRTLHMFNHLEYDT
HCCCHHHHCCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHCCCCCE
LTLAGEYARDEGKYLPRNYFPGDDPQAMPANTWRGHGHLLYGNWINETYQTTPYDLADIG
EEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA