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The map label for this gene is ribBA [H]

Identifier: 87198544

GI number: 87198544

Start: 561623

End: 562768

Strand: Direct

Name: ribBA [H]

Synonym: Saro_0520

Alternate gene names: 87198544

Gene position: 561623-562768 (Clockwise)

Preceding gene: 87198543

Following gene: 87198546

Centisome position: 15.77

GC content: 63.18

Gene sequence:

>1146_bases
ATGACCCCGGCCGAGATCTCCCCGATCGAAGATATCATCCGCGAAGCCGTGGAAGGCAGACCCTTCATTCTCGTCGACGC
GGATGACCGCGAGAACGAAGGCGACATCATCATCCCGGCGCAGTTCGCCACGCCCGCGCAGATCAGCTTCATGGCTTGTC
ATGCGCGGGGGTTGATCTGTCTTGCGATTACGCAGGAGCGTTCCTCGCAACTGCAGCTCAGGCCGATGGCACCGCGCAAT
GAGTCCGGCTACGGCACGGCATTCACCGTCTCCATCGAGGCGAAGGAAGGCGTCACGACGGGCATTTCCGCCCATGACCG
GGCCAGGACAATTGCCGTCGCGGTCGATCCGACGAAGGGAGTAGACGACCTGGTGACGCCCGGGCATGTATTCCCGCTCA
CCGCCCGGGATGGCGGCGTGCTTGTCCGGGCCGGGCATACCGAGGCTGCCGTCGACATTTCCCGGCTCGGCGGGCTTACA
CCTGCCGGTGTGATCTGCGAGGTCATGAATGACGACGGCACTATGGCGCGCCTGCCGGACCTGAAGATTTTCGCCGCGAA
GCATGGCCTGAAAATAGGGACGATCGCCGATCTCATCGCCTACCGTCGCTCGTCGGAGCAGCTCGTGGAGGAGATGGCGT
CGGCGCCGTTCCAGAGCCACTTCTGTCCTTCGCCGATGACGGTGCACGTCTACAGGAACAAGATTGACGGAGGCGAGCAT
GTCGCACTGGTCAAGGGCGAGATCCGCGCCGACCAGGATACGCTGGTACGCGTACACCAGGTCGACCTGACCACCGACGT
GCTCGGCTGGAACACGGCTTCGCCGGAATACCTGCGACGTGCCCTTCGTTTCATTTCCGATCATTCGGGACCGGGCGTTG
TCGTGCTGGTGCGCGATCCCGATCCGGAATCCATTTCCCGCCGTGTCGCGGGCGGACGGCGCGAGTATCACGAGAAGAAT
GCCAACCGTGACTACGGCATCGGGGCGCAGATCCTGATCGATCTCGGCGTCCGGCAGATGACCTTGCTGACTTCGAGCAA
GGCGAAGCTGGCCGCGCTTCAGGGGTTCGGCCTGACGATCAACGGACGCACCGAACTGCGGGAGAACCGTCCGGATTCCC
CGATCCGCGTACGCTCCGATTTCTGA

Upstream 100 bases:

>100_bases
GCGGAGCTGCGCAACATGGCGCTGGCGATGCTTGCAGATCAGAAGGCGGTTTGACGATGCGAAGCGATCAGGTTGCAGCC
GCGTGGAAGGAACGCGAGCA

Downstream 100 bases:

>100_bases
GCCCGACCCTTTGCGGCGCGTTACGCTACCGCTTTGACGGGCGCGGCAAACGCGGCGACGATCTGGCCGATGGTGTCTTC
GACCGCATCCTCGAAGCGTT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTPAEISPIEDIIREAVEGRPFILVDADDRENEGDIIIPAQFATPAQISFMACHARGLICLAITQERSSQLQLRPMAPRN
ESGYGTAFTVSIEAKEGVTTGISAHDRARTIAVAVDPTKGVDDLVTPGHVFPLTARDGGVLVRAGHTEAAVDISRLGGLT
PAGVICEVMNDDGTMARLPDLKIFAAKHGLKIGTIADLIAYRRSSEQLVEEMASAPFQSHFCPSPMTVHVYRNKIDGGEH
VALVKGEIRADQDTLVRVHQVDLTTDVLGWNTASPEYLRRALRFISDHSGPGVVVLVRDPDPESISRRVAGGRREYHEKN
ANRDYGIGAQILIDLGVRQMTLLTSSKAKLAALQGFGLTINGRTELRENRPDSPIRVRSDF

Sequences:

>Translated_381_residues
MTPAEISPIEDIIREAVEGRPFILVDADDRENEGDIIIPAQFATPAQISFMACHARGLICLAITQERSSQLQLRPMAPRN
ESGYGTAFTVSIEAKEGVTTGISAHDRARTIAVAVDPTKGVDDLVTPGHVFPLTARDGGVLVRAGHTEAAVDISRLGGLT
PAGVICEVMNDDGTMARLPDLKIFAAKHGLKIGTIADLIAYRRSSEQLVEEMASAPFQSHFCPSPMTVHVYRNKIDGGEH
VALVKGEIRADQDTLVRVHQVDLTTDVLGWNTASPEYLRRALRFISDHSGPGVVVLVRDPDPESISRRVAGGRREYHEKN
ANRDYGIGAQILIDLGVRQMTLLTSSKAKLAALQGFGLTINGRTELRENRPDSPIRVRSDF
>Mature_380_residues
TPAEISPIEDIIREAVEGRPFILVDADDRENEGDIIIPAQFATPAQISFMACHARGLICLAITQERSSQLQLRPMAPRNE
SGYGTAFTVSIEAKEGVTTGISAHDRARTIAVAVDPTKGVDDLVTPGHVFPLTARDGGVLVRAGHTEAAVDISRLGGLTP
AGVICEVMNDDGTMARLPDLKIFAAKHGLKIGTIADLIAYRRSSEQLVEEMASAPFQSHFCPSPMTVHVYRNKIDGGEHV
ALVKGEIRADQDTLVRVHQVDLTTDVLGWNTASPEYLRRALRFISDHSGPGVVVLVRDPDPESISRRVAGGRREYHEKNA
NRDYGIGAQILIDLGVRQMTLLTSSKAKLAALQGFGLTINGRTELRENRPDSPIRVRSDF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=199, Percent_Identity=50.7537688442211, Blast_Score=205, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=38.3495145631068, Blast_Score=153, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 41410; Mature: 41278

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAEISPIEDIIREAVEGRPFILVDADDRENEGDIIIPAQFATPAQISFMACHARGLIC
CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEE
LAITQERSSQLQLRPMAPRNESGYGTAFTVSIEAKEGVTTGISAHDRARTIAVAVDPTKG
EEEECCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCC
VDDLVTPGHVFPLTARDGGVLVRAGHTEAAVDISRLGGLTPAGVICEVMNDDGTMARLPD
HHHHCCCCCEEEEEECCCCEEEEECCCHHHEEHHHHCCCCCCCEEEEEECCCCCEEECCC
LKIFAAKHGLKIGTIADLIAYRRSSEQLVEEMASAPFQSHFCPSPMTVHVYRNKIDGGEH
EEEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCHHCCCCCCCEEEEEECCCCCCCE
VALVKGEIRADQDTLVRVHQVDLTTDVLGWNTASPEYLRRALRFISDHSGPGVVVLVRDP
EEEEECCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
DPESISRRVAGGRREYHEKNANRDYGIGAQILIDLGVRQMTLLTSSKAKLAALQGFGLTI
CHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCEEEEEECCCEEE
NGRTELRENRPDSPIRVRSDF
CCCHHHHCCCCCCCEEEECCC
>Mature Secondary Structure 
TPAEISPIEDIIREAVEGRPFILVDADDRENEGDIIIPAQFATPAQISFMACHARGLIC
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEE
LAITQERSSQLQLRPMAPRNESGYGTAFTVSIEAKEGVTTGISAHDRARTIAVAVDPTKG
EEEECCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCC
VDDLVTPGHVFPLTARDGGVLVRAGHTEAAVDISRLGGLTPAGVICEVMNDDGTMARLPD
HHHHCCCCCEEEEEECCCCEEEEECCCHHHEEHHHHCCCCCCCEEEEEECCCCCEEECCC
LKIFAAKHGLKIGTIADLIAYRRSSEQLVEEMASAPFQSHFCPSPMTVHVYRNKIDGGEH
EEEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCHHCCCCCCCEEEEEECCCCCCCE
VALVKGEIRADQDTLVRVHQVDLTTDVLGWNTASPEYLRRALRFISDHSGPGVVVLVRDP
EEEEECCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
DPESISRRVAGGRREYHEKNANRDYGIGAQILIDLGVRQMTLLTSSKAKLAALQGFGLTI
CHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCEEEEEECCCEEE
NGRTELRENRPDSPIRVRSDF
CCCHHHHCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]