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The map label for this gene is hemA [H]

Identifier: 86751077

GI number: 86751077

Start: 4533532

End: 4534743

Strand: Reverse

Name: hemA [H]

Synonym: RPB_3969

Alternate gene names: 86751077

Gene position: 4534743-4533532 (Counterclockwise)

Preceding gene: 86751078

Following gene: 86751075

Centisome position: 85.05

GC content: 67.08

Gene sequence:

>1212_bases
ATGAACTACGAAGCCTATTTCCGCCGTCAGCTCGAAGGCCTGCATCGTGAGGGCCGGTATCGGGTGTTCGCCGATCTGGA
ACGCCATGCCGGCGCCTATCCCCGCGCGACGCATCACCGGCCGGACGGCACCGGCGACGTGACGGTGTGGTGCTCCAACG
ATTACCTCGGCATGGGCCAGCACCCGGCGGTGCTGAAGGCGATGCACGAGGCGCTGGACAGCTGCGGCGCCGGCGCCGGC
GGCACCCGCAACATCGCGGGAACGAATCACTATCACGTGCTGCTCGAGCAGGAGCTGGCGGCGCTGCACGGCAAGGAATC
CGCGCTGCTGTTCACCTCCGGCTACGTCTCCAACTGGGCGTCGCTGTCGACGCTGGCGTCGCGCATGCCCGGCTGCGTGA
TCCTGTCCGACGAGCTCAACCACGCCTCGATGATCGAGGGCATCCGCCACAGCCGCAGCGAAACCCGAATCTTCGCGCAC
AACGACCCGCGCGACCTCGAGCGCAAGCTTGCCGATCTCGATCCGCATGCGCCCAAGTTGGTCGCCTTCGAGTCGGTGTA
TTCGATGGATGGCGATATCGCTCCGATCGCCGAGATCTGCGACGTCGCCGATGCGGCCAACGCCATGACCTATCTCGATG
AAGTCCATGGTGTCGGGCTGTACGGCCCGAACGGCGGCGGCATTGCGGATCGCGAGGGCCTCAGCCATCGCCTCACCATC
ATCGAGGGCACCCTGGCCAAAGCGTTCGGCGTGGTCGGCGGCTACATTGCCGGCTCCGCGGCGGTGTGCGATTTCGTCCG
CAGCTTCGCTTCCGGCTTCATCTTCAGCACCTCGCCGCCGCCCGCAGTGGCCGCCGGCGCGCTGGCGAGCATCCGGCATC
TGCGCGCCTCTTCCATCGAGCGCGAACGCCATCAGGACCGGGTGGCGCGACTGCGCGCCCGGCTCGATCAGGCCGGCGTG
GCCCACATGCCGAACCCCAGCCATATCGTGCCGGTGATGGTCGGCGACGCAGCGCTGTGCAAGCAGATCAGTGACGAGCT
GATCAACCGCTACGGCATCTATGTTCAGCCGATCAACTATCCGACCGTCCCGCGTGGCACCGAGCGGCTGCGGATCACGC
CGTCGCCGCAGCACTCCGACGCGGACATCGAGCATCTGGTCCAGGCGCTCAGCGAAATCTGGGCTCGCGTCGGCCTCGCC
AAGGCGGCCTGA

Upstream 100 bases:

>100_bases
TCCGCCAGACTTTTCTCGAACAGCATTCGCGCAGTGGTCTGGCGCCGGCCCGGGTCGGAATCTCAGCGGAACCGGCCGCG
ACCATCAACGGGAGGACGTC

Downstream 100 bases:

>100_bases
GCACTCTATCGGCTTTCGTTTCGGAAGCAGACGCGCGCCGCGAGGCGCGCGTTTTGCGTTCGACGCACACGACGAAGTCG
ATGGTGAGGCGTGGGGTCGA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNYEAYFRRQLEGLHREGRYRVFADLERHAGAYPRATHHRPDGTGDVTVWCSNDYLGMGQHPAVLKAMHEALDSCGAGAG
GTRNIAGTNHYHVLLEQELAALHGKESALLFTSGYVSNWASLSTLASRMPGCVILSDELNHASMIEGIRHSRSETRIFAH
NDPRDLERKLADLDPHAPKLVAFESVYSMDGDIAPIAEICDVADAANAMTYLDEVHGVGLYGPNGGGIADREGLSHRLTI
IEGTLAKAFGVVGGYIAGSAAVCDFVRSFASGFIFSTSPPPAVAAGALASIRHLRASSIERERHQDRVARLRARLDQAGV
AHMPNPSHIVPVMVGDAALCKQISDELINRYGIYVQPINYPTVPRGTERLRITPSPQHSDADIEHLVQALSEIWARVGLA
KAA

Sequences:

>Translated_403_residues
MNYEAYFRRQLEGLHREGRYRVFADLERHAGAYPRATHHRPDGTGDVTVWCSNDYLGMGQHPAVLKAMHEALDSCGAGAG
GTRNIAGTNHYHVLLEQELAALHGKESALLFTSGYVSNWASLSTLASRMPGCVILSDELNHASMIEGIRHSRSETRIFAH
NDPRDLERKLADLDPHAPKLVAFESVYSMDGDIAPIAEICDVADAANAMTYLDEVHGVGLYGPNGGGIADREGLSHRLTI
IEGTLAKAFGVVGGYIAGSAAVCDFVRSFASGFIFSTSPPPAVAAGALASIRHLRASSIERERHQDRVARLRARLDQAGV
AHMPNPSHIVPVMVGDAALCKQISDELINRYGIYVQPINYPTVPRGTERLRITPSPQHSDADIEHLVQALSEIWARVGLA
KAA
>Mature_403_residues
MNYEAYFRRQLEGLHREGRYRVFADLERHAGAYPRATHHRPDGTGDVTVWCSNDYLGMGQHPAVLKAMHEALDSCGAGAG
GTRNIAGTNHYHVLLEQELAALHGKESALLFTSGYVSNWASLSTLASRMPGCVILSDELNHASMIEGIRHSRSETRIFAH
NDPRDLERKLADLDPHAPKLVAFESVYSMDGDIAPIAEICDVADAANAMTYLDEVHGVGLYGPNGGGIADREGLSHRLTI
IEGTLAKAFGVVGGYIAGSAAVCDFVRSFASGFIFSTSPPPAVAAGALASIRHLRASSIERERHQDRVARLRARLDQAGV
AHMPNPSHIVPVMVGDAALCKQISDELINRYGIYVQPINYPTVPRGTERLRITPSPQHSDADIEHLVQALSEIWARVGLA
KAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=52.1091811414392, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=52.1091811414392, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=52.1091811414392, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=50.6203473945409, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=50.6203473945409, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=37.0466321243523, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI284448556, Length=351, Percent_Identity=38.1766381766382, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI4758668, Length=386, Percent_Identity=29.2746113989637, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI119220554, Length=418, Percent_Identity=27.2727272727273, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI5454084, Length=243, Percent_Identity=27.5720164609054, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1790046, Length=391, Percent_Identity=34.5268542199489, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=37.5, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71994529, Length=401, Percent_Identity=32.6683291770574, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=30, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=373, Percent_Identity=27.6139410187668, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=373, Percent_Identity=27.6139410187668, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=227, Percent_Identity=28.6343612334802, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=227, Percent_Identity=28.6343612334802, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=423, Percent_Identity=47.9905437352246, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=27.5675675675676, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=24.8062015503876, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=47.7611940298507, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24662918, Length=353, Percent_Identity=36.2606232294618, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17136286, Length=353, Percent_Identity=30.8781869688385, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24653280, Length=295, Percent_Identity=27.1186440677966, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653276, Length=295, Percent_Identity=27.1186440677966, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653278, Length=295, Percent_Identity=27.1186440677966, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 43679; Mature: 43679

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYEAYFRRQLEGLHREGRYRVFADLERHAGAYPRATHHRPDGTGDVTVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
HPAVLKAMHEALDSCGAGAGGTRNIAGTNHYHVLLEQELAALHGKESALLFTSGYVSNWA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCEEEEECCHHHHHH
SLSTLASRMPGCVILSDELNHASMIEGIRHSRSETRIFAHNDPRDLERKLADLDPHAPKL
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCHH
VAFESVYSMDGDIAPIAEICDVADAANAMTYLDEVHGVGLYGPNGGGIADREGLSHRLTI
EEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEE
IEGTLAKAFGVVGGYIAGSAAVCDFVRSFASGFIFSTSPPPAVAAGALASIRHLRASSIE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
RERHQDRVARLRARLDQAGVAHMPNPSHIVPVMVGDAALCKQISDELINRYGIYVQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVPRGTERLRITPSPQHSDADIEHLVQALSEIWARVGLAKAA
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYEAYFRRQLEGLHREGRYRVFADLERHAGAYPRATHHRPDGTGDVTVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
HPAVLKAMHEALDSCGAGAGGTRNIAGTNHYHVLLEQELAALHGKESALLFTSGYVSNWA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCEEEEECCHHHHHH
SLSTLASRMPGCVILSDELNHASMIEGIRHSRSETRIFAHNDPRDLERKLADLDPHAPKL
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCHH
VAFESVYSMDGDIAPIAEICDVADAANAMTYLDEVHGVGLYGPNGGGIADREGLSHRLTI
EEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEE
IEGTLAKAFGVVGGYIAGSAAVCDFVRSFASGFIFSTSPPPAVAAGALASIRHLRASSIE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
RERHQDRVARLRARLDQAGVAHMPNPSHIVPVMVGDAALCKQISDELINRYGIYVQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVPRGTERLRITPSPQHSDADIEHLVQALSEIWARVGLAKAA
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]