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The map label for this gene is pleC [H]

Identifier: 86750506

GI number: 86750506

Start: 3880910

End: 3882502

Strand: Direct

Name: pleC [H]

Synonym: RPB_3395

Alternate gene names: 86750506

Gene position: 3880910-3882502 (Clockwise)

Preceding gene: 86750505

Following gene: 86750507

Centisome position: 72.79

GC content: 66.85

Gene sequence:

>1593_bases
ATGAGTGAGCCCGCCGAAAAGCCCGAAGTCTTCCAGCTTCCGGCTGAGTCCCCGGTGGTCGCCCCGGCACGCAACCGGCG
CGCTGCGGCTCAACGCGTCCGCGAAGCGCGCGACCGGCTGACCTCGACCAGCGGCACCCGCCCCGCCTTCGACCACGAAC
TGGTCCGGCAATTCGCGCAGACCCGATTGTCGGCGTCCTTCGTCATCATGCTGCTGGTGGTGGTCACCGGCATCCTGTTC
GCATTCTGGTTCGATCCGGTCACCGCCGGCGCCTGGACCGTCGGGATGCTGTGCATCCACGCCGTGATGATCCGCAACTG
CAGCCGCTTCCTGCAGGAGCCCGCCTCGCCGCCCCGCACCCGAAGCTGGCGACGCCGCTTCGTCGCGCTCGATCTGCTCT
ACGGGCTCGCCTGGACCACGATCCTGGTGCATCCGCTCGGGCTGACGGTCGTCTCCAACACGCTGCTGATGTTCCTGATG
CTGCTGGTGGTGGCGGTGTCGAGCATGCTGGCGGCCAGCCTGCCGATCGCCGCGCTGGCGGCGACCGTCCCGGTCACCGC
CGCGATCACGCTGAACTTCGTGCTCGGCGGCACTTTCGACAGCTACGTGCTGGCGGCGCTGACCGTCGCGGCGGAAGGTT
ACTTCGCGCTGCTGGCGCATCGCCTGCATTCGACGACGCTGGCGACGCTCGAGGCGCGCGCCGAGAAGGACGCACTGATC
GGCGAGCTGGAACAGGCCAAGGCGATTTCCGACGAGGCGCGGCATCGCGCCGAGGCCGCCAACGTCGCCAAATCGCGGTT
CCTGGCGCAGATGAGCCACGAGCTGCGCACGCCGCTCAACGCCATCCTCGGCTTTTCCGAAGTGATGAAGAGCGAGATTT
TCGGCGCCCACGCGGTGCCGGTGTACAAGGAATACTCGGCGGACATCCACAACTCCGGCGTCCACCTGCTCAATCTGATC
AACGAAATCCTCGACCTGTCGCGGATCGAGGCGGGTCGCTACGAACTCAACGAGGAAGCGATCTCGCTGGTCCATGTGGT
GACGGACTGCCATCATCTGCTGAAGCTGCGCGCCTCCAGCCGCGGCATCACCATCCACGAAGTGTTCGAACAGGGCATGC
CGCGGATCTGGGGCGACGAGCGCGCGGTGCGTCAGGTGGTGCTCAACCTGCTCTCCAACTCGATCAAGTTCACGCCGCAG
GGCGGCGAAATCTGGCTCAAGGTCGGCTGGACCGCGTCCGGCGGACAGTATCTCAGCGTCAAGGACACCGGCTCGGGCAT
CCCCGAAGAGGAAATCCCGGTGGTGCTGGCGTCGTTCGGCCAGGGCTCCAATTCGATCAAATCCGCCGAACAGGGCGCTG
GCCTCGGCCTGCCGATCGCCAAGAGCCTGGTCGACATGCACGGCGGCACCTTCACGCTGAAATCGAAGCTGCGGATCGGC
ACCGAAGTGATCGTCACCTTCCCGCCGGAGCGGGTGATGTCGGCGCTGGCGCCGATGGCCGACGAGGCGCCGCTGCAGCC
CGGCTTGGTCGAGAACGACGACCGCAGCCGCGCGCGCGGCAAGCCGATCATGAACGCCGGCACCGGGCTGTAG

Upstream 100 bases:

>100_bases
TTAACCGGAATATCATTCCCTCGGAGGCTACTCTCGACGATTGCAGCCAAGGATAGGCTGGTGGTGCTGCGCGCGTTTTT
GCGCTGGAATTGTGTTGGTG

Downstream 100 bases:

>100_bases
CGATGGGGACTTGCGCACATCACCCGATGTCCGCCACGATCGGGCATGAGCCTCGAATCCCCCTGCATCGCGGTCTGCGT
GATCCATCCGCAGAGCGGCC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSEPAEKPEVFQLPAESPVVAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQFAQTRLSASFVIMLLVVVTGILF
AFWFDPVTAGAWTVGMLCIHAVMIRNCSRFLQEPASPPRTRSWRRRFVALDLLYGLAWTTILVHPLGLTVVSNTLLMFLM
LLVVAVSSMLAASLPIAALAATVPVTAAITLNFVLGGTFDSYVLAALTVAAEGYFALLAHRLHSTTLATLEARAEKDALI
GELEQAKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPVYKEYSADIHNSGVHLLNLI
NEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRASSRGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNSIKFTPQ
GGEIWLKVGWTASGGQYLSVKDTGSGIPEEEIPVVLASFGQGSNSIKSAEQGAGLGLPIAKSLVDMHGGTFTLKSKLRIG
TEVIVTFPPERVMSALAPMADEAPLQPGLVENDDRSRARGKPIMNAGTGL

Sequences:

>Translated_530_residues
MSEPAEKPEVFQLPAESPVVAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQFAQTRLSASFVIMLLVVVTGILF
AFWFDPVTAGAWTVGMLCIHAVMIRNCSRFLQEPASPPRTRSWRRRFVALDLLYGLAWTTILVHPLGLTVVSNTLLMFLM
LLVVAVSSMLAASLPIAALAATVPVTAAITLNFVLGGTFDSYVLAALTVAAEGYFALLAHRLHSTTLATLEARAEKDALI
GELEQAKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPVYKEYSADIHNSGVHLLNLI
NEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRASSRGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNSIKFTPQ
GGEIWLKVGWTASGGQYLSVKDTGSGIPEEEIPVVLASFGQGSNSIKSAEQGAGLGLPIAKSLVDMHGGTFTLKSKLRIG
TEVIVTFPPERVMSALAPMADEAPLQPGLVENDDRSRARGKPIMNAGTGL
>Mature_529_residues
SEPAEKPEVFQLPAESPVVAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQFAQTRLSASFVIMLLVVVTGILFA
FWFDPVTAGAWTVGMLCIHAVMIRNCSRFLQEPASPPRTRSWRRRFVALDLLYGLAWTTILVHPLGLTVVSNTLLMFLML
LVVAVSSMLAASLPIAALAATVPVTAAITLNFVLGGTFDSYVLAALTVAAEGYFALLAHRLHSTTLATLEARAEKDALIG
ELEQAKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPVYKEYSADIHNSGVHLLNLIN
EILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRASSRGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNSIKFTPQG
GEIWLKVGWTASGGQYLSVKDTGSGIPEEEIPVVLASFGQGSNSIKSAEQGAGLGLPIAKSLVDMHGGTFTLKSKLRIGT
EVIVTFPPERVMSALAPMADEAPLQPGLVENDDRSRARGKPIMNAGTGL

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=33.4745762711864, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=28.8389513108614, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=34.5238095238095, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87081816, Length=269, Percent_Identity=33.457249070632, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI145693157, Length=268, Percent_Identity=31.7164179104478, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=29.2181069958848, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082128, Length=213, Percent_Identity=30.5164319248826, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=27.4678111587983, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=275, Percent_Identity=25.0909090909091, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=24.3589743589744, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=24.8995983935743, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=25.9615384615385, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790300, Length=248, Percent_Identity=24.1935483870968, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=21.8340611353712, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57543; Mature: 57412

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50109 HIS_KIN ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPAEKPEVFQLPAESPVVAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQFAQ
CCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TRLSASFVIMLLVVVTGILFAFWFDPVTAGAWTVGMLCIHAVMIRNCSRFLQEPASPPRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RSWRRRFVALDLLYGLAWTTILVHPLGLTVVSNTLLMFLMLLVVAVSSMLAASLPIAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ATVPVTAAITLNFVLGGTFDSYVLAALTVAAEGYFALLAHRLHSTTLATLEARAEKDALI
HHHHHHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GELEQAKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VYKEYSADIHNSGVHLLNLINEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRASS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNSIKFTPQGGEIWLKVGWTASGGQYLSV
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEECCCCCEEEE
KDTGSGIPEEEIPVVLASFGQGSNSIKSAEQGAGLGLPIAKSLVDMHGGTFTLKSKLRIG
ECCCCCCCCHHHCCCEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHCCC
TEVIVTFPPERVMSALAPMADEAPLQPGLVENDDRSRARGKPIMNAGTGL
CEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SEPAEKPEVFQLPAESPVVAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQFAQ
CCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TRLSASFVIMLLVVVTGILFAFWFDPVTAGAWTVGMLCIHAVMIRNCSRFLQEPASPPRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RSWRRRFVALDLLYGLAWTTILVHPLGLTVVSNTLLMFLMLLVVAVSSMLAASLPIAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ATVPVTAAITLNFVLGGTFDSYVLAALTVAAEGYFALLAHRLHSTTLATLEARAEKDALI
HHHHHHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GELEQAKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VYKEYSADIHNSGVHLLNLINEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRASS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNSIKFTPQGGEIWLKVGWTASGGQYLSV
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEECCCCCEEEE
KDTGSGIPEEEIPVVLASFGQGSNSIKSAEQGAGLGLPIAKSLVDMHGGTFTLKSKLRIG
ECCCCCCCCHHHCCCEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHCCC
TEVIVTFPPERVMSALAPMADEAPLQPGLVENDDRSRARGKPIMNAGTGL
CEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]