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The map label for this gene is cobM [H]

Identifier: 86750295

GI number: 86750295

Start: 3640962

End: 3641741

Strand: Direct

Name: cobM [H]

Synonym: RPB_3184

Alternate gene names: 86750295

Gene position: 3640962-3641741 (Clockwise)

Preceding gene: 86750294

Following gene: 86750296

Centisome position: 68.29

GC content: 70.13

Gene sequence:

>780_bases
ATGACGGTCCACTTCATCGGCGCCGGCCCCGGCGCGCCCGACCTGATCACGGTGCGCGGCCGCGATCTGGTGATGCGCTG
CCCGGTCTGCCTCTACGCGGGATCGCTGGTGCCGCGCGAGCTGATCACGCTGTGCCCGCCCGGCGCCCGCGTGGTCGACA
CCGCGCCGCTCGATCTCGACGCAATCACGAGAGAATTCGTCGCCGCCACCGAAGCCGGCCACGATGTGGCACGGCTGCAT
TCCGGCGATTTGTCGGTGTGGAGCGCGATGGGCGAGCAGATCCGCCGGCTCGAGGCTCACGGCATCCCCTACACCGTCAC
GCCCGGCGTGCCGTCATTCGCTGCCGCCGCGGCGGCGCTCGGGCGCGAACTGACACTGCCCGAAGTCGCCCAGACCGTGG
TGCTGACGCGCACCTCCGGCCGCGCCTCGGCGATGCCGCCGCGCGAAAACCTGGACGCGTATGCGGCGACCGGCGCGACG
CTGGCGATCCATCTGTCGATCCACGTGATCAATAGCGTCGTCGAGAAACTGCGCCCGCATTACGGCGATGATTGCGCCGT
CGCCGTCGTCGTTCGCGCGAGCTGGCCCGAAGAGCAGATCATCCGCGGCACGCTGACGACGATCGCCGCGCAGGTCGCGG
AGGCCGGCATCGACCGCACCGCGCTGATCCTGATCGGGCCGTCGCTCGCAGCGAGCGATTTCCGCAATAGCGCGCTCTAC
AGCACGGACTACGACCGGCGCTACCGTCGCTCCGCGGAGGACGATCGTGCCCGCGACTGA

Upstream 100 bases:

>100_bases
CGCTCGCCGCGGCGGGGCCTGCCGCCCGCCTTGCGGTGACGCGGCTGATATCAAGCGACCGCCAGGCGACCGCCGCCGTC
GCCATCGAGGAGCCACCGCA

Downstream 100 bases:

>100_bases
TCGCACAACCAGCGCTGCGAGGCTCGGCACACCGCCGGGGCTGATCATCGCCGCGCCGTCGACCAACAGCGGCAAGACCA
CGGTGACGCTGGCGTTGCTC

Product: precorrin-4 C11-methyltransferase

Products: NA

Alternate protein names: Precorrin-3 methylase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPRELITLCPPGARVVDTAPLDLDAITREFVAATEAGHDVARLH
SGDLSVWSAMGEQIRRLEAHGIPYTVTPGVPSFAAAAAALGRELTLPEVAQTVVLTRTSGRASAMPPRENLDAYAATGAT
LAIHLSIHVINSVVEKLRPHYGDDCAVAVVVRASWPEEQIIRGTLTTIAAQVAEAGIDRTALILIGPSLAASDFRNSALY
STDYDRRYRRSAEDDRARD

Sequences:

>Translated_259_residues
MTVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPRELITLCPPGARVVDTAPLDLDAITREFVAATEAGHDVARLH
SGDLSVWSAMGEQIRRLEAHGIPYTVTPGVPSFAAAAAALGRELTLPEVAQTVVLTRTSGRASAMPPRENLDAYAATGAT
LAIHLSIHVINSVVEKLRPHYGDDCAVAVVVRASWPEEQIIRGTLTTIAAQVAEAGIDRTALILIGPSLAASDFRNSALY
STDYDRRYRRSAEDDRARD
>Mature_258_residues
TVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPRELITLCPPGARVVDTAPLDLDAITREFVAATEAGHDVARLHS
GDLSVWSAMGEQIRRLEAHGIPYTVTPGVPSFAAAAAALGRELTLPEVAQTVVLTRTSGRASAMPPRENLDAYAATGATL
AIHLSIHVINSVVEKLRPHYGDDCAVAVVVRASWPEEQIIRGTLTTIAAQVAEAGIDRTALILIGPSLAASDFRNSALYS
TDYDRRYRRSAEDDRARD

Specific function: Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=241, Percent_Identity=26.5560165975104, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322922, Length=253, Percent_Identity=23.7154150197628, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.133 [H]

Molecular weight: Translated: 27659; Mature: 27528

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPRELITLCPPGARVVDTAPLDLD
CEEEEEECCCCCCCEEEECCCCEEEECCHHHHHCCCCHHHHHHHCCCCCEEEECCCCCHH
AITREFVAATEAGHDVARLHSGDLSVWSAMGEQIRRLEAHGIPYTVTPGVPSFAAAAAAL
HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
GRELTLPEVAQTVVLTRTSGRASAMPPRENLDAYAATGATLAIHLSIHVINSVVEKLRPH
CCCCCCHHHHHEEEEEECCCCCCCCCCHHCCCHHHCCCCEEEEEEHHHHHHHHHHHHCCC
YGDDCAVAVVVRASWPEEQIIRGTLTTIAAQVAEAGIDRTALILIGPSLAASDFRNSALY
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCC
STDYDRRYRRSAEDDRARD
CCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPRELITLCPPGARVVDTAPLDLD
EEEEEECCCCCCCEEEECCCCEEEECCHHHHHCCCCHHHHHHHCCCCCEEEECCCCCHH
AITREFVAATEAGHDVARLHSGDLSVWSAMGEQIRRLEAHGIPYTVTPGVPSFAAAAAAL
HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
GRELTLPEVAQTVVLTRTSGRASAMPPRENLDAYAATGATLAIHLSIHVINSVVEKLRPH
CCCCCCHHHHHEEEEEECCCCCCCCCCHHCCCHHHCCCCEEEEEEHHHHHHHHHHHHCCC
YGDDCAVAVVVRASWPEEQIIRGTLTTIAAQVAEAGIDRTALILIGPSLAASDFRNSALY
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCC
STDYDRRYRRSAEDDRARD
CCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 8226690 [H]