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The map label for this gene is accC [H]

Identifier: 86750137

GI number: 86750137

Start: 3442308

End: 3443663

Strand: Direct

Name: accC [H]

Synonym: RPB_3020

Alternate gene names: 86750137

Gene position: 3442308-3443663 (Clockwise)

Preceding gene: 86750136

Following gene: 86750138

Centisome position: 64.56

GC content: 65.71

Gene sequence:

>1356_bases
ATGTTCGATAAAATTCTCATAGCCAATCGCGGCGAGATCGCTCTGCGGGTTCTGCGTGCGTGCAAGGAACTGGGCATTGC
CACGGTCGCCGTGCATTCGACCGCCGACGCGGACGCGATGCATGTCCGGCTCGCGGACGAAAGCGTCTGTATCGGCCCGC
CGCCGTCCAAGGACAGCTATCTCAACATCCCGGCGCTGCTGGCGGCCTGCGAGATCACCGGCGCCGACGCGGTGCATCCG
GGCTATGGATTTCTATCCGAGAATGCCCGTTTCGCCGAGATTCTCGCCGACCACAATCTGCATTTCATCGGCCCCAAGGC
CGAGCACATCCGGCTGATGGGCGACAAGATCGAGGCGAAGAAGACCGCCAGGCGCCTGGGCATCCCCGTGGTGCCGGGCT
CGGACGGCGCGGTCGGCCCGGACGACGACGCGATGTCGATCGCCAGGGAGATCGGCTTTCCGGTGCTGGTCAAGGCCGCC
GCCGGCGGCGGTGGCCGCGGCATGAAGGTCGCGCACACCGCCGAAGACCTGTCGATGGCGATCTCGACCGCGGGCAACGA
GGCCAAGGCCGCCTTCGGCGACGCCTCGGTCTATCTGGAGAAGTATCTGCAGAAGCCGCGCCACATCGAAATCCAGGTGC
TGGGTGACGGCCGCGGCGGCGCGATCCATCTCGGCGAGCGTGACTGCTCGCTGCAGCGGCGGCACCAGAAGGTCTGGGAA
GAGAGCCCCTCCCCGGTGATCAGCGCGGAAGCCCGCGCCCGGATCGGCGGCATCTGCGCCAAGGCGATGCAGGACATGAG
CTATGTCGGCGTCGGCACCATCGAATTCCTCTACGAGGACGGCGAATTCTACTTCATCGAGATGAACACCCGGATCCAGG
TCGAGCATCCGGTCACGGAGATGATCACCGGGATCGATCTGGTGCTGGAGCAGATCCGGATCGCCGCCGGCGGCGACCTG
CCGGTGTCGCAGGACGAGATCGTGCTCAACGGCCACGCCATCGAGTGCCGGATCAACGCCGAGAATCCGGTGAGCTTCCG
GCCGTCGCCGGGCAAGATCGCGCGTTATCATCCACCCGGCGGCCTCGGCGTCCGGATCGATTCCGCAGTCTTCCAAGGCT
ACACCATCCCGCCTTATTACGACTCGCTTGTCGGCAAGCTGATCGTCCACGGCAAGACCCGCGGCGAGTGCCTGATGCGG
CTGCGGCGGGCGCTGGACGAGATGGTGGTCGACGGCATCGAGACCACACTGCCGCTGTTCCGCGCACTGGTGCGGGAACC
GGGGATCATCGACGGCGATTATCATATCCACTGGCTGGAGCAGTATCTCGCCGGCGTCGCCCTCGAGGGCCGCTGA

Upstream 100 bases:

>100_bases
GTCGCGAATGGCGAGTGGCGAATAGAGCTGCATCGCAACGCCATCCGCCCCCCATTCGCCACTCGCCATTTGCAATTCGC
CTCTCAATCCGGTGGCCCCG

Downstream 100 bases:

>100_bases
AGAATATTTGCGTCGGGCGTGGAACCAAGTTCCGGCTCCCGCGTTAGCGTGGCTGCAGATTTGGCCGCCTTGCGGGGATT
GTTCTTGCTTTGTTTCAAAT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNIPALLAACEITGADAVHP
GYGFLSENARFAEILADHNLHFIGPKAEHIRLMGDKIEAKKTARRLGIPVVPGSDGAVGPDDDAMSIAREIGFPVLVKAA
AGGGGRGMKVAHTAEDLSMAISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
ESPSPVISAEARARIGGICAKAMQDMSYVGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PVSQDEIVLNGHAIECRINAENPVSFRPSPGKIARYHPPGGLGVRIDSAVFQGYTIPPYYDSLVGKLIVHGKTRGECLMR
LRRALDEMVVDGIETTLPLFRALVREPGIIDGDYHIHWLEQYLAGVALEGR

Sequences:

>Translated_451_residues
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNIPALLAACEITGADAVHP
GYGFLSENARFAEILADHNLHFIGPKAEHIRLMGDKIEAKKTARRLGIPVVPGSDGAVGPDDDAMSIAREIGFPVLVKAA
AGGGGRGMKVAHTAEDLSMAISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
ESPSPVISAEARARIGGICAKAMQDMSYVGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PVSQDEIVLNGHAIECRINAENPVSFRPSPGKIARYHPPGGLGVRIDSAVFQGYTIPPYYDSLVGKLIVHGKTRGECLMR
LRRALDEMVVDGIETTLPLFRALVREPGIIDGDYHIHWLEQYLAGVALEGR
>Mature_451_residues
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNIPALLAACEITGADAVHP
GYGFLSENARFAEILADHNLHFIGPKAEHIRLMGDKIEAKKTARRLGIPVVPGSDGAVGPDDDAMSIAREIGFPVLVKAA
AGGGGRGMKVAHTAEDLSMAISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
ESPSPVISAEARARIGGICAKAMQDMSYVGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PVSQDEIVLNGHAIECRINAENPVSFRPSPGKIARYHPPGGLGVRIDSAVFQGYTIPPYYDSLVGKLIVHGKTRGECLMR
LRRALDEMVVDGIETTLPLFRALVREPGIIDGDYHIHWLEQYLAGVALEGR

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=49.3212669683258, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.3212669683258, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.3212669683258, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=44.5701357466063, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=44.7191011235955, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=44.7191011235955, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=44.7191011235955, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=29.2397660818713, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI38679960, Length=512, Percent_Identity=28.90625, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679971, Length=512, Percent_Identity=28.90625, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI38679974, Length=512, Percent_Identity=28.90625, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679977, Length=512, Percent_Identity=28.90625, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679967, Length=512, Percent_Identity=28.90625, Blast_Score=222, Evalue=5e-58,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=61.036036036036, Blast_Score=543, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.3800904977376, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=439, Percent_Identity=43.5079726651481, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=41.3333333333333, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=28.7968441814596, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=28.7968441814596, Blast_Score=211, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=26.7893660531697, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319685, Length=427, Percent_Identity=42.1545667447307, Blast_Score=348, Evalue=8e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=42, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=41.834451901566, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=30.1556420233463, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=440, Percent_Identity=32.5, Blast_Score=212, Evalue=8e-56,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=44.0449438202247, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=42.7872860635697, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI161076407, Length=507, Percent_Identity=28.5996055226824, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24586460, Length=507, Percent_Identity=28.5996055226824, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI161076409, Length=507, Percent_Identity=28.5996055226824, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24586458, Length=507, Percent_Identity=28.5996055226824, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48806; Mature: 48806

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSY
CCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCE
LNIPALLAACEITGADAVHPGYGFLSENARFAEILADHNLHFIGPKAEHIRLMGDKIEAK
ECHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHEEEEECCHHHHH
KTARRLGIPVVPGSDGAVGPDDDAMSIAREIGFPVLVKAAAGGGGRGMKVAHTAEDLSMA
HHHHHCCCEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECHHHHHHH
ISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
HHCCCCCCHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPVISAEARARIGGICAKAMQDMSYVGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTE
CCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDLVLEQIRIAAGGDLPVSQDEIVLNGHAIECRINAENPVSFRPSPGKIARYHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCEEECCCC
GLGVRIDSAVFQGYTIPPYYDSLVGKLIVHGKTRGECLMRLRRALDEMVVDGIETTLPLF
CCEEEEEHHHHCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RALVREPGIIDGDYHIHWLEQYLAGVALEGR
HHHHHCCCEECCCCHHHHHHHHHHCEECCCC
>Mature Secondary Structure
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSY
CCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCE
LNIPALLAACEITGADAVHPGYGFLSENARFAEILADHNLHFIGPKAEHIRLMGDKIEAK
ECHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHEEEEECCHHHHH
KTARRLGIPVVPGSDGAVGPDDDAMSIAREIGFPVLVKAAAGGGGRGMKVAHTAEDLSMA
HHHHHCCCEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECHHHHHHH
ISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
HHCCCCCCHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPVISAEARARIGGICAKAMQDMSYVGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTE
CCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDLVLEQIRIAAGGDLPVSQDEIVLNGHAIECRINAENPVSFRPSPGKIARYHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCEEECCCC
GLGVRIDSAVFQGYTIPPYYDSLVGKLIVHGKTRGECLMRLRRALDEMVVDGIETTLPLF
CCEEEEEHHHHCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RALVREPGIIDGDYHIHWLEQYLAGVALEGR
HHHHHCCCEECCCCHHHHHHHHHHCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]