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The map label for this gene is nuoE1 [H]

Identifier: 86749695

GI number: 86749695

Start: 2958333

End: 2959082

Strand: Direct

Name: nuoE1 [H]

Synonym: RPB_2577

Alternate gene names: 86749695

Gene position: 2958333-2959082 (Clockwise)

Preceding gene: 86749694

Following gene: 86749696

Centisome position: 55.49

GC content: 65.2

Gene sequence:

>750_bases
ATGTCCGTTCGTCGTCTGGCTCCCAAGGAGCTGCAGCCTGAAAGCTTCGCCTTCACCGAGGAGAACCTCGCCTGGGCCAA
GCGCGAGATTACCAAGTACCCGCCCGCGCGCCAGTTCTCGGCGGTGATCGCGATCATGTGGCGGGCGCAAGAGCAGTGCG
GCGGCTGGCTTCCGGAAGCGGCGATCCGCGTCATCAGCGACATGCTCGAGATGCCGCATATCCGCGCGCTCGAAGTCGCG
ACCTTCTACACGATGTTCCAGCTCAATCCGGTCGGTAAGAAAGCGCATGTTCAGGTCTGCGGCACCACGCCGTGCCGGCT
GCGCGGCGCCGGCGAACTGATCGAAGTCTGCAAGAGCAGGATCCATCACGACCCGTTCCATCTGTCGGCCGACGGCGACT
TCTCGTGGGAAGAGGTCGAATGTGCCGGCGCCTGTGTGAATGCGCCGATGGTGCAGATCTGGAAGGATACCTACGAGGAT
CTGACGCCGGAGAGCCTGAACAAGGTGCTCGACGGTTTCGCCGCCGGGAACCCGCCGAAGCCCGGCCCGCAGAATGGCCG
CCAGTACGCGGCGCCGATCACCGGGCCGACGACGCTGAAGACCGGTGGGATCAACGTCGCCACCGACACCAATGACGGCC
CGGCGCTGACCGATCAAGAGCCGAAGCGCACCACCGAAGCCGCAAATACGCGAGAGCGGCCCGATCCGAAGGCGCCGGCC
GCCGACGCCAGCGAAAAGAACCCGCCATGA

Upstream 100 bases:

>100_bases
ATGTCGGCTACAACGTCATCGGTACCGCGAGCGCGTTCTGGTTGGCCCGGATCGAAAATCTGAATGCGAGCGCGGCCAAA
CGCGCGATGAGAAACTGATC

Downstream 100 bases:

>100_bases
CCGAGCCGAGCAAGGCGGCCTCGGGCCGCGCGGAGAGGGCCGAACCGATGCGCCAGCCGTTCTATATCGCGATGCACGCG
GTGGTCGCCGCGGGCTTCAT

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 1; NDH-1 subunit E 1 [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSVRRLAPKELQPESFAFTEENLAWAKREITKYPPARQFSAVIAIMWRAQEQCGGWLPEAAIRVISDMLEMPHIRALEVA
TFYTMFQLNPVGKKAHVQVCGTTPCRLRGAGELIEVCKSRIHHDPFHLSADGDFSWEEVECAGACVNAPMVQIWKDTYED
LTPESLNKVLDGFAAGNPPKPGPQNGRQYAAPITGPTTLKTGGINVATDTNDGPALTDQEPKRTTEAANTRERPDPKAPA
ADASEKNPP

Sequences:

>Translated_249_residues
MSVRRLAPKELQPESFAFTEENLAWAKREITKYPPARQFSAVIAIMWRAQEQCGGWLPEAAIRVISDMLEMPHIRALEVA
TFYTMFQLNPVGKKAHVQVCGTTPCRLRGAGELIEVCKSRIHHDPFHLSADGDFSWEEVECAGACVNAPMVQIWKDTYED
LTPESLNKVLDGFAAGNPPKPGPQNGRQYAAPITGPTTLKTGGINVATDTNDGPALTDQEPKRTTEAANTRERPDPKAPA
ADASEKNPP
>Mature_248_residues
SVRRLAPKELQPESFAFTEENLAWAKREITKYPPARQFSAVIAIMWRAQEQCGGWLPEAAIRVISDMLEMPHIRALEVAT
FYTMFQLNPVGKKAHVQVCGTTPCRLRGAGELIEVCKSRIHHDPFHLSADGDFSWEEVECAGACVNAPMVQIWKDTYEDL
TPESLNKVLDGFAAGNPPKPGPQNGRQYAAPITGPTTLKTGGINVATDTNDGPALTDQEPKRTTEAANTRERPDPKAPAA
DASEKNPP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=199, Percent_Identity=41.2060301507538, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1788621, Length=162, Percent_Identity=28.3950617283951, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561328, Length=185, Percent_Identity=46.4864864864865, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI18859877, Length=199, Percent_Identity=41.7085427135678, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI21355353, Length=186, Percent_Identity=37.6344086021505, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 27320; Mature: 27189

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRRLAPKELQPESFAFTEENLAWAKREITKYPPARQFSAVIAIMWRAQEQCGGWLPEA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
AIRVISDMLEMPHIRALEVATFYTMFQLNPVGKKAHVQVCGTTPCRLRGAGELIEVCKSR
HHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEECCCHHHHHHHHHH
IHHDPFHLSADGDFSWEEVECAGACVNAPMVQIWKDTYEDLTPESLNKVLDGFAAGNPPK
HCCCCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
PGPQNGRQYAAPITGPTTLKTGGINVATDTNDGPALTDQEPKRTTEAANTRERPDPKAPA
CCCCCCCEEECCCCCCCEEECCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
ADASEKNPP
CCCCCCCCC
>Mature Secondary Structure 
SVRRLAPKELQPESFAFTEENLAWAKREITKYPPARQFSAVIAIMWRAQEQCGGWLPEA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
AIRVISDMLEMPHIRALEVATFYTMFQLNPVGKKAHVQVCGTTPCRLRGAGELIEVCKSR
HHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEECCCHHHHHHHHHH
IHHDPFHLSADGDFSWEEVECAGACVNAPMVQIWKDTYEDLTPESLNKVLDGFAAGNPPK
HCCCCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
PGPQNGRQYAAPITGPTTLKTGGINVATDTNDGPALTDQEPKRTTEAANTRERPDPKAPA
CCCCCCCEEECCCCCCCEEECCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
ADASEKNPP
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]