Click here to switch to the map view.

The map label for this gene is lhr [C]

Identifier: 86749662

GI number: 86749662

Start: 2912490

End: 2914745

Strand: Direct

Name: lhr [C]

Synonym: RPB_2543

Alternate gene names: 86749662

Gene position: 2912490-2914745 (Clockwise)

Preceding gene: 86749661

Following gene: 86749664

Centisome position: 54.63

GC content: 65.16

Gene sequence:

>2256_bases
ATGAGCTCACCAAGCTTCGCCTCCCTTGAGGGAGCCTACGATCGCCTGCATCCGAAGGTCCGGCGTTGGATCCGGGATCA
GGGCTGGAATGAGCTGCGCGAGATCCAGGCGCGCGCCATTGTGGCCGCGCTCGATGGCGCCGGCGACATCCTGATCGCCG
CGTCGACCGCCGCCGGCAAGACCGAGGCGGCATTCCTGCCGATTCTGACCGCGGTGGCGGACCGAACGCAGTCGGGGTTC
TCGGTGCTCTACGTCAGCCCGCTGAAGGCGCTGATCAATGATCAATTCCGCCGGCTCGAGACGCTCTGCGAGGCCATGGA
AATCCCCGTGGTGAAGTGGCACGGCGATGCCTCGCCATCCGCGAAGAGGAAGGCGATCGACAAACCGGAGGGCGTCGCAC
TGATCACGCCGGAATCGATCGAGGCTATGTTCACCCGAAGGCCGGCCGACGCAAAGCGGTTGCTCGCCGCGGCGGACTTC
ATCGTCGTCGACGAGGTGCACTCTTTCCTGCAGGGTCCGCGCGGCCTTCACGTGGCCAGCCTGCTCAAGCGGATCGACGC
GATGGCGCCGACCAGTGCGAGGCGGGTGGGACTGTCGGCAACTATAGGTGATCTGCGGCAGGCGGCCGCCTGGTTGAGAC
CCGTCGATCCGGACCGGGTCGACATCCTGCAGGCCAAGTCGGACGCGCCCGAGCTGCGTCTGCAGGTGAGAGGCTATTCG
GAGCCGCCGGACCTCGACGATCCGGACCACGCCGAAGGGGTTGCGGAGGCGGACGAAGAGCCGGCGTCGGATGCGCTCCC
GCAGCGCATCGCCCTCGACTACATCGCCGACCACCTCTTCGGCACATTGCGCGGCTCCAACAACCTGGTCTTCGGCGGCT
CGCGCCGTACGGTAGAGTCGGCGGCCGACCGGCTGCGCCGCCGCTGCGAGAAGGCGAACGTCCCGAACGAGTTTTTCCCG
CACCATGGCAGCCTGTCGAAGGTGCTGCGCGAGGAGCTGGAGATCCGGCTGAAGGACGGGAAGCTTCCGACCACGGCCGT
GTGCACGTCGACGCTCGAGCTTGGGGTGGACATTGGATCGGTGAAGTCGGTGGCCCAGATCGGGGCACCGCGTGCCTTGG
CATCCGTGCGCCAGCGGCTGGGTCGGACGGGCCGCCGCGCCGGCACCCCGGCCATCCTCCGGATCTATGTGCGCGAACCG
TACATCAGCCGGAAATCAGGTCTTCTGGACCGACTCCACATGAACACCGTGCGCTCGGTCGCGATCGTTCGGCTGCTGCT
GGCGGGCTTCGTCGAGCCGGCGGCGCCAAGCCCCGAGATTCCGTCGACGCTCATCCACCAGATCCTTTCCGTGATCGCGG
AGCGGGGTGGCATTTCGCCCAAGCCGCTCTTCGATCTCCTGTGCGGACCGGGGCCATTCGCGTCGATCGGTACATCGGAC
TTCGCGGGCCTGCTGCGCCACCTCGGTTCGACGGACATTCGCTTTCTCGAACAGGCACCGGACGGCACACTGATGCTCGG
CTCTGAAGGCGAGAAGATCGTCCAGTCGCGAAGCTTCTTCGCGGTCTTCGAGACACCCGAGGAATGGCGCCTCACGGTCG
GCGGCCGCACCTTGGGGACTTTGCCGATCTCGTATCCCGTGAACATCGGCAGCCTCGTCGTATTCGCCGGGCAGCGGTGG
ATCGTACGCGAGATCGACGAAAAGACCCGAACACTCTTGGTAGCTCCGCATCGCGGAGGTGTCGTTCCTCGGTTCGAACG
GAATACTTTCGAACCTGCACACGATCGGCTGATTGCCGAGATGAAGGCGGTCTACGAAGACGACGATGTGCCGCCCTATC
TCGACCAGAGCGGAAGGGACCTGCTGTCGGCGGGCCGGGAGACCTTCCGCGACTGGGATCTCGACATTACGACCCAGGTG
CAGGAGGAAGCCGATCTGCACCTGTTTCTCTGGCGAGGCACGCAGGCGACGGCCGTCTTCGGCGCCGCGTTGTCGATGGC
GGGACTCGAATGCGAGGTCCACGATCTCGGTCTGATCCTTCCGAAGACGAAAGGAGAGGAGGTGAATCCGATCCTCGAAA
AGCTCGCCGCCATGGAGAAGATCGACCCGATGGACGTCGCCGAGTTCGTCAAGAATATCGGTGGGGGGAAGTTTCGGGAG
TCCGTGCCGGCACCGCTCGCGCGGAAGCAATGGGCCGATCAGAACGCTCCGTTGATCAGGACGGCGCAGACGATGGCGAG
AACGGTGTTGATGTGA

Upstream 100 bases:

>100_bases
AAGTGGCAGGATCTCCTGGGGCAGGTCGAGGTCGCCCCGGACGCTCCTGATACCCAGCCGACCACGGAAGGCGAGACGTC
CAACTCGGGCGAGGAGGGTG

Downstream 100 bases:

>100_bases
GCACCGCCGCCTCGATGCGGACGAACCATTCTGCTTGTTTTATTTGCGATCTACGTTTTGGCGTACGGCTTATTCTTGCG
AGCCGGTCTTTTGACTAGCC

Product: DEAD/DEAH box helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MSSPSFASLEGAYDRLHPKVRRWIRDQGWNELREIQARAIVAALDGAGDILIAASTAAGKTEAAFLPILTAVADRTQSGF
SVLYVSPLKALINDQFRRLETLCEAMEIPVVKWHGDASPSAKRKAIDKPEGVALITPESIEAMFTRRPADAKRLLAAADF
IVVDEVHSFLQGPRGLHVASLLKRIDAMAPTSARRVGLSATIGDLRQAAAWLRPVDPDRVDILQAKSDAPELRLQVRGYS
EPPDLDDPDHAEGVAEADEEPASDALPQRIALDYIADHLFGTLRGSNNLVFGGSRRTVESAADRLRRRCEKANVPNEFFP
HHGSLSKVLREELEIRLKDGKLPTTAVCTSTLELGVDIGSVKSVAQIGAPRALASVRQRLGRTGRRAGTPAILRIYVREP
YISRKSGLLDRLHMNTVRSVAIVRLLLAGFVEPAAPSPEIPSTLIHQILSVIAERGGISPKPLFDLLCGPGPFASIGTSD
FAGLLRHLGSTDIRFLEQAPDGTLMLGSEGEKIVQSRSFFAVFETPEEWRLTVGGRTLGTLPISYPVNIGSLVVFAGQRW
IVREIDEKTRTLLVAPHRGGVVPRFERNTFEPAHDRLIAEMKAVYEDDDVPPYLDQSGRDLLSAGRETFRDWDLDITTQV
QEEADLHLFLWRGTQATAVFGAALSMAGLECEVHDLGLILPKTKGEEVNPILEKLAAMEKIDPMDVAEFVKNIGGGKFRE
SVPAPLARKQWADQNAPLIRTAQTMARTVLM

Sequences:

>Translated_751_residues
MSSPSFASLEGAYDRLHPKVRRWIRDQGWNELREIQARAIVAALDGAGDILIAASTAAGKTEAAFLPILTAVADRTQSGF
SVLYVSPLKALINDQFRRLETLCEAMEIPVVKWHGDASPSAKRKAIDKPEGVALITPESIEAMFTRRPADAKRLLAAADF
IVVDEVHSFLQGPRGLHVASLLKRIDAMAPTSARRVGLSATIGDLRQAAAWLRPVDPDRVDILQAKSDAPELRLQVRGYS
EPPDLDDPDHAEGVAEADEEPASDALPQRIALDYIADHLFGTLRGSNNLVFGGSRRTVESAADRLRRRCEKANVPNEFFP
HHGSLSKVLREELEIRLKDGKLPTTAVCTSTLELGVDIGSVKSVAQIGAPRALASVRQRLGRTGRRAGTPAILRIYVREP
YISRKSGLLDRLHMNTVRSVAIVRLLLAGFVEPAAPSPEIPSTLIHQILSVIAERGGISPKPLFDLLCGPGPFASIGTSD
FAGLLRHLGSTDIRFLEQAPDGTLMLGSEGEKIVQSRSFFAVFETPEEWRLTVGGRTLGTLPISYPVNIGSLVVFAGQRW
IVREIDEKTRTLLVAPHRGGVVPRFERNTFEPAHDRLIAEMKAVYEDDDVPPYLDQSGRDLLSAGRETFRDWDLDITTQV
QEEADLHLFLWRGTQATAVFGAALSMAGLECEVHDLGLILPKTKGEEVNPILEKLAAMEKIDPMDVAEFVKNIGGGKFRE
SVPAPLARKQWADQNAPLIRTAQTMARTVLM
>Mature_750_residues
SSPSFASLEGAYDRLHPKVRRWIRDQGWNELREIQARAIVAALDGAGDILIAASTAAGKTEAAFLPILTAVADRTQSGFS
VLYVSPLKALINDQFRRLETLCEAMEIPVVKWHGDASPSAKRKAIDKPEGVALITPESIEAMFTRRPADAKRLLAAADFI
VVDEVHSFLQGPRGLHVASLLKRIDAMAPTSARRVGLSATIGDLRQAAAWLRPVDPDRVDILQAKSDAPELRLQVRGYSE
PPDLDDPDHAEGVAEADEEPASDALPQRIALDYIADHLFGTLRGSNNLVFGGSRRTVESAADRLRRRCEKANVPNEFFPH
HGSLSKVLREELEIRLKDGKLPTTAVCTSTLELGVDIGSVKSVAQIGAPRALASVRQRLGRTGRRAGTPAILRIYVREPY
ISRKSGLLDRLHMNTVRSVAIVRLLLAGFVEPAAPSPEIPSTLIHQILSVIAERGGISPKPLFDLLCGPGPFASIGTSDF
AGLLRHLGSTDIRFLEQAPDGTLMLGSEGEKIVQSRSFFAVFETPEEWRLTVGGRTLGTLPISYPVNIGSLVVFAGQRWI
VREIDEKTRTLLVAPHRGGVVPRFERNTFEPAHDRLIAEMKAVYEDDDVPPYLDQSGRDLLSAGRETFRDWDLDITTQVQ
EEADLHLFLWRGTQATAVFGAALSMAGLECEVHDLGLILPKTKGEEVNPILEKLAAMEKIDPMDVAEFVKNIGGGKFRES
VPAPLARKQWADQNAPLIRTAQTMARTVLM

Specific function: Unknown

COG id: COG1201

COG function: function code R; Lhr-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1787942, Length=649, Percent_Identity=26.040061633282, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17537127, Length=317, Percent_Identity=25.2365930599369, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17537519, Length=201, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI9755332, Length=380, Percent_Identity=25.2631578947368, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321020, Length=406, Percent_Identity=24.8768472906404, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574898, Length=393, Percent_Identity=24.6819338422392, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24647182, Length=437, Percent_Identity=22.6544622425629, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR013701
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR017170 [H]

Pfam domain/function: PF00270 DEAD; PF08494 DEAD_assoc; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 82225; Mature: 82094

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPSFASLEGAYDRLHPKVRRWIRDQGWNELREIQARAIVAALDGAGDILIAASTAAGK
CCCCCCCHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCEEEEECCCCCC
TEAAFLPILTAVADRTQSGFSVLYVSPLKALINDQFRRLETLCEAMEIPVVKWHGDASPS
CHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
AKRKAIDKPEGVALITPESIEAMFTRRPADAKRLLAAADFIVVDEVHSFLQGPRGLHVAS
HHHHCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLKRIDAMAPTSARRVGLSATIGDLRQAAAWLRPVDPDRVDILQAKSDAPELRLQVRGYS
HHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCCEEEEEECCC
EPPDLDDPDHAEGVAEADEEPASDALPQRIALDYIADHLFGTLRGSNNLVFGGSRRTVES
CCCCCCCCCHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHH
AADRLRRRCEKANVPNEFFPHHGSLSKVLREELEIRLKDGKLPTTAVCTSTLELGVDIGS
HHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCCHHH
VKSVAQIGAPRALASVRQRLGRTGRRAGTPAILRIYVREPYISRKSGLLDRLHMNTVRSV
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
AIVRLLLAGFVEPAAPSPEIPSTLIHQILSVIAERGGISPKPLFDLLCGPGPFASIGTSD
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHH
FAGLLRHLGSTDIRFLEQAPDGTLMLGSEGEKIVQSRSFFAVFETPEEWRLTVGGRTLGT
HHHHHHHCCCCHHHHHHCCCCCEEEECCCCHHHHHCCCEEEEECCCCCEEEEECCCEEEE
LPISYPVNIGSLVVFAGQRWIVREIDEKTRTLLVAPHRGGVVPRFERNTFEPAHDRLIAE
ECEECCCCCCCEEEECCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
MKAVYEDDDVPPYLDQSGRDLLSAGRETFRDWDLDITTQVQEEADLHLFLWRGTQATAVF
HHHHHCCCCCCCCCCCCCHHHHHHCHHHHHHCCCCEEEHHHCCCCEEEEEEECCCHHHHH
GAALSMAGLECEVHDLGLILPKTKGEEVNPILEKLAAMEKIDPMDVAEFVKNIGGGKFRE
HHHHHHCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHH
SVPAPLARKQWADQNAPLIRTAQTMARTVLM
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSPSFASLEGAYDRLHPKVRRWIRDQGWNELREIQARAIVAALDGAGDILIAASTAAGK
CCCCCCHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCEEEEECCCCCC
TEAAFLPILTAVADRTQSGFSVLYVSPLKALINDQFRRLETLCEAMEIPVVKWHGDASPS
CHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
AKRKAIDKPEGVALITPESIEAMFTRRPADAKRLLAAADFIVVDEVHSFLQGPRGLHVAS
HHHHCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLKRIDAMAPTSARRVGLSATIGDLRQAAAWLRPVDPDRVDILQAKSDAPELRLQVRGYS
HHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCCEEEEEECCC
EPPDLDDPDHAEGVAEADEEPASDALPQRIALDYIADHLFGTLRGSNNLVFGGSRRTVES
CCCCCCCCCHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHH
AADRLRRRCEKANVPNEFFPHHGSLSKVLREELEIRLKDGKLPTTAVCTSTLELGVDIGS
HHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCCHHH
VKSVAQIGAPRALASVRQRLGRTGRRAGTPAILRIYVREPYISRKSGLLDRLHMNTVRSV
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
AIVRLLLAGFVEPAAPSPEIPSTLIHQILSVIAERGGISPKPLFDLLCGPGPFASIGTSD
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHH
FAGLLRHLGSTDIRFLEQAPDGTLMLGSEGEKIVQSRSFFAVFETPEEWRLTVGGRTLGT
HHHHHHHCCCCHHHHHHCCCCCEEEECCCCHHHHHCCCEEEEECCCCCEEEEECCCEEEE
LPISYPVNIGSLVVFAGQRWIVREIDEKTRTLLVAPHRGGVVPRFERNTFEPAHDRLIAE
ECEECCCCCCCEEEECCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
MKAVYEDDDVPPYLDQSGRDLLSAGRETFRDWDLDITTQVQEEADLHLFLWRGTQATAVF
HHHHHCCCCCCCCCCCCCHHHHHHCHHHHHHCCCCEEEHHHCCCCEEEEEEECCCHHHHH
GAALSMAGLECEVHDLGLILPKTKGEEVNPILEKLAAMEKIDPMDVAEFVKNIGGGKFRE
HHHHHHCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHH
SVPAPLARKQWADQNAPLIRTAQTMARTVLM
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]