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The map label for this gene is fabF [H]

Identifier: 86749589

GI number: 86749589

Start: 2824800

End: 2826065

Strand: Direct

Name: fabF [H]

Synonym: RPB_2469

Alternate gene names: 86749589

Gene position: 2824800-2826065 (Clockwise)

Preceding gene: 86749588

Following gene: 86749590

Centisome position: 52.98

GC content: 64.38

Gene sequence:

>1266_bases
ATGAGACGTGTCGTCGTCACAGGCCTTGGCATGGTTTCGCCGCTCGGCTGTGGCGTCGATTCGACCTGGAGCCGGATTCT
CAAAGGCGAAAGCGGCGCGCGCAAGATCGACGCTTTCGATGTTTCCGATCTGACCAGCCAGATCGCCTGCATCATCCCGC
GTGGTGACGGCACCGACGGCACCTATAACGCCGATCAATGGATGGAGCCGAAAGACCAGCGCAAGGTCGACGACTTCATC
GTCTATGCAATGTGTGCGGCGCGTCAGGCTCTCGACGACGCCGGCTGGCATCCCTCCACCGAAGAAGAGCGCTGCGCCTC
GGGCGTTTTGATCGGCTCCGGCATCGGGGGCCTGCAGGGCATCGCCGAGACGGCGCTCGTTCTGAAGGAACGCGGGCCGC
GCAAAATCTCGCCGTTCTTCATTCCGGGTCGTCTGATCAACCTCGCCTCGGGTTACGTATCGATCGAGTTCGGGCTCAAG
GGGCCGAACCACTCCGTCGTTACGGCATGCTCGACCGGCGCGCATGCGATCGGCGACGCGTCGCGACTGATCGCGCTCGG
TGACGCCGACATCATGGTCGCCGGCGGCACCGAATCCCCGATCAGCCGTCTGGCGATGGCCGGCTTCTGCGCCGCGCGCG
CGCTGTCGACCGGTTTCAACGAGAACCCGCAGAAGGCGTCGCGGCCCTACGACAAGGATCGCGACGGTTTTGTGATGGGC
GAAGGCGCCGGCATCGTCGTGCTCGAGGAGTACGAACATGCGAAAGCGCGCGGCGCGCGGATCTACGCCGAAGTGATCGG
CTACGGTCTGACCGGCGACGCCTATCACATCACGGCACCGACCCCGGACGGCGACGGCGCGTTCCGCTGCATGAGCGCCG
CGATCAAACGCGCCGGCATCTCGGTCTCGGATATCGACTACATCAACGCGCACGGCACCTCGACGCCGCTTGGCGACGAG
ATCGAACTCGGCGCCGCGCAACGGTTGCTCGGCAATGCCGCGTCACGCGTGTCGATGTCGTCGACCAAATCCTCGATCGG
CCATTTGCTCGGCGCGGCCGGTGCGGTCGAAGCGATCTTCAGCGTGCTGGCGATTCGCGACAACGTTGCGCCGCCGACCA
TCAATCTCGACAACCCGTCGGTCGAGACCGCGATCGACCTCGTGCCGTGGAAACCGCGCGAACGTGAAATCAACGTCGCG
CTGTCGAACTCTTTCGGCTTTGGCGGGACTAATGCATCGTTGATCCTGCAGCGCGTCGCCGATTGA

Upstream 100 bases:

>100_bases
GCTGACGCCCTGCGCGGTGACGATGGAGCCGGACGGACCGTGATGAACGGTCCACCGGCTTCTTGCTTTGGACCGCGCAT
TCTGGCCCGGAGTACGGAAA

Downstream 100 bases:

>100_bases
AGGCGTTGCAGGCACTTCAACGTTTCGCCGTAATCCCTGCTAAAACCTACGACATTAGGCGATATGGGAGTATGATCGGC
GACGGCCCGACGAGGTCTGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRRVVVTGLGMVSPLGCGVDSTWSRILKGESGARKIDAFDVSDLTSQIACIIPRGDGTDGTYNADQWMEPKDQRKVDDFI
VYAMCAARQALDDAGWHPSTEEERCASGVLIGSGIGGLQGIAETALVLKERGPRKISPFFIPGRLINLASGYVSIEFGLK
GPNHSVVTACSTGAHAIGDASRLIALGDADIMVAGGTESPISRLAMAGFCAARALSTGFNENPQKASRPYDKDRDGFVMG
EGAGIVVLEEYEHAKARGARIYAEVIGYGLTGDAYHITAPTPDGDGAFRCMSAAIKRAGISVSDIDYINAHGTSTPLGDE
IELGAAQRLLGNAASRVSMSSTKSSIGHLLGAAGAVEAIFSVLAIRDNVAPPTINLDNPSVETAIDLVPWKPREREINVA
LSNSFGFGGTNASLILQRVAD

Sequences:

>Translated_421_residues
MRRVVVTGLGMVSPLGCGVDSTWSRILKGESGARKIDAFDVSDLTSQIACIIPRGDGTDGTYNADQWMEPKDQRKVDDFI
VYAMCAARQALDDAGWHPSTEEERCASGVLIGSGIGGLQGIAETALVLKERGPRKISPFFIPGRLINLASGYVSIEFGLK
GPNHSVVTACSTGAHAIGDASRLIALGDADIMVAGGTESPISRLAMAGFCAARALSTGFNENPQKASRPYDKDRDGFVMG
EGAGIVVLEEYEHAKARGARIYAEVIGYGLTGDAYHITAPTPDGDGAFRCMSAAIKRAGISVSDIDYINAHGTSTPLGDE
IELGAAQRLLGNAASRVSMSSTKSSIGHLLGAAGAVEAIFSVLAIRDNVAPPTINLDNPSVETAIDLVPWKPREREINVA
LSNSFGFGGTNASLILQRVAD
>Mature_421_residues
MRRVVVTGLGMVSPLGCGVDSTWSRILKGESGARKIDAFDVSDLTSQIACIIPRGDGTDGTYNADQWMEPKDQRKVDDFI
VYAMCAARQALDDAGWHPSTEEERCASGVLIGSGIGGLQGIAETALVLKERGPRKISPFFIPGRLINLASGYVSIEFGLK
GPNHSVVTACSTGAHAIGDASRLIALGDADIMVAGGTESPISRLAMAGFCAARALSTGFNENPQKASRPYDKDRDGFVMG
EGAGIVVLEEYEHAKARGARIYAEVIGYGLTGDAYHITAPTPDGDGAFRCMSAAIKRAGISVSDIDYINAHGTSTPLGDE
IELGAAQRLLGNAASRVSMSSTKSSIGHLLGAAGAVEAIFSVLAIRDNVAPPTINLDNPSVETAIDLVPWKPREREINVA
LSNSFGFGGTNASLILQRVAD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=51.9138755980861, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI223972627, Length=193, Percent_Identity=43.5233160621762, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI41872631, Length=360, Percent_Identity=25.5555555555556, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=53.6992840095465, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1788663, Length=426, Percent_Identity=38.0281690140845, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=38.2978723404255, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=43.7735849056604, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=356, Percent_Identity=25.561797752809, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=353, Percent_Identity=27.1954674220963, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=41.0835214446953, Blast_Score=301, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=48.9260143198091, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19920632, Length=281, Percent_Identity=25.2669039145907, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221330659, Length=277, Percent_Identity=25.2707581227437, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24581345, Length=347, Percent_Identity=25.0720461095101, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44155; Mature: 44155

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGMVSPLGCGVDSTWSRILKGESGARKIDAFDVSDLTSQIACIIPRGDGTDG
CCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCEECCCCHHHHCCCEEEEEECCCCCCC
TYNADQWMEPKDQRKVDDFIVYAMCAARQALDDAGWHPSTEEERCASGVLIGSGIGGLQG
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEECCCCHHHH
IAETALVLKERGPRKISPFFIPGRLINLASGYVSIEFGLKGPNHSVVTACSTGAHAIGDA
HHHHHHHHHCCCCCCCCCEECCCHHEEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCC
SRLIALGDADIMVAGGTESPISRLAMAGFCAARALSTGFNENPQKASRPYDKDRDGFVMG
CEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEE
EGAGIVVLEEYEHAKARGARIYAEVIGYGLTGDAYHITAPTPDGDGAFRCMSAAIKRAGI
CCCCEEEEECCCCHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
SVSDIDYINAHGTSTPLGDEIELGAAQRLLGNAASRVSMSSTKSSIGHLLGAAGAVEAIF
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVLAIRDNVAPPTINLDNPSVETAIDLVPWKPREREINVALSNSFGFGGTNASLILQRVA
HHHHHHCCCCCCEEECCCCCHHHEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHC
D
C
>Mature Secondary Structure
MRRVVVTGLGMVSPLGCGVDSTWSRILKGESGARKIDAFDVSDLTSQIACIIPRGDGTDG
CCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCEECCCCHHHHCCCEEEEEECCCCCCC
TYNADQWMEPKDQRKVDDFIVYAMCAARQALDDAGWHPSTEEERCASGVLIGSGIGGLQG
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEECCCCHHHH
IAETALVLKERGPRKISPFFIPGRLINLASGYVSIEFGLKGPNHSVVTACSTGAHAIGDA
HHHHHHHHHCCCCCCCCCEECCCHHEEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCC
SRLIALGDADIMVAGGTESPISRLAMAGFCAARALSTGFNENPQKASRPYDKDRDGFVMG
CEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEE
EGAGIVVLEEYEHAKARGARIYAEVIGYGLTGDAYHITAPTPDGDGAFRCMSAAIKRAGI
CCCCEEEEECCCCHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
SVSDIDYINAHGTSTPLGDEIELGAAQRLLGNAASRVSMSSTKSSIGHLLGAAGAVEAIF
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVLAIRDNVAPPTINLDNPSVETAIDLVPWKPREREINVALSNSFGFGGTNASLILQRVA
HHHHHHCCCCCCEEECCCCCHHHEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]