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The map label for this gene is fabD [H]

Identifier: 86749586

GI number: 86749586

Start: 2822434

End: 2823393

Strand: Direct

Name: fabD [H]

Synonym: RPB_2466

Alternate gene names: 86749586

Gene position: 2822434-2823393 (Clockwise)

Preceding gene: 86749580

Following gene: 86749587

Centisome position: 52.94

GC content: 69.9

Gene sequence:

>960_bases
ATGACGGCAGCATTCACATTCCCAGGGCAGGGCTCGCAGGCGGTCGGCATGGGCAAGGCGCTGGCCGATGCCTTTCCTGC
GGCAAAGGCGGTGTTCGACGAGGTCGACGCCGCGCTCGGCGAAAAGCTGACGGCGACCATCTGGGAAGGGCCGGCAGAGA
CGCTGCAACTCACCGAGAACGCCCAGCCGGCGCTGATGGCGGTGTCGCTCGCCGCGCTGCGGGTGCTCGAAAGCGAGGCC
GGGATCTCGGTTGGACGCGATGCGGCCTTCGTCGCCGGGCATTCGCTGGGTGAATATTCGGCGCTGGCAGCCGCGGGCGC
GCTGACGGTCAGCGATACCGCTCGGCTGCTGCGCATCCGGGGCCGTGCGATGCAGAAGGCCGTTCCGGTCGGCGTCGGCG
CGATGGCCGCGCTGCTCGGGCTCGACTACGAGGCCGCCGTGGCGGTCGCGAGCGAAGCGGCCCAGGGCCAGGTTTGCCAG
GCCGCCAACGACAATGGCGGCGGACAGGTCGTGGTCTCCGGCCACAAGGAGGCGGTGGAGCGCGCCGTCGAGATCGCCAA
GGGCAAGGGCGCCAAGCGCGCGATGCTGCTGCCGGTGTCGGCGCCGTTCCATTGCGCCCTGATGCAGCCCGCGGCCGAGG
CGATGGCGGAAGCTTTGGCGGGTGTGGCGATCCAGTCGCCCGCCGTGCCGCTGGTTTGCAACGTTCTGGCCGCGCCGATT
ACCGACCCGGATGAGATTCGCCGCCGGCTGATCGAACAGGTCACCGGCACCGTGCGTTGGCGCGAGTCAGTGGCCTATAT
GGCTGGCCACGGCGTCAGCCGTTTTCTCGAGATCGGCGCCGGCAAGGTGCTGAGCGGACTGGTCAAGCGGATCGCCGACG
GCGCGACCGGCGTCGCGATCGGCAATCCCAACGATATCGCGGCCGCCAAGGACGCACTCACGGCCGGGCGTTCGGCGTAA

Upstream 100 bases:

>100_bases
GCCGGCCGGGCTCTTGCGCTGCGGATTTGCGCGGTCAACTTGACACGACATGCCCGCGCGGTGTCTTACGGCGCCACTTC
AGACAGGTTCAGGAACGCAG

Downstream 100 bases:

>100_bases
CCGGCGGCGAAGGAGACGACATGTTCGATTTGACGGGACGAACCGCGCTGGTCACCGGCGCGACCGGGGGCATCGGCGGC
GCGATCGCGCAGGCCCTACA

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTAAFTFPGQGSQAVGMGKALADAFPAAKAVFDEVDAALGEKLTATIWEGPAETLQLTENAQPALMAVSLAALRVLESEA
GISVGRDAAFVAGHSLGEYSALAAAGALTVSDTARLLRIRGRAMQKAVPVGVGAMAALLGLDYEAAVAVASEAAQGQVCQ
AANDNGGGQVVVSGHKEAVERAVEIAKGKGAKRAMLLPVSAPFHCALMQPAAEAMAEALAGVAIQSPAVPLVCNVLAAPI
TDPDEIRRRLIEQVTGTVRWRESVAYMAGHGVSRFLEIGAGKVLSGLVKRIADGATGVAIGNPNDIAAAKDALTAGRSA

Sequences:

>Translated_319_residues
MTAAFTFPGQGSQAVGMGKALADAFPAAKAVFDEVDAALGEKLTATIWEGPAETLQLTENAQPALMAVSLAALRVLESEA
GISVGRDAAFVAGHSLGEYSALAAAGALTVSDTARLLRIRGRAMQKAVPVGVGAMAALLGLDYEAAVAVASEAAQGQVCQ
AANDNGGGQVVVSGHKEAVERAVEIAKGKGAKRAMLLPVSAPFHCALMQPAAEAMAEALAGVAIQSPAVPLVCNVLAAPI
TDPDEIRRRLIEQVTGTVRWRESVAYMAGHGVSRFLEIGAGKVLSGLVKRIADGATGVAIGNPNDIAAAKDALTAGRSA
>Mature_318_residues
TAAFTFPGQGSQAVGMGKALADAFPAAKAVFDEVDAALGEKLTATIWEGPAETLQLTENAQPALMAVSLAALRVLESEAG
ISVGRDAAFVAGHSLGEYSALAAAGALTVSDTARLLRIRGRAMQKAVPVGVGAMAALLGLDYEAAVAVASEAAQGQVCQA
ANDNGGGQVVVSGHKEAVERAVEIAKGKGAKRAMLLPVSAPFHCALMQPAAEAMAEALAGVAIQSPAVPLVCNVLAAPIT
DPDEIRRRLIEQVTGTVRWRESVAYMAGHGVSRFLEIGAGKVLSGLVKRIADGATGVAIGNPNDIAAAKDALTAGRSA

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=295, Percent_Identity=32.8813559322034, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI27477045, Length=106, Percent_Identity=39.622641509434, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787334, Length=306, Percent_Identity=49.6732026143791, Blast_Score=264, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71984332, Length=294, Percent_Identity=31.6326530612245, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=291, Percent_Identity=27.8350515463918, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24665753, Length=302, Percent_Identity=35.7615894039735, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32255; Mature: 32124

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAFTFPGQGSQAVGMGKALADAFPAAKAVFDEVDAALGEKLTATIWEGPAETLQLTEN
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHEECCC
AQPALMAVSLAALRVLESEAGISVGRDAAFVAGHSLGEYSALAAAGALTVSDTARLLRIR
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHCCEEHHHHHHHHHHH
GRAMQKAVPVGVGAMAALLGLDYEAAVAVASEAAQGQVCQAANDNGGGQVVVSGHKEAVE
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCCCCEEEECCCHHHHH
RAVEIAKGKGAKRAMLLPVSAPFHCALMQPAAEAMAEALAGVAIQSPAVPLVCNVLAAPI
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TDPDEIRRRLIEQVTGTVRWRESVAYMAGHGVSRFLEIGAGKVLSGLVKRIADGATGVAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
GNPNDIAAAKDALTAGRSA
CCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAAFTFPGQGSQAVGMGKALADAFPAAKAVFDEVDAALGEKLTATIWEGPAETLQLTEN
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHEECCC
AQPALMAVSLAALRVLESEAGISVGRDAAFVAGHSLGEYSALAAAGALTVSDTARLLRIR
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHCCEEHHHHHHHHHHH
GRAMQKAVPVGVGAMAALLGLDYEAAVAVASEAAQGQVCQAANDNGGGQVVVSGHKEAVE
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCCCCEEEECCCHHHHH
RAVEIAKGKGAKRAMLLPVSAPFHCALMQPAAEAMAEALAGVAIQSPAVPLVCNVLAAPI
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TDPDEIRRRLIEQVTGTVRWRESVAYMAGHGVSRFLEIGAGKVLSGLVKRIADGATGVAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
GNPNDIAAAKDALTAGRSA
CCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]