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The map label for this gene is rnr [H]

Identifier: 86749538

GI number: 86749538

Start: 2769863

End: 2772214

Strand: Reverse

Name: rnr [H]

Synonym: RPB_2418

Alternate gene names: 86749538

Gene position: 2772214-2769863 (Counterclockwise)

Preceding gene: 86749539

Following gene: 86749537

Centisome position: 52.0

GC content: 67.98

Gene sequence:

>2352_bases
GTGAGCAAGACGCGCGACGACAAGTTCCCGGACAAGGCCACGCTCCTCGCCTTTATCCGCGCGCATCCCGGCAAGGTCGG
CACCCGCGAGATCGCCCGCGAGTTCGGCCTGAAGAATGCCGATCGTGCCGAACTGAAGCGCCGTCTCAAGGAACTGTCCG
ACGACGGCGCGATCCGCAAGAGCGGCCGCCGCAAGGTCGCCGAGCCGGCCACCCTGCCCCCGACGCTGTTGGCGGATATC
ACCGCGCGCGATAGCGACGGCGAACTGATCGCCACCCCGTCTGAATGGGACGAGCAGGACGGCGAGCCGCCGAAGATCCG
CATCCACACCCCGCGCCGGCCCAAGCCCGGCACCGCCGCCGGCCTCGGCGACCGCGCGCTGCTGCATGTCGAGCCGGCCG
AGGCGCCCGAGCAAGGTCCCGCTTATGTCGGCCGCGTCATTCGCGTGCTCGATCGCGGCAAGCCGCGCATTCTGGGGATT
TTTCGCGCCACGCCGCAGGGCGGCGGCCGGCTTGTCCCGGTCGACAAGAAGCAGGCCGGGCGCGAACTCAACATCGCGCC
GCACGATGCCGGCGGCGCGCAGGACGGCGACCTCGTCAGCGTCGACCTGATCCGCAGCCGCGGCTATGGCCTGTCGTCCG
GCCGCGTCAAGGAACGGCTCGGCTCGCTCGCGACCGAAAAAGCCGTCAGCCTGATCGCAATCCACTCCCACGACATCCCG
CAGGAATTCTCGACGACCGCGTTGCGCGAATCCGAAGCCGCCGAGCCGGCGACGCTGAAGGGCCGCGAGGACTGGCGCGA
GCTGCCGCTGGTGACGATCGATCCGCCCGACGCCAAGGACCACGACGACGCGGTCCACGCCGAGCCGGATCCCGACCCCA
ACAACAAAGGCGGCGTGATCCTGCACGTCGCGATCGCCGACGTCGCCTACTACGTGCGGCCGGACTCGGCGCTCGATCGC
GACGCGCTACGGCGCGGCAATTCGGTGTACTTCCCCGACCGCGTCGTGCCGATGCTGCCGGAGCGGATTTCCAACGATCT
GTGCTCGCTGAAGCCCGGCGAGCCCCGCGGCGCTCTCGCGGTCCGCATGGTGATCGGCGCCGACGGCCGCAAGCGCTCGC
ATTCGTTTCATCGCGTGCTGATGCGCTCGGCCGCGAAGCTGAACTACGCGCAGGCCCAGGCCGCGATCGACGGCCGGCCC
GACGACACCACCGGCCCGCTGCTCGACACGATTTTGAAGCCGCTCTACGACGCCTATGCGATCGTCAAGCGCGGCCGCGA
CGAGCGCGATCCGCTCGATCTCGATCTGCCCGAGCGCAAGATCATCCTGAAGCCCGACGGCACCGTCGACCGCGTCATCG
TTCCGGAGCGGCTCGACGCGCATAAATTGATCGAGGAATTCATGATCCTCGCCAACGTCGCCGCGGCCGAGATGCTCGAA
AAGAAAGCGCTGCCGCTGATCTATCGGGTGCACGACGAACCGAGCGTGGAGAAGGTCCACAACCTCGTCGACTTCCTGAA
GACGCTGGATCTGTCCTTCGCCAAGGGCGGAGCGCTGAAGCCGGCGCAGTTCAACCGCATCCTGGCGATGGTCAAAGGCG
AAGACGCCGAGCCGCTGGTCAACGAAGTGGTGCTGCGCTCGCAGGCGCAGGCCGAATATGCCTCCGAGAATTACGGCCAT
TTCGGCCTGAACCTGCGCCGCTACGCGCATTTCACCTCGCCGATCCGCCGCTACGCCGATCTCGTGGTGCACCGCGCGCT
GATCCGCGCGCTCAACCTCGGCGACGGCGCGCTGCCGCAGACCGAGACGGTGGAAACGCTGGCCGAAGTCGCAGCCCAGA
TCTCACTGACCGAACGCCGCGCGATGAAGGCCGAGCGCGAGACGGTCGACCGGCTGATCGCGCATCACCTCGCCGACCGC
ATCGGCGCGACCTTCCAGGGCCGCGTCTCCGGCGTCACCAAGGCCGGCCTGTTCGTCAAGCTGAGCGACACCGGCGCCGA
CGGACTGATTCCGATCCGCACGCTCGGCGACGAGTATTACAACTACGACGAAACCCGCCACGCGCTGATCGGCTCGCGCA
GCGGTGCCATGCATCGGCTGGGGGACGTCGTCGACGTCCGTCTGGTAGAAGCAGCCCCTGTGGCTGGCGCGTTGCGGTTC
GAGCTATTAAGTGAATCGCGAAGCGTCGCGCGCGGGCCACGCAAGGGAGCGTACAAGGGTCGCGCCAAGGCGGTGGAACC
GGCAAAGGGCGGCGCCAAAATCGGGCGCAGCGCGCGAAGCAAGGCCGGCAAGCCGAAGGCTGCGAAGCCGTCGAAGCGCA
AGGCGAACAAGCCCGGAAAGGGAACGCGATGA

Upstream 100 bases:

>100_bases
GCGCGCCGGTGAAAGCCAAGACGTCAACGACCAAGCCTAAAGCCGCGGCAGCCAAGCCGAAATCACCCGCCAAAAAGAGC
GCGGCCAAGAACGGATAGAT

Downstream 100 bases:

>100_bases
AGACCGTTGTGAATCGTGCACCGATCGTCTGGCCGTCGGACAACGCTCCCGCCGAAGATCGCAATGTCTGGCAGGCGATG
TGGCGCGGCTTTCGCGGCCG

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 783; Mature: 782

Protein sequence:

>783_residues
MSKTRDDKFPDKATLLAFIRAHPGKVGTREIAREFGLKNADRAELKRRLKELSDDGAIRKSGRRKVAEPATLPPTLLADI
TARDSDGELIATPSEWDEQDGEPPKIRIHTPRRPKPGTAAGLGDRALLHVEPAEAPEQGPAYVGRVIRVLDRGKPRILGI
FRATPQGGGRLVPVDKKQAGRELNIAPHDAGGAQDGDLVSVDLIRSRGYGLSSGRVKERLGSLATEKAVSLIAIHSHDIP
QEFSTTALRESEAAEPATLKGREDWRELPLVTIDPPDAKDHDDAVHAEPDPDPNNKGGVILHVAIADVAYYVRPDSALDR
DALRRGNSVYFPDRVVPMLPERISNDLCSLKPGEPRGALAVRMVIGADGRKRSHSFHRVLMRSAAKLNYAQAQAAIDGRP
DDTTGPLLDTILKPLYDAYAIVKRGRDERDPLDLDLPERKIILKPDGTVDRVIVPERLDAHKLIEEFMILANVAAAEMLE
KKALPLIYRVHDEPSVEKVHNLVDFLKTLDLSFAKGGALKPAQFNRILAMVKGEDAEPLVNEVVLRSQAQAEYASENYGH
FGLNLRRYAHFTSPIRRYADLVVHRALIRALNLGDGALPQTETVETLAEVAAQISLTERRAMKAERETVDRLIAHHLADR
IGATFQGRVSGVTKAGLFVKLSDTGADGLIPIRTLGDEYYNYDETRHALIGSRSGAMHRLGDVVDVRLVEAAPVAGALRF
ELLSESRSVARGPRKGAYKGRAKAVEPAKGGAKIGRSARSKAGKPKAAKPSKRKANKPGKGTR

Sequences:

>Translated_783_residues
MSKTRDDKFPDKATLLAFIRAHPGKVGTREIAREFGLKNADRAELKRRLKELSDDGAIRKSGRRKVAEPATLPPTLLADI
TARDSDGELIATPSEWDEQDGEPPKIRIHTPRRPKPGTAAGLGDRALLHVEPAEAPEQGPAYVGRVIRVLDRGKPRILGI
FRATPQGGGRLVPVDKKQAGRELNIAPHDAGGAQDGDLVSVDLIRSRGYGLSSGRVKERLGSLATEKAVSLIAIHSHDIP
QEFSTTALRESEAAEPATLKGREDWRELPLVTIDPPDAKDHDDAVHAEPDPDPNNKGGVILHVAIADVAYYVRPDSALDR
DALRRGNSVYFPDRVVPMLPERISNDLCSLKPGEPRGALAVRMVIGADGRKRSHSFHRVLMRSAAKLNYAQAQAAIDGRP
DDTTGPLLDTILKPLYDAYAIVKRGRDERDPLDLDLPERKIILKPDGTVDRVIVPERLDAHKLIEEFMILANVAAAEMLE
KKALPLIYRVHDEPSVEKVHNLVDFLKTLDLSFAKGGALKPAQFNRILAMVKGEDAEPLVNEVVLRSQAQAEYASENYGH
FGLNLRRYAHFTSPIRRYADLVVHRALIRALNLGDGALPQTETVETLAEVAAQISLTERRAMKAERETVDRLIAHHLADR
IGATFQGRVSGVTKAGLFVKLSDTGADGLIPIRTLGDEYYNYDETRHALIGSRSGAMHRLGDVVDVRLVEAAPVAGALRF
ELLSESRSVARGPRKGAYKGRAKAVEPAKGGAKIGRSARSKAGKPKAAKPSKRKANKPGKGTR
>Mature_782_residues
SKTRDDKFPDKATLLAFIRAHPGKVGTREIAREFGLKNADRAELKRRLKELSDDGAIRKSGRRKVAEPATLPPTLLADIT
ARDSDGELIATPSEWDEQDGEPPKIRIHTPRRPKPGTAAGLGDRALLHVEPAEAPEQGPAYVGRVIRVLDRGKPRILGIF
RATPQGGGRLVPVDKKQAGRELNIAPHDAGGAQDGDLVSVDLIRSRGYGLSSGRVKERLGSLATEKAVSLIAIHSHDIPQ
EFSTTALRESEAAEPATLKGREDWRELPLVTIDPPDAKDHDDAVHAEPDPDPNNKGGVILHVAIADVAYYVRPDSALDRD
ALRRGNSVYFPDRVVPMLPERISNDLCSLKPGEPRGALAVRMVIGADGRKRSHSFHRVLMRSAAKLNYAQAQAAIDGRPD
DTTGPLLDTILKPLYDAYAIVKRGRDERDPLDLDLPERKIILKPDGTVDRVIVPERLDAHKLIEEFMILANVAAAEMLEK
KALPLIYRVHDEPSVEKVHNLVDFLKTLDLSFAKGGALKPAQFNRILAMVKGEDAEPLVNEVVLRSQAQAEYASENYGHF
GLNLRRYAHFTSPIRRYADLVVHRALIRALNLGDGALPQTETVETLAEVAAQISLTERRAMKAERETVDRLIAHHLADRI
GATFQGRVSGVTKAGLFVKLSDTGADGLIPIRTLGDEYYNYDETRHALIGSRSGAMHRLGDVVDVRLVEAAPVAGALRFE
LLSESRSVARGPRKGAYKGRAKAVEPAKGGAKIGRSARSKAGKPKAAKPSKRKANKPGKGTR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=477, Percent_Identity=28.5115303983228, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI190014623, Length=477, Percent_Identity=28.3018867924528, Blast_Score=171, Evalue=4e-42,
Organism=Homo sapiens, GI134288890, Length=366, Percent_Identity=33.3333333333333, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI19115966, Length=502, Percent_Identity=28.0876494023904, Blast_Score=131, Evalue=3e-30,
Organism=Homo sapiens, GI219521928, Length=502, Percent_Identity=28.0876494023904, Blast_Score=131, Evalue=3e-30,
Organism=Homo sapiens, GI156105693, Length=462, Percent_Identity=25.1082251082251, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI156105695, Length=462, Percent_Identity=25.1082251082251, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI87082383, Length=718, Percent_Identity=36.0724233983287, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1787542, Length=474, Percent_Identity=32.0675105485232, Blast_Score=170, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI212645896, Length=480, Percent_Identity=30.8333333333333, Blast_Score=178, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17553506, Length=433, Percent_Identity=30.0230946882217, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324552, Length=449, Percent_Identity=30.2895322939866, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24649634, Length=507, Percent_Identity=28.7968441814596, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19922976, Length=394, Percent_Identity=28.1725888324873, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24654597, Length=394, Percent_Identity=28.1725888324873, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24654592, Length=394, Percent_Identity=28.1725888324873, Blast_Score=132, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85519; Mature: 85387

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTRDDKFPDKATLLAFIRAHPGKVGTREIAREFGLKNADRAELKRRLKELSDDGAIRK
CCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHH
SGRRKVAEPATLPPTLLADITARDSDGELIATPSEWDEQDGEPPKIRIHTPRRPKPGTAA
CCCCCCCCCCCCCHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCC
GLGDRALLHVEPAEAPEQGPAYVGRVIRVLDRGKPRILGIFRATPQGGGRLVPVDKKQAG
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEECCHHHCC
RELNIAPHDAGGAQDGDLVSVDLIRSRGYGLSSGRVKERLGSLATEKAVSLIAIHSHDIP
CCCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
QEFSTTALRESEAAEPATLKGREDWRELPLVTIDPPDAKDHDDAVHAEPDPDPNNKGGVI
HHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
LHVAIADVAYYVRPDSALDRDALRRGNSVYFPDRVVPMLPERISNDLCSLKPGEPRGALA
EEEHHHHEEEEECCCCCCCHHHHHCCCCEECCCCHHHHHHHHHCCCHHCCCCCCCCCCEE
VRMVIGADGRKRSHSFHRVLMRSAAKLNYAQAQAAIDGRPDDTTGPLLDTILKPLYDAYA
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IVKRGRDERDPLDLDLPERKIILKPDGTVDRVIVPERLDAHKLIEEFMILANVAAAEMLE
HHHCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
KKALPLIYRVHDEPSVEKVHNLVDFLKTLDLSFAKGGALKPAQFNRILAMVKGEDAEPLV
HCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHEECCCCCCHHH
NEVVLRSQAQAEYASENYGHFGLNLRRYAHFTSPIRRYADLVVHRALIRALNLGDGALPQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TETVETLAEVAAQISLTERRAMKAERETVDRLIAHHLADRIGATFQGRVSGVTKAGLFVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEECCEEEE
LSDTGADGLIPIRTLGDEYYNYDETRHALIGSRSGAMHRLGDVVDVRLVEAAPVAGALRF
EECCCCCCCEEHHHHCHHHHCCCHHHHHHHCCCCCHHHHHCCHHEEEEECCCCCHHHHHH
ELLSESRSVARGPRKGAYKGRAKAVEPAKGGAKIGRSARSKAGKPKAAKPSKRKANKPGK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCHHHHHCCCCCCCCCCCHHCCCCCCC
GTR
CCC
>Mature Secondary Structure 
SKTRDDKFPDKATLLAFIRAHPGKVGTREIAREFGLKNADRAELKRRLKELSDDGAIRK
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHH
SGRRKVAEPATLPPTLLADITARDSDGELIATPSEWDEQDGEPPKIRIHTPRRPKPGTAA
CCCCCCCCCCCCCHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCC
GLGDRALLHVEPAEAPEQGPAYVGRVIRVLDRGKPRILGIFRATPQGGGRLVPVDKKQAG
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEECCHHHCC
RELNIAPHDAGGAQDGDLVSVDLIRSRGYGLSSGRVKERLGSLATEKAVSLIAIHSHDIP
CCCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
QEFSTTALRESEAAEPATLKGREDWRELPLVTIDPPDAKDHDDAVHAEPDPDPNNKGGVI
HHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
LHVAIADVAYYVRPDSALDRDALRRGNSVYFPDRVVPMLPERISNDLCSLKPGEPRGALA
EEEHHHHEEEEECCCCCCCHHHHHCCCCEECCCCHHHHHHHHHCCCHHCCCCCCCCCCEE
VRMVIGADGRKRSHSFHRVLMRSAAKLNYAQAQAAIDGRPDDTTGPLLDTILKPLYDAYA
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IVKRGRDERDPLDLDLPERKIILKPDGTVDRVIVPERLDAHKLIEEFMILANVAAAEMLE
HHHCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
KKALPLIYRVHDEPSVEKVHNLVDFLKTLDLSFAKGGALKPAQFNRILAMVKGEDAEPLV
HCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHEECCCCCCHHH
NEVVLRSQAQAEYASENYGHFGLNLRRYAHFTSPIRRYADLVVHRALIRALNLGDGALPQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TETVETLAEVAAQISLTERRAMKAERETVDRLIAHHLADRIGATFQGRVSGVTKAGLFVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEECCEEEE
LSDTGADGLIPIRTLGDEYYNYDETRHALIGSRSGAMHRLGDVVDVRLVEAAPVAGALRF
EECCCCCCCEEHHHHCHHHHCCCHHHHHHHCCCCCHHHHHCCHHEEEEECCCCCHHHHHH
ELLSESRSVARGPRKGAYKGRAKAVEPAKGGAKIGRSARSKAGKPKAAKPSKRKANKPGK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCHHHHHCCCCCCCCCCCHHCCCCCCC
GTR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]