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The map label for this gene is macA [H]

Identifier: 86749356

GI number: 86749356

Start: 2560189

End: 2561403

Strand: Reverse

Name: macA [H]

Synonym: RPB_2236

Alternate gene names: 86749356

Gene position: 2561403-2560189 (Counterclockwise)

Preceding gene: 86749357

Following gene: 86749355

Centisome position: 48.04

GC content: 64.94

Gene sequence:

>1215_bases
ATGTTCACAGTGAAGCGCGTCGCCGTTGCCGGCGCGGTGTTGATTGCATTGATTGCGGGATGGCTGATCAAGGACAGGCT
GTCTGGGAGGCCTACGGAGACCCTGACGACGGCGCCGGTGCAGATCGCGGATATCGAAGACACCGTACTGGCCAGCGGCA
CCTTGAAGCCGATCAAGATGGTGGCGGTCGGCGCGCAGGTCTCCGGTCGAGTCACATCGCTCAAGGTCCGGGTCGGCGAC
AGGGTCAGGCTCGGCGACCAGATCGCGCAGATCGATCCTGTCACCAAGCAGAACGATCTGCGCACGGCGGAAGCGGCGCT
GCAGAACATGCGCGCGCAGCGCGCCGAGAAGGAAGCGACGCTGGCGCTGGCAGAGGCCTCGCTGGCGCGGCACAACGTCA
CCTTCGCCCAGAAGGCGACCTCGCGCGCCGACTTCGAGAGCGCGGAAGCGACCGTGAAACAAACCCGCGCGCAGATCGCG
GCGCTCGACGCACAGATCACGGAATCGATCGTGTCGGTCGAGAACGCACGCGTCAATCTCGACTACACCAGGATCATCGC
GCCGATCGACGGCACCGTGCTCGCCGTCGTCACCCAGGAAGGCCAGACCGTCAATGCGGTCCAATCGGCGCCGACCATCG
TGATCCTCGGTGAGGTCGGGACGATGACGATCCGCGCGGAGATTTCCGAAGTCGACGTGATCAAGATCAGGCCCGGCCAG
GACGTCTATTTCAACATCCTCGGCGACCCCGACCATCGCTACGATGCGCGGCTCGATTTCATCGAGCCCGCACCGGAATC
GATCAAGAACGACAGCAGCTTCAGTTCGACCAGCACGACGTCGAGCAGTTCATCGTCCTCGAGCAGTTCGACCTCAGCGA
TCTACTACAACGGCATCTTCAGCGCGCCCAATCCGGACGGCCTGCTGCGCACCTACATGACCGCGGAAGTCCATATCGTC
GTGGCGCAGGCGAAAGGCGTGATGACGATCCCGTCGGCGGCGCTGACCCAGCGCAACCCGGACGGCAGCTATCAGGTCGA
GGTCAAAGACGCCGCCGGCGCCGCAGCGACGCGCGCGATCCGGATCGGCATCAACAACAAGCTGACGGCCGAGGTCCGCT
CCGGCCTCTCGGTGGGCGAGGACGTCGTGGTGCGCAAGGCCGCGCCCGAAACGAAGCAATCGTCGGGTCCCCCCGGCCCG
CCGCCCGGAATGTGA

Upstream 100 bases:

>100_bases
CGCGTTTTCAGCCATGAAGTCTCGCCGCAGCGGCCCGGTTCACGAAGCCGGGCGGTGCGGATATTTCACCAGGGCCGCCG
GCCCGAGGGATCGACCACCG

Downstream 100 bases:

>100_bases
GCGATGGCCGGTTCGACCATCGAGTTGCGCGGCCTGCGCCGCGAATTCCCTTCCGGCGAGGCGACGGTCGTCGCGCTGCA
GGATCTCGATCTCACGATCG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MFTVKRVAVAGAVLIALIAGWLIKDRLSGRPTETLTTAPVQIADIEDTVLASGTLKPIKMVAVGAQVSGRVTSLKVRVGD
RVRLGDQIAQIDPVTKQNDLRTAEAALQNMRAQRAEKEATLALAEASLARHNVTFAQKATSRADFESAEATVKQTRAQIA
ALDAQITESIVSVENARVNLDYTRIIAPIDGTVLAVVTQEGQTVNAVQSAPTIVILGEVGTMTIRAEISEVDVIKIRPGQ
DVYFNILGDPDHRYDARLDFIEPAPESIKNDSSFSSTSTTSSSSSSSSSSTSAIYYNGIFSAPNPDGLLRTYMTAEVHIV
VAQAKGVMTIPSAALTQRNPDGSYQVEVKDAAGAAATRAIRIGINNKLTAEVRSGLSVGEDVVVRKAAPETKQSSGPPGP
PPGM

Sequences:

>Translated_404_residues
MFTVKRVAVAGAVLIALIAGWLIKDRLSGRPTETLTTAPVQIADIEDTVLASGTLKPIKMVAVGAQVSGRVTSLKVRVGD
RVRLGDQIAQIDPVTKQNDLRTAEAALQNMRAQRAEKEATLALAEASLARHNVTFAQKATSRADFESAEATVKQTRAQIA
ALDAQITESIVSVENARVNLDYTRIIAPIDGTVLAVVTQEGQTVNAVQSAPTIVILGEVGTMTIRAEISEVDVIKIRPGQ
DVYFNILGDPDHRYDARLDFIEPAPESIKNDSSFSSTSTTSSSSSSSSSSTSAIYYNGIFSAPNPDGLLRTYMTAEVHIV
VAQAKGVMTIPSAALTQRNPDGSYQVEVKDAAGAAATRAIRIGINNKLTAEVRSGLSVGEDVVVRKAAPETKQSSGPPGP
PPGM
>Mature_404_residues
MFTVKRVAVAGAVLIALIAGWLIKDRLSGRPTETLTTAPVQIADIEDTVLASGTLKPIKMVAVGAQVSGRVTSLKVRVGD
RVRLGDQIAQIDPVTKQNDLRTAEAALQNMRAQRAEKEATLALAEASLARHNVTFAQKATSRADFESAEATVKQTRAQIA
ALDAQITESIVSVENARVNLDYTRIIAPIDGTVLAVVTQEGQTVNAVQSAPTIVILGEVGTMTIRAEISEVDVIKIRPGQ
DVYFNILGDPDHRYDARLDFIEPAPESIKNDSSFSSTSTTSSSSSSSSSSTSAIYYNGIFSAPNPDGLLRTYMTAEVHIV
VAQAKGVMTIPSAALTQRNPDGSYQVEVKDAAGAAATRAIRIGINNKLTAEVRSGLSVGEDVVVRKAAPETKQSSGPPGP
PPGM

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=385, Percent_Identity=37.9220779220779, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082036, Length=353, Percent_Identity=26.628895184136, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789929, Length=340, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42705; Mature: 42705

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTVKRVAVAGAVLIALIAGWLIKDRLSGRPTETLTTAPVQIADIEDTVLASGTLKPIKM
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEEECCCCCEECCCCCCCEEE
VAVGAQVSGRVTSLKVRVGDRVRLGDQIAQIDPVTKQNDLRTAEAALQNMRAQRAEKEAT
EEECCCCCCCEEEEEEEECCEEECCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LALAEASLARHNVTFAQKATSRADFESAEATVKQTRAQIAALDAQITESIVSVENARVNL
HHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
DYTRIIAPIDGTVLAVVTQEGQTVNAVQSAPTIVILGEVGTMTIRAEISEVDVIKIRPGQ
EEEEEEECCCCEEEEEEECCCCEEEHHHCCCEEEEEECCCEEEEEEEECCEEEEEECCCC
DVYFNILGDPDHRYDARLDFIEPAPESIKNDSSFSSTSTTSSSSSSSSSSTSAIYYNGIF
CEEEEEECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEE
SAPNPDGLLRTYMTAEVHIVVAQAKGVMTIPSAALTQRNPDGSYQVEVKDAAGAAATRAI
CCCCCCCCEEEEEEEEEEEEEEECCCEEECCCHHHHCCCCCCCEEEEEECCCCCCEEEEE
RIGINNKLTAEVRSGLSVGEDVVVRKAAPETKQSSGPPGPPPGM
EEECCCEEHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFTVKRVAVAGAVLIALIAGWLIKDRLSGRPTETLTTAPVQIADIEDTVLASGTLKPIKM
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEEECCCCCEECCCCCCCEEE
VAVGAQVSGRVTSLKVRVGDRVRLGDQIAQIDPVTKQNDLRTAEAALQNMRAQRAEKEAT
EEECCCCCCCEEEEEEEECCEEECCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LALAEASLARHNVTFAQKATSRADFESAEATVKQTRAQIAALDAQITESIVSVENARVNL
HHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
DYTRIIAPIDGTVLAVVTQEGQTVNAVQSAPTIVILGEVGTMTIRAEISEVDVIKIRPGQ
EEEEEEECCCCEEEEEEECCCCEEEHHHCCCEEEEEECCCEEEEEEEECCEEEEEECCCC
DVYFNILGDPDHRYDARLDFIEPAPESIKNDSSFSSTSTTSSSSSSSSSSTSAIYYNGIF
CEEEEEECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEE
SAPNPDGLLRTYMTAEVHIVVAQAKGVMTIPSAALTQRNPDGSYQVEVKDAAGAAATRAI
CCCCCCCCEEEEEEEEEEEEEEECCCEEECCCHHHHCCCCCCCEEEEEECCCCCCEEEEE
RIGINNKLTAEVRSGLSVGEDVVVRKAAPETKQSSGPPGPPPGM
EEECCCEEHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]