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The map label for this gene is envZ [H]

Identifier: 86749083

GI number: 86749083

Start: 2227354

End: 2228682

Strand: Reverse

Name: envZ [H]

Synonym: RPB_1960

Alternate gene names: 86749083

Gene position: 2228682-2227354 (Counterclockwise)

Preceding gene: 86749084

Following gene: 86749081

Centisome position: 41.8

GC content: 67.87

Gene sequence:

>1329_bases
ATGCTCGAGCGGCTCGGCAGGTTTCGATTCAGCGGCATCCGCAGCCAGATCGCGGTGCTGGTGTTGGCGTCGCTCATCGG
GACGCAGTTGCTGATCATGGCGACTTTCCTGCTGCGCGGGCCGGACCGCTTCGGTCCGCCCGAACATCGGCGCGAGCAGT
TCGAAATCGCGGTCCTTCTGATCGCGGCGACTCCCGAGGAGCAGAGGCCGCAGCTCGTCGAACAAATCACCAGGACATTC
CCTCACCTCGAACTCCGCCTGCTCGACGCCGCCGCGGTGCCGCCGCGGTCCGACCGCGAACTGCCGGAAATTCGCGACGT
CGCGCGCACGCTCGGACCATTGGCGAGGGTGTTCGCGCTGCCCGGCGCGGAGCCGCCGCAAGTCGGCATTGCGTTGCCGG
ACGGGACCGCGATCGCCGCCGCGATTCCGGAGATGCGAGGCCGGCCTCCGATCTCGAACGGGCCGTGGATGAGTGCGTTC
GCCGGCGTGATCATCAGCCTCGCGATGTTCGGCCTGTGGGCCGACCGGGCGCTGTCGACGCCGCTGTCGGAATTCGCTGC
CGCGGCGGAAAACTTCAAGCTGGACGGCACCGACGAGCCGCTGGCCGAGAGCGGGCCGGACGAAATCCGCTCGCTGGCGC
GGGCCATGAACCGGTCGCGCAACCGGATCACGGCGCTGATCGACGACCGCACCCGGACACTGGCTGCGATCGGCCACGAC
CTGCGCACCCCGATCACGCGGCTGCGGCTGCGCAGCGAATTCATCGAGGACGCCACCCAGCGCGACAACATGCTGCGCGA
TCTCGACCAGATGCGCTCGATGCTCGACGCGGTGCTGTCGTTCCTGCGCACCGGCCGCGCGCTGGAACCGATGACGCGGA
TCGATCTGGCGAGCACGCTGCAACTGATCACCGATCAGTTCACCGATCTGGGCCACAAGGTGACTTATCTGGGGCCTGAA
CATGCCGAATTGTTGGCGCGGCCGGACGATATCCGACGCGCCGTCACCAATCTGGTCGACAACGCAGTTCGCTATGGAAA
GGACATCCTGGTCCGGCTGGAAGCGTCGCCCGGGCGCGTCACGATCGAGGTCGAAGACGACGGCCCCGGCATTCCCGAAG
CCTGCAAGGCCGACGTGATCGAGCCGTTCGTGCGCGGCGACGATGCGCGCAACATGGACGAGACCTCCGGCTTCGGCCTC
GGCCTCTCGATCGCCCGGACCATCGTGCAGAATCACGGCGGCGAACTGACGCTGCGCGACCGCAAGCCGCACGGCCTGAT
CGTGCGGCTCGACCTCCCCGGACAGCAGCAGGACAGCGGCGCCGCGTGA

Upstream 100 bases:

>100_bases
CGCAGAGCGTCAGCATCATCAAGACGGTGCGCTCCGGCGGCTATATGTTCACGCCCGCCGTCGAAACGGTTTGATCGAGG
CCGCTGCGGCCGGAGGCTTC

Downstream 100 bases:

>100_bases
GCCGGCGTCCCGATCAGTTCGCGGGCGTGACCTTCGGCGCGGCGCCGTGCAGCGCGCCCGGCCGGCGCAAATGGATGGTC
GCGACGTCGTCGGAATACAC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLERLGRFRFSGIRSQIAVLVLASLIGTQLLIMATFLLRGPDRFGPPEHRREQFEIAVLLIAATPEEQRPQLVEQITRTF
PHLELRLLDAAAVPPRSDRELPEIRDVARTLGPLARVFALPGAEPPQVGIALPDGTAIAAAIPEMRGRPPISNGPWMSAF
AGVIISLAMFGLWADRALSTPLSEFAAAAENFKLDGTDEPLAESGPDEIRSLARAMNRSRNRITALIDDRTRTLAAIGHD
LRTPITRLRLRSEFIEDATQRDNMLRDLDQMRSMLDAVLSFLRTGRALEPMTRIDLASTLQLITDQFTDLGHKVTYLGPE
HAELLARPDDIRRAVTNLVDNAVRYGKDILVRLEASPGRVTIEVEDDGPGIPEACKADVIEPFVRGDDARNMDETSGFGL
GLSIARTIVQNHGGELTLRDRKPHGLIVRLDLPGQQQDSGAA

Sequences:

>Translated_442_residues
MLERLGRFRFSGIRSQIAVLVLASLIGTQLLIMATFLLRGPDRFGPPEHRREQFEIAVLLIAATPEEQRPQLVEQITRTF
PHLELRLLDAAAVPPRSDRELPEIRDVARTLGPLARVFALPGAEPPQVGIALPDGTAIAAAIPEMRGRPPISNGPWMSAF
AGVIISLAMFGLWADRALSTPLSEFAAAAENFKLDGTDEPLAESGPDEIRSLARAMNRSRNRITALIDDRTRTLAAIGHD
LRTPITRLRLRSEFIEDATQRDNMLRDLDQMRSMLDAVLSFLRTGRALEPMTRIDLASTLQLITDQFTDLGHKVTYLGPE
HAELLARPDDIRRAVTNLVDNAVRYGKDILVRLEASPGRVTIEVEDDGPGIPEACKADVIEPFVRGDDARNMDETSGFGL
GLSIARTIVQNHGGELTLRDRKPHGLIVRLDLPGQQQDSGAA
>Mature_442_residues
MLERLGRFRFSGIRSQIAVLVLASLIGTQLLIMATFLLRGPDRFGPPEHRREQFEIAVLLIAATPEEQRPQLVEQITRTF
PHLELRLLDAAAVPPRSDRELPEIRDVARTLGPLARVFALPGAEPPQVGIALPDGTAIAAAIPEMRGRPPISNGPWMSAF
AGVIISLAMFGLWADRALSTPLSEFAAAAENFKLDGTDEPLAESGPDEIRSLARAMNRSRNRITALIDDRTRTLAAIGHD
LRTPITRLRLRSEFIEDATQRDNMLRDLDQMRSMLDAVLSFLRTGRALEPMTRIDLASTLQLITDQFTDLGHKVTYLGPE
HAELLARPDDIRRAVTNLVDNAVRYGKDILVRLEASPGRVTIEVEDDGPGIPEACKADVIEPFVRGDDARNMDETSGFGL
GLSIARTIVQNHGGELTLRDRKPHGLIVRLDLPGQQQDSGAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=37.4545454545455, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1790551, Length=273, Percent_Identity=29.6703296703297, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1787894, Length=271, Percent_Identity=30.2583025830258, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=27.5303643724696, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082128, Length=258, Percent_Identity=27.5193798449612, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=24.8299319727891, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=322, Percent_Identity=27.9503105590062, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=28.9473684210526, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=205, Percent_Identity=27.8048780487805, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=27.4678111587983, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=29.7959183673469, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=24.2914979757085, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48640; Mature: 48640

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLGRFRFSGIRSQIAVLVLASLIGTQLLIMATFLLRGPDRFGPPEHRREQFEIAVLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEE
IAATPEEQRPQLVEQITRTFPHLELRLLDAAAVPPRSDRELPEIRDVARTLGPLARVFAL
EEECCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
PGAEPPQVGIALPDGTAIAAAIPEMRGRPPISNGPWMSAFAGVIISLAMFGLWADRALST
CCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PLSEFAAAAENFKLDGTDEPLAESGPDEIRSLARAMNRSRNRITALIDDRTRTLAAIGHD
CHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHH
LRTPITRLRLRSEFIEDATQRDNMLRDLDQMRSMLDAVLSFLRTGRALEPMTRIDLASTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QLITDQFTDLGHKVTYLGPEHAELLARPDDIRRAVTNLVDNAVRYGKDILVRLEASPGRV
HHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEE
TIEVEDDGPGIPEACKADVIEPFVRGDDARNMDETSGFGLGLSIARTIVQNHGGELTLRD
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
RKPHGLIVRLDLPGQQQDSGAA
CCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLERLGRFRFSGIRSQIAVLVLASLIGTQLLIMATFLLRGPDRFGPPEHRREQFEIAVLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEE
IAATPEEQRPQLVEQITRTFPHLELRLLDAAAVPPRSDRELPEIRDVARTLGPLARVFAL
EEECCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
PGAEPPQVGIALPDGTAIAAAIPEMRGRPPISNGPWMSAFAGVIISLAMFGLWADRALST
CCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PLSEFAAAAENFKLDGTDEPLAESGPDEIRSLARAMNRSRNRITALIDDRTRTLAAIGHD
CHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHH
LRTPITRLRLRSEFIEDATQRDNMLRDLDQMRSMLDAVLSFLRTGRALEPMTRIDLASTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QLITDQFTDLGHKVTYLGPEHAELLARPDDIRRAVTNLVDNAVRYGKDILVRLEASPGRV
HHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEE
TIEVEDDGPGIPEACKADVIEPFVRGDDARNMDETSGFGLGLSIARTIVQNHGGELTLRD
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
RKPHGLIVRLDLPGQQQDSGAA
CCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]