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The map label for this gene is hisG

Identifier: 86748968

GI number: 86748968

Start: 2111308

End: 2112285

Strand: Reverse

Name: hisG

Synonym: RPB_1845

Alternate gene names: 86748968

Gene position: 2112285-2111308 (Counterclockwise)

Preceding gene: 86748969

Following gene: 86748967

Centisome position: 39.62

GC content: 67.89

Gene sequence:

>978_bases
ATGACCGCACCGTTCGTTCTTGCGGTCCCCTCCAAGGGCCGCCTGCAGGAAAACGCCGAAGCCTTCTTCGCCCGCGCCGG
CCTGGCGCTGTCGAAGCCCGGCGGCGCCCGCGACTATCGCGGCACCATCGCGGGCCTCGACAATGTCGAGGTCGCCTATC
TGTCGGCCAGCGAGATCGCCGCCAATCTGGCGCGCGGCTCGGTGCATTTCGGCGTCACCGGCGAGGATCTGCTGCGCGAG
AGCATTGCCGACGCCGACCGCCGCGTGCTGCTGATCGACGGGCTCGGCTTCGGCTACGCCAATGTGGTGGTCGCGGTGCC
GCAGGCCTGGATCGACGTCCGCACCATGGCGGATCTCGACGACGTCACCACCGGCTTTCGCGCCCAGCACAATCGAAGGA
TGCGGGTCGCGACCAAATACATCAACCTGACGCGCGGCTTCTTCGCCCAGCACAATGTCGTCGACTACCGCATCGTCGAG
AGCGCCGGCGCCACCGAGGGCGCGCCCGCAGTCGGCACCGCCGAGATGATCGTCGACATCACCACCACCGGCGCGACGCT
CGCCGCCAACGGCCTCAAGGTGCTCGACGACGGAATCATGCTGCGCAGCCAGGCCAATCTGGTCGCCTCGCGCGACGCCG
ATTGGTCGGACGAGGTGCGGGAGACAGCGCGCGTCATCCTCGACCAGATTGCCTCGCGTGCCCGCGCCAGCAAGTACAAG
GAAGTCCGCACCCGCTTCGCGGGCTGCAACGAGGCGCTGCTCGCCGAGGCGCACAAGCGGTTCGGCGTGGTGTCGCCGTT
CGGCGGCCCGACCTCCTCGGGGATGCTGACGCTGCACTGCCCGCCAGCGCAGATCTACGGGCTCGGCAGCTTCCTGCGCG
AGCACGGCGCCGACACGGTGTCGGTCGCCTCGCTCGACTACGTGTTCGACAAGGACAATCCGCTGTTCAGCAAACTTGCA
GCATTCCTGCGGCAATAA

Upstream 100 bases:

>100_bases
TGAGCCAGCTCGGCGCGAGCGCCCCGATCCCCGCGGTCGGGTTCTCGATCTGGATCGAGGCGATGACGCAGTCCGGCCCC
GCCAACATTGGGAGCGCGTC

Downstream 100 bases:

>100_bases
TACTTGGTTATGGTTCCGCCCGGCATCGCGACAGTGCCGACGCCGCATCTGATCGCGGGCACGGTGCGGAACTAACAACG
CAGCAAGCGAAGCCGGGACC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTAPFVLAVPSKGRLQENAEAFFARAGLALSKPGGARDYRGTIAGLDNVEVAYLSASEIAANLARGSVHFGVTGEDLLRE
SIADADRRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLDDVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVE
SAGATEGAPAVGTAEMIVDITTTGATLAANGLKVLDDGIMLRSQANLVASRDADWSDEVRETARVILDQIASRARASKYK
EVRTRFAGCNEALLAEAHKRFGVVSPFGGPTSSGMLTLHCPPAQIYGLGSFLREHGADTVSVASLDYVFDKDNPLFSKLA
AFLRQ

Sequences:

>Translated_325_residues
MTAPFVLAVPSKGRLQENAEAFFARAGLALSKPGGARDYRGTIAGLDNVEVAYLSASEIAANLARGSVHFGVTGEDLLRE
SIADADRRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLDDVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVE
SAGATEGAPAVGTAEMIVDITTTGATLAANGLKVLDDGIMLRSQANLVASRDADWSDEVRETARVILDQIASRARASKYK
EVRTRFAGCNEALLAEAHKRFGVVSPFGGPTSSGMLTLHCPPAQIYGLGSFLREHGADTVSVASLDYVFDKDNPLFSKLA
AFLRQ
>Mature_324_residues
TAPFVLAVPSKGRLQENAEAFFARAGLALSKPGGARDYRGTIAGLDNVEVAYLSASEIAANLARGSVHFGVTGEDLLRES
IADADRRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLDDVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVES
AGATEGAPAVGTAEMIVDITTTGATLAANGLKVLDDGIMLRSQANLVASRDADWSDEVRETARVILDQIASRARASKYKE
VRTRFAGCNEALLAEAHKRFGVVSPFGGPTSSGMLTLHCPPAQIYGLGSFLREHGADTVSVASLDYVFDKDNPLFSKLAA
FLRQ

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=246, Percent_Identity=26.8292682926829, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_RHOP2 (Q2IZ07)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_485464.1
- ProteinModelPortal:   Q2IZ07
- SMR:   Q2IZ07
- STRING:   Q2IZ07
- GeneID:   3909004
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1845
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   RMRVATK
- ProtClustDB:   PRK00489
- BioCyc:   RPAL316058:RPB_1845-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 34909; Mature: 34778

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPFVLAVPSKGRLQENAEAFFARAGLALSKPGGARDYRGTIAGLDNVEVAYLSASEIA
CCCCEEEECCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCEECCCCCCEEEEEEHHHHH
ANLARGSVHFGVTGEDLLRESIADADRRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLD
HHHHCCCEEECCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHEEECCHHHHHHHHHHCHH
DVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVESAGATEGAPAVGTAEMIVDI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
TTTGATLAANGLKVLDDGIMLRSQANLVASRDADWSDEVRETARVILDQIASRARASKYK
ECCCCEECCCCCEEECCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EVRTRFAGCNEALLAEAHKRFGVVSPFGGPTSSGMLTLHCPPAQIYGLGSFLREHGADTV
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEE
SVASLDYVFDKDNPLFSKLAAFLRQ
EEEEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TAPFVLAVPSKGRLQENAEAFFARAGLALSKPGGARDYRGTIAGLDNVEVAYLSASEIA
CCCEEEECCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCEECCCCCCEEEEEEHHHHH
ANLARGSVHFGVTGEDLLRESIADADRRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLD
HHHHCCCEEECCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHEEECCHHHHHHHHHHCHH
DVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVESAGATEGAPAVGTAEMIVDI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
TTTGATLAANGLKVLDDGIMLRSQANLVASRDADWSDEVRETARVILDQIASRARASKYK
ECCCCEECCCCCEEECCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EVRTRFAGCNEALLAEAHKRFGVVSPFGGPTSSGMLTLHCPPAQIYGLGSFLREHGADTV
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEE
SVASLDYVFDKDNPLFSKLAAFLRQ
EEEEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA