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The map label for this gene is pepA [H]

Identifier: 86748900

GI number: 86748900

Start: 2037959

End: 2039341

Strand: Reverse

Name: pepA [H]

Synonym: RPB_1777

Alternate gene names: 86748900

Gene position: 2039341-2037959 (Counterclockwise)

Preceding gene: 86748902

Following gene: 86748899

Centisome position: 38.25

GC content: 69.99

Gene sequence:

>1383_bases
ATGTCCTCCTTGTTCGCCACCGCCCCGGAACCGACCGCCATTCCGATTTCCTTCGTCACCCGCGCCGGCTGGGAGGTGCT
GTGCGCGACGCTGCCGGAGGCCGCGCAGCGATTCGCGCGCGCGCACGGCTACAGCGGCAAGCCGGGGCAGTTCCTCGCTC
TGCCGACGCCGGAGGGCGACATCGGTCATGTCCTGTTCGGCCTCGACGAGCCCGACGCGCGCGGGCACGATCCGTTTCGC
GCCGGGCAATTGCCGGGCCTGCTGCCGCCCGGCGTGTATCGCCTCGCCAACGCGCCGCACGACACACGGCTCGCAGTGCT
GGCGTTCGCGCTCGGCGTCTACAAATTCGGCCGCTATCGCACCGCCGAGCCGCCGGCCGTCAAACTGGTGCCGCCGGACG
GCATCGACGTCGCCGCGATCGCGCGCGCGGTCGAGGCTGCGACGCTGGCGCGCGACCTGATCAACACGCCGTCGAACGAC
ATGGGGCCGGCCGAACTCGCCGACGCCGCGCAGGCGCTGGCGCAACGCTTCGGCGCGGATTTCACCTGCGTCGTCGGCGA
ACAGCTGACGACACGCAACTTCCCGCTGATCCACGCCGTCGGCATGGCGGCGACGCGCGCGCCGCGGCTGATCGATTTCA
CCTGGGGCGATCCGGCACATCCGAAGGTGACGCTGGTCGGCAAGGGCGTCTGCTTCGACACCGGCGGCCTCGACCTCAAG
CCGTCGAGCGCGATGCTGATCATGAAGAAGGACATGGGCGGCGCGGCCAATGTGCTGGCGCTGGCCGCGATGATCATGGA
CGCGAAGTTGAAACTGCGGCTGCGCGTGCTGATCCCCGCGGTCGAGAACGCGGTCGCCGGCAACGCGATGCGGCCGCTCG
ATATCTTCCCGTCGCGCAAGGGCCCGACGGTGGAGATCGGCAACACCGACGCCGAGGGCCGGCTGGTGCTGGCCGACGCG
CTCGCTTACGCCGACGAGGAGGCGCCCGATCTGCTGATCGATCTCGGCACGCTGACCGGCGCCGCGCGCGTCGCGCTCGG
TCCGGATCTGCCGCCCTACTACACGGATGACGAGACGCTGGCGCTCGACCTGGCGCGCTGCGCCAAGGCCGAGAACGATC
CGCTGTGGCGGCTGCCGCTGTGGGGAGCCTACGATTCCTGGCTGGACTCGAAGGTCGCCAACATCAACAACGCGCCCTCC
GGCGGCTTTGCCGGCTCGATCACCTGTGCGCTGTTCCTGCAGCGCTTCGTCGAGTCCGCCAAGAGCTGGCTGCATGTCGA
CATCTACGGCTGGACGCCGAAGGCCAAGCCGGCGCGGCCCGAAGGCGGCGAGTGCCAGGCCGCGCGCGCGATCTTCGCAT
TGCTGAGCGAACGCTATGGCTGA

Upstream 100 bases:

>100_bases
ACAAATTCCAACAGGAGCCCAGCAATAGAGCGTTAACCCTAATGTCCGGTTAATCACCGCGATCCCTCCCCTCGCCTCGA
ATCGACTCGAAAGACCCCGC

Downstream 100 bases:

>100_bases
TCTGAAGCTCGATCCGCGGCTGACGCCGGCGCGGCCGGATCTCGCGGCGAAACATCTCGAAGGCCGGGTGAGCGCGGACC
GTTTCGTCGACGGCGAAATC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSSLFATAPEPTAIPISFVTRAGWEVLCATLPEAAQRFARAHGYSGKPGQFLALPTPEGDIGHVLFGLDEPDARGHDPFR
AGQLPGLLPPGVYRLANAPHDTRLAVLAFALGVYKFGRYRTAEPPAVKLVPPDGIDVAAIARAVEAATLARDLINTPSND
MGPAELADAAQALAQRFGADFTCVVGEQLTTRNFPLIHAVGMAATRAPRLIDFTWGDPAHPKVTLVGKGVCFDTGGLDLK
PSSAMLIMKKDMGGAANVLALAAMIMDAKLKLRLRVLIPAVENAVAGNAMRPLDIFPSRKGPTVEIGNTDAEGRLVLADA
LAYADEEAPDLLIDLGTLTGAARVALGPDLPPYYTDDETLALDLARCAKAENDPLWRLPLWGAYDSWLDSKVANINNAPS
GGFAGSITCALFLQRFVESAKSWLHVDIYGWTPKAKPARPEGGECQAARAIFALLSERYG

Sequences:

>Translated_460_residues
MSSLFATAPEPTAIPISFVTRAGWEVLCATLPEAAQRFARAHGYSGKPGQFLALPTPEGDIGHVLFGLDEPDARGHDPFR
AGQLPGLLPPGVYRLANAPHDTRLAVLAFALGVYKFGRYRTAEPPAVKLVPPDGIDVAAIARAVEAATLARDLINTPSND
MGPAELADAAQALAQRFGADFTCVVGEQLTTRNFPLIHAVGMAATRAPRLIDFTWGDPAHPKVTLVGKGVCFDTGGLDLK
PSSAMLIMKKDMGGAANVLALAAMIMDAKLKLRLRVLIPAVENAVAGNAMRPLDIFPSRKGPTVEIGNTDAEGRLVLADA
LAYADEEAPDLLIDLGTLTGAARVALGPDLPPYYTDDETLALDLARCAKAENDPLWRLPLWGAYDSWLDSKVANINNAPS
GGFAGSITCALFLQRFVESAKSWLHVDIYGWTPKAKPARPEGGECQAARAIFALLSERYG
>Mature_459_residues
SSLFATAPEPTAIPISFVTRAGWEVLCATLPEAAQRFARAHGYSGKPGQFLALPTPEGDIGHVLFGLDEPDARGHDPFRA
GQLPGLLPPGVYRLANAPHDTRLAVLAFALGVYKFGRYRTAEPPAVKLVPPDGIDVAAIARAVEAATLARDLINTPSNDM
GPAELADAAQALAQRFGADFTCVVGEQLTTRNFPLIHAVGMAATRAPRLIDFTWGDPAHPKVTLVGKGVCFDTGGLDLKP
SSAMLIMKKDMGGAANVLALAAMIMDAKLKLRLRVLIPAVENAVAGNAMRPLDIFPSRKGPTVEIGNTDAEGRLVLADAL
AYADEEAPDLLIDLGTLTGAARVALGPDLPPYYTDDETLALDLARCAKAENDPLWRLPLWGAYDSWLDSKVANINNAPSG
GFAGSITCALFLQRFVESAKSWLHVDIYGWTPKAKPARPEGGECQAARAIFALLSERYG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=341, Percent_Identity=32.258064516129, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI47155554, Length=365, Percent_Identity=32.6027397260274, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI87082123, Length=286, Percent_Identity=40.9090909090909, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1790710, Length=372, Percent_Identity=34.4086021505376, Blast_Score=164, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=310, Percent_Identity=34.5161290322581, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=211, Percent_Identity=32.2274881516588, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355725, Length=285, Percent_Identity=32.280701754386, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24661038, Length=285, Percent_Identity=32.280701754386, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221379063, Length=302, Percent_Identity=30.794701986755, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221379062, Length=302, Percent_Identity=30.794701986755, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21357381, Length=302, Percent_Identity=30.794701986755, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21355645, Length=340, Percent_Identity=25.2941176470588, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662223, Length=340, Percent_Identity=25.2941176470588, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129969, Length=298, Percent_Identity=27.5167785234899, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19922386, Length=299, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24662227, Length=336, Percent_Identity=25.5952380952381, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161077148, Length=297, Percent_Identity=27.6094276094276, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI20130057, Length=297, Percent_Identity=27.6094276094276, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI20129963, Length=336, Percent_Identity=26.7857142857143, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646701, Length=214, Percent_Identity=29.9065420560748, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646703, Length=214, Percent_Identity=29.9065420560748, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358201, Length=214, Percent_Identity=29.9065420560748, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 48865; Mature: 48733

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLFATAPEPTAIPISFVTRAGWEVLCATLPEAAQRFARAHGYSGKPGQFLALPTPEGD
CCCCCCCCCCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
IGHVLFGLDEPDARGHDPFRAGQLPGLLPPGVYRLANAPHDTRLAVLAFALGVYKFGRYR
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
TAEPPAVKLVPPDGIDVAAIARAVEAATLARDLINTPSNDMGPAELADAAQALAQRFGAD
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
FTCVVGEQLTTRNFPLIHAVGMAATRAPRLIDFTWGDPAHPKVTLVGKGVCFDTGGLDLK
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCEEEECCCCCCC
PSSAMLIMKKDMGGAANVLALAAMIMDAKLKLRLRVLIPAVENAVAGNAMRPLDIFPSRK
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEEEHHHHHHHCCCCCCCCCCCCCCC
GPTVEIGNTDAEGRLVLADALAYADEEAPDLLIDLGTLTGAARVALGPDLPPYYTDDETL
CCEEEECCCCCCCEEEEEHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCCHH
ALDLARCAKAENDPLWRLPLWGAYDSWLDSKVANINNAPSGGFAGSITCALFLQRFVESA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
KSWLHVDIYGWTPKAKPARPEGGECQAARAIFALLSERYG
HCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSLFATAPEPTAIPISFVTRAGWEVLCATLPEAAQRFARAHGYSGKPGQFLALPTPEGD
CCCCCCCCCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
IGHVLFGLDEPDARGHDPFRAGQLPGLLPPGVYRLANAPHDTRLAVLAFALGVYKFGRYR
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
TAEPPAVKLVPPDGIDVAAIARAVEAATLARDLINTPSNDMGPAELADAAQALAQRFGAD
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
FTCVVGEQLTTRNFPLIHAVGMAATRAPRLIDFTWGDPAHPKVTLVGKGVCFDTGGLDLK
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCEEEECCCCCCC
PSSAMLIMKKDMGGAANVLALAAMIMDAKLKLRLRVLIPAVENAVAGNAMRPLDIFPSRK
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEEEHHHHHHHCCCCCCCCCCCCCCC
GPTVEIGNTDAEGRLVLADALAYADEEAPDLLIDLGTLTGAARVALGPDLPPYYTDDETL
CCEEEECCCCCCCEEEEEHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCCHH
ALDLARCAKAENDPLWRLPLWGAYDSWLDSKVANINNAPSGGFAGSITCALFLQRFVESA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
KSWLHVDIYGWTPKAKPARPEGGECQAARAIFALLSERYG
HCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA