BacMap

Definition	Rhodopseudomonas palustris HaA2, complete genome.
Accession	NC_007778
Length	5,331,656

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The map label for this gene is fixR [H]

Identifier: 86748081

GI number: 86748081

Start: 1105469

End: 1106341

Strand: Direct

Name: fixR [H]

Synonym: RPB_0956

Alternate gene names: 86748081

Gene position: 1105469-1106341 (Clockwise)

Preceding gene: 86748079

Following gene: 86748082

Centisome position: 20.73

GC content: 64.6

Gene sequence:

>873_bases
GTGCACAGCGAGCCGTTGCAGGCCGAACGGCCGGGGCATCCGGGAGGGCATGGACCGGACAGTCATGGACCGGGACAGCC
AGCGGTCGGCGTCGGGGCCTGTCCGTTTCACAACGATCAACATCAAGCCCGTTCGGGCAAGCAGAAAACGCTGGTGTTGA
CCGGCGCCTCTCGCGGCATCGGCCACGCCACCGGGAAGCTGTTCTCCGATGCCGGATGGCGGATCATCACCTGCTCGCGC
CAGCCGTTTTCGGACGATCGCTGTCCGTGGGCCACCGGCATGGAAAACCATGTCGCCGTCGAACTGGCCGATCACCGGGC
ACTGCCGCGCGCGATCGATGAGCTCAAGGAAAAACTCGGCGGCGGACCGCTCAGCGCCTTGATCAATAACGCCGCGATCT
CGCCGAAGAGCCCGGAAGGCGAGCGCCTCACCTCCCTGAATACGCCGGTCGGGACCTGGATGAGCGTGTTCCACGTCAAT
CTGCTGGCGCCGGTGATGCTGGCGCAAGGCCTGTTCGACGAATTGCGCGCCGGCAGCGGCTCGATCGTCAATGTCACCTC
GATCGTCGGTTCGCGCGTGCACCCGTTTGCCGGCAGCGCCTATGCCACGTCCAAGGCGGCGCTGACCTGCCTCACCCGCG
AGATGGCGCACGACTACGCACCCTATGGCATTCGCGTGAACGCGATCGCGCCGGGTGAGATCAAGACCGATATCTTGTCG
CCCGAAACCGAGGCGATGCTGGCGCCGACGATCCCGATGCGCCGTATCGGGACACCGGAGGAAGTGGCAAAGGTGATGTT
CTTTCTTTGCTCGGATGCCGCCAGCTATGTCACCGGCGAAGAAATTCACATCAACGGCGGCCAGCGCGTCTAG

Upstream 100 bases:

>100_bases
AGCTGGCAACAGGGCGCCGAAATCGCCTGAAAGTCGAGCAAGCACCCACTGGCCCAGTTCGTGCAATGCCTGCACCATGA
GACAAGCAATGGAGGCACCC

Downstream 100 bases:

>100_bases
CGAATAGCTCGCAATTAGTTTGTTGGTATCTTTGCCGTCTCGGCGCGACTGCGTGTCTTTTCATCGACTTGTTTTGCGCT
GCATCAATGCGAAGCGCGGC

Product: Short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MHSEPLQAERPGHPGGHGPDSHGPGQPAVGVGACPFHNDQHQARSGKQKTLVLTGASRGIGHATGKLFSDAGWRIITCSR
QPFSDDRCPWATGMENHVAVELADHRALPRAIDELKEKLGGGPLSALINNAAISPKSPEGERLTSLNTPVGTWMSVFHVN
LLAPVMLAQGLFDELRAGSGSIVNVTSIVGSRVHPFAGSAYATSKAALTCLTREMAHDYAPYGIRVNAIAPGEIKTDILS
PETEAMLAPTIPMRRIGTPEEVAKVMFFLCSDAASYVTGEEIHINGGQRV

Sequences:

>Translated_290_residues
MHSEPLQAERPGHPGGHGPDSHGPGQPAVGVGACPFHNDQHQARSGKQKTLVLTGASRGIGHATGKLFSDAGWRIITCSR
QPFSDDRCPWATGMENHVAVELADHRALPRAIDELKEKLGGGPLSALINNAAISPKSPEGERLTSLNTPVGTWMSVFHVN
LLAPVMLAQGLFDELRAGSGSIVNVTSIVGSRVHPFAGSAYATSKAALTCLTREMAHDYAPYGIRVNAIAPGEIKTDILS
PETEAMLAPTIPMRRIGTPEEVAKVMFFLCSDAASYVTGEEIHINGGQRV
>Mature_290_residues
MHSEPLQAERPGHPGGHGPDSHGPGQPAVGVGACPFHNDQHQARSGKQKTLVLTGASRGIGHATGKLFSDAGWRIITCSR
QPFSDDRCPWATGMENHVAVELADHRALPRAIDELKEKLGGGPLSALINNAAISPKSPEGERLTSLNTPVGTWMSVFHVN
LLAPVMLAQGLFDELRAGSGSIVNVTSIVGSRVHPFAGSAYATSKAALTCLTREMAHDYAPYGIRVNAIAPGEIKTDILS
PETEAMLAPTIPMRRIGTPEEVAKVMFFLCSDAASYVTGEEIHINGGQRV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=31.496062992126, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=30.1652892561983, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=30.8, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=28.8537549407115, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI126723750, Length=152, Percent_Identity=35.5263157894737, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI59889578, Length=239, Percent_Identity=29.2887029288703, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=28.968253968254, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=27.7992277992278, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=31.4009661835749, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=29.9212598425197, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4503301, Length=237, Percent_Identity=29.1139240506329, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI66933014, Length=154, Percent_Identity=29.2207792207792, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=200, Percent_Identity=27.5, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI119392083, Length=192, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI150247226, Length=208, Percent_Identity=24.0384615384615, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=30.6772908366534, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=32.4427480916031, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=31.8897637795276, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=28.1746031746032, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=29.6, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=29.8387096774194, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=28.0632411067194, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=33.7448559670782, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082160, Length=261, Percent_Identity=28.3524904214559, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=27.843137254902, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789208, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=34, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=31.496062992126, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=30.9803921568627, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=30.7392996108949, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=29.5880149812734, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=31.5589353612167, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=30.2681992337165, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=29.5454545454545, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=29.1187739463602, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=29.6577946768061, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=27.8195488721804, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=29.1338582677165, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=30.2238805970149, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=29.3893129770992, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=27.9693486590038, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=28.5171102661597, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=27.8884462151394, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=26.9961977186312, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=28.030303030303, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=27.0992366412214, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=26.9961977186312, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=200, Percent_Identity=31.5, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=28.735632183908, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=26.171875, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=260, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=141, Percent_Identity=34.7517730496454, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322067, Length=209, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=35.4330708661417, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=28.5140562248996, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=31.496062992126, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=31.7460317460317, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571526, Length=263, Percent_Identity=31.5589353612167, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644337, Length=255, Percent_Identity=32.5490196078431, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=30.8880308880309, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=30.3149606299213, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 30732; Mature: 30732

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSEPLQAERPGHPGGHGPDSHGPGQPAVGVGACPFHNDQHQARSGKQKTLVLTGASRGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
GHATGKLFSDAGWRIITCSRQPFSDDRCPWATGMENHVAVELADHRALPRAIDELKEKLG
CHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
GGPLSALINNAAISPKSPEGERLTSLNTPVGTWMSVFHVNLLAPVMLAQGLFDELRAGSG
CCHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SIVNVTSIVGSRVHPFAGSAYATSKAALTCLTREMAHDYAPYGIRVNAIAPGEIKTDILS
CEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCC
PETEAMLAPTIPMRRIGTPEEVAKVMFFLCSDAASYVTGEEIHINGGQRV
CCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure
MHSEPLQAERPGHPGGHGPDSHGPGQPAVGVGACPFHNDQHQARSGKQKTLVLTGASRGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
GHATGKLFSDAGWRIITCSRQPFSDDRCPWATGMENHVAVELADHRALPRAIDELKEKLG
CHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
GGPLSALINNAAISPKSPEGERLTSLNTPVGTWMSVFHVNLLAPVMLAQGLFDELRAGSG
CCHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SIVNVTSIVGSRVHPFAGSAYATSKAALTCLTREMAHDYAPYGIRVNAIAPGEIKTDILS
CEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCC
PETEAMLAPTIPMRRIGTPEEVAKVMFFLCSDAASYVTGEEIHINGGQRV
CCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3313281; 11157954; 12597275 [H]