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The map label for this gene is crp [H]

Identifier: 86748019

GI number: 86748019

Start: 1026040

End: 1026720

Strand: Direct

Name: crp [H]

Synonym: RPB_0893

Alternate gene names: 86748019

Gene position: 1026040-1026720 (Clockwise)

Preceding gene: 86748014

Following gene: 86748027

Centisome position: 19.24

GC content: 66.67

Gene sequence:

>681_bases
ATGAGTACGCAGGCCGAATTCGCGGTCATTCTGAAGCTGAATCCCTTGTTCGCCGATCTCGGTCCCGAGGAACTGCAGCG
GATCGCCGGGCTGTGTCATACGCAGCAGCTCAATGCCGGCGAAATGTTGTTCCAGAAGGGTGACGACGGCGACGCGTTGT
TCGGCGTGCGGCGCGGCCAGATCCGGATCGAGACCGGCGCCTCCGACGGCAGCCGGCTGACGCTGAATTTCCTCGGCCCC
GGCGATTTGTTCGGCGAGGTCGCGGTGCTGGATGGCCAGAGCCGCACCGCCGACGCCACGGCCGGCGAACCCACTGAACT
GTTCGTGCTGCGGCGTGACGATTTCCTCGGTCATCTCGAGCGCGAACCGAAGCTCGCGGTGAAACTGATCGCACTGCTGT
GCCAGCGCATCCGCTGGATGAGCGAGCGCATGGAGGAATCGGTGCTGCAGCCGCTGCCGGTGCGGCTGGCCCGAAGACTG
TGCGCGCTCGCGGCCGATTTCGGCGCCGAGGTGCACATCTCGCAGGAGCAGCTCGGCGTGTTCGTCGGCGCGGCGCGCGA
GAGCGTCAACCGCCAGCTGCAGAGCTGGCGCAAGGACGGCATCCTCGATCTGCACCGCGGCCGCATCCTGCTGAAGAACA
TGGGCCGCCTGACGCAAGTCGCGCGCAGCCAGGAGCGCTGA

Upstream 100 bases:

>100_bases
TGAGAGCCGGACATTCTGTGACGCGTGGCACATTTTGTTTGAACCATTGTCCCTCTCACGCGGCTAAACGGTAAGTGACA
TTCTGGGGGCGATCATCGCG

Downstream 100 bases:

>100_bases
TCGGGAATCGACGACATCGTCGTCGTCATTCCGGGATGCGCTGCGGCGCAGGGCAGACCCGGAATCCATACGCACTGCGG
GCCCGTCGAGGCCGCGCGTC

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSTQAEFAVILKLNPLFADLGPEELQRIAGLCHTQQLNAGEMLFQKGDDGDALFGVRRGQIRIETGASDGSRLTLNFLGP
GDLFGEVAVLDGQSRTADATAGEPTELFVLRRDDFLGHLEREPKLAVKLIALLCQRIRWMSERMEESVLQPLPVRLARRL
CALAADFGAEVHISQEQLGVFVGAARESVNRQLQSWRKDGILDLHRGRILLKNMGRLTQVARSQER

Sequences:

>Translated_226_residues
MSTQAEFAVILKLNPLFADLGPEELQRIAGLCHTQQLNAGEMLFQKGDDGDALFGVRRGQIRIETGASDGSRLTLNFLGP
GDLFGEVAVLDGQSRTADATAGEPTELFVLRRDDFLGHLEREPKLAVKLIALLCQRIRWMSERMEESVLQPLPVRLARRL
CALAADFGAEVHISQEQLGVFVGAARESVNRQLQSWRKDGILDLHRGRILLKNMGRLTQVARSQER
>Mature_225_residues
STQAEFAVILKLNPLFADLGPEELQRIAGLCHTQQLNAGEMLFQKGDDGDALFGVRRGQIRIETGASDGSRLTLNFLGPG
DLFGEVAVLDGQSRTADATAGEPTELFVLRRDDFLGHLEREPKLAVKLIALLCQRIRWMSERMEESVLQPLPVRLARRLC
ALAADFGAEVHISQEQLGVFVGAARESVNRQLQSWRKDGILDLHRGRILLKNMGRLTQVARSQER

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=188, Percent_Identity=23.4042553191489, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25126; Mature: 24995

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00889 CNMP_BINDING_2 ; PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQAEFAVILKLNPLFADLGPEELQRIAGLCHTQQLNAGEMLFQKGDDGDALFGVRRGQ
CCCCCCEEEEEEECHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEECCE
IRIETGASDGSRLTLNFLGPGDLFGEVAVLDGQSRTADATAGEPTELFVLRRDDFLGHLE
EEEEECCCCCCEEEEEECCCCCHHCCEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHCC
REPKLAVKLIALLCQRIRWMSERMEESVLQPLPVRLARRLCALAADFGAEVHISQEQLGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECHHHHHH
FVGAARESVNRQLQSWRKDGILDLHRGRILLKNMGRLTQVARSQER
HHHHHHHHHHHHHHHHHHCCCEEHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STQAEFAVILKLNPLFADLGPEELQRIAGLCHTQQLNAGEMLFQKGDDGDALFGVRRGQ
CCCCCEEEEEEECHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEECCE
IRIETGASDGSRLTLNFLGPGDLFGEVAVLDGQSRTADATAGEPTELFVLRRDDFLGHLE
EEEEECCCCCCEEEEEECCCCCHHCCEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHCC
REPKLAVKLIALLCQRIRWMSERMEESVLQPLPVRLARRLCALAADFGAEVHISQEQLGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECHHHHHH
FVGAARESVNRQLQSWRKDGILDLHRGRILLKNMGRLTQVARSQER
HHHHHHHHHHHHHHHHHHCCCEEHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]