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The map label for this gene is acdA [H]

Identifier: 86747846

GI number: 86747846

Start: 807470

End: 808546

Strand: Reverse

Name: acdA [H]

Synonym: RPB_0720

Alternate gene names: 86747846

Gene position: 808546-807470 (Counterclockwise)

Preceding gene: 86747847

Following gene: 86747845

Centisome position: 15.17

GC content: 70.75

Gene sequence:

>1077_bases
ATGCTGCAAAACGCCAGCCAGGCCGTCGGCGAAATCACCCAGCGCTGGCGTGCGATCGACGCCACCGAGCGCCGCGCGGA
TCCGTTCGGCGCGATGCGTCGCGCGGGCCTGTTCCGGATCGGACTGCCGGGCGGTGACGCATCGCTGGATAGTTTTACGG
CGATCGCAGTTGCCGAGCAGGCGATGGCCGCGGCGACCGGGGAACTCGGCCTGGCCACAGCCTTCGCCGGGCGGCAACTG
ATCGCGCGGTTCTTCATCGCCGGCTTTTCCGACGACGCGCAGCGCAGTGATCTGCTACCGCGCATCGCTACGGGCGATTG
CTGGGCCGCGGTGGCGATCTCCGAGCCCGGTGCCGGCGCGCATCCGAAACATCTGCAGACCGCCGCCGAGCCGCAGGGCG
ACAGTTTCGCGATCAGCGGCCGCAAGGCCTGGATCACCAACGGCCCGGTCGCCGACCTCTTCCTGGTGCTGGCGATCGTC
GCGATCGAGGACGGTCGCAAGCGCTACGGCCTGTTCGCCGTGCCGCGCGATACGCCGGGGCTGACCATCACGCCGATGCC
GTCGCTCGACGTGCTGGCGCCGGCGTCGCATTGCGAGCTCACGCTGGACAATTGCGTCGTGCCGGCCTCGGCGCGGATCG
GCGGCGCGCGCGACGCCTATCCGGCGATGGCGCTGCCGTTTCGCGACATCGAGGACACCGTCGGCACCGCGACCACCGCC
GGCTTTCTGGCGTGGCTGCTGCGGGCGATCGCCGCGCAAATCGAGCCGAGCGAGGACCACGCGCTGCGGCTCGGGCGTCT
CAAAGGGCAAGTCGCGCTGATCGAGACCGCGAGCCGCGCCGCCGTGCTGTCGCTCGACGACGGTACGCCGCCGGTGCCGG
CGCGCCTGATCGGCATCCGCGCGCTGGCCGGCAGCATCGTCGACGACGTTCGCGCGCATTTCGCCGTGGCGCGGACCGAC
GACCGCATCAGCCGCGCGCTGGCTGGTTTCGACGTCCTCGCCAATGTCGCGCGCGAGCCGCGCAAGCAGCGGCAGATCAC
TCTCGGCCAATCTCTCTGGAGCGCACGACGCGAATGA

Upstream 100 bases:

>100_bases
CCGTTCGACGGAATGGAAGAATCCGCTCGCGACGGCGGCCGGGTTATTCTAGACAGCAAGGTGACCTTTCGCTCCGGACA
ACCACAATCGGTCCCTTTTC

Downstream 100 bases:

>100_bases
CCACACATCTGCCGACCTCCTCCATCGACGCCGTCACCGCGGGCCTCGCATCGGTCGGCTACATCGCCAGCCGGCAGATT
GCGACCGCGGTGTATCTCGC

Product: Acyl-CoA dehydrogenase-like

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MLQNASQAVGEITQRWRAIDATERRADPFGAMRRAGLFRIGLPGGDASLDSFTAIAVAEQAMAAATGELGLATAFAGRQL
IARFFIAGFSDDAQRSDLLPRIATGDCWAAVAISEPGAGAHPKHLQTAAEPQGDSFAISGRKAWITNGPVADLFLVLAIV
AIEDGRKRYGLFAVPRDTPGLTITPMPSLDVLAPASHCELTLDNCVVPASARIGGARDAYPAMALPFRDIEDTVGTATTA
GFLAWLLRAIAAQIEPSEDHALRLGRLKGQVALIETASRAAVLSLDDGTPPVPARLIGIRALAGSIVDDVRAHFAVARTD
DRISRALAGFDVLANVAREPRKQRQITLGQSLWSARRE

Sequences:

>Translated_358_residues
MLQNASQAVGEITQRWRAIDATERRADPFGAMRRAGLFRIGLPGGDASLDSFTAIAVAEQAMAAATGELGLATAFAGRQL
IARFFIAGFSDDAQRSDLLPRIATGDCWAAVAISEPGAGAHPKHLQTAAEPQGDSFAISGRKAWITNGPVADLFLVLAIV
AIEDGRKRYGLFAVPRDTPGLTITPMPSLDVLAPASHCELTLDNCVVPASARIGGARDAYPAMALPFRDIEDTVGTATTA
GFLAWLLRAIAAQIEPSEDHALRLGRLKGQVALIETASRAAVLSLDDGTPPVPARLIGIRALAGSIVDDVRAHFAVARTD
DRISRALAGFDVLANVAREPRKQRQITLGQSLWSARRE
>Mature_358_residues
MLQNASQAVGEITQRWRAIDATERRADPFGAMRRAGLFRIGLPGGDASLDSFTAIAVAEQAMAAATGELGLATAFAGRQL
IARFFIAGFSDDAQRSDLLPRIATGDCWAAVAISEPGAGAHPKHLQTAAEPQGDSFAISGRKAWITNGPVADLFLVLAIV
AIEDGRKRYGLFAVPRDTPGLTITPMPSLDVLAPASHCELTLDNCVVPASARIGGARDAYPAMALPFRDIEDTVGTATTA
GFLAWLLRAIAAQIEPSEDHALRLGRLKGQVALIETASRAAVLSLDDGTPPVPARLIGIRALAGSIVDDVRAHFAVARTD
DRISRALAGFDVLANVAREPRKQRQITLGQSLWSARRE

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958414, Length=265, Percent_Identity=26.0377358490566, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI226958412, Length=287, Percent_Identity=26.1324041811847, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4501859, Length=129, Percent_Identity=35.6589147286822, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI187960098, Length=165, Percent_Identity=33.9393939393939, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4557231, Length=165, Percent_Identity=33.9393939393939, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI76496475, Length=154, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI4557235, Length=154, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=186, Percent_Identity=31.1827956989247, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=207, Percent_Identity=29.4685990338164, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=136, Percent_Identity=34.5588235294118, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508101, Length=129, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71985184, Length=160, Percent_Identity=29.375, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71985192, Length=175, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17505929, Length=238, Percent_Identity=30.2521008403361, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551932, Length=205, Percent_Identity=27.8048780487805, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666513, Length=133, Percent_Identity=36.0902255639098, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646207, Length=130, Percent_Identity=36.1538461538462, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356377, Length=185, Percent_Identity=28.1081081081081, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24660351, Length=163, Percent_Identity=34.3558282208589, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355753, Length=134, Percent_Identity=32.089552238806, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 37900; Mature: 37900

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQNASQAVGEITQRWRAIDATERRADPFGAMRRAGLFRIGLPGGDASLDSFTAIAVAEQ
CCCCHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHH
AMAAATGELGLATAFAGRQLIARFFIAGFSDDAQRSDLLPRIATGDCWAAVAISEPGAGA
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCC
HPKHLQTAAEPQGDSFAISGRKAWITNGPVADLFLVLAIVAIEDGRKRYGLFAVPRDTPG
CCHHHHHCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
LTITPMPSLDVLAPASHCELTLDNCVVPASARIGGARDAYPAMALPFRDIEDTVGTATTA
EEECCCCCCCCCCCCCCCEEECCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHH
GFLAWLLRAIAAQIEPSEDHALRLGRLKGQVALIETASRAAVLSLDDGTPPVPARLIGIR
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHH
ALAGSIVDDVRAHFAVARTDDRISRALAGFDVLANVAREPRKQRQITLGQSLWSARRE
HHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLQNASQAVGEITQRWRAIDATERRADPFGAMRRAGLFRIGLPGGDASLDSFTAIAVAEQ
CCCCHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHH
AMAAATGELGLATAFAGRQLIARFFIAGFSDDAQRSDLLPRIATGDCWAAVAISEPGAGA
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCC
HPKHLQTAAEPQGDSFAISGRKAWITNGPVADLFLVLAIVAIEDGRKRYGLFAVPRDTPG
CCHHHHHCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
LTITPMPSLDVLAPASHCELTLDNCVVPASARIGGARDAYPAMALPFRDIEDTVGTATTA
EEECCCCCCCCCCCCCCCEEECCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHH
GFLAWLLRAIAAQIEPSEDHALRLGRLKGQVALIETASRAAVLSLDDGTPPVPARLIGIR
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHH
ALAGSIVDDVRAHFAVARTDDRISRALAGFDVLANVAREPRKQRQITLGQSLWSARRE
HHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]