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The map label for this gene is purC2 [H]

Identifier: 86747828

GI number: 86747828

Start: 788071

End: 788988

Strand: Reverse

Name: purC2 [H]

Synonym: RPB_0702

Alternate gene names: 86747828

Gene position: 788988-788071 (Counterclockwise)

Preceding gene: 86747829

Following gene: 86747827

Centisome position: 14.8

GC content: 68.74

Gene sequence:

>918_bases
ATGACCACGATGCTCTCGAGCGACCTGCCGCTGCCGAAGATCGGCCGCGGCAAGGTGCGCGACATCTATGCCGTCGACGC
CGACCGGCTGCTGCTGGTGACCACCGACCGGATCAGCGCCTTCGACGTGGTGATGGCCGAGACCATCCCGATGAAGGGCG
CGGTGCTGACGCAGATCAGCGCCTGGTGGTTCGACCAGCTCGGCGGCGTGGTGCCGCACCACATGATCAGCGCCGACACC
GCCGAGATCGTCGACGCCGTGCCGGCGCTGCAGGATCATCGCGCGACCCTCGCCGGCCGGACCATGCTGTGCCGGCGCAC
CACCGTGTTTCCGGTCGAATGCGTCATCCGCGGCTACATCACCGGTTCGGCCTGGAAGGAATACGCCGCGACCGGCACGC
TGGCCGGCGAGCCGCTGCCCGAGGGCCTGCAGGAAAGCGAGCATCTTCCCGCGCCGATCTTCTCGCCGGCGACCAAGGCC
GAGACCGGCCATGACGAGAACATCACCATCGCCCGAATGCGCGCCATCGTCGGCGACGAAGACGCCTATACGCTGGAGAG
CATGACGCGCGCGGTCTACACCCAAGGCGAGGCGATCGCCCGCGAGCAGGGCATCATCATCGCCGACACCAAATTCGAAT
TCGGCCGCGACGCCGACGGCCGGATCATTCTGATCGACGAGGTGATGACGCCGGATTCGTCGCGGTTCTGGGCCGCCGAC
GCCTACCAGCCGGGCCGGCCGCAGCCGTCTTTCGACAAGCAGCCGCTGCGCGACCATCTCGACGCCGAGCGCCGCGCCGG
CCGCTGGAACGGCGAAGCGCCGCCGCCGAAACTGCCCGACGTGGTGGTCGCTGCAACCAGCGCGCGCTATCTCGACGCCT
ATCGCCGGCTGACGGGCGCCGATCTCGCGATCTCCTGA

Upstream 100 bases:

>100_bases
CGAGAGCGAGTTCATTCCGCTGCCGGAATGATACACTCTCCGCTCCCATCGTTCCGCGCCGCCGGCCTGCCGGCGACGCC
TGTCGCCTGAAAGACCGCCC

Downstream 100 bases:

>100_bases
CATGACGTAGCGCAAGGCGGCGCCGGGTGCGGCGGGCATTGATCGCCCGAGATGACTGCCTCTGGAGAAGACCCATGCCG
ACCCAGAACACGGTGCTGAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase 2 [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTTMLSSDLPLPKIGRGKVRDIYAVDADRLLLVTTDRISAFDVVMAETIPMKGAVLTQISAWWFDQLGGVVPHHMISADT
AEIVDAVPALQDHRATLAGRTMLCRRTTVFPVECVIRGYITGSAWKEYAATGTLAGEPLPEGLQESEHLPAPIFSPATKA
ETGHDENITIARMRAIVGDEDAYTLESMTRAVYTQGEAIAREQGIIIADTKFEFGRDADGRIILIDEVMTPDSSRFWAAD
AYQPGRPQPSFDKQPLRDHLDAERRAGRWNGEAPPPKLPDVVVAATSARYLDAYRRLTGADLAIS

Sequences:

>Translated_305_residues
MTTMLSSDLPLPKIGRGKVRDIYAVDADRLLLVTTDRISAFDVVMAETIPMKGAVLTQISAWWFDQLGGVVPHHMISADT
AEIVDAVPALQDHRATLAGRTMLCRRTTVFPVECVIRGYITGSAWKEYAATGTLAGEPLPEGLQESEHLPAPIFSPATKA
ETGHDENITIARMRAIVGDEDAYTLESMTRAVYTQGEAIAREQGIIIADTKFEFGRDADGRIILIDEVMTPDSSRFWAAD
AYQPGRPQPSFDKQPLRDHLDAERRAGRWNGEAPPPKLPDVVVAATSARYLDAYRRLTGADLAIS
>Mature_304_residues
TTMLSSDLPLPKIGRGKVRDIYAVDADRLLLVTTDRISAFDVVMAETIPMKGAVLTQISAWWFDQLGGVVPHHMISADTA
EIVDAVPALQDHRATLAGRTMLCRRTTVFPVECVIRGYITGSAWKEYAATGTLAGEPLPEGLQESEHLPAPIFSPATKAE
TGHDENITIARMRAIVGDEDAYTLESMTRAVYTQGEAIAREQGIIIADTKFEFGRDADGRIILIDEVMTPDSSRFWAADA
YQPGRPQPSFDKQPLRDHLDAERRAGRWNGEAPPPKLPDVVVAATSARYLDAYRRLTGADLAIS

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=47.972972972973, Blast_Score=269, Evalue=5e-73,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33419; Mature: 33288

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTMLSSDLPLPKIGRGKVRDIYAVDADRLLLVTTDRISAFDVVMAETIPMKGAVLTQIS
CCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHH
AWWFDQLGGVVPHHMISADTAEIVDAVPALQDHRATLAGRTMLCRRTTVFPVECVIRGYI
HHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHC
TGSAWKEYAATGTLAGEPLPEGLQESEHLPAPIFSPATKAETGHDENITIARMRAIVGDE
CCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEHEEHHHHHCCC
DAYTLESMTRAVYTQGEAIAREQGIIIADTKFEFGRDADGRIILIDEVMTPDSSRFWAAD
CHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEC
AYQPGRPQPSFDKQPLRDHLDAERRAGRWNGEAPPPKLPDVVVAATSARYLDAYRRLTGA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCC
DLAIS
CEECC
>Mature Secondary Structure 
TTMLSSDLPLPKIGRGKVRDIYAVDADRLLLVTTDRISAFDVVMAETIPMKGAVLTQIS
CCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHH
AWWFDQLGGVVPHHMISADTAEIVDAVPALQDHRATLAGRTMLCRRTTVFPVECVIRGYI
HHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHC
TGSAWKEYAATGTLAGEPLPEGLQESEHLPAPIFSPATKAETGHDENITIARMRAIVGDE
CCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEHEEHHHHHCCC
DAYTLESMTRAVYTQGEAIAREQGIIIADTKFEFGRDADGRIILIDEVMTPDSSRFWAAD
CHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEC
AYQPGRPQPSFDKQPLRDHLDAERRAGRWNGEAPPPKLPDVVVAATSARYLDAYRRLTGA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCC
DLAIS
CEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]