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The map label for this gene is galU [C]

Identifier: 86747753

GI number: 86747753

Start: 708337

End: 709059

Strand: Direct

Name: galU [C]

Synonym: RPB_0627

Alternate gene names: 86747753

Gene position: 708337-709059 (Clockwise)

Preceding gene: 86747752

Following gene: 86747754

Centisome position: 13.29

GC content: 68.05

Gene sequence:

>723_bases
ATGTCCGTTCAACCTTCAAAAGCGATGGTTCTCGCCGCTGGTTTGGGCCTGCGGATGCGCCCGCTCACCGACCACATGCC
GAAGCCGCTGGTGTCGGTCGCCGGCAAGCCGCTGCTCGATCACGTGCTCGACCGGCTCGCCGATGCCGGCGTCGCCGAGG
CCGTGGTCAACGTGCATTATCTCCCCGACCAGATCATCGATCACACCGCCGCGCGGAAAAGCCCGCGCGTGATCATTTCG
GACGAGCGCGACGTCGTGCTCGGCACCGGTGGCGCGGTGGTGAAGGCGCTGCCGCTGCTCGGCGAGGCGCCGTTCTATCA
TCTCAACGCCGATACGCTGTGGATCGACGGCGTCCGGCCGAATCTGGCGCGGCTGGCCGATGCGTTCGATCCGGCGCGGA
TGGATATTCTGCTGCTGATGGCGCCGACCGCCGGCAGCATCGGCTATGCCGGCAAGGGCGACTTCGCCATGGCGGCCGAC
GGCACCTTGAGCAAGCGCAAGGAGAACGAGGTGACGCCGTTCGTCTATGCGGGCGTCGCCATCATGCAGCCCGCGATCTT
CCAGGACGCGCCGCAAGGCGAGTTCTCGCTGACGACGCTGTTCGACCGCGCCGCCGCGCAGCAGCGGCTGTTCGGGCTGC
GGCTCGACGGCGTCTGGATGCATGTCGGAACTCCGGACGCGGTCGCCGCGGCCGAGCGCGCCTATCTGGCCAGCGTCGCG
TGA

Upstream 100 bases:

>100_bases
AATACCCAAAGATCGCCAAGATGAGCGCCGATAGACCGGCTGGTGCTGCGTGATACAATCGATTCGCACCGAGCCGGTCG
GGTCCCAACAACGAGCGACG

Downstream 100 bases:

>100_bases
CGCGCCGCCCGGCACCTCCCGTGCCGGTCCGCCGCATGCCATGATCGCCTGATCGCCGAATCAGGATTGTCATGCGCGTT
TTCAGTGTCCCGCCCTCCGC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSVQPSKAMVLAAGLGLRMRPLTDHMPKPLVSVAGKPLLDHVLDRLADAGVAEAVVNVHYLPDQIIDHTAARKSPRVIIS
DERDVVLGTGGAVVKALPLLGEAPFYHLNADTLWIDGVRPNLARLADAFDPARMDILLLMAPTAGSIGYAGKGDFAMAAD
GTLSKRKENEVTPFVYAGVAIMQPAIFQDAPQGEFSLTTLFDRAAAQQRLFGLRLDGVWMHVGTPDAVAAAERAYLASVA

Sequences:

>Translated_240_residues
MSVQPSKAMVLAAGLGLRMRPLTDHMPKPLVSVAGKPLLDHVLDRLADAGVAEAVVNVHYLPDQIIDHTAARKSPRVIIS
DERDVVLGTGGAVVKALPLLGEAPFYHLNADTLWIDGVRPNLARLADAFDPARMDILLLMAPTAGSIGYAGKGDFAMAAD
GTLSKRKENEVTPFVYAGVAIMQPAIFQDAPQGEFSLTTLFDRAAAQQRLFGLRLDGVWMHVGTPDAVAAAERAYLASVA
>Mature_239_residues
SVQPSKAMVLAAGLGLRMRPLTDHMPKPLVSVAGKPLLDHVLDRLADAGVAEAVVNVHYLPDQIIDHTAARKSPRVIISD
ERDVVLGTGGAVVKALPLLGEAPFYHLNADTLWIDGVRPNLARLADAFDPARMDILLLMAPTAGSIGYAGKGDFAMAADG
TLSKRKENEVTPFVYAGVAIMQPAIFQDAPQGEFSLTTLFDRAAAQQRLFGLRLDGVWMHVGTPDAVAAAERAYLASVA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=242, Percent_Identity=28.099173553719, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI11761619, Length=242, Percent_Identity=28.099173553719, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=228, Percent_Identity=29.3859649122807, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355443, Length=241, Percent_Identity=26.9709543568465, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644084, Length=241, Percent_Identity=26.9709543568465, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 25545; Mature: 25414

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQPSKAMVLAAGLGLRMRPLTDHMPKPLVSVAGKPLLDHVLDRLADAGVAEAVVNVHY
CCCCCCCEEEEEECCCCEECCCHHCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHEEE
LPDQIIDHTAARKSPRVIISDERDVVLGTGGAVVKALPLLGEAPFYHLNADTLWIDGVRP
CCHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCEEEECCCEEEEECCCC
NLARLADAFDPARMDILLLMAPTAGSIGYAGKGDFAMAADGTLSKRKENEVTPFVYAGVA
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHH
IMQPAIFQDAPQGEFSLTTLFDRAAAQQRLFGLRLDGVWMHVGTPDAVAAAERAYLASVA
HHCHHHHCCCCCCCEEHHHHHHHHHHHHHHHEEEECCEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVQPSKAMVLAAGLGLRMRPLTDHMPKPLVSVAGKPLLDHVLDRLADAGVAEAVVNVHY
CCCCCCEEEEEECCCCEECCCHHCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHEEE
LPDQIIDHTAARKSPRVIISDERDVVLGTGGAVVKALPLLGEAPFYHLNADTLWIDGVRP
CCHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCEEEECCCEEEEECCCC
NLARLADAFDPARMDILLLMAPTAGSIGYAGKGDFAMAADGTLSKRKENEVTPFVYAGVA
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHH
IMQPAIFQDAPQGEFSLTTLFDRAAAQQRLFGLRLDGVWMHVGTPDAVAAAERAYLASVA
HHCHHHHCCCCCCCEEHHHHHHHHHHHHHHHEEEECCEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA