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The map label for this gene is groEL

Identifier: 86609080

GI number: 86609080

Start: 1690530

End: 1692164

Strand: Reverse

Name: groEL

Synonym: CYB_1618

Alternate gene names: 86609080

Gene position: 1692164-1690530 (Counterclockwise)

Preceding gene: 86609081

Following gene: 86609079

Centisome position: 55.54

GC content: 59.33

Gene sequence:

>1635_bases
ATGGCCAAATCAATCATCTTCAGTGAAGAAGCCCGCCGCGCTCTAGAGCACGGCATGGATATTTTGGCAGAAGCCGTAGC
CGTTACCCTGGGTCCCAAAGGGCGCAACGTCGTGCTGGAGAAGAAGTTTGGCGCCCCCCAAATCATCAACGACGGGGTAA
CCATTGCCAAAGAAATCGAGCTGGAAGACCATATTGAGAACACAGGCGTTTCCTTGATCCGGCAGGCGGCTTCCAAGACC
AATGACACGGCTGGGGATGGCACCACCACGGCCACGGTCTTGGCTCACGCCATGGTGAAAGAAGGTCTGAAAAACGTGGC
TGCCGGCGCCAACCCGATTGCCCTAAAGCGAGGGATCGACAAGGCGGTGAAGTTTTTGGTAGACAAAATCGCCGAACATG
CCCGCCCGGTCGAAGATTCCAAAGCCATTGCCCAGGTGGCGGCCATTTCCGCCGGTAACGATGAAGAAGTGGGCCGTATG
ATTGCCGAGGCCATGGACAAGGTGGGCCGCGAAGGGGTGATCTCCCTGGAAGAAGGCAAGTCCATGACCACCGAGCTGGA
AGTGACGGAAGGGATGCGCTTCGACAAGGGCTACATCTCCCCTTACTTCGTCACCGATACCGAGCGGATGGAAGCGGTTC
TGGAAAACCCCTACATCCTCATCACCGATAAGAAGATCACCCTGGTGCAAGACCTGGTACCGGTTCTGGAGCAGGTGGCC
CGCGCCGGTCGTCCTCTGCTGATCATCGCCGAAGACATCGAGAAAGAAGCGCTGGCTACCCTGGTGGTGAACAAGCTGCG
GGGTGTGCTGAGCGTGGTAGCGGTAAAAGCCCCTGGCTTCGGGGATCGCCGCAAGGCCATGCTGGAAGACATCGCCATCC
TGACCGGCGGTGAGGTGATCAGCGAAGAGCGAGGCCTGAAGCTGGAGAACGCTCGCCTCGATTCCTTCGGCACTGCCCGT
CGCGTCACGGTGACCAAGGACAACACCACCATCGTGGCGGAAGGCAACGAAGCGGCTGTGAAAGCCCGTTGCGAGCAAAT
TCGTCGCCAAATTGAGGAAACCGACTCCACCTACGACAAAGAAAAACTGCAAGAGCGCCTGGCCAAGCTCTCCGGCGGTG
TGGCAGTGATCAAAGTGGGCGCGGCCACTGAAACCGAGATGAAAGACCGCAAGTTGCGCCTGGAAGATGCCATCAACGCC
ACCAAAGCGGCGGTAGAAGAAGGGATCGTTCCCGGCGGCGGTACCACCTTGGCACACCTGATCCCAGTGGTAACCGAGTG
GGCGCAAGCCAACCTGTCCGGCGATGAACTGGTGGGGGCCAACCTGGTCGCCCGCGCTCTGGGCGCTCCGCTGCGCCGCA
TTGCTGAGAACGCCGGCCAAAACGGCTCCATTGTGCTGGAGCGGGTGAAAGATAAGCCCTTCAACACCGGCTACGATGCC
CAGAACGACGCCTTCGTGGATATGTTCGAGGCGGGCATTGTAGACCCGGCCAAGGTTACCCGTTCTGCCCTGCAAAACGC
CGCTTCCATTGCGGGGATGGTGCTGACCACTGAAGCGATCGTGGTGGACAAGCCCGAGCCCAAAACCAACACGCCGGCAA
GCAGCGGCAGCGGCATGAGTGACTACGACTACTAA

Upstream 100 bases:

>100_bases
TGTTCAGTAATGGTCAGTGATTCAGCAGCAGTTCAACGAACGATTGAATCCTTGAGACTCTGTTTCACCCTTACCTGCAT
TTGCATCGGAGAGGTTGACT

Downstream 100 bases:

>100_bases
TCCGTTGACCGCCACAGCGAGGTGGATCCCTGAGGCTCACCGAAGAGCCCATGGGCACTTCGCTTCCTGGCCAGGCATCT
TGGATGAATCTTTCGGGATC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKSIIFSEEARRALEHGMDILAEAVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVSLIRQAASKT
NDTAGDGTTTATVLAHAMVKEGLKNVAAGANPIALKRGIDKAVKFLVDKIAEHARPVEDSKAIAQVAAISAGNDEEVGRM
IAEAMDKVGREGVISLEEGKSMTTELEVTEGMRFDKGYISPYFVTDTERMEAVLENPYILITDKKITLVQDLVPVLEQVA
RAGRPLLIIAEDIEKEALATLVVNKLRGVLSVVAVKAPGFGDRRKAMLEDIAILTGGEVISEERGLKLENARLDSFGTAR
RVTVTKDNTTIVAEGNEAAVKARCEQIRRQIEETDSTYDKEKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLIPVVTEWAQANLSGDELVGANLVARALGAPLRRIAENAGQNGSIVLERVKDKPFNTGYDA
QNDAFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTEAIVVDKPEPKTNTPASSGSGMSDYDY

Sequences:

>Translated_544_residues
MAKSIIFSEEARRALEHGMDILAEAVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVSLIRQAASKT
NDTAGDGTTTATVLAHAMVKEGLKNVAAGANPIALKRGIDKAVKFLVDKIAEHARPVEDSKAIAQVAAISAGNDEEVGRM
IAEAMDKVGREGVISLEEGKSMTTELEVTEGMRFDKGYISPYFVTDTERMEAVLENPYILITDKKITLVQDLVPVLEQVA
RAGRPLLIIAEDIEKEALATLVVNKLRGVLSVVAVKAPGFGDRRKAMLEDIAILTGGEVISEERGLKLENARLDSFGTAR
RVTVTKDNTTIVAEGNEAAVKARCEQIRRQIEETDSTYDKEKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLIPVVTEWAQANLSGDELVGANLVARALGAPLRRIAENAGQNGSIVLERVKDKPFNTGYDA
QNDAFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTEAIVVDKPEPKTNTPASSGSGMSDYDY
>Mature_543_residues
AKSIIFSEEARRALEHGMDILAEAVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVSLIRQAASKTN
DTAGDGTTTATVLAHAMVKEGLKNVAAGANPIALKRGIDKAVKFLVDKIAEHARPVEDSKAIAQVAAISAGNDEEVGRMI
AEAMDKVGREGVISLEEGKSMTTELEVTEGMRFDKGYISPYFVTDTERMEAVLENPYILITDKKITLVQDLVPVLEQVAR
AGRPLLIIAEDIEKEALATLVVNKLRGVLSVVAVKAPGFGDRRKAMLEDIAILTGGEVISEERGLKLENARLDSFGTARR
VTVTKDNTTIVAEGNEAAVKARCEQIRRQIEETDSTYDKEKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINAT
KAAVEEGIVPGGGTTLAHLIPVVTEWAQANLSGDELVGANLVARALGAPLRRIAENAGQNGSIVLERVKDKPFNTGYDAQ
NDAFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTEAIVVDKPEPKTNTPASSGSGMSDYDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=46.6793168880455, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=46.6793168880455, Blast_Score=484, Evalue=1e-136,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=58.7901701323251, Blast_Score=600, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=46.969696969697, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=46.1904761904762, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=50, Blast_Score=513, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322524, Length=583, Percent_Identity=21.7838765008576, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=47.6280834914611, Blast_Score=490, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=47.6280834914611, Blast_Score=490, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=46.5779467680608, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=46.5779467680608, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=46.5779467680608, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=41.1764705882353, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=37.1482176360225, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=37.1482176360225, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_SYNJB (Q2JL43)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_477842.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2JL43
- SMR:   Q2JL43
- STRING:   Q2JL43
- GeneID:   3901738
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1618
- TIGR:   CYB_1618
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   ATSQANE
- ProtClustDB:   PRK00013
- BioCyc:   SSP321332:CYB_1618-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58158; Mature: 58027

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSIIFSEEARRALEHGMDILAEAVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVSLIRQAASKTNDTAGDGTTTATVLAHAMVKEGLKNVAAGANPIALKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVKFLVDKIAEHARPVEDSKAIAQVAAISAGNDEEVGRMIAEAMDKVGREGVISLEEGK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFVTDTERMEAVLENPYILITDKKITLVQDLVPVLEQVA
CCEEEEEHHCCCEECCCCCCCEEECCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RAGRPLLIIAEDIEKEALATLVVNKLRGVLSVVAVKAPGFGDRRKAMLEDIAILTGGEVI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
SEERGLKLENARLDSFGTARRVTVTKDNTTIVAEGNEAAVKARCEQIRRQIEETDSTYDK
HHCCCCEEECCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
EKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IPVVTEWAQANLSGDELVGANLVARALGAPLRRIAENAGQNGSIVLERVKDKPFNTGYDA
HHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
QNDAFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTEAIVVDKPEPKTNTPASSGSGMS
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCC
DYDY
CCCC
>Mature Secondary Structure 
AKSIIFSEEARRALEHGMDILAEAVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVSLIRQAASKTNDTAGDGTTTATVLAHAMVKEGLKNVAAGANPIALKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVKFLVDKIAEHARPVEDSKAIAQVAAISAGNDEEVGRMIAEAMDKVGREGVISLEEGK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFVTDTERMEAVLENPYILITDKKITLVQDLVPVLEQVA
CCEEEEEHHCCCEECCCCCCCEEECCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RAGRPLLIIAEDIEKEALATLVVNKLRGVLSVVAVKAPGFGDRRKAMLEDIAILTGGEVI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
SEERGLKLENARLDSFGTARRVTVTKDNTTIVAEGNEAAVKARCEQIRRQIEETDSTYDK
HHCCCCEEECCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
EKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IPVVTEWAQANLSGDELVGANLVARALGAPLRRIAENAGQNGSIVLERVKDKPFNTGYDA
HHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
QNDAFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTEAIVVDKPEPKTNTPASSGSGMS
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCC
DYDY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA