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The map label for this gene is merR1 [H]

Identifier: 86608567

GI number: 86608567

Start: 1125636

End: 1126115

Strand: Reverse

Name: merR1 [H]

Synonym: CYB_1088

Alternate gene names: 86608567

Gene position: 1126115-1125636 (Counterclockwise)

Preceding gene: 86608568

Following gene: 86608563

Centisome position: 36.96

GC content: 57.08

Gene sequence:

>480_bases
TTGTCTGCCAGCCTGAAGATCGGCCAGGTGGCATTGGCAGCTGGCTTGTCCGTGCGCACGGTGCGTTACTACGAGTCGAT
TGGCCTGCTGAAGCCAACGGTGGAACGGGCGGAGTCCAGCTATCGATTGTTCGACCCTTCGGTTTTGGTTCGCCTGGCTT
TTATCCGCCGCTGCCAGAGCCTGGGCCTGAGCTTAGAAGAAATCCGCCAAATCCTGGATGTCCACGACCGAGGGGAGCAG
CCTTGTCCAGAAATTCGCCAGCATCTGCAAGGCAAGCTGCAGGAGATTGAACAGCGAATTGCCGATCTGCAAGCGCTGAA
AAGCCAAATTCAAGGTCTCCTCTCCGATTGGCAAATCACCCCTGCGGCTGCTGATGAAAAAGAGGTGATCTGCCCGATTT
TGCAAAAACCAGAGGCCAGGGGCGGCAAGGGCAACAGCCGTTACTCCACCGTTACCGACTTGGCCAAGTTGCGCGGCTGA

Upstream 100 bases:

>100_bases
CGGAGCGCTTTGCGTCAGCATGAGTGTGGGAGTATGTCACGCTGAAGAAATCTACAGGGATCCAGTTGGGGACATGTCGA
ATCCTGCTGCTGTCCAGGAC

Downstream 100 bases:

>100_bases
TCCACATCGGCTCCGCGGCGCAAAGCCATGGCGTAGGCGAACAACTGCAGGGGGATCACGTTCAGAACCGCCGACAACAG
GGGTGTCGTGCTGGGCACCT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MSASLKIGQVALAAGLSVRTVRYYESIGLLKPTVERAESSYRLFDPSVLVRLAFIRRCQSLGLSLEEIRQILDVHDRGEQ
PCPEIRQHLQGKLQEIEQRIADLQALKSQIQGLLSDWQITPAAADEKEVICPILQKPEARGGKGNSRYSTVTDLAKLRG

Sequences:

>Translated_159_residues
MSASLKIGQVALAAGLSVRTVRYYESIGLLKPTVERAESSYRLFDPSVLVRLAFIRRCQSLGLSLEEIRQILDVHDRGEQ
PCPEIRQHLQGKLQEIEQRIADLQALKSQIQGLLSDWQITPAAADEKEVICPILQKPEARGGKGNSRYSTVTDLAKLRG
>Mature_158_residues
SASLKIGQVALAAGLSVRTVRYYESIGLLKPTVERAESSYRLFDPSVLVRLAFIRRCQSLGLSLEEIRQILDVHDRGEQP
CPEIRQHLQGKLQEIEQRIADLQALKSQIQGLLSDWQITPAAADEKEVICPILQKPEARGGKGNSRYSTVTDLAKLRG

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=140, Percent_Identity=37.8571428571429, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1786695, Length=132, Percent_Identity=26.5151515151515, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 17709; Mature: 17577

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASLKIGQVALAAGLSVRTVRYYESIGLLKPTVERAESSYRLFDPSVLVRLAFIRRCQS
CCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LGLSLEEIRQILDVHDRGEQPCPEIRQHLQGKLQEIEQRIADLQALKSQIQGLLSDWQIT
HCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAAADEKEVICPILQKPEARGGKGNSRYSTVTDLAKLRG
CCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SASLKIGQVALAAGLSVRTVRYYESIGLLKPTVERAESSYRLFDPSVLVRLAFIRRCQS
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LGLSLEEIRQILDVHDRGEQPCPEIRQHLQGKLQEIEQRIADLQALKSQIQGLLSDWQIT
HCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAAADEKEVICPILQKPEARGGKGNSRYSTVTDLAKLRG
CCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]