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The map label for this gene is hemL [H]

Identifier: 86608491

GI number: 86608491

Start: 1050866

End: 1052176

Strand: Direct

Name: hemL [H]

Synonym: CYB_1012

Alternate gene names: 86608491

Gene position: 1050866-1052176 (Clockwise)

Preceding gene: 86608490

Following gene: 86608492

Centisome position: 34.49

GC content: 61.33

Gene sequence:

>1311_bases
ATGACCAGCACTCTCCACTCCACCTCGTTTAACACCACCCGCTCCAAGCAGGTTTTTGCCCGGGCACAAAGCCTCATGCC
GGGGGGGGTTAGTTCTCCGGTACGGGCCTTCAAGTCGGTGGGCGGGGATCCCGTCGTGTTCGACCGTGTCTCAGGGGCCT
ACGCCTGGGATGTGGACGGCAACCAATACATCGACTACATCGGCAGTTGGGGGCCGGCGATTGTTGGCCACGCTCACCCC
GAGGTCATTGAGGCTCTGCGCCGAGCTTTGGAGAAAGGCACCAGCTTCGGCGCCCCTTGCGTTCTGGAAAATGAGCTGGC
GGAGCGGGTCATTGAGGCGGTGCCCAGTGTGGAGATGGTGCGCTTTGTCAATTCCGGCACCGAAGCTTGCATGGCGGTGC
TGCGCTTGATGCGGGCCTATACCGGTCGGGAAAAGGTGATCAAGTTTGAGGGCTGCTACCACGGCCATGCGGACATGTTT
TTGGTGAAGGCCGGTTCGGGGGTGGCCACGCTGGGCTTGCCAGACTCGCCGGGGGTGCCCAAGGCAGCTACCAGCGCTAC
GCTGACGGCTCCCTACAACGACCTGGAGGCAGTCAAGGCCCTGTTTGAACAGCACCCCGACTCCATTGCCGGAGTCATCC
TAGAGCCGGTGGTGGGCAATGCCGGCTTTATTCCCCCCCAGCCGGGCTTCTTGGAAGGCTTGCGAGATCTCACCCAAAAG
TACGGGGCCCTGCTGGTATTTGACGAGGTGATGACCGGCTTTCGCATCAGCTATGGCGGTGTACAGGCCAAGTTTGGGGT
CATCCCCGATTTAACGACCCTGGGCAAGGTCATCGGCGGCGGCCTGCCGGTGGGGGCCTACGGCGGTCGGCGAGAAATTA
TGGAAATGGTGGCTCCAGCGGGGCCGATGTATCAGGCAGGGACTCTTTCCGGCAACCCCCTGGCCATGACAGCAGGGATC
CAGACACTGGATATTTTGCGTCGTCCGGGCACCTACGAGTACCTGGAGCGGATTACCGAGAAGTTGGCGACGGGGCTATT
GCAGATCGCGCGGGAAACGGGGCATGAGATGTGCGGGGGCTATCTGCCCGGCATGTTTGGCTTCTTTTTTACTGCCGGCC
CAGTGCGCAACTACGAAGAGGCCAAGACTTCCGATCTGCAGAAATTTGCCCGCTTCCATCGCGGCATGTTGGAGCGGGGA
GTCTATCTGGCGCCCTCGCAATTTGAGGCCGGCTTCACCTCCCTGGCCCACACAGAGGCCGATGTGGAGAAAACTCTAGC
CGCCGCGCGAGAGGTGTTGAGCACCCTCTGA

Upstream 100 bases:

>100_bases
GGCAGGGATGGGTTTGTAGTTTCATGGTCGGTAAAAGGGCTCACCAGAAAGCTCCCTTGCTTGCTAGCCTTGGTAATGCG
TTGAAAGCTCCTTATGCTCT

Downstream 100 bases:

>100_bases
GTCTGCAATTCACCCTCTTTCGAGGCGGGATCCCTGCCATGGCCGAGCACATCCACCGCAACTGGAGCATCACTACCCAA
GCTACAGAGAAGGGGTTTAT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTSTLHSTSFNTTRSKQVFARAQSLMPGGVSSPVRAFKSVGGDPVVFDRVSGAYAWDVDGNQYIDYIGSWGPAIVGHAHP
EVIEALRRALEKGTSFGAPCVLENELAERVIEAVPSVEMVRFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMF
LVKAGSGVATLGLPDSPGVPKAATSATLTAPYNDLEAVKALFEQHPDSIAGVILEPVVGNAGFIPPQPGFLEGLRDLTQK
YGALLVFDEVMTGFRISYGGVQAKFGVIPDLTTLGKVIGGGLPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGI
QTLDILRRPGTYEYLERITEKLATGLLQIARETGHEMCGGYLPGMFGFFFTAGPVRNYEEAKTSDLQKFARFHRGMLERG
VYLAPSQFEAGFTSLAHTEADVEKTLAAAREVLSTL

Sequences:

>Translated_436_residues
MTSTLHSTSFNTTRSKQVFARAQSLMPGGVSSPVRAFKSVGGDPVVFDRVSGAYAWDVDGNQYIDYIGSWGPAIVGHAHP
EVIEALRRALEKGTSFGAPCVLENELAERVIEAVPSVEMVRFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMF
LVKAGSGVATLGLPDSPGVPKAATSATLTAPYNDLEAVKALFEQHPDSIAGVILEPVVGNAGFIPPQPGFLEGLRDLTQK
YGALLVFDEVMTGFRISYGGVQAKFGVIPDLTTLGKVIGGGLPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGI
QTLDILRRPGTYEYLERITEKLATGLLQIARETGHEMCGGYLPGMFGFFFTAGPVRNYEEAKTSDLQKFARFHRGMLERG
VYLAPSQFEAGFTSLAHTEADVEKTLAAAREVLSTL
>Mature_435_residues
TSTLHSTSFNTTRSKQVFARAQSLMPGGVSSPVRAFKSVGGDPVVFDRVSGAYAWDVDGNQYIDYIGSWGPAIVGHAHPE
VIEALRRALEKGTSFGAPCVLENELAERVIEAVPSVEMVRFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFL
VKAGSGVATLGLPDSPGVPKAATSATLTAPYNDLEAVKALFEQHPDSIAGVILEPVVGNAGFIPPQPGFLEGLRDLTQKY
GALLVFDEVMTGFRISYGGVQAKFGVIPDLTTLGKVIGGGLPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIQ
TLDILRRPGTYEYLERITEKLATGLLQIARETGHEMCGGYLPGMFGFFFTAGPVRNYEEAKTSDLQKFARFHRGMLERGV
YLAPSQFEAGFTSLAHTEADVEKTLAAAREVLSTL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=316, Percent_Identity=29.4303797468354, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI37574042, Length=312, Percent_Identity=29.1666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI24119277, Length=343, Percent_Identity=27.6967930029155, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13994255, Length=340, Percent_Identity=26.4705882352941, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI226442705, Length=309, Percent_Identity=27.5080906148867, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226442709, Length=278, Percent_Identity=28.4172661870504, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI284507298, Length=165, Percent_Identity=31.5151515151515, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786349, Length=425, Percent_Identity=55.0588235294118, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI1789016, Length=351, Percent_Identity=31.6239316239316, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1789759, Length=315, Percent_Identity=33.6507936507937, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788044, Length=316, Percent_Identity=33.2278481012658, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI145693181, Length=327, Percent_Identity=30.5810397553517, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1787560, Length=311, Percent_Identity=29.903536977492, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786991, Length=370, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71992977, Length=409, Percent_Identity=26.6503667481663, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=301, Percent_Identity=29.5681063122924, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=167, Percent_Identity=33.5329341317365, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323470, Length=304, Percent_Identity=27.9605263157895, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=314, Percent_Identity=25.796178343949, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356575, Length=318, Percent_Identity=28.9308176100629, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21357415, Length=300, Percent_Identity=26.6666666666667, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46729; Mature: 46598

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTLHSTSFNTTRSKQVFARAQSLMPGGVSSPVRAFKSVGGDPVVFDRVSGAYAWDVDG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCC
NQYIDYIGSWGPAIVGHAHPEVIEALRRALEKGTSFGAPCVLENELAERVIEAVPSVEMV
CHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCHHHH
RFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVP
HHHHCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCC
KAATSATLTAPYNDLEAVKALFEQHPDSIAGVILEPVVGNAGFIPPQPGFLEGLRDLTQK
CCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGALLVFDEVMTGFRISYGGVQAKFGVIPDLTTLGKVIGGGLPVGAYGGRREIMEMVAPA
HCCEEEHHHHHHCCEEECCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCC
GPMYQAGTLSGNPLAMTAGIQTLDILRRPGTYEYLERITEKLATGLLQIARETGHEMCGG
CCCCCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YLPGMFGFFFTAGPVRNYEEAKTSDLQKFARFHRGMLERGVYLAPSQFEAGFTSLAHTEA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHH
DVEKTLAAAREVLSTL
HHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TSTLHSTSFNTTRSKQVFARAQSLMPGGVSSPVRAFKSVGGDPVVFDRVSGAYAWDVDG
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCC
NQYIDYIGSWGPAIVGHAHPEVIEALRRALEKGTSFGAPCVLENELAERVIEAVPSVEMV
CHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCHHHH
RFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVP
HHHHCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCC
KAATSATLTAPYNDLEAVKALFEQHPDSIAGVILEPVVGNAGFIPPQPGFLEGLRDLTQK
CCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGALLVFDEVMTGFRISYGGVQAKFGVIPDLTTLGKVIGGGLPVGAYGGRREIMEMVAPA
HCCEEEHHHHHHCCEEECCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCC
GPMYQAGTLSGNPLAMTAGIQTLDILRRPGTYEYLERITEKLATGLLQIARETGHEMCGG
CCCCCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YLPGMFGFFFTAGPVRNYEEAKTSDLQKFARFHRGMLERGVYLAPSQFEAGFTSLAHTEA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHH
DVEKTLAAAREVLSTL
HHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA