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The map label for this gene is cobW [H]

Identifier: 86608334

GI number: 86608334

Start: 885361

End: 886419

Strand: Reverse

Name: cobW [H]

Synonym: CYB_0852

Alternate gene names: 86608334

Gene position: 886419-885361 (Counterclockwise)

Preceding gene: 86608335

Following gene: 86608332

Centisome position: 29.09

GC content: 60.72

Gene sequence:

>1059_bases
ATGCACAAGATCCCTGTTACCGTCATCACCGGATTTCTGGGATCCGGCAAGACCACGGTGATCCGTCACCTTTTGCTCAA
CAACCAGGGCCGCCGCATTGCCGTGTTGGTTAACGAGTTTGGCGAAGTGGGCATCGACGGCGAGTTGCTGCGGGACTGCC
AACGGTGTGAGGGGGAGGGATCCATCCCCATTTTGGAGCTGGCCAACGGCTGTCTCTGCTGCACGGTGCAGGAGGAGTTC
TTGCCCACCATGGAAGCTTTGTTGCAACGGCGGGCAGAGCTGGACTGCATCCTGATCGAGACTTCAGGATTGGCCTTGCC
CAAGCCCCTGGTGCAGGCTTTCCGCTGGCCCACCATTCGTACAGGCGCCACGGTGGATGCGGTGATTACGGTGGTGGATG
GTCAGGCTCTGGCCTCCGGGCAACTGGTGGGGGATCCGGCGGCCCTGGAGGCGCAGCGGCAGGCTGACGAAAGTTTGGAC
CATGAGACTCCGCTTGAGGAATTGTTTGAGGATCAGTTGAGCTGTGCCGATTTGGTGGTGCTCACCAAGGTGGATCAGAT
TACCCAAGAGGAGCAAGCTCGGGTGGAAAGCTGGCTGCGGCACCACTTGCGCCCTGAGGTTCAAATCCTCCCTTGTGAGC
GGGGGCAGGTTCCCCCAGAAGTGCTCTTGGGCTTTAATGCGGCGGTGGAAGACCAGCTCGAGCGCCGCCCCAGCCACCAC
GATCACGGGGAGGAGCATGAGCACGAAGCTTTTGAGTCTTTCTACCTCAGCTTGGAGGGAGGTTATGAGCCGGGATCCCT
GGTGGCTCAGCTACGCCAGTTGGCCCAAGAGGAATGTCTTTACCGGATAAAAGGGTTTGTGGCCGTCCCCTACAAGCCGA
TGCGCCTGGTGCTGCAGGGGGTGGGATCCCGATTTGAAACCTACTACGACCGCCCCTGGCGACCCCAGGAGCCGCGCTTG
ACCCGACTGGTGCTGATTGGGCAAAACCTCAACCGCGAGCGCATTGCCGCCCAGCTCCAGGCCTTGGCCATCAGAGAAAC
GGTGTCCCCCACCGGCTGA

Upstream 100 bases:

>100_bases
GGCCCCCATACCGGGGGCCTTTTTTGGGCATCCCCCCCTCAAGGATTGGCAGAAAGAAAGTTTGGGGTGGAAACTGAAGA
GCGCTGAGTCATCAGAGCAG

Downstream 100 bases:

>100_bases
TCCCTGTCGGAGGCGAGTGGGATCCCTTGGGTCCTCGGCTCTCATCCCCCCGTCCCAGAGGGAAAGGAAGCAGCGTCCAG
TTCTACTGTTACTCAAAGGT

Product: cobalamin biosynthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MHKIPVTVITGFLGSGKTTVIRHLLLNNQGRRIAVLVNEFGEVGIDGELLRDCQRCEGEGSIPILELANGCLCCTVQEEF
LPTMEALLQRRAELDCILIETSGLALPKPLVQAFRWPTIRTGATVDAVITVVDGQALASGQLVGDPAALEAQRQADESLD
HETPLEELFEDQLSCADLVVLTKVDQITQEEQARVESWLRHHLRPEVQILPCERGQVPPEVLLGFNAAVEDQLERRPSHH
DHGEEHEHEAFESFYLSLEGGYEPGSLVAQLRQLAQEECLYRIKGFVAVPYKPMRLVLQGVGSRFETYYDRPWRPQEPRL
TRLVLIGQNLNRERIAAQLQALAIRETVSPTG

Sequences:

>Translated_352_residues
MHKIPVTVITGFLGSGKTTVIRHLLLNNQGRRIAVLVNEFGEVGIDGELLRDCQRCEGEGSIPILELANGCLCCTVQEEF
LPTMEALLQRRAELDCILIETSGLALPKPLVQAFRWPTIRTGATVDAVITVVDGQALASGQLVGDPAALEAQRQADESLD
HETPLEELFEDQLSCADLVVLTKVDQITQEEQARVESWLRHHLRPEVQILPCERGQVPPEVLLGFNAAVEDQLERRPSHH
DHGEEHEHEAFESFYLSLEGGYEPGSLVAQLRQLAQEECLYRIKGFVAVPYKPMRLVLQGVGSRFETYYDRPWRPQEPRL
TRLVLIGQNLNRERIAAQLQALAIRETVSPTG
>Mature_352_residues
MHKIPVTVITGFLGSGKTTVIRHLLLNNQGRRIAVLVNEFGEVGIDGELLRDCQRCEGEGSIPILELANGCLCCTVQEEF
LPTMEALLQRRAELDCILIETSGLALPKPLVQAFRWPTIRTGATVDAVITVVDGQALASGQLVGDPAALEAQRQADESLD
HETPLEELFEDQLSCADLVVLTKVDQITQEEQARVESWLRHHLRPEVQILPCERGQVPPEVLLGFNAAVEDQLERRPSHH
DHGEEHEHEAFESFYLSLEGGYEPGSLVAQLRQLAQEECLYRIKGFVAVPYKPMRLVLQGVGSRFETYYDRPWRPQEPRL
TRLVLIGQNLNRERIAAQLQALAIRETVSPTG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=366, Percent_Identity=29.2349726775956, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI33469141, Length=366, Percent_Identity=29.2349726775956, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI148727351, Length=366, Percent_Identity=29.2349726775956, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI146231952, Length=366, Percent_Identity=29.5081967213115, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI223941779, Length=363, Percent_Identity=28.6501377410468, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI223941776, Length=355, Percent_Identity=27.6056338028169, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI119120938, Length=135, Percent_Identity=42.2222222222222, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082430, Length=349, Percent_Identity=29.512893982808, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788499, Length=335, Percent_Identity=28.955223880597, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324356, Length=368, Percent_Identity=26.0869565217391, Blast_Score=102, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39342; Mature: 39342

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKIPVTVITGFLGSGKTTVIRHLLLNNQGRRIAVLVNEFGEVGIDGELLRDCQRCEGEG
CCCCCHHHEECCCCCCHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHCCCC
SIPILELANGCLCCTVQEEFLPTMEALLQRRAELDCILIETSGLALPKPLVQAFRWPTIR
CCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCC
TGATVDAVITVVDGQALASGQLVGDPAALEAQRQADESLDHETPLEELFEDQLSCADLVV
CCCCHHHEEEEECCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LTKVDQITQEEQARVESWLRHHLRPEVQILPCERGQVPPEVLLGFNAAVEDQLERRPSHH
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCHHHHHHHHHCCCCC
DHGEEHEHEAFESFYLSLEGGYEPGSLVAQLRQLAQEECLYRIKGFVAVPYKPMRLVLQG
CCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHH
VGSRFETYYDRPWRPQEPRLTRLVLIGQNLNRERIAAQLQALAIRETVSPTG
HHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHKIPVTVITGFLGSGKTTVIRHLLLNNQGRRIAVLVNEFGEVGIDGELLRDCQRCEGEG
CCCCCHHHEECCCCCCHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHCCCC
SIPILELANGCLCCTVQEEFLPTMEALLQRRAELDCILIETSGLALPKPLVQAFRWPTIR
CCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCC
TGATVDAVITVVDGQALASGQLVGDPAALEAQRQADESLDHETPLEELFEDQLSCADLVV
CCCCHHHEEEEECCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LTKVDQITQEEQARVESWLRHHLRPEVQILPCERGQVPPEVLLGFNAAVEDQLERRPSHH
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCHHHHHHHHHCCCCC
DHGEEHEHEAFESFYLSLEGGYEPGSLVAQLRQLAQEECLYRIKGFVAVPYKPMRLVLQG
CCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHH
VGSRFETYYDRPWRPQEPRLTRLVLIGQNLNRERIAAQLQALAIRETVSPTG
HHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]