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The map label for this gene is rnc [H]

Identifier: 86608239

GI number: 86608239

Start: 777394

End: 778116

Strand: Direct

Name: rnc [H]

Synonym: CYB_0755

Alternate gene names: 86608239

Gene position: 777394-778116 (Clockwise)

Preceding gene: 86608237

Following gene: 86608240

Centisome position: 25.52

GC content: 59.2

Gene sequence:

>723_bases
ATGGTTGAGTTGATCCCGCCCCGTCGCCGTGCCTTGGAGCATTTGCTGGCCCGCCTTGGATTCAGGGATCCGGCTTTGCT
GGAACAACTGCGTTGGGATCTGCTGGATCAGGCTCTGATTCACCCTTCTCTGGATGGCCGACGGAACAACGATCGGCTGG
AGTTGTTGGGGGATTCTGTCCTGCGAATTTTGGTTACGGAATTCTTGTTTCAGTCCTATCCCCATCTGTCGGTGGGAGAG
CTGACCGCGATTCGCTCCGACCTGACCAGCGATGCTTACCTGGCAGAACTGGCGGATCTGCACGGCTTGGATCGCTACCT
CGAGGTGGGATCCAGCTCTCAAAACGACTTGGCCGGACGGGGTCGGCGGCTGGCGGATGCTTTCGAGGCTCTGCTTGGGG
CTTTTTATCTCAGTTGGGGTATTTACACGCTGCCCAGGCTGCATCCCTGGCTGGATCCCTACTTACACCGACGAGTGGAG
CAATGGTTCCAAGACCCCACTCGGCGCAACCCCAAAGCAGCCTTGCAAGAACTGACCCAACGCCTTTGGGGTAGCCTGCC
CGAATACCGCCTGGTGGCCGCCCAGGAGCATCCCCCTCATTTCACCATGGAAGTTTGGGGGCAAGGGCGGTGCTGGGGCC
GCGGTGAAGGTCGCTCGAAAAAGGCTGCGGAAATGGCCGCCGCTGCTCAAGCCTACGAACACTTGCAGTCGGAGAAGACA
TGA

Upstream 100 bases:

>100_bases
CCGCCTGAGCGGGGATCCCGGCCTGGGTGAGATGGCTCAGGTCAAAATGGTTGCAAGCTGTGCAGTTCTGACCGCTAAGG
CAACGTCAGCACCTGAGTGT

Downstream 100 bases:

>100_bases
GAGGCAACCACCGCTACGAGTTGGCCAGTTGGTTGTTTTTGCTGGGGAGCAGCCTGTTTGCGGCGAGCGAGGTGATGACC
TTGGGTAGCGACCCCTCTCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III 2; RNase III 2 [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MVELIPPRRRALEHLLARLGFRDPALLEQLRWDLLDQALIHPSLDGRRNNDRLELLGDSVLRILVTEFLFQSYPHLSVGE
LTAIRSDLTSDAYLAELADLHGLDRYLEVGSSSQNDLAGRGRRLADAFEALLGAFYLSWGIYTLPRLHPWLDPYLHRRVE
QWFQDPTRRNPKAALQELTQRLWGSLPEYRLVAAQEHPPHFTMEVWGQGRCWGRGEGRSKKAAEMAAAAQAYEHLQSEKT

Sequences:

>Translated_240_residues
MVELIPPRRRALEHLLARLGFRDPALLEQLRWDLLDQALIHPSLDGRRNNDRLELLGDSVLRILVTEFLFQSYPHLSVGE
LTAIRSDLTSDAYLAELADLHGLDRYLEVGSSSQNDLAGRGRRLADAFEALLGAFYLSWGIYTLPRLHPWLDPYLHRRVE
QWFQDPTRRNPKAALQELTQRLWGSLPEYRLVAAQEHPPHFTMEVWGQGRCWGRGEGRSKKAAEMAAAAQAYEHLQSEKT
>Mature_240_residues
MVELIPPRRRALEHLLARLGFRDPALLEQLRWDLLDQALIHPSLDGRRNNDRLELLGDSVLRILVTEFLFQSYPHLSVGE
LTAIRSDLTSDAYLAELADLHGLDRYLEVGSSSQNDLAGRGRRLADAFEALLGAFYLSWGIYTLPRLHPWLDPYLHRRVE
QWFQDPTRRNPKAALQELTQRLWGSLPEYRLVAAQEHPPHFTMEVWGQGRCWGRGEGRSKKAAEMAAAAQAYEHLQSEKT

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=192, Percent_Identity=30.2083333333333, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI155030234, Length=192, Percent_Identity=30.2083333333333, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788920, Length=196, Percent_Identity=31.6326530612245, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137682, Length=195, Percent_Identity=31.2820512820513, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27556; Mature: 27556

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELIPPRRRALEHLLARLGFRDPALLEQLRWDLLDQALIHPSLDGRRNNDRLELLGDSV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LRILVTEFLFQSYPHLSVGELTAIRSDLTSDAYLAELADLHGLDRYLEVGSSSQNDLAGR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GRRLADAFEALLGAFYLSWGIYTLPRLHPWLDPYLHRRVEQWFQDPTRRNPKAALQELTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RLWGSLPEYRLVAAQEHPPHFTMEVWGQGRCWGRGEGRSKKAAEMAAAAQAYEHLQSEKT
HHHCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVELIPPRRRALEHLLARLGFRDPALLEQLRWDLLDQALIHPSLDGRRNNDRLELLGDSV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LRILVTEFLFQSYPHLSVGELTAIRSDLTSDAYLAELADLHGLDRYLEVGSSSQNDLAGR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GRRLADAFEALLGAFYLSWGIYTLPRLHPWLDPYLHRRVEQWFQDPTRRNPKAALQELTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RLWGSLPEYRLVAAQEHPPHFTMEVWGQGRCWGRGEGRSKKAAEMAAAAQAYEHLQSEKT
HHHCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]