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The map label for this gene is htrA [H]

Identifier: 86608125

GI number: 86608125

Start: 646851

End: 648092

Strand: Direct

Name: htrA [H]

Synonym: CYB_0636

Alternate gene names: 86608125

Gene position: 646851-648092 (Clockwise)

Preceding gene: 86608120

Following gene: 86608126

Centisome position: 21.23

GC content: 61.11

Gene sequence:

>1242_bases
ATGGCGCGGATTCTACGGCATACACTTTTGGCGATGGCTCTGTTTGGTGGAGGCGTCGCAGGTGGGGTCTGGCTATCGTC
TCGAGCGGGGCAGGAGTGGTTACAGCAAACTCCCCTGATCACTTGGACGCGACGGGCCAGTGAGGGAGTGGGATCCCTTT
TGCCCTGGTCTGAGCCCCGCCCTGAGGCTGCGAATTCTGCTCCTCCCGCCGATGCTGTCCGGCCTTCCAATTTTATTGCT
GCAGTCGCCCAAAAGGTCGGCCCAGCGGTGGTGCGCATCGATGCCACCCGCACTGTGTCGAGGGGGGTCAACCCAGAACT
GTTCAACCAGCCCCTGTTTCGCCGCTTCTTTGGAAATCAGATACCGCAGTTGCCGCAGGAGTTTCAGCAGGAGGGCACCG
GATCGGGCTTTATCATCGACGCCAGTGGCCTGATCCTCACCAACGCCCATGTGGTGGAAGGCAGCGAGCGGGTCAGGGTT
CACCTGCTGGATGGGCGCACCTTTGAAGGGGAGGTGAAGGGCTCAGACCCGGTTACCGATATCGCGGTGATCAAGATTGA
GGGGGAGAATCTGCCCACGGTTACTTTGGGCAACTCTGACTTGGTGCGACCGGGGGATTGGGCCATCGCCATTGGCAACC
CGCTGGGCCTGGACAATACCGTAACTGCTGGGATCATCAGCGCCGTCGGGCGCTCCTCCGGGCAAATTGGGGCTGTCAAC
AAGCGGGTGACTTTCCTGCAAACGGATGCGGCCATTAACCCCGGCAACTCGGGTGGCCCACTGCTGGATGCGGAAGGCCG
CGTGATTGGGGTGAATACGGCCATCTTCCAGCGGGCCCAGAGTGTGGGCTTTGCCATCCCCATCAACCGCGCCATGGAAA
TTGCCGAGCAATTGATCCGGAATGGTCGGGTAGAGCACGCTTTCTTGGGCATTCGCATGATCACCCTCAACCCCGACATT
GTGGCCCGCCTCAACCGCGACCCCGCTCGCCCCACCACGCTGACGGTGGAAGAAGGGGTTTTGATCGGGCAGGTGATTCC
GGGATCCCCGGCTGAGGAGATTGGCTTGCGGGAGGGGGATGTGATCACTGAAATCAATGGGCAGGCCATCCACGATGCCG
AGCAGGTGCAGCAGTTGGTGGAAGCCGCTGGGGTGGGCAATACGCTGACGCTGCGGGTCATCCGCGATGGACAGGCGCGC
ACCTTCCAGGTGAAAACTGGAGTGCTGCCCGTAGACTTCTAA

Upstream 100 bases:

>100_bases
AGAATAGACCAGGAGTGAACTGGGTCTTGATGGCGTAAGTCGGGGGAGCGGGTTCACGCCTTTTGAGTCTTGGCGATACG
GCTTAGCTTTGGGAGGGAGC

Downstream 100 bases:

>100_bases
GCAGTTTTATGTGCCGTCAATTTACTGATCCCCGTGACACAATGACCCTAGAGGCGGGGATCCAGATATGGCTTGGGCAG
TTGGTGAACAATTGCAAGGG

Product: S1C family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MARILRHTLLAMALFGGGVAGGVWLSSRAGQEWLQQTPLITWTRRASEGVGSLLPWSEPRPEAANSAPPADAVRPSNFIA
AVAQKVGPAVVRIDATRTVSRGVNPELFNQPLFRRFFGNQIPQLPQEFQQEGTGSGFIIDASGLILTNAHVVEGSERVRV
HLLDGRTFEGEVKGSDPVTDIAVIKIEGENLPTVTLGNSDLVRPGDWAIAIGNPLGLDNTVTAGIISAVGRSSGQIGAVN
KRVTFLQTDAAINPGNSGGPLLDAEGRVIGVNTAIFQRAQSVGFAIPINRAMEIAEQLIRNGRVEHAFLGIRMITLNPDI
VARLNRDPARPTTLTVEEGVLIGQVIPGSPAEEIGLREGDVITEINGQAIHDAEQVQQLVEAAGVGNTLTLRVIRDGQAR
TFQVKTGVLPVDF

Sequences:

>Translated_413_residues
MARILRHTLLAMALFGGGVAGGVWLSSRAGQEWLQQTPLITWTRRASEGVGSLLPWSEPRPEAANSAPPADAVRPSNFIA
AVAQKVGPAVVRIDATRTVSRGVNPELFNQPLFRRFFGNQIPQLPQEFQQEGTGSGFIIDASGLILTNAHVVEGSERVRV
HLLDGRTFEGEVKGSDPVTDIAVIKIEGENLPTVTLGNSDLVRPGDWAIAIGNPLGLDNTVTAGIISAVGRSSGQIGAVN
KRVTFLQTDAAINPGNSGGPLLDAEGRVIGVNTAIFQRAQSVGFAIPINRAMEIAEQLIRNGRVEHAFLGIRMITLNPDI
VARLNRDPARPTTLTVEEGVLIGQVIPGSPAEEIGLREGDVITEINGQAIHDAEQVQQLVEAAGVGNTLTLRVIRDGQAR
TFQVKTGVLPVDF
>Mature_412_residues
ARILRHTLLAMALFGGGVAGGVWLSSRAGQEWLQQTPLITWTRRASEGVGSLLPWSEPRPEAANSAPPADAVRPSNFIAA
VAQKVGPAVVRIDATRTVSRGVNPELFNQPLFRRFFGNQIPQLPQEFQQEGTGSGFIIDASGLILTNAHVVEGSERVRVH
LLDGRTFEGEVKGSDPVTDIAVIKIEGENLPTVTLGNSDLVRPGDWAIAIGNPLGLDNTVTAGIISAVGRSSGQIGAVNK
RVTFLQTDAAINPGNSGGPLLDAEGRVIGVNTAIFQRAQSVGFAIPINRAMEIAEQLIRNGRVEHAFLGIRMITLNPDIV
ARLNRDPARPTTLTVEEGVLIGQVIPGSPAEEIGLREGDVITEINGQAIHDAEQVQQLVEAAGVGNTLTLRVIRDGQART
FQVKTGVLPVDF

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=325, Percent_Identity=37.8461538461538, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI22129776, Length=315, Percent_Identity=37.4603174603175, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI7019477, Length=312, Percent_Identity=41.9871794871795, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI24308541, Length=328, Percent_Identity=35.0609756097561, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI21614538, Length=311, Percent_Identity=27.0096463022508, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789629, Length=333, Percent_Identity=38.1381381381381, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1786356, Length=353, Percent_Identity=37.9603399433428, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1789630, Length=374, Percent_Identity=34.2245989304813, Blast_Score=163, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24646839, Length=334, Percent_Identity=38.9221556886228, Blast_Score=197, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43947; Mature: 43815

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILRHTLLAMALFGGGVAGGVWLSSRAGQEWLQQTPLITWTRRASEGVGSLLPWSEPR
CHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCEEEECCHHCCCCCCCCCCCCC
PEAANSAPPADAVRPSNFIAAVAQKVGPAVVRIDATRTVSRGVNPELFNQPLFRRFFGNQ
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHCCCCHHHHCCHHHHHHHCCC
IPQLPQEFQQEGTGSGFIIDASGLILTNAHVVEGSERVRVHLLDGRTFEGEVKGSDPVTD
CCHHHHHHHHCCCCCEEEEECCCEEEEEEEEECCCCEEEEEEECCCEEECCCCCCCCCCE
IAVIKIEGENLPTVTLGNSDLVRPGDWAIAIGNPLGLDNTVTAGIISAVGRSSGQIGAVN
EEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEECCC
KRVTFLQTDAAINPGNSGGPLLDAEGRVIGVNTAIFQRAQSVGFAIPINRAMEIAEQLIR
CEEEEEEECCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHCCEEEEHHHHHHHHHHHHH
NGRVEHAFLGIRMITLNPDIVARLNRDPARPTTLTVEEGVLIGQVIPGSPAEEIGLREGD
CCCEEEEEEEEEEEEECCHHHEECCCCCCCCEEEEEECCEEEEEECCCCCHHHCCCCCCC
VITEINGQAIHDAEQVQQLVEAAGVGNTLTLRVIRDGQARTFQVKTGVLPVDF
EEEECCCCEECCHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCEECCC
>Mature Secondary Structure 
ARILRHTLLAMALFGGGVAGGVWLSSRAGQEWLQQTPLITWTRRASEGVGSLLPWSEPR
HHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCEEEECCHHCCCCCCCCCCCCC
PEAANSAPPADAVRPSNFIAAVAQKVGPAVVRIDATRTVSRGVNPELFNQPLFRRFFGNQ
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHCCCCHHHHCCHHHHHHHCCC
IPQLPQEFQQEGTGSGFIIDASGLILTNAHVVEGSERVRVHLLDGRTFEGEVKGSDPVTD
CCHHHHHHHHCCCCCEEEEECCCEEEEEEEEECCCCEEEEEEECCCEEECCCCCCCCCCE
IAVIKIEGENLPTVTLGNSDLVRPGDWAIAIGNPLGLDNTVTAGIISAVGRSSGQIGAVN
EEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEECCC
KRVTFLQTDAAINPGNSGGPLLDAEGRVIGVNTAIFQRAQSVGFAIPINRAMEIAEQLIR
CEEEEEEECCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHCCEEEEHHHHHHHHHHHHH
NGRVEHAFLGIRMITLNPDIVARLNRDPARPTTLTVEEGVLIGQVIPGSPAEEIGLREGD
CCCEEEEEEEEEEEEECCHHHEECCCCCCCCEEEEEECCEEEEEECCCCCHHHCCCCCCC
VITEINGQAIHDAEQVQQLVEAAGVGNTLTLRVIRDGQARTFQVKTGVLPVDF
EEEECCCCEECCHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]