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The map label for this gene is moeA [H]

Identifier: 86607706

GI number: 86607706

Start: 216392

End: 217609

Strand: Reverse

Name: moeA [H]

Synonym: CYB_0206

Alternate gene names: 86607706

Gene position: 217609-216392 (Counterclockwise)

Preceding gene: 86607716

Following gene: 86607705

Centisome position: 7.14

GC content: 63.88

Gene sequence:

>1218_bases
ATGCTGCCGGTGGCGGAAGCAGAAGCCCTGATTTTGCAGGCGGTTCAGCCGCTGGGCCCAGAGTGGGTGGAGCTGGGATC
CGCCCAAGGCCGCGTTCTCAGCCAAACTGTGTATAGCCCCCAGGATTTTCCGGCCCATCCCACCTCCAGTATGGATGGCT
ATGCCGTGCGCCATGAAGATGTGCAAGCGGGGATCCCTTGTGAGCTGCAGGTGATTGAGACTCTCCCCGCCGGAAAGGCA
CCCACCCGAGAGCTCCAGCCTGGACAAGCGGTGCGTCTCTACACCGGCTCCCTCTTGCCCAGCGGTGCGGACACCGTGGT
GATGCAGGAATACACGCAGCAACCTTCGCCAGGAACCGTTCGCCTCTTGCAGCGTCCGCAGCGGGGCCAATTTGTCCGGC
CTCAGGGAGACTTTGCCCGCCAGGGGGATCCCCTCCTGCCGGCAGGGCAGGCTTTGGGCGGAGCGGAGCTAGCCGTTTTG
GCCGCCATCCGACAGGCGATGGTGCCGGTGTTTCGTCAGCCTCGGGTGGCCCTGTTCTCGACAGGGGATGAGTTGGTGCC
CATCCAGCAGGTGCCGGAGCCGGGGCAGGTTGTGGATTCCAACCAGTACGGCTTAGCGGCTCTGGTCAAGGCAGCGGGTG
GGATCCCGATCCAGTTGGGCATCGTGCCGGATCGGCCCCAGGTGTTGCGGCAGGTCGTCCAGCAGGCCCTGGCCTCTGCC
GATGGGGTGATCTCTTCTGGAGGGGTATCGGTGGGGGATTTTGACCTGGTGGAAAAGGTGCTGGAGGAGTTGGGAGGCGA
GATTTTCATCCGCAGCGTGGCCATCAAGCCGGGCAAACCCCTGACGGTGGCTCGTTTTCCCAATCCCCACGGCCCCCCCA
AGCTCTACTTTGGCCTGCCGGGCAACCCTGCCTCTGCCCTGGTGACCTTCTGGCGCTTTTTGCACCCGGCCCTGCGAAAA
ATGGGCGGATCCCTGCCCCCCTACTGGCAGATCCTCTCCGCCTTCAGCGCTGTGGATCTGCATGCCGACGGTCGGCGGGA
ACACTACCTCTGGGGACGGCTGCAGGTCAGGCCTGAGGGGATCCAATTTCAGCCCGCCGCCAACCTCAATTCCGGCAATC
TCATCAGTCTGGCCGGCTGTAATGCCTTGGCTGTGCTGCCAGTAGGGACAACCCAGATCCCTGCTGGTTCGCCCGTTCAG
GTGCTGCAACTGCCCTGA

Upstream 100 bases:

>100_bases
GGCCGCTGTCCGCAGTTTAAGTTGTTTTTAATGGCCTTGGCGGAACCGACTTCTGGATGCTGAAGATAAGGTGTTGGAGA
AGGGGGTTGTAAAAGCCGTG

Downstream 100 bases:

>100_bases
AGATCCCTGGCCCTCCTCTCGCTGCTGCTGGAATAGCCGCCATAGTCAATCCAAATAACAATGAGACGCTAGCCAGTACA
ACAGTTCCGTCTGCAACAGC

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLPVAEAEALILQAVQPLGPEWVELGSAQGRVLSQTVYSPQDFPAHPTSSMDGYAVRHEDVQAGIPCELQVIETLPAGKA
PTRELQPGQAVRLYTGSLLPSGADTVVMQEYTQQPSPGTVRLLQRPQRGQFVRPQGDFARQGDPLLPAGQALGGAELAVL
AAIRQAMVPVFRQPRVALFSTGDELVPIQQVPEPGQVVDSNQYGLAALVKAAGGIPIQLGIVPDRPQVLRQVVQQALASA
DGVISSGGVSVGDFDLVEKVLEELGGEIFIRSVAIKPGKPLTVARFPNPHGPPKLYFGLPGNPASALVTFWRFLHPALRK
MGGSLPPYWQILSAFSAVDLHADGRREHYLWGRLQVRPEGIQFQPAANLNSGNLISLAGCNALAVLPVGTTQIPAGSPVQ
VLQLP

Sequences:

>Translated_405_residues
MLPVAEAEALILQAVQPLGPEWVELGSAQGRVLSQTVYSPQDFPAHPTSSMDGYAVRHEDVQAGIPCELQVIETLPAGKA
PTRELQPGQAVRLYTGSLLPSGADTVVMQEYTQQPSPGTVRLLQRPQRGQFVRPQGDFARQGDPLLPAGQALGGAELAVL
AAIRQAMVPVFRQPRVALFSTGDELVPIQQVPEPGQVVDSNQYGLAALVKAAGGIPIQLGIVPDRPQVLRQVVQQALASA
DGVISSGGVSVGDFDLVEKVLEELGGEIFIRSVAIKPGKPLTVARFPNPHGPPKLYFGLPGNPASALVTFWRFLHPALRK
MGGSLPPYWQILSAFSAVDLHADGRREHYLWGRLQVRPEGIQFQPAANLNSGNLISLAGCNALAVLPVGTTQIPAGSPVQ
VLQLP
>Mature_405_residues
MLPVAEAEALILQAVQPLGPEWVELGSAQGRVLSQTVYSPQDFPAHPTSSMDGYAVRHEDVQAGIPCELQVIETLPAGKA
PTRELQPGQAVRLYTGSLLPSGADTVVMQEYTQQPSPGTVRLLQRPQRGQFVRPQGDFARQGDPLLPAGQALGGAELAVL
AAIRQAMVPVFRQPRVALFSTGDELVPIQQVPEPGQVVDSNQYGLAALVKAAGGIPIQLGIVPDRPQVLRQVVQQALASA
DGVISSGGVSVGDFDLVEKVLEELGGEIFIRSVAIKPGKPLTVARFPNPHGPPKLYFGLPGNPASALVTFWRFLHPALRK
MGGSLPPYWQILSAFSAVDLHADGRREHYLWGRLQVRPEGIQFQPAANLNSGNLISLAGCNALAVLPVGTTQIPAGSPVQ
VLQLP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=394, Percent_Identity=37.0558375634518, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI66932975, Length=394, Percent_Identity=37.0558375634518, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1787049, Length=315, Percent_Identity=42.2222222222222, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI25147659, Length=324, Percent_Identity=36.1111111111111, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=296, Percent_Identity=26.3513513513513, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136978, Length=405, Percent_Identity=31.1111111111111, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24638841, Length=405, Percent_Identity=31.1111111111111, Blast_Score=145, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43075; Mature: 43075

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPVAEAEALILQAVQPLGPEWVELGSAQGRVLSQTVYSPQDFPAHPTSSMDGYAVRHED
CCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCC
VQAGIPCELQVIETLPAGKAPTRELQPGQAVRLYTGSLLPSGADTVVMQEYTQQPSPGTV
CCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEE
RLLQRPQRGQFVRPQGDFARQGDPLLPAGQALGGAELAVLAAIRQAMVPVFRQPRVALFS
HEECCCCCCCEECCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
TGDELVPIQQVPEPGQVVDSNQYGLAALVKAAGGIPIQLGIVPDRPQVLRQVVQQALASA
CCCCEEEHHCCCCCCCEECCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHC
DGVISSGGVSVGDFDLVEKVLEELGGEIFIRSVAIKPGKPLTVARFPNPHGPPKLYFGLP
CCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECC
GNPASALVTFWRFLHPALRKMGGSLPPYWQILSAFSAVDLHADGRREHYLWGRLQVRPEG
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCEEEEEEEEECCCC
IQFQPAANLNSGNLISLAGCNALAVLPVGTTQIPAGSPVQVLQLP
EEECCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MLPVAEAEALILQAVQPLGPEWVELGSAQGRVLSQTVYSPQDFPAHPTSSMDGYAVRHED
CCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCC
VQAGIPCELQVIETLPAGKAPTRELQPGQAVRLYTGSLLPSGADTVVMQEYTQQPSPGTV
CCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEE
RLLQRPQRGQFVRPQGDFARQGDPLLPAGQALGGAELAVLAAIRQAMVPVFRQPRVALFS
HEECCCCCCCEECCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
TGDELVPIQQVPEPGQVVDSNQYGLAALVKAAGGIPIQLGIVPDRPQVLRQVVQQALASA
CCCCEEEHHCCCCCCCEECCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHC
DGVISSGGVSVGDFDLVEKVLEELGGEIFIRSVAIKPGKPLTVARFPNPHGPPKLYFGLP
CCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECC
GNPASALVTFWRFLHPALRKMGGSLPPYWQILSAFSAVDLHADGRREHYLWGRLQVRPEG
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCEEEEEEEEECCCC
IQFQPAANLNSGNLISLAGCNALAVLPVGTTQIPAGSPVQVLQLP
EEECCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]