Click here to switch to the map view.

The map label for this gene is oxyR

Identifier: 86360737

GI number: 86360737

Start: 2500

End: 3414

Strand: Reverse

Name: oxyR

Synonym: RHE_PF00003

Alternate gene names: 86360737

Gene position: 3414-2500 (Counterclockwise)

Preceding gene: 86360741

Following gene: NA

Centisome position: 0.53

GC content: 63.28

Gene sequence:

>915_bases
ATGAAAAATCTTACCCTGAAACAGCTGCGGTATTTTGAAGCTTTGGCAAGGGACGGCCGATTTCGCCGTGCCGCCGATGC
CTGCGCCATCTCCCAGCCGGCGCTTTCCATGCAGATCAAAGAACTTGAGCAGGAGTTGGGCAGCGAGCTCTTCGAGCGCA
GCGCCCGCGAGGTGAAGCTCACTCCCTTCGGCCAGACCTTTGCACTGCGCGTTCGCGACATCCTGCGCGCCGTCGACGAG
CTCGGCGAGTTTGCCCGCGCCTCGCGCGACAGCTTCCTCACGCGTCTGCGCATCGGCATCATCCCGACGATCGCGCCCTA
TCTGCTGCCTACTGTTATAAACGATCTTAACAAAAGCTTCGCCGGAATTCAGATCGAGGTGCGCGAAACGCAGACGGGCA
AGCTGGTTCATGAACTGGCGCAGGGCCAGCTCGATATGGCAATCGTCGCGCTGCCGGTGTCTGAACCTTCGCTGACCGAA
CTCGAGCTGTTCAGGGAAGAGTTCGTGCTGGTCCGGCCCCACGAGGACGGCGACAAGCCGGTGCCCGAGCGCGAGGCGCT
GCGCGAAATGCGGCTGCTGCTGCTCGAAGAGGGGCACTGCTTCCGCGACCAGGCCCTGTCATTCTGCAAGGTCGGGGCTG
CCCGCCCGCGGGAAATCATGGAAGGCAGTTCGCTCTCCACGCTCGTCCAGATGGTCGGCGCCGGCATCGGCGTCACTCTG
ATCCCGGAAATGGCCGTTCCCGTCGAAACGCGCTCGGCCCACGTCTCGATCTCACGTTTTCCGTCGCCGCAGCCGTCGCG
AACCATCGGCATGGTTTGGCGCAATTCCACGCCGATGGCCAAGCAGTTGCAGGAGGTTGGCGAGGCGGTGCGCCGGTCGG
CGGAGACGATGCGTCAGCAGTATGGCGGCGGGTGA

Upstream 100 bases:

>100_bases
GAGCCGAGCTAGCGCCCCACTCTCTCCCTTGCAGTCTTCATATCGGAACCGTTCAATAATTTTAAGTTGGATTTACTGAT
TGCTGCGATAAGCTCGGCTT

Downstream 100 bases:

>100_bases
CGGACTTGGCCCGCTGGCGCCCCGAGACCTTCCCTTGCGGGAAAGGGTTGAGGAACGATAAGCGGCCAGAGCCTTCGTCT
TACGGCCGTCGCTTGAACGT

Product: hydrogen peroxide sensing transcriptional regulator protein, LysR family

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERSAREVKLTPFGQTFALRVRDILRAVDE
LGEFARASRDSFLTRLRIGIIPTIAPYLLPTVINDLNKSFAGIQIEVRETQTGKLVHELAQGQLDMAIVALPVSEPSLTE
LELFREEFVLVRPHEDGDKPVPEREALREMRLLLLEEGHCFRDQALSFCKVGAARPREIMEGSSLSTLVQMVGAGIGVTL
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVGEAVRRSAETMRQQYGGG

Sequences:

>Translated_304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERSAREVKLTPFGQTFALRVRDILRAVDE
LGEFARASRDSFLTRLRIGIIPTIAPYLLPTVINDLNKSFAGIQIEVRETQTGKLVHELAQGQLDMAIVALPVSEPSLTE
LELFREEFVLVRPHEDGDKPVPEREALREMRLLLLEEGHCFRDQALSFCKVGAARPREIMEGSSLSTLVQMVGAGIGVTL
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVGEAVRRSAETMRQQYGGG
>Mature_304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERSAREVKLTPFGQTFALRVRDILRAVDE
LGEFARASRDSFLTRLRIGIIPTIAPYLLPTVINDLNKSFAGIQIEVRETQTGKLVHELAQGQLDMAIVALPVSEPSLTE
LELFREEFVLVRPHEDGDKPVPEREALREMRLLLLEEGHCFRDQALSFCKVGAARPREIMEGSSLSTLVQMVGAGIGVTL
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVGEAVRRSAETMRQQYGGG

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=293, Percent_Identity=39.5904436860068, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=33.0578512396694, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787806, Length=273, Percent_Identity=25.2747252747253, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693105, Length=279, Percent_Identity=27.9569892473118, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=28.8617886178862, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788748, Length=308, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788887, Length=281, Percent_Identity=28.8256227758007, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788297, Length=311, Percent_Identity=25.7234726688103, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=30.4526748971193, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=32.1917808219178, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081904, Length=294, Percent_Identity=27.2108843537415, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI145693193, Length=122, Percent_Identity=35.2459016393443, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=26.8774703557312, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789506, Length=246, Percent_Identity=26.0162601626016, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789173, Length=194, Percent_Identity=30.4123711340206, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790783, Length=274, Percent_Identity=25.1824817518248, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=25.3061224489796, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=24.7011952191235, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789492, Length=285, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1788626, Length=255, Percent_Identity=28.6274509803922, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI87082132, Length=266, Percent_Identity=22.1804511278195, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33970; Mature: 33970

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERSAREVKL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
TPFGQTFALRVRDILRAVDELGEFARASRDSFLTRLRIGIIPTIAPYLLPTVINDLNKSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIQIEVRETQTGKLVHELAQGQLDMAIVALPVSEPSLTELELFREEFVLVRPHEDGDKP
CCEEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHEEEECCCCCCCCC
VPEREALREMRLLLLEEGHCFRDQALSFCKVGAARPREIMEGSSLSTLVQMVGAGIGVTL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCEEE
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVGEAVRRSAETMRQQ
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
YGGG
HCCC
>Mature Secondary Structure
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERSAREVKL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
TPFGQTFALRVRDILRAVDELGEFARASRDSFLTRLRIGIIPTIAPYLLPTVINDLNKSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIQIEVRETQTGKLVHELAQGQLDMAIVALPVSEPSLTELELFREEFVLVRPHEDGDKP
CCEEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHEEEECCCCCCCCC
VPEREALREMRLLLLEEGHCFRDQALSFCKVGAARPREIMEGSSLSTLVQMVGAGIGVTL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCEEE
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVGEAVRRSAETMRQQ
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
YGGG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]