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The map label for this gene is lspA

Identifier: 85859342

GI number: 85859342

Start: 1540712

End: 1541197

Strand: Direct

Name: lspA

Synonym: SYN_01453

Alternate gene names: 85859342

Gene position: 1540712-1541197 (Clockwise)

Preceding gene: 85859341

Following gene: 85859345

Centisome position: 48.46

GC content: 50.0

Gene sequence:

>486_bases
ATGAAAAAACCCCTGATTCTTTTTTTAATCACAGCCGGACTTGTGCTTCTGCTGGACCAGTTCACGAAGTTCTATGTGGC
CTCTCACTTCTGGCTTCATGAATCGCTCCCGGTTATCGATGGGTTTTTCAACATTACTTATATCCGGAACCCTGGGGCCG
CCTTTGGCTTTCTGGCCGGGGCGCCTCTCTTATTCCGGGGATTGTTCTTTACCTCGGTAACGCTTATCGCCGCCGGTCTG
ATTCTTTTTTATCTCATCAAGAACCGGGTCAGTGATCTGATGATGGTGATTCCACTGGCTCTGGTCCTTGCCGGAGCCAT
GGGTAACCTTGTGGACCGCATCCGCTTTGGCGAAGTGATCGATTTTCTGGATGTCTACATCGGCAGGTATCATTGGCCTG
CATTCAACATTGCCGATACGGCCATCTCCATCGGAGTGCTTTTCCTGGTCGTGGACATGATCCAGAAGCAGAAAGAGAAA
TCTTGA

Upstream 100 bases:

>100_bases
AATGCAATCGCTGCTGGATGTACAGTGAACTCGTCGGGGTTGATACGGAATATCCTGAGGTCTGTGAGCGGTGCCTCAAA
AATCTTAAGGCATAAACAGG

Downstream 100 bases:

>100_bases
GAAAAGGGTGCACTGAAACATGAGCCGGCTGGCGTTGTACCGAAAGGAAATGATAGTCTGATCTCCGGAAGATATTCGAG
TTTTCCCGTCGCCTTTACCA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MKKPLILFLITAGLVLLLDQFTKFYVASHFWLHESLPVIDGFFNITYIRNPGAAFGFLAGAPLLFRGLFFTSVTLIAAGL
ILFYLIKNRVSDLMMVIPLALVLAGAMGNLVDRIRFGEVIDFLDVYIGRYHWPAFNIADTAISIGVLFLVVDMIQKQKEK
S

Sequences:

>Translated_161_residues
MKKPLILFLITAGLVLLLDQFTKFYVASHFWLHESLPVIDGFFNITYIRNPGAAFGFLAGAPLLFRGLFFTSVTLIAAGL
ILFYLIKNRVSDLMMVIPLALVLAGAMGNLVDRIRFGEVIDFLDVYIGRYHWPAFNIADTAISIGVLFLVVDMIQKQKEK
S
>Mature_161_residues
MKKPLILFLITAGLVLLLDQFTKFYVASHFWLHESLPVIDGFFNITYIRNPGAAFGFLAGAPLLFRGLFFTSVTLIAAGL
ILFYLIKNRVSDLMMVIPLALVLAGAMGNLVDRIRFGEVIDFLDVYIGRYHWPAFNIADTAISIGVLFLVVDMIQKQKEK
S

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=148, Percent_Identity=32.4324324324324, Blast_Score=87, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SYNAS (Q2LTG5)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461544.1
- STRING:   Q2LTG5
- MEROPS:   A08.001
- GeneID:   3883722
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01453
- NMPDR:   fig|56780.10.peg.1488
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   MATRNNG
- PhylomeDB:   Q2LTG5
- BioCyc:   SACI56780:SYN_01453-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18046; Mature: 18046

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 112-112 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

HASH(0x1554e6f0)-; HASH(0x1548e7d4)-; HASH(0x15db94e8)-; HASH(0x15faf76c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPLILFLITAGLVLLLDQFTKFYVASHFWLHESLPVIDGFFNITYIRNPGAAFGFLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEEECCCCHHHHHHC
APLLFRGLFFTSVTLIAAGLILFYLIKNRVSDLMMVIPLALVLAGAMGNLVDRIRFGEVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFLDVYIGRYHWPAFNIADTAISIGVLFLVVDMIQKQKEKS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MKKPLILFLITAGLVLLLDQFTKFYVASHFWLHESLPVIDGFFNITYIRNPGAAFGFLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEEECCCCHHHHHHC
APLLFRGLFFTSVTLIAAGLILFYLIKNRVSDLMMVIPLALVLAGAMGNLVDRIRFGEVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFLDVYIGRYHWPAFNIADTAISIGVLFLVVDMIQKQKEKS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA