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The map label for this gene is atoC [H]

Identifier: 85859324

GI number: 85859324

Start: 1519124

End: 1520494

Strand: Direct

Name: atoC [H]

Synonym: SYN_02530

Alternate gene names: 85859324

Gene position: 1519124-1520494 (Clockwise)

Preceding gene: 85859323

Following gene: 85859332

Centisome position: 47.78

GC content: 48.58

Gene sequence:

>1371_bases
ATGGCAACAATCCTTGTCGTTGATGATGATAAGGGGATGAGAGAATTTCTCGATATAATGCTGACCAGGGAAGGTTATGA
TGTCAGTTGCGCCCGAGATGCCGGGGAAGGATTGGACCGTTGCCGGAAGCAGCGCTTCGACCTGATCATCACCGATCTGA
GAATGCCCAAAATCGACGGGATCGAATTTCTCAAGTCCGTCAAGGATGTTTCTCCTGAATCTCTGGTAATCCTGATTACG
GCTTATGCCTCCGGAGAGACGGCGGTCAGGGCAATGAAAGAGGGAGCTTACGATTATATCGAGAAGGATTTCAACATCGA
AGAATTTACGTCGACGATCCGAAGTGCCCTGGAGTCCAACGGCAGGATGCAGGATGACGCAAAATTTATCCGGGACATCG
AAAATTCAGTCTGCTTTGGCGAAATCATCGGGAAAAGCAGGGAAATGCTCAAGGTTTATTCCCTGATCAAGAAAGTGGCT
GATACGACGGCCAATGTTCTGATTCTCGGGGAAAGCGGAACGGGAAAAGAGCTTGTTGCCAAGGCCATCCATGAGAACAG
CCCAAGAAAAGACATGCCTTTTGTCGTGATCAATTGCGGCGGCATACCGGAAAATCTTCTGGAAAGCGAGCTGTTCGGTT
ATCTCAAAGGATCCTTTACGGGAGCCTACGCGGATAAGCCGGGACTGTTTGAGATCGCCCGGGGCGGGACGATTTTCCTC
GATGAAGTGGCCGAGCTGCCCCCCGTTCTTCAAGTCAAGCTTTTAAGAGTCGTTCAGGAAAAAACCTTTCTGAGAATCGG
CGGCACGGAAAATATTCGCGTCGATGTACGGATTATCTCGGCGACAAACCGGAATCTCGAGGAGATGGTCCAGAAAGGGG
ATTTCCGGGAGGATCTTTATTACCGGTTGAATGTCATCCCGATCTCCATTCCGCCCTTGAGGGAACGAAAGGATGACATC
CCCGTCCTGACAAAGTACTTCATTGAAAAATATTCCCGTGAATTCGGCAAAGGGATTAAAAATATCTCTAATTATGCCCT
GGAACTTCTCATGGACTATTCTTTTCCGGGGAATGTCCGGGAGCTGGAAAACATTATCGAAAGAAGCGTGGCCCTGGAGC
ATTCCAGCATCGTCCTTCCTGAGAATCTGATGATTTCCCGAGAGAATTCGGCAGCAAAGCACGAGACATTCAAAATTGAG
AATATCCCTGATCAGGGTTTGAATCTGAACGATGAACTGGCAAGATTCGAACGGGCCATAATCGGAAAAGCCCTTGAGAA
ATCAAAGGGATCAAAAACGAAGGCGGCGGAACTTCTGATGATCAGCTTTGATTCGCTTCGTTATCGCATCGAGAAACTCG
GGATTGGGTAA

Upstream 100 bases:

>100_bases
TCTCCGGGTCTGCCTGCCGAAAAATCAGGAATTGGCGGAAACGGAAACAATTTTCACGAAGGATGTCCGGGTTGCTTGAG
TTTTAAGGGAGGAGGAAGGT

Downstream 100 bases:

>100_bases
CACCCTTATCTTAAACACTGTTTGAACAAACCAGTTAAAGACCTCGGAAATTCCAGATTCCTCAGTTGCCGCGAATCGTG
ATGTCCTTCATTTTCAATTG

Product: two-component response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MATILVVDDDKGMREFLDIMLTREGYDVSCARDAGEGLDRCRKQRFDLIITDLRMPKIDGIEFLKSVKDVSPESLVILIT
AYASGETAVRAMKEGAYDYIEKDFNIEEFTSTIRSALESNGRMQDDAKFIRDIENSVCFGEIIGKSREMLKVYSLIKKVA
DTTANVLILGESGTGKELVAKAIHENSPRKDMPFVVINCGGIPENLLESELFGYLKGSFTGAYADKPGLFEIARGGTIFL
DEVAELPPVLQVKLLRVVQEKTFLRIGGTENIRVDVRIISATNRNLEEMVQKGDFREDLYYRLNVIPISIPPLRERKDDI
PVLTKYFIEKYSREFGKGIKNISNYALELLMDYSFPGNVRELENIIERSVALEHSSIVLPENLMISRENSAAKHETFKIE
NIPDQGLNLNDELARFERAIIGKALEKSKGSKTKAAELLMISFDSLRYRIEKLGIG

Sequences:

>Translated_456_residues
MATILVVDDDKGMREFLDIMLTREGYDVSCARDAGEGLDRCRKQRFDLIITDLRMPKIDGIEFLKSVKDVSPESLVILIT
AYASGETAVRAMKEGAYDYIEKDFNIEEFTSTIRSALESNGRMQDDAKFIRDIENSVCFGEIIGKSREMLKVYSLIKKVA
DTTANVLILGESGTGKELVAKAIHENSPRKDMPFVVINCGGIPENLLESELFGYLKGSFTGAYADKPGLFEIARGGTIFL
DEVAELPPVLQVKLLRVVQEKTFLRIGGTENIRVDVRIISATNRNLEEMVQKGDFREDLYYRLNVIPISIPPLRERKDDI
PVLTKYFIEKYSREFGKGIKNISNYALELLMDYSFPGNVRELENIIERSVALEHSSIVLPENLMISRENSAAKHETFKIE
NIPDQGLNLNDELARFERAIIGKALEKSKGSKTKAAELLMISFDSLRYRIEKLGIG
>Mature_455_residues
ATILVVDDDKGMREFLDIMLTREGYDVSCARDAGEGLDRCRKQRFDLIITDLRMPKIDGIEFLKSVKDVSPESLVILITA
YASGETAVRAMKEGAYDYIEKDFNIEEFTSTIRSALESNGRMQDDAKFIRDIENSVCFGEIIGKSREMLKVYSLIKKVAD
TTANVLILGESGTGKELVAKAIHENSPRKDMPFVVINCGGIPENLLESELFGYLKGSFTGAYADKPGLFEIARGGTIFLD
EVAELPPVLQVKLLRVVQEKTFLRIGGTENIRVDVRIISATNRNLEEMVQKGDFREDLYYRLNVIPISIPPLRERKDDIP
VLTKYFIEKYSREFGKGIKNISNYALELLMDYSFPGNVRELENIIERSVALEHSSIVLPENLMISRENSAAKHETFKIEN
IPDQGLNLNDELARFERAIIGKALEKSKGSKTKAAELLMISFDSLRYRIEKLGIG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=42.4778761061947, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1790437, Length=449, Percent_Identity=41.6481069042316, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=36.830835117773, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1788905, Length=377, Percent_Identity=42.4403183023873, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI87082117, Length=345, Percent_Identity=44.3478260869565, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=43.4782608695652, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1789087, Length=251, Percent_Identity=51.792828685259, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI87082152, Length=347, Percent_Identity=41.7867435158501, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1786524, Length=338, Percent_Identity=40.2366863905325, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=38.3177570093458, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1787583, Length=343, Percent_Identity=35.8600583090379, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789828, Length=222, Percent_Identity=35.1351351351351, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87081858, Length=303, Percent_Identity=29.042904290429, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786911, Length=120, Percent_Identity=34.1666666666667, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789809, Length=115, Percent_Identity=34.7826086956522, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082012, Length=117, Percent_Identity=29.9145299145299, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790860, Length=129, Percent_Identity=28.6821705426357, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786599, Length=116, Percent_Identity=31.0344827586207, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51394; Mature: 51263

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATILVVDDDKGMREFLDIMLTREGYDVSCARDAGEGLDRCRKQRFDLIITDLRMPKIDG
CEEEEEEECCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCEEEECCCCCCCCH
IEFLKSVKDVSPESLVILITAYASGETAVRAMKEGAYDYIEKDFNIEEFTSTIRSALESN
HHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCC
GRMQDDAKFIRDIENSVCFGEIIGKSREMLKVYSLIKKVADTTANVLILGESGTGKELVA
CCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
KAIHENSPRKDMPFVVINCGGIPENLLESELFGYLKGSFTGAYADKPGLFEIARGGTIFL
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEE
DEVAELPPVLQVKLLRVVQEKTFLRIGGTENIRVDVRIISATNRNLEEMVQKGDFREDLY
HHHHHCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEECCCCCHHHHHHCCCCCCCCE
YRLNVIPISIPPLRERKDDIPVLTKYFIEKYSREFGKGIKNISNYALELLMDYSFPGNVR
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELENIIERSVALEHSSIVLPENLMISRENSAAKHETFKIENIPDQGLNLNDELARFERAI
HHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
IGKALEKSKGSKTKAAELLMISFDSLRYRIEKLGIG
HHHHHHHCCCCCHHHHHEEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATILVVDDDKGMREFLDIMLTREGYDVSCARDAGEGLDRCRKQRFDLIITDLRMPKIDG
EEEEEEECCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCEEEECCCCCCCCH
IEFLKSVKDVSPESLVILITAYASGETAVRAMKEGAYDYIEKDFNIEEFTSTIRSALESN
HHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCC
GRMQDDAKFIRDIENSVCFGEIIGKSREMLKVYSLIKKVADTTANVLILGESGTGKELVA
CCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
KAIHENSPRKDMPFVVINCGGIPENLLESELFGYLKGSFTGAYADKPGLFEIARGGTIFL
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEE
DEVAELPPVLQVKLLRVVQEKTFLRIGGTENIRVDVRIISATNRNLEEMVQKGDFREDLY
HHHHHCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEECCCCCHHHHHHCCCCCCCCE
YRLNVIPISIPPLRERKDDIPVLTKYFIEKYSREFGKGIKNISNYALELLMDYSFPGNVR
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELENIIERSVALEHSSIVLPENLMISRENSAAKHETFKIENIPDQGLNLNDELARFERAI
HHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
IGKALEKSKGSKTKAAELLMISFDSLRYRIEKLGIG
HHHHHHHCCCCCHHHHHEEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]