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The map label for this gene is kinA [H]

Identifier: 85859323

GI number: 85859323

Start: 1517372

End: 1519102

Strand: Direct

Name: kinA [H]

Synonym: SYN_02531

Alternate gene names: 85859323

Gene position: 1517372-1519102 (Clockwise)

Preceding gene: 85859318

Following gene: 85859324

Centisome position: 47.73

GC content: 48.01

Gene sequence:

>1731_bases
ATGAAGTCTCATGAAAATTCCTCAATGCGGGAAGTGATATTGCTGGAAAGATTGCGCTGGCTGATTGTCTGCCGGGTGGC
CATTGCCACTTTTCTTCTGGTAATCATCATTTTCATCGACCTCAAACAGACATCCCTTTACCCGGAGATCCGCTTTCCAT
CCTTTTACAGCCTCATTCTCACCACCTATATCATCTCTTTCATCTATGTTTTTTTGCTGAAAGTCGTCAAAAACTCTCAT
CTTCATGCCTATATTCAGATGGTCTGCGATGTGTTTCTGATTACGCTTCTCGTTCATATCACCGGTGGCGTCAGCAGCAT
CTATTCCGTTCTCTATCCCATGGTTATCATTTACACCGTACTGTTTGCGGAAAGAAAAGGAGGATTAATCGTGGCCACCG
CCTGCAGTCTCTCCTATGGCCTTCTTCTGAATCTGGAATATTTCGCTGTGATTGCCCCGCAGTATCAGTCGATTATCCCG
GAAGTCCAGAGAAATGCCGGATATCTCTATTCGAGAATATTCATTCATGCGCTGTCATTTTATATCGTGGCTTTCCTTGC
AAGTTTCGTGATCGAACAGGAAAAAACCGCCAGGACGCTTCTTGCTGAAAAGGAAAATGCCTTCGATCAGCTGGATCTTC
TGCACCAGAGCATTATCGAGTCGGTCGATGCGGGCATTTTGACCATCGATATGGAAGACCGGATCAAATCCTTCAATCGT
GCTGCGGTCGACATAACAGGTCTTTCAGTCGCGGATGTTCTGAATCGAAGTATTCATGAGGTCTTTCCCGGCTATGCTTC
TCTATTCGCCCGATATTCCTGCATCCAGACGGGTAAGAGTTCGGGCAGGCGAATGGAAATGAACATCAGGAACCGGAATA
ATGAGGAACTGATCCTTGGCTGTTCCCTGTCGCGGCTCAGAGGAAGCCAGGGAGAGCACATAGGAGAAATCCTGATTTTT
CAGGACTTGACTTCCATCAAGAAAATCGAGGCCGCCTATGAAAAAAGCCGGCGTTTTGCCTTTATCGGGGAAATGGCCGC
AGGCCTGGCTCATGAAATCAGAAACCCGCTGGCTGCCATCAGCGGTTCGATTCATATGTTGAAAAAAGATCTGAAGCTGG
ATCCAACGGACGAGCGGCTCATGAAGATCATTCTCAGAGGAAAGGATCAGCTCGAAAATTTCATGAAGGATTTCCTTCTG
CTTGCCAAGCCGGCTGCAGGTGAGAAGGAATGGATGAATCTCAATGCTCTGATCGATGAAATCCTTGAATCTCTTGTTTA
TATTCCGGACTGGTCAGAGAACATCACGGTGGAGAAAAACTATCCGGAACCTTCCCTGTTGTACGCGAACAAAAGAGAAA
TGCAGCATGTCATCTGGAATCTTATCCTCAATGCCCTGCAGGCCATGCCCCGGGGAGGGCGTCTGCATATCAGAACAACC
CCTGTGGTGGTTATGAACGAACGCCAATGTGTTCAACTGGACATCGAAGACAGCGGTGAAGGCATTTCCAGAGAAGATAT
GAACCGGATCTTCGAGCCTTTCTTTACGACCAAGGAGAGGGGGACAGGGCTCGGTCTGGCGGTGGTCGGGAAGATCATCG
AGAATTATTCCGGAACGATCACGATAACCAGCGAAAAGGAAAAAGGGACCCGTCTCCGGGTCTGCCTGCCGAAAAATCAG
GAATTGGCGGAAACGGAAACAATTTTCACGAAGGATGTCCGGGTTGCTTGA

Upstream 100 bases:

>100_bases
ATAGCATGGCGTCGTTTTTGACAGATAAAACTCTTTCGTGAAAACACCGCAAATATTGAAGAGATAAAATTTTCTGCAGG
AAGAAGGTATATGTTTTGAA

Downstream 100 bases:

>100_bases
GTTTTAAGGGAGGAGGAAGGTATGGCAACAATCCTTGTCGTTGATGATGATAAGGGGATGAGAGAATTTCTCGATATAAT
GCTGACCAGGGAAGGTTATG

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MKSHENSSMREVILLERLRWLIVCRVAIATFLLVIIIFIDLKQTSLYPEIRFPSFYSLILTTYIISFIYVFLLKVVKNSH
LHAYIQMVCDVFLITLLVHITGGVSSIYSVLYPMVIIYTVLFAERKGGLIVATACSLSYGLLLNLEYFAVIAPQYQSIIP
EVQRNAGYLYSRIFIHALSFYIVAFLASFVIEQEKTARTLLAEKENAFDQLDLLHQSIIESVDAGILTIDMEDRIKSFNR
AAVDITGLSVADVLNRSIHEVFPGYASLFARYSCIQTGKSSGRRMEMNIRNRNNEELILGCSLSRLRGSQGEHIGEILIF
QDLTSIKKIEAAYEKSRRFAFIGEMAAGLAHEIRNPLAAISGSIHMLKKDLKLDPTDERLMKIILRGKDQLENFMKDFLL
LAKPAAGEKEWMNLNALIDEILESLVYIPDWSENITVEKNYPEPSLLYANKREMQHVIWNLILNALQAMPRGGRLHIRTT
PVVVMNERQCVQLDIEDSGEGISREDMNRIFEPFFTTKERGTGLGLAVVGKIIENYSGTITITSEKEKGTRLRVCLPKNQ
ELAETETIFTKDVRVA

Sequences:

>Translated_576_residues
MKSHENSSMREVILLERLRWLIVCRVAIATFLLVIIIFIDLKQTSLYPEIRFPSFYSLILTTYIISFIYVFLLKVVKNSH
LHAYIQMVCDVFLITLLVHITGGVSSIYSVLYPMVIIYTVLFAERKGGLIVATACSLSYGLLLNLEYFAVIAPQYQSIIP
EVQRNAGYLYSRIFIHALSFYIVAFLASFVIEQEKTARTLLAEKENAFDQLDLLHQSIIESVDAGILTIDMEDRIKSFNR
AAVDITGLSVADVLNRSIHEVFPGYASLFARYSCIQTGKSSGRRMEMNIRNRNNEELILGCSLSRLRGSQGEHIGEILIF
QDLTSIKKIEAAYEKSRRFAFIGEMAAGLAHEIRNPLAAISGSIHMLKKDLKLDPTDERLMKIILRGKDQLENFMKDFLL
LAKPAAGEKEWMNLNALIDEILESLVYIPDWSENITVEKNYPEPSLLYANKREMQHVIWNLILNALQAMPRGGRLHIRTT
PVVVMNERQCVQLDIEDSGEGISREDMNRIFEPFFTTKERGTGLGLAVVGKIIENYSGTITITSEKEKGTRLRVCLPKNQ
ELAETETIFTKDVRVA
>Mature_576_residues
MKSHENSSMREVILLERLRWLIVCRVAIATFLLVIIIFIDLKQTSLYPEIRFPSFYSLILTTYIISFIYVFLLKVVKNSH
LHAYIQMVCDVFLITLLVHITGGVSSIYSVLYPMVIIYTVLFAERKGGLIVATACSLSYGLLLNLEYFAVIAPQYQSIIP
EVQRNAGYLYSRIFIHALSFYIVAFLASFVIEQEKTARTLLAEKENAFDQLDLLHQSIIESVDAGILTIDMEDRIKSFNR
AAVDITGLSVADVLNRSIHEVFPGYASLFARYSCIQTGKSSGRRMEMNIRNRNNEELILGCSLSRLRGSQGEHIGEILIF
QDLTSIKKIEAAYEKSRRFAFIGEMAAGLAHEIRNPLAAISGSIHMLKKDLKLDPTDERLMKIILRGKDQLENFMKDFLL
LAKPAAGEKEWMNLNALIDEILESLVYIPDWSENITVEKNYPEPSLLYANKREMQHVIWNLILNALQAMPRGGRLHIRTT
PVVVMNERQCVQLDIEDSGEGISREDMNRIFEPFFTTKERGTGLGLAVVGKIIENYSGTITITSEKEKGTRLRVCLPKNQ
ELAETETIFTKDVRVA

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=366, Percent_Identity=30.0546448087432, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=31.25, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790300, Length=209, Percent_Identity=32.0574162679426, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=279, Percent_Identity=26.8817204301075, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788713, Length=264, Percent_Identity=24.2424242424242, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=23.4126984126984, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=27.6, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=26.3636363636364, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=27.2357723577236, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI145693157, Length=354, Percent_Identity=24.8587570621469, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65427; Mature: 65427

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHENSSMREVILLERLRWLIVCRVAIATFLLVIIIFIDLKQTSLYPEIRFPSFYSLIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
TTYIISFIYVFLLKVVKNSHLHAYIQMVCDVFLITLLVHITGGVSSIYSVLYPMVIIYTV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFAERKGGLIVATACSLSYGLLLNLEYFAVIAPQYQSIIPEVQRNAGYLYSRIFIHALSF
HHHHCCCCEEEEEHHCCHHHHHEEEHHHEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHH
YIVAFLASFVIEQEKTARTLLAEKENAFDQLDLLHQSIIESVDAGILTIDMEDRIKSFNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCC
AAVDITGLSVADVLNRSIHEVFPGYASLFARYSCIQTGKSSGRRMEMNIRNRNNEELILG
CEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
CSLSRLRGSQGEHIGEILIFQDLTSIKKIEAAYEKSRRFAFIGEMAAGLAHEIRNPLAAI
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCHHHHH
SGSIHMLKKDLKLDPTDERLMKIILRGKDQLENFMKDFLLLAKPAAGEKEWMNLNALIDE
CCHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ILESLVYIPDWSENITVEKNYPEPSLLYANKREMQHVIWNLILNALQAMPRGGRLHIRTT
HHHHHEECCCCCCCEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PVVVMNERQCVQLDIEDSGEGISREDMNRIFEPFFTTKERGTGLGLAVVGKIIENYSGTI
CEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEE
TITSEKEKGTRLRVCLPKNQELAETETIFTKDVRVA
EEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSHENSSMREVILLERLRWLIVCRVAIATFLLVIIIFIDLKQTSLYPEIRFPSFYSLIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
TTYIISFIYVFLLKVVKNSHLHAYIQMVCDVFLITLLVHITGGVSSIYSVLYPMVIIYTV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFAERKGGLIVATACSLSYGLLLNLEYFAVIAPQYQSIIPEVQRNAGYLYSRIFIHALSF
HHHHCCCCEEEEEHHCCHHHHHEEEHHHEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHH
YIVAFLASFVIEQEKTARTLLAEKENAFDQLDLLHQSIIESVDAGILTIDMEDRIKSFNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCC
AAVDITGLSVADVLNRSIHEVFPGYASLFARYSCIQTGKSSGRRMEMNIRNRNNEELILG
CEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
CSLSRLRGSQGEHIGEILIFQDLTSIKKIEAAYEKSRRFAFIGEMAAGLAHEIRNPLAAI
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCHHHHH
SGSIHMLKKDLKLDPTDERLMKIILRGKDQLENFMKDFLLLAKPAAGEKEWMNLNALIDE
CCHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ILESLVYIPDWSENITVEKNYPEPSLLYANKREMQHVIWNLILNALQAMPRGGRLHIRTT
HHHHHEECCCCCCCEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PVVVMNERQCVQLDIEDSGEGISREDMNRIFEPFFTTKERGTGLGLAVVGKIIENYSGTI
CEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEE
TITSEKEKGTRLRVCLPKNQELAETETIFTKDVRVA
EEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]