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The map label for this gene is pepA [H]

Identifier: 85859288

GI number: 85859288

Start: 1472645

End: 1474225

Strand: Direct

Name: pepA [H]

Synonym: SYN_02170

Alternate gene names: 85859288

Gene position: 1472645-1474225 (Clockwise)

Preceding gene: 85859287

Following gene: 85859290

Centisome position: 46.32

GC content: 53.51

Gene sequence:

>1581_bases
TTGACAATAACGAATAGAGCGGATATTTCAAACGAGAGTTTTATAAAAATGGAGGAGAAATCGATGGAAGTAACCATTAA
ATCAGGACGACTGGTCGATGCCGAGGCGGAGATCCTTTTGCTGACGTTCTTTGAAGGAATGCAGGAGCTCCCCGTAGCGG
CAAAATCTCTTGATGAACGTTATGGCGGCATTATAAGTCAAATCATTAAAGACCGAGATTTTGAAGGCAGACTCCATCAG
ATCTCCCTGGTCTATAACGGGGCGGATGCCCCGGCTAAGAGGATTATCCTGGTCGGTTTGGGAAAGAAGGCTGAGTTTGA
TCTGGAAAAATTGCGCGCGGCTTTTTCCCGGGCGGCACAGCATGTCAGAAGCATGAATATCAAAGTTTTGACTTCCTTTG
TGAATTTTCCGGAATGGTCTTCCTGCCTTTTCACTCATGATGAGCTGGCTGAAGCTGTTGTCGAGGGGGTACTCCTTGGC
CTTTATCAATTCACCCCTTACAAGACCGTGGAACGGGAAAACATCAAAGAACTGGATCAATTCATTCTTCTTGAGGAGAA
ACCGGAGAATCTTTCCGTCCTCAGCGAAGCAACACGAAGGGCAGAGACCATAGCCCGGGCTGTCTGGTTCGCCCGGGATC
TCGTTTCCTCTCCGGGCAACGAAATGACACCGCAGATCCTGGCGGCAAAGGCACTGGAAATGGTTTCCACCCGTAATAAG
ATCGAAGCGACAGTCCTTGATGATGCGCAGATCGGAGAAATCGGCATGCATGCCATCCTGGCTGTGGCCCAGGGAAGCCA
CGAACCACCGCGGTTCATTATTATGAATTACAAGGGAGCGGAAAGCAGGGAAGGGGCTATTGTTCTGGTCGGCAAAGGGA
TCACTTTTGACAGCGGCGGGATCAGCCTCAAACCCGCGGAGAAGATGGGGGAGATGAAATCCGACATGGCCGGAGCCGCG
GCGGTGATTGCCACGCTTATGGCGGCGGCGGACCTGGATTTGCCGGTAAACCTCGTCGGCCTCGTTCCCACAACGGAGAA
TCTTCCCGGCGGTCGCGCATATAGGCCCGGAGACGTCCTGAAATCACTTTCCGGGCAGACTATCGAGGTGATTTCCACGG
ATGCGGAAGGGCGGCTGATCCTCGCCGACGCTCTGACCTATGCGGAAAAATATAATCCATCGGCGGTAGTTGATATCGCC
ACGCTGACCGGCGCCTGCATCGTCGCCCTGGGGGATCTGGCCATCGGAATGATGGGCACAGACGAATCTCTCAAGAAGGA
GGTCGCCGCCGCAGGGGAACGCACCGGCGAAAGAGTCTGGGAACTTCCACTCTGGAAGGAATATCATGAGTTGATCAAAA
GCGATATCGCTGACTACAAAAACACGGGCGGACGGTTCGGCGGGGCAATTACGGCGGCGGCTTTTCTCAGCAAATTTATC
GGGGATTATCCCTGGGTGCATCTTGACATCGCCGGCCCTTCCTGGCTGGATAAAGACCGCTCCTATGTGCCGAAAGGGGC
GTCAGGAATCGGTGTCCGGCTGCTGATCTCATGGCTGAGAACCCGACTGGTTAACGCGTGA

Upstream 100 bases:

>100_bases
TAACTTCTTCATTATTGACATATGTCTTCGGCCGGCTTCGAAACGGGAAGAAATTGAGTCACACAAAACCCTTTCGATAC
GAAAATGAAAAAGAAGAGGT

Downstream 100 bases:

>100_bases
AAACGGTCTTTGAAATTGAAAAAAAGAATATCCTCCGGCAAGATTGACTCGTTCAGGCAGGGAAGGCGGTGAGACGGTAG
ATGGGTGTTATTTTGAAGGT

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTITNRADISNESFIKMEEKSMEVTIKSGRLVDAEAEILLLTFFEGMQELPVAAKSLDERYGGIISQIIKDRDFEGRLHQ
ISLVYNGADAPAKRIILVGLGKKAEFDLEKLRAAFSRAAQHVRSMNIKVLTSFVNFPEWSSCLFTHDELAEAVVEGVLLG
LYQFTPYKTVERENIKELDQFILLEEKPENLSVLSEATRRAETIARAVWFARDLVSSPGNEMTPQILAAKALEMVSTRNK
IEATVLDDAQIGEIGMHAILAVAQGSHEPPRFIIMNYKGAESREGAIVLVGKGITFDSGGISLKPAEKMGEMKSDMAGAA
AVIATLMAAADLDLPVNLVGLVPTTENLPGGRAYRPGDVLKSLSGQTIEVISTDAEGRLILADALTYAEKYNPSAVVDIA
TLTGACIVALGDLAIGMMGTDESLKKEVAAAGERTGERVWELPLWKEYHELIKSDIADYKNTGGRFGGAITAAAFLSKFI
GDYPWVHLDIAGPSWLDKDRSYVPKGASGIGVRLLISWLRTRLVNA

Sequences:

>Translated_526_residues
MTITNRADISNESFIKMEEKSMEVTIKSGRLVDAEAEILLLTFFEGMQELPVAAKSLDERYGGIISQIIKDRDFEGRLHQ
ISLVYNGADAPAKRIILVGLGKKAEFDLEKLRAAFSRAAQHVRSMNIKVLTSFVNFPEWSSCLFTHDELAEAVVEGVLLG
LYQFTPYKTVERENIKELDQFILLEEKPENLSVLSEATRRAETIARAVWFARDLVSSPGNEMTPQILAAKALEMVSTRNK
IEATVLDDAQIGEIGMHAILAVAQGSHEPPRFIIMNYKGAESREGAIVLVGKGITFDSGGISLKPAEKMGEMKSDMAGAA
AVIATLMAAADLDLPVNLVGLVPTTENLPGGRAYRPGDVLKSLSGQTIEVISTDAEGRLILADALTYAEKYNPSAVVDIA
TLTGACIVALGDLAIGMMGTDESLKKEVAAAGERTGERVWELPLWKEYHELIKSDIADYKNTGGRFGGAITAAAFLSKFI
GDYPWVHLDIAGPSWLDKDRSYVPKGASGIGVRLLISWLRTRLVNA
>Mature_525_residues
TITNRADISNESFIKMEEKSMEVTIKSGRLVDAEAEILLLTFFEGMQELPVAAKSLDERYGGIISQIIKDRDFEGRLHQI
SLVYNGADAPAKRIILVGLGKKAEFDLEKLRAAFSRAAQHVRSMNIKVLTSFVNFPEWSSCLFTHDELAEAVVEGVLLGL
YQFTPYKTVERENIKELDQFILLEEKPENLSVLSEATRRAETIARAVWFARDLVSSPGNEMTPQILAAKALEMVSTRNKI
EATVLDDAQIGEIGMHAILAVAQGSHEPPRFIIMNYKGAESREGAIVLVGKGITFDSGGISLKPAEKMGEMKSDMAGAAA
VIATLMAAADLDLPVNLVGLVPTTENLPGGRAYRPGDVLKSLSGQTIEVISTDAEGRLILADALTYAEKYNPSAVVDIAT
LTGACIVALGDLAIGMMGTDESLKKEVAAAGERTGERVWELPLWKEYHELIKSDIADYKNTGGRFGGAITAAAFLSKFIG
DYPWVHLDIAGPSWLDKDRSYVPKGASGIGVRLLISWLRTRLVNA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=470, Percent_Identity=38.5106382978723, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI47155554, Length=337, Percent_Identity=32.9376854599407, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790710, Length=511, Percent_Identity=40.1174168297456, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=34.2767295597484, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=354, Percent_Identity=33.8983050847458, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=354, Percent_Identity=29.3785310734463, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24661038, Length=374, Percent_Identity=36.3636363636364, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI21355725, Length=374, Percent_Identity=36.6310160427808, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI20129969, Length=461, Percent_Identity=30.8026030368764, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI21355645, Length=456, Percent_Identity=29.3859649122807, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24662223, Length=456, Percent_Identity=29.3859649122807, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI161077148, Length=453, Percent_Identity=30.0220750551876, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20130057, Length=453, Percent_Identity=30.0220750551876, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24662227, Length=462, Percent_Identity=28.5714285714286, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129963, Length=449, Percent_Identity=31.1804008908686, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI19922386, Length=455, Percent_Identity=30.1098901098901, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21357381, Length=347, Percent_Identity=32.8530259365994, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI221379063, Length=347, Percent_Identity=32.8530259365994, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI221379062, Length=347, Percent_Identity=32.8530259365994, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646701, Length=348, Percent_Identity=26.1494252873563, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646703, Length=348, Percent_Identity=26.1494252873563, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358201, Length=348, Percent_Identity=26.1494252873563, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 57262; Mature: 57130

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITNRADISNESFIKMEEKSMEVTIKSGRLVDAEAEILLLTFFEGMQELPVAAKSLDER
CCCCCCCCCCCCCEEEEECCCEEEEEECCEEECCCCCEEEEHHHHHHHHCCHHHHHHHHH
YGGIISQIIKDRDFEGRLHQISLVYNGADAPAKRIILVGLGKKAEFDLEKLRAAFSRAAQ
HHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
HVRSMNIKVLTSFVNFPEWSSCLFTHDELAEAVVEGVLLGLYQFTPYKTVERENIKELDQ
HHHHCCHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FILLEEKPENLSVLSEATRRAETIARAVWFARDLVSSPGNEMTPQILAAKALEMVSTRNK
HEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
IEATVLDDAQIGEIGMHAILAVAQGSHEPPRFIIMNYKGAESREGAIVLVGKGITFDSGG
EEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEECCCC
ISLKPAEKMGEMKSDMAGAAAVIATLMAAADLDLPVNLVGLVPTTENLPGGRAYRPGDVL
CEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
KSLSGQTIEVISTDAEGRLILADALTYAEKYNPSAVVDIATLTGACIVALGDLAIGMMGT
HHCCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHEECCC
DESLKKEVAAAGERTGERVWELPLWKEYHELIKSDIADYKNTGGRFGGAITAAAFLSKFI
CHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GDYPWVHLDIAGPSWLDKDRSYVPKGASGIGVRLLISWLRTRLVNA
CCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TITNRADISNESFIKMEEKSMEVTIKSGRLVDAEAEILLLTFFEGMQELPVAAKSLDER
CCCCCCCCCCCCEEEEECCCEEEEEECCEEECCCCCEEEEHHHHHHHHCCHHHHHHHHH
YGGIISQIIKDRDFEGRLHQISLVYNGADAPAKRIILVGLGKKAEFDLEKLRAAFSRAAQ
HHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
HVRSMNIKVLTSFVNFPEWSSCLFTHDELAEAVVEGVLLGLYQFTPYKTVERENIKELDQ
HHHHCCHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FILLEEKPENLSVLSEATRRAETIARAVWFARDLVSSPGNEMTPQILAAKALEMVSTRNK
HEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
IEATVLDDAQIGEIGMHAILAVAQGSHEPPRFIIMNYKGAESREGAIVLVGKGITFDSGG
EEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEECCCC
ISLKPAEKMGEMKSDMAGAAAVIATLMAAADLDLPVNLVGLVPTTENLPGGRAYRPGDVL
CEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
KSLSGQTIEVISTDAEGRLILADALTYAEKYNPSAVVDIATLTGACIVALGDLAIGMMGT
HHCCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHEECCC
DESLKKEVAAAGERTGERVWELPLWKEYHELIKSDIADYKNTGGRFGGAITAAAFLSKFI
CHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GDYPWVHLDIAGPSWLDKDRSYVPKGASGIGVRLLISWLRTRLVNA
CCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA