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The map label for this gene is mmgC [H]

Identifier: 85375698

GI number: 85375698

Start: 2886002

End: 2887288

Strand: Direct

Name: mmgC [H]

Synonym: ELI_14355

Alternate gene names: 85375698

Gene position: 2886002-2887288 (Clockwise)

Preceding gene: 85375697

Following gene: 85375699

Centisome position: 94.55

GC content: 62.94

Gene sequence:

>1287_bases
ATGGATTTCACCATCCCGCAGGAGCTCGAGGATTATTACGCCGAGCTCGAAAAGTTCATCGAGGACGAGATCATCCCGCT
CGAACAGCAGGACGACAATATCCGCTTCTTCGATCACCGCCGCGAATGGGCGCGGACCGATTTCGAGGCAGGAGGACTTC
CGCGCGAGGAATGGGAAGCGCTGCTGGTCGAGGCCAAGCGCCGCGCCGACAAGGCCGGGCACTGGCGCTTCTCCGCGCCC
AAGAAGTATGGCGGCAAGGATGGCTCCAACCTGTGGATGGCGGTGATCCGCGACCGCTTCGCGCAGCGCGGGCTGGGGCT
GCATAACGATTTGCAGAACGAGCACAGCATCGTCGGCAATTTCCCCTTCGTCGAAATGTACGAGCAATGGGGCACCGAGG
AGCAGAAGCAGGAATTCATCCTCGGCGGTTTCGAAGGCACCCGCCGGGTCGCCTTCGGCCTGACCGAACCCGATCACGGC
AGCGACGCTACCCACATGGAAACCCGCGCCGTGCGCGAGACGCGCGATGGGGTCGATGGGTGGCTCATCAACGGCGAGAA
GATGTGGATCACCGGCATGCATGTCGCCACGCATTGCGCGATGTTCTGCCGCACCGATGGCGAGGATGGCGATGCGCGCG
GGATCACGTGCCTGCTCGTGCCCAACCCCACCGAAGGGCTGGAGATCGAGGAGTGGATGTGGACCTTCAACATGCCCACC
GATCACCCGCGCCTCAGCGTGAAGGATGTTTGGGTGCCCGAAAGCGCCATGCTGGGCCGTGAGGGTCTCGGCCTCGCGCT
GGCGCAAAGCTTCGTGCACCAGAACCGCATCCGGCAGGCGGCGAGTTCGCTGGGCGCGGCGCAATTCTGCGTCGAGGAAA
GCGTCAAATACGCCCGCGAGCGCAAGCCGTTCGGTGAAGAGCTGGCGAAGAACCAGGCGATCCAGTTTCCGCTGGTCGAG
CTGGCGACGCAATGCGAGATGCTGCGCCTGCTGATCTACAAGACCGCTTGGGAGATGGACAACATGCCGCACGCGGAAAT
CGAGAAGACGATCTCCGACAAGGTCAGCATGTGCAATTACTGGGCGAACCGGCTGGTGTGCCAGGCCGCCGACCGGGCGA
TGCAGGTGCATGGCGGGATCGGCTATTCGCGGCACAAACCGTTCGAGCACATCTATCGCCACCACCGCCGCTATCGCATC
ACCGAAGGCGCGGAAGAGATCCAGATGCGCAAGGTCGCGGCCTATCTGTTCGGCTATCTGGGGCCAAGGAAGGGCGAGTT
CGACTAG

Upstream 100 bases:

>100_bases
CGGCAAGCCGCGCTGGAAGTGATTACCGTCAATTCGCCGAAATATCCGGCCCTTGCCGAGGCGCTGGAAAAATGGACCCT
GCCGAGAGAGGACTAAGCCC

Downstream 100 bases:

>100_bases
TCTTTGGTGGAACGCGGTGCGATGCAGGTCGAGCAAGCACTTGATCCGATGCGGTATCTCGGGCCACAATCGGACCGGAT
AAAGAATCGGGACGCACCTA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDFTIPQELEDYYAELEKFIEDEIIPLEQQDDNIRFFDHRREWARTDFEAGGLPREEWEALLVEAKRRADKAGHWRFSAP
KKYGGKDGSNLWMAVIRDRFAQRGLGLHNDLQNEHSIVGNFPFVEMYEQWGTEEQKQEFILGGFEGTRRVAFGLTEPDHG
SDATHMETRAVRETRDGVDGWLINGEKMWITGMHVATHCAMFCRTDGEDGDARGITCLLVPNPTEGLEIEEWMWTFNMPT
DHPRLSVKDVWVPESAMLGREGLGLALAQSFVHQNRIRQAASSLGAAQFCVEESVKYARERKPFGEELAKNQAIQFPLVE
LATQCEMLRLLIYKTAWEMDNMPHAEIEKTISDKVSMCNYWANRLVCQAADRAMQVHGGIGYSRHKPFEHIYRHHRRYRI
TEGAEEIQMRKVAAYLFGYLGPRKGEFD

Sequences:

>Translated_428_residues
MDFTIPQELEDYYAELEKFIEDEIIPLEQQDDNIRFFDHRREWARTDFEAGGLPREEWEALLVEAKRRADKAGHWRFSAP
KKYGGKDGSNLWMAVIRDRFAQRGLGLHNDLQNEHSIVGNFPFVEMYEQWGTEEQKQEFILGGFEGTRRVAFGLTEPDHG
SDATHMETRAVRETRDGVDGWLINGEKMWITGMHVATHCAMFCRTDGEDGDARGITCLLVPNPTEGLEIEEWMWTFNMPT
DHPRLSVKDVWVPESAMLGREGLGLALAQSFVHQNRIRQAASSLGAAQFCVEESVKYARERKPFGEELAKNQAIQFPLVE
LATQCEMLRLLIYKTAWEMDNMPHAEIEKTISDKVSMCNYWANRLVCQAADRAMQVHGGIGYSRHKPFEHIYRHHRRYRI
TEGAEEIQMRKVAAYLFGYLGPRKGEFD
>Mature_428_residues
MDFTIPQELEDYYAELEKFIEDEIIPLEQQDDNIRFFDHRREWARTDFEAGGLPREEWEALLVEAKRRADKAGHWRFSAP
KKYGGKDGSNLWMAVIRDRFAQRGLGLHNDLQNEHSIVGNFPFVEMYEQWGTEEQKQEFILGGFEGTRRVAFGLTEPDHG
SDATHMETRAVRETRDGVDGWLINGEKMWITGMHVATHCAMFCRTDGEDGDARGITCLLVPNPTEGLEIEEWMWTFNMPT
DHPRLSVKDVWVPESAMLGREGLGLALAQSFVHQNRIRQAASSLGAAQFCVEESVKYARERKPFGEELAKNQAIQFPLVE
LATQCEMLRLLIYKTAWEMDNMPHAEIEKTISDKVSMCNYWANRLVCQAADRAMQVHGGIGYSRHKPFEHIYRHHRRYRI
TEGAEEIQMRKVAAYLFGYLGPRKGEFD

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=400, Percent_Identity=29.25, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4501859, Length=339, Percent_Identity=30.0884955752212, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI187960098, Length=419, Percent_Identity=27.9236276849642, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557231, Length=420, Percent_Identity=28.0952380952381, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7656849, Length=353, Percent_Identity=28.328611898017, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4501857, Length=414, Percent_Identity=27.0531400966184, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI21361497, Length=425, Percent_Identity=25.6470588235294, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI38505218, Length=300, Percent_Identity=27.3333333333333, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI211971008, Length=296, Percent_Identity=26.6891891891892, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI48976061, Length=296, Percent_Identity=26.6891891891892, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226958412, Length=395, Percent_Identity=23.5443037974684, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=24.5562130177515, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI76496475, Length=415, Percent_Identity=24.8192771084337, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4557235, Length=415, Percent_Identity=24.8192771084337, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI7669494, Length=200, Percent_Identity=33, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4503943, Length=200, Percent_Identity=33, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786223, Length=370, Percent_Identity=25.9459459459459, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081958, Length=410, Percent_Identity=23.9024390243902, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87081702, Length=255, Percent_Identity=25.8823529411765, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=409, Percent_Identity=30.0733496332518, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17534899, Length=420, Percent_Identity=30.4761904761905, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=430, Percent_Identity=25.8139534883721, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17533517, Length=353, Percent_Identity=28.6118980169972, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508101, Length=338, Percent_Identity=28.9940828402367, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17506239, Length=347, Percent_Identity=28.2420749279539, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985184, Length=284, Percent_Identity=29.2253521126761, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17505929, Length=289, Percent_Identity=29.0657439446367, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17551932, Length=285, Percent_Identity=28.0701754385965, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71990804, Length=268, Percent_Identity=29.4776119402985, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=416, Percent_Identity=25.4807692307692, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17538396, Length=354, Percent_Identity=25.4237288135593, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32563615, Length=244, Percent_Identity=30.7377049180328, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71985192, Length=242, Percent_Identity=26.4462809917355, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982178, Length=228, Percent_Identity=28.0701754385965, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=209, Percent_Identity=28.2296650717703, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646207, Length=304, Percent_Identity=33.8815789473684, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24660351, Length=400, Percent_Identity=30.25, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24666513, Length=316, Percent_Identity=31.3291139240506, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21356377, Length=301, Percent_Identity=29.2358803986711, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21355753, Length=392, Percent_Identity=24.4897959183673, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281363737, Length=427, Percent_Identity=25.7611241217799, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19920834, Length=215, Percent_Identity=34.4186046511628, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 49455; Mature: 49455

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTIPQELEDYYAELEKFIEDEIIPLEQQDDNIRFFDHRREWARTDFEAGGLPREEWEA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHH
LLVEAKRRADKAGHWRFSAPKKYGGKDGSNLWMAVIRDRFAQRGLGLHNDLQNEHSIVGN
HHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCEECC
FPFVEMYEQWGTEEQKQEFILGGFEGTRRVAFGLTEPDHGSDATHMETRAVRETRDGVDG
CCHHHHHHHHCCHHHHHHHEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCE
WLINGEKMWITGMHVATHCAMFCRTDGEDGDARGITCLLVPNPTEGLEIEEWMWTFNMPT
EEECCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHEEEECCCC
DHPRLSVKDVWVPESAMLGREGLGLALAQSFVHQNRIRQAASSLGAAQFCVEESVKYARE
CCCCCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKPFGEELAKNQAIQFPLVELATQCEMLRLLIYKTAWEMDNMPHAEIEKTISDKVSMCNY
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
WANRLVCQAADRAMQVHGGIGYSRHKPFEHIYRHHRRYRITEGAEEIQMRKVAAYLFGYL
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHC
GPRKGEFD
CCCCCCCC
>Mature Secondary Structure
MDFTIPQELEDYYAELEKFIEDEIIPLEQQDDNIRFFDHRREWARTDFEAGGLPREEWEA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHH
LLVEAKRRADKAGHWRFSAPKKYGGKDGSNLWMAVIRDRFAQRGLGLHNDLQNEHSIVGN
HHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCEECC
FPFVEMYEQWGTEEQKQEFILGGFEGTRRVAFGLTEPDHGSDATHMETRAVRETRDGVDG
CCHHHHHHHHCCHHHHHHHEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCE
WLINGEKMWITGMHVATHCAMFCRTDGEDGDARGITCLLVPNPTEGLEIEEWMWTFNMPT
EEECCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHEEEECCCC
DHPRLSVKDVWVPESAMLGREGLGLALAQSFVHQNRIRQAASSLGAAQFCVEESVKYARE
CCCCCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKPFGEELAKNQAIQFPLVELATQCEMLRLLIYKTAWEMDNMPHAEIEKTISDKVSMCNY
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
WANRLVCQAADRAMQVHGGIGYSRHKPFEHIYRHHRRYRITEGAEEIQMRKVAAYLFGYL
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHC
GPRKGEFD
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]