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The map label for this gene is apt

Identifier: 85375557

GI number: 85375557

Start: 2750528

End: 2751064

Strand: Direct

Name: apt

Synonym: ELI_13650

Alternate gene names: 85375557

Gene position: 2750528-2751064 (Clockwise)

Preceding gene: 85375556

Following gene: 85375558

Centisome position: 90.11

GC content: 67.04

Gene sequence:

>537_bases
ATGACGGTCGAGGAACTGAAGGCGCTGATCCGGACCGTGCCGGACTTTCCCGCGCCCGGTATCCAGTTCCGCGACATCAC
GACCCTGCTGGCACATGGCGAAGGCCTCGCTGCGACCATGCGGCACCTGGGCGAGGCCGCGCGTCTGGCCGGGGCGGAAG
CGATCGCCGGCATGGAGGCGCGTGGTTTCATCTTCGGTGCCGGCGTGGCGGTCGAACTCGGTCTTGGTTTCCTGCCGATC
CGCAAGCCGGGCAAACTGCCGGCCAGCACGATCGGTGTCGATTACGATCTCGAATACGGCACCGACCGGCTGGAGATCGA
TCCCGGCGCTGTCGAGGCGGGCCAGAAGGTCGTCATCGTCGACGATCTCATCGCCACCGGAGGCACGGCACTGGCGGCAG
CGAAGCTGTTGCGGCAGGCGGGAGCGGAGGTCGGGCAGGCGCTTTTCGTGATCGACCTCCCGGAACTCGGCGGAGCGCAG
CGCCTGCGCGACACGGGCATCACGGTCGATTCGCTGATGGCTTTTGACGGGCATTGA

Upstream 100 bases:

>100_bases
CGAAGAAGGCCAAATAGGCCGACTTTCGCGCAGCAACGCAATTGACAGCGCCCCTCCATCCCTGTGATGCGAGGGGCGCT
TTGCATTCGAGGGGGCGGAA

Downstream 100 bases:

>100_bases
TGGCGCGCGATTGAAAATTCGCGGAAAGATTCGCGTTTTCGCCCATTGTGCTACTGACGCGGCAGGGAGGAATCGCTTTT
AGCATGGAATCGCAGGCACT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MTVEELKALIRTVPDFPAPGIQFRDITTLLAHGEGLAATMRHLGEAARLAGAEAIAGMEARGFIFGAGVAVELGLGFLPI
RKPGKLPASTIGVDYDLEYGTDRLEIDPGAVEAGQKVVIVDDLIATGGTALAAAKLLRQAGAEVGQALFVIDLPELGGAQ
RLRDTGITVDSLMAFDGH

Sequences:

>Translated_178_residues
MTVEELKALIRTVPDFPAPGIQFRDITTLLAHGEGLAATMRHLGEAARLAGAEAIAGMEARGFIFGAGVAVELGLGFLPI
RKPGKLPASTIGVDYDLEYGTDRLEIDPGAVEAGQKVVIVDDLIATGGTALAAAKLLRQAGAEVGQALFVIDLPELGGAQ
RLRDTGITVDSLMAFDGH
>Mature_177_residues
TVEELKALIRTVPDFPAPGIQFRDITTLLAHGEGLAATMRHLGEAARLAGAEAIAGMEARGFIFGAGVAVELGLGFLPIR
KPGKLPASTIGVDYDLEYGTDRLEIDPGAVEAGQKVVIVDDLIATGGTALAAAKLLRQAGAEVGQALFVIDLPELGGAQR
LRDTGITVDSLMAFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=157, Percent_Identity=47.1337579617834, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI71773201, Length=122, Percent_Identity=50, Blast_Score=112, Evalue=2e-25,
Organism=Escherichia coli, GI1786675, Length=176, Percent_Identity=53.4090909090909, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=175, Percent_Identity=42.8571428571429, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=40, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=163, Percent_Identity=38.0368098159509, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=43.4782608695652, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_ERYLH (Q2N669)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459619.1
- HSSP:   P07741
- ProteinModelPortal:   Q2N669
- SMR:   Q2N669
- STRING:   Q2N669
- GeneID:   3870430
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_13650
- NMPDR:   fig|314225.3.peg.288
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q2N669
- ProtClustDB:   PRK02304
- BioCyc:   ELIT314225:ELI_13650-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18474; Mature: 18342

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEELKALIRTVPDFPAPGIQFRDITTLLAHGEGLAATMRHLGEAARLAGAEAIAGMEA
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RGFIFGAGVAVELGLGFLPIRKPGKLPASTIGVDYDLEYGTDRLEIDPGAVEAGQKVVIV
CCEEEECCEEEEECCCEEECCCCCCCCHHHCCCEEECCCCCCEEEECCCCCCCCCEEEEE
DDLIATGGTALAAAKLLRQAGAEVGQALFVIDLPELGGAQRLRDTGITVDSLMAFDGH
ECHHHCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure 
TVEELKALIRTVPDFPAPGIQFRDITTLLAHGEGLAATMRHLGEAARLAGAEAIAGMEA
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RGFIFGAGVAVELGLGFLPIRKPGKLPASTIGVDYDLEYGTDRLEIDPGAVEAGQKVVIV
CCEEEECCEEEEECCCEEECCCCCCCCHHHCCCEEECCCCCCEEEECCCCCCCCCEEEEE
DDLIATGGTALAAAKLLRQAGAEVGQALFVIDLPELGGAQRLRDTGITVDSLMAFDGH
ECHHHCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA