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The map label for this gene is aes [C]

Identifier: 85374952

GI number: 85374952

Start: 2152669

End: 2153538

Strand: Reverse

Name: aes [C]

Synonym: ELI_10625

Alternate gene names: 85374952

Gene position: 2153538-2152669 (Counterclockwise)

Preceding gene: 85374953

Following gene: 85374951

Centisome position: 70.55

GC content: 67.7

Gene sequence:

>870_bases
ATGAACCGGCAAGCCATCGGCAGTGTGTTTGCTTTAGCGCTCCTGCTCGGCACGGGTGCAGCCTGTTCGCCGCTCAAGAC
CTTCAACGCCATCATCCCCAAGGATGGCGCTTCGAGCCAGACAGCCAAGGCGGTCGCCTATGGCACCGACGAGCGGCAAA
GGCTCGATATCTTCACGCCCGACGCTCCGCTTGCCGCGGGCGAGGCCCGCCCCGTGGTGGTGTTCTTCTACGGCGGCAGC
TGGAACAGCGGCACGCGCACCGGGTATGACTTTGTCGGGCGGGCGCTGGCGGCGCGGGGCTATGTCACGCTGGTGCCCGA
TTACCGGCTGGTGCCGGATGTGCGCTACCCCGCCTTCGTCGAAGACGGCGCGGCCGCGGTGCGCTGGGCGCGCGAGAATG
CGGCGCAATATGGCGGTGATGCGGACCGGATCGTCCTCGTCGGCCATTCCGCCGGGGCCTACATCGCTGCCATGCTGGCG
CTCGACGAGCGCTGGCTCGGGCCGGATCGCGCGGCGGTAAGAGGCTGGGCAGGGCTGGCAGGGCCATACGATTTCGCGCC
GTTCGACGGTGAGGTCACGCGCGCAGCCTTCGGCAACTGGCCCGATCCCGCCGAGACCCAGCCGATCACCTGGGCGGGCG
CGGGCGACCCGTCGACGCTGCTGCTGACCGGCGGTGACGATACCACGGTGGAACCGCGCAATAGCTACGAGCTGGCGCAG
AAACTGCGCGCGAGCGGGGTGCCAGCGCAAGTGAAGGTTTATGACGGCGTCGGCCATATCGGTATCGTCACATCCATCGC
CAAGCCGCTGCGCGGCAATTCTCCTGCGCTGGACGATATCGCGACGTTTGTCGAAACGGTCGCCCGGTGA

Upstream 100 bases:

>100_bases
CGCGCAAACATCCCGCCGCCTTCCCCGAACTCCACATCACCAGCAGTGAAAAGGGTCTCGGCATTGCCGCCCTGCGCGCC
GCCGTGGTGGCGGATGCTTC

Downstream 100 bases:

>100_bases
TCCGTTCAGGCTCGACACTCACAGGCTGAACGCCTAACGCCGCGACACAATGCAGAGTTCGGCAAGGTGGAGCCACGCAT
GAAACTGATTATCGGCAACA

Product: carboxylesterase family protein

Products: alcohol; a carboxylate [C]

Alternate protein names: Alpha/Beta Hydrolase Fold-3 Domain Protein; Lipase; Alpha/Beta Hydrolase Domain-Containing Protein; Esterase; Carboxylesterase Family Protein; Carboxylesterase; Esterase/Lipase; Esterase/Lipase/Thioesterase; Lipase/Esterase; Alpha/Beta Hydrolase; Hydrolase; Lipase Active Site; Alpha/Beta Hydrolase Fold-3 Domain-Containing Protein; Pectinesterase; Alpha/Beta Hydrolase Fold; Carboxylesterase Type B; Alpha/Beta Hydrolase Family Protein; Conserved Domain Protein; Aylformamidase; Esterase/Lipase-Like Protein; Alpha/Beta Hydrolase Protein; Para-Nitrobenzyl Esterase

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNRQAIGSVFALALLLGTGAACSPLKTFNAIIPKDGASSQTAKAVAYGTDERQRLDIFTPDAPLAAGEARPVVVFFYGGS
WNSGTRTGYDFVGRALAARGYVTLVPDYRLVPDVRYPAFVEDGAAAVRWARENAAQYGGDADRIVLVGHSAGAYIAAMLA
LDERWLGPDRAAVRGWAGLAGPYDFAPFDGEVTRAAFGNWPDPAETQPITWAGAGDPSTLLLTGGDDTTVEPRNSYELAQ
KLRASGVPAQVKVYDGVGHIGIVTSIAKPLRGNSPALDDIATFVETVAR

Sequences:

>Translated_289_residues
MNRQAIGSVFALALLLGTGAACSPLKTFNAIIPKDGASSQTAKAVAYGTDERQRLDIFTPDAPLAAGEARPVVVFFYGGS
WNSGTRTGYDFVGRALAARGYVTLVPDYRLVPDVRYPAFVEDGAAAVRWARENAAQYGGDADRIVLVGHSAGAYIAAMLA
LDERWLGPDRAAVRGWAGLAGPYDFAPFDGEVTRAAFGNWPDPAETQPITWAGAGDPSTLLLTGGDDTTVEPRNSYELAQ
KLRASGVPAQVKVYDGVGHIGIVTSIAKPLRGNSPALDDIATFVETVAR
>Mature_289_residues
MNRQAIGSVFALALLLGTGAACSPLKTFNAIIPKDGASSQTAKAVAYGTDERQRLDIFTPDAPLAAGEARPVVVFFYGGS
WNSGTRTGYDFVGRALAARGYVTLVPDYRLVPDVRYPAFVEDGAAAVRWARENAAQYGGDADRIVLVGHSAGAYIAAMLA
LDERWLGPDRAAVRGWAGLAGPYDFAPFDGEVTRAAFGNWPDPAETQPITWAGAGDPSTLLLTGGDDTTVEPRNSYELAQ
KLRASGVPAQVKVYDGVGHIGIVTSIAKPLRGNSPALDDIATFVETVAR

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI192807282, Length=254, Percent_Identity=26.3779527559055, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI224465228, Length=259, Percent_Identity=25.8687258687259, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.1.- [C]

Molecular weight: Translated: 30475; Mature: 30475

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRQAIGSVFALALLLGTGAACSPLKTFNAIIPKDGASSQTAKAVAYGTDERQRLDIFTP
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEECC
DAPLAAGEARPVVVFFYGGSWNSGTRTGYDFVGRALAARGYVTLVPDYRLVPDVRYPAFV
CCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCEECCCCCCCCEE
EDGAAAVRWARENAAQYGGDADRIVLVGHSAGAYIAAMLALDERWLGPDRAAVRGWAGLA
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
GPYDFAPFDGEVTRAAFGNWPDPAETQPITWAGAGDPSTLLLTGGDDTTVEPRNSYELAQ
CCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCHHHHHH
KLRASGVPAQVKVYDGVGHIGIVTSIAKPLRGNSPALDDIATFVETVAR
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNRQAIGSVFALALLLGTGAACSPLKTFNAIIPKDGASSQTAKAVAYGTDERQRLDIFTP
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEECC
DAPLAAGEARPVVVFFYGGSWNSGTRTGYDFVGRALAARGYVTLVPDYRLVPDVRYPAFV
CCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCEECCCCCCCCEE
EDGAAAVRWARENAAQYGGDADRIVLVGHSAGAYIAAMLALDERWLGPDRAAVRGWAGLA
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
GPYDFAPFDGEVTRAAFGNWPDPAETQPITWAGAGDPSTLLLTGGDDTTVEPRNSYELAQ
CCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCHHHHHH
KLRASGVPAQVKVYDGVGHIGIVTSIAKPLRGNSPALDDIATFVETVAR
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA